Genomes and Genes
Affiliation: Stanford University
- Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colonAida Habtezion
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 108:1445-50. 2011..Therefore, unlike the proapoptotic effect of K8 mutation or absence in hepatocytes, lack of K8 confers resistance to colonocyte apoptosis in a microflora-dependent manner...
- Panhematin provides a therapeutic benefit in experimental pancreatitisAida Habtezion
University of Michigan Medical School, Department of Molecular and Integrative Physiology, Ann Arbor, Michigan, USA
Gut 60:671-9. 2011..In this study, we tested the utility of Panhematin, a water-soluble haemin formulation, in activating and inducing pancreatic HO-1, and as a therapeutic agent in treating mouse acute pancreatitis...
- Heme oxygenase-1 is induced in peripheral blood mononuclear cells of patients with acute pancreatitis: a potential therapeutic targetAida Habtezion
Stanford Univ School of Medicine, Dept of Medicine, Division of Gastroenterology and Hepatology, 300 Pasteur Dr, Stanford, CA 94305, USA
Am J Physiol Gastrointest Liver Physiol 300:G12-20. 2011..Leukocytes from AP patients or mice with AP are primed for HO-1 induction by Panhematin, which suggests that Panhematin could offer a therapeutic benefit...
- CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host diseaseHusein Hadeiba
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 9:1253-60. 2008..Our results identify a highly immunosuppressive population of pDCs present in lymphoid tissues...
- Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central toleranceHusein Hadeiba
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 36:438-50. 2012..Thus, peripheral pDCs can contribute to immune tolerance through CCR9-dependent transport of peripheral Ags and subsequent deletion of Ag-reactive thymocytes...
- CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epitheliumTracy L Staton
Program in Immunology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 7:482-8. 2006..These studies challenge the present understanding of naive alphabeta T cell trafficking and suggest that RTEs may be involved in maintaining a diverse immune repertoire at mucosal surfaces...
- Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosisGuo Zhong Tao
Department of Surgery, Stanford University, Palo Alto, CA 94305, USA
J Cell Sci 122:3851-5. 2009..The effects of keratin mutation on mitochondria are likely to contribute to hepatocyte predisposition to apoptosis and oxidative injury, and to play a pathogenic role in keratin-mutation-related human liver disease...
- Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitisJing Xue
Stanford University School of Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Stanford, California, USA
Gastroenterology 143:1670-80. 2012..We investigated sources and role of IL-22 in the pancreas, along with the effects of AhR activation on IL-22 expression and AP progression in mice...
- DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27Hekla Sigmundsdottir
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 8:285-93. 2007..Our findings support a model in which dendritic cells process and 'interpret' locally produced metabolites to 'program' T cell homing and microenvironmental positioning...
- Short-term homing assay reveals a critical role for lymphocyte function-associated antigen-1 in the hepatic recruitment of lymphocytes in graft-versus-host diseaseTohru Sato
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, and the Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
J Hepatol 44:1132-40. 2006..Although adhesive mechanisms have been implicated in the biology of GvHD hepatitis, the identity of homing receptors involved in the initial recruitment of cells from the blood is not known...
- Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 inductionIkuo Nakamichi
Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California, USA
J Clin Invest 115:3007-14. 2005..Therefore, hemin-like compounds or hemin-activated macrophages may offer novel therapeutic approaches for preventing acute pancreatitis and its pulmonary complication via upregulation of HO-1...
- Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatmentAida Habtezion
Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
J Cell Sci 118:1971-80. 2005..These mice provide a model to investigate epithelial-leukocyte and epithelial-microbial cross-talk...
- Lymphocyte Homing Mechanisms in Normal & Inflamed ColonAida Habtezion; Fiscal Year: 2007..The proposed study should improve our understanding of immune cell trafficking to the colon, offer insights into possible IBD pathogenic mechanisms, and potentially unfold new therapeutic targets to consider for IBD ..