Aida Habtezion

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint Leukocyte Trafficking to the Small Intestine and Colon
    Aida Habtezion
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California Electronic address
    Gastroenterology 150:340-54. 2016
  2. pmc Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon
    Aida Habtezion
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 108:1445-50. 2011
  3. pmc Panhematin provides a therapeutic benefit in experimental pancreatitis
    Aida Habtezion
    University of Michigan Medical School, Department of Molecular and Integrative Physiology, Ann Arbor, Michigan, USA
    Gut 60:671-9. 2011
  4. pmc Heme oxygenase-1 is induced in peripheral blood mononuclear cells of patients with acute pancreatitis: a potential therapeutic target
    Aida Habtezion
    Stanford Univ School of Medicine, Dept of Medicine, Division of Gastroenterology and Hepatology, 300 Pasteur Dr, Stanford, CA 94305, USA
    Am J Physiol Gastrointest Liver Physiol 300:G12-20. 2011
  5. pmc CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease
    Husein Hadeiba
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 9:1253-60. 2008
  6. pmc Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance
    Husein Hadeiba
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 36:438-50. 2012
  7. ncbi request reprint CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium
    Tracy L Staton
    Program in Immunology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 7:482-8. 2006
  8. pmc Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis
    Guo Zhong Tao
    Department of Surgery, Stanford University, Palo Alto, CA 94305, USA
    J Cell Sci 122:3851-5. 2009
  9. pmc Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis
    Jing Xue
    Stanford University School of Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Stanford, California, USA
    Gastroenterology 143:1670-80. 2012
  10. ncbi request reprint DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27
    Hekla Sigmundsdottir
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 8:285-93. 2007

Collaborators

Detail Information

Publications19

  1. doi request reprint Leukocyte Trafficking to the Small Intestine and Colon
    Aida Habtezion
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California Electronic address
    Gastroenterology 150:340-54. 2016
    ..We review the mechanisms for innate and adaptive leukocyte localization to the intestinal tract and GALT, and discuss their relevance to human intestinal homeostasis and inflammation. ..
  2. pmc Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon
    Aida Habtezion
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 108:1445-50. 2011
    ..Therefore, unlike the proapoptotic effect of K8 mutation or absence in hepatocytes, lack of K8 confers resistance to colonocyte apoptosis in a microflora-dependent manner...
  3. pmc Panhematin provides a therapeutic benefit in experimental pancreatitis
    Aida Habtezion
    University of Michigan Medical School, Department of Molecular and Integrative Physiology, Ann Arbor, Michigan, USA
    Gut 60:671-9. 2011
    ..In this study, we tested the utility of Panhematin, a water-soluble haemin formulation, in activating and inducing pancreatic HO-1, and as a therapeutic agent in treating mouse acute pancreatitis...
  4. pmc Heme oxygenase-1 is induced in peripheral blood mononuclear cells of patients with acute pancreatitis: a potential therapeutic target
    Aida Habtezion
    Stanford Univ School of Medicine, Dept of Medicine, Division of Gastroenterology and Hepatology, 300 Pasteur Dr, Stanford, CA 94305, USA
    Am J Physiol Gastrointest Liver Physiol 300:G12-20. 2011
    ..Leukocytes from AP patients or mice with AP are primed for HO-1 induction by Panhematin, which suggests that Panhematin could offer a therapeutic benefit...
  5. pmc CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease
    Husein Hadeiba
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 9:1253-60. 2008
    ..Our results identify a highly immunosuppressive population of pDCs present in lymphoid tissues...
  6. pmc Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance
    Husein Hadeiba
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 36:438-50. 2012
    ..Thus, peripheral pDCs can contribute to immune tolerance through CCR9-dependent transport of peripheral Ags and subsequent deletion of Ag-reactive thymocytes...
  7. ncbi request reprint CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium
    Tracy L Staton
    Program in Immunology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 7:482-8. 2006
    ..These studies challenge the present understanding of naive alphabeta T cell trafficking and suggest that RTEs may be involved in maintaining a diverse immune repertoire at mucosal surfaces...
  8. pmc Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis
    Guo Zhong Tao
    Department of Surgery, Stanford University, Palo Alto, CA 94305, USA
    J Cell Sci 122:3851-5. 2009
    ..The effects of keratin mutation on mitochondria are likely to contribute to hepatocyte predisposition to apoptosis and oxidative injury, and to play a pathogenic role in keratin-mutation-related human liver disease...
  9. pmc Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis
    Jing Xue
    Stanford University School of Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Stanford, California, USA
    Gastroenterology 143:1670-80. 2012
    ..We investigated sources and role of IL-22 in the pancreas, along with the effects of AhR activation on IL-22 expression and AP progression in mice...
  10. ncbi request reprint DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27
    Hekla Sigmundsdottir
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 8:285-93. 2007
    ..Our findings support a model in which dendritic cells process and 'interpret' locally produced metabolites to 'program' T cell homing and microenvironmental positioning...
  11. doi request reprint Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice
    Diana M Toivola
    Department of Science and Engineering, Department of Biosciences, and Department of Cell Biology, Abo Akademi University, Turku, Finland Division of Gastroenterology and Hepatology, Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, California, USA Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA and Veterans Affairs Ann Arbor Health Care System, Ann Arbor, Michigan, USA
    FASEB J 29:5081-9. 2015
    ..Toivola, D. M., Habtezion, A., Misiorek, J. O., Zhang, L., Nyström, J. H., Sharpe, O., Robinson, W. H., Kwan, R., Omary, M. B. Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice. ..
  12. pmc Role and species-specific expression of colon T cell homing receptor GPR15 in colitis
    Linh P Nguyen
    1 Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA 2 The Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System and The Palo Alto Veterans Institute for Research, Palo Alto, California, USA
    Nat Immunol 16:207-13. 2015
    ..Our results highlight species differences in GPR15 regulation and suggest it as a potential therapeutic target for colitis. ..
  13. doi request reprint Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis
    Jing Xue
    Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Commun 6:7158. 2015
    ..Our study challenges and identifies pathways involved in crosstalk between macrophages and PSCs that can be targeted to reverse or halt pancreatic fibrosis progression. ..
  14. pmc Protective role of hemeoxygenase-1 in gastrointestinal diseases
    Marisol Chang
    Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA
    Cell Mol Life Sci 72:1161-73. 2015
    ..Cytoprotective, anti-inflammatory, anti-proliferative, antioxidant, and anti-apoptotic activities of HO-1 make it a promising if not ideal therapeutic target for inflammatory diseases of the gastrointestinal system. ..
  15. pmc A Thermo-Sensitive Delivery Platform for Topical Administration of Inflammatory Bowel Disease Therapies
    Sidhartha R Sinha
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California Electronic address
    Gastroenterology 149:52-55.e2. 2015
    ..Image analysis showed that enemas delivered with and without the platform reached similar distances in the colons of mice, but greater colonic retention was achieved by using the platform. ..
  16. doi request reprint Immune cells and immune-based therapy in pancreatitis
    Jing Xue
    Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA
    Immunol Res 58:378-86. 2014
    ..Differences between experimental and clinical pancreatitis need consideration, and when therapies are tested, models with established disease ought to be included...
  17. ncbi request reprint Short-term homing assay reveals a critical role for lymphocyte function-associated antigen-1 in the hepatic recruitment of lymphocytes in graft-versus-host disease
    Tohru Sato
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, and the Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    J Hepatol 44:1132-40. 2006
    ..Although adhesive mechanisms have been implicated in the biology of GvHD hepatitis, the identity of homing receptors involved in the initial recruitment of cells from the blood is not known...
  18. pmc Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction
    Ikuo Nakamichi
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California, USA
    J Clin Invest 115:3007-14. 2005
    ..Therefore, hemin-like compounds or hemin-activated macrophages may offer novel therapeutic approaches for preventing acute pancreatitis and its pulmonary complication via upregulation of HO-1...
  19. ncbi request reprint Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment
    Aida Habtezion
    Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
    J Cell Sci 118:1971-80. 2005
    ..These mice provide a model to investigate epithelial-leukocyte and epithelial-microbial cross-talk...