Research Topics
| C GuilleminaultSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Orthodontic expansion treatment and adenotonsillectomy in the treatment of obstructive sleep apnea in prepubertal childrenChristian Guilleminault
Stanford University Sleep Medicine Program, Stanford, CA, USA
Sleep 31:953-7. 2008..In addition, if both therapies are required, the order in which to perform these interventions needs to be determined...
Apparent life-threatening events, facial dysmorphia and sleep-disordered breathingC Guilleminault
Stanford University Sleep Disorders Center, CA 94305, USA
Eur J Pediatr 159:444-9. 2000..This mild facial dysmorphia needs to be recognized early to distinguish these infants from other infants with apparent life-threatening events and to initiate appropriate treatment...
Preliminary observations on the effects of sleep time in a sleep restriction paradigmChristian Guilleminault
Stanford University Sleep Disorders Clinic, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA
Sleep Med 4:177-84. 2003..To evaluate of the effect of 7 days of sleep restriction--with sleep placed at the beginning of night or early morning hours - on sleep variables, maintenance of wakefulness test, and serum leptin...
Atypical sexual behavior during sleepChristian Guilleminault
Sleep Disorders Center, Stanford University, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA
Psychosom Med 64:328-36. 2002..This article reports a case series of atypical sexual behavior during sleep, which is often harmful to patients or bed partners...
Sleep and wakefulness in somnambulism: a spectral analysis studyC Guilleminault
Stanford Sleep Disorders Clinic and Research Center, Stanford University, Suite 3301, 401 Quarry Road, Stanford, CA 94605, USA
J Psychosom Res 51:411-6. 2001..The sleep structure and the dynamics of EEG slow-wave activity (SWA) were investigated in 12 young adults and age- and gender-matched controls...
Non-REM-sleep instability in recurrent sleepwalking in pre-pubertal childrenChristian Guilleminault
Stanford University Sleep Disorders Clinic, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA
Sleep Med 6:515-21. 2005..We questioned whether or not the sleep of pre-pubertal children with recurrent sleepwalking was different from that recorded in normal children...
Heart rate variability, sympathetic and vagal balance and EEG arousals in upper airway resistance and mild obstructive sleep apnea syndromesChristian Guilleminault
Stanford Sleep Disorders Center, Stanford University, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA
Sleep Med 6:451-7. 2005....
Sleepwalking and sleep terrors in prepubertal children: what triggers them?Christian Guilleminault
Stanford University Sleep Disorders Clinic, Stanford, California 94305, USA
Pediatrics 111:e17-25. 2003..To evaluate the clinical presentation and polysomnography of prepubertal children with repetitive sleep terrors and sleepwalking, to compare them with a control group, and to evaluate the treatment of associated sleep disorders...
Sleep-disordered breathing and hypotensionC Guilleminault
Stanford University Sleep Disorders Center, Stanford University, Stanford, California 94403, USA
Am J Respir Crit Care Med 164:1242-7. 2001..4 +/- 1.1 mm Hg) (p < 0.01). We conclude that approximately one fifth of subjects with UARS have low BP and complain of OI. Tilt-table testing may be indicated to confirm orthostatic intolerance in subjects with UARS...
Sleep-disordered breathing. A view at the beginning of the new MillenniumC Guilleminault
Stanford Sleep Disorders Clinic and Research Center, Stanford, California, USA
Dent Clin North Am 45:643-56. 2001..These measures in conjunction with other simultaneous, noninvasive modalities may prove to be effective...
Chronic insomnia, premenopausal women and sleep disordered breathing: part 2. Comparison of nondrug treatment trials in normal breathing and UARS post menopausal women complaining of chronic insomniaChristian Guilleminault
Stanford University Sleep Disorders Clinic, Stanford 94305, USA
J Psychosom Res 53:617-23. 2002..The 68 individuals with normal breathing were randomly allocated to immediate behavioral treatment of insomnia or delay treatment of insomnia. The delay treatment received a list of 10 sleep hygiene recommendations by mail...
Chronic insomnia, postmenopausal women, and sleep disordered breathing: part 1. Frequency of sleep disordered breathing in a cohortChristian Guilleminault
Stanford Sleep Center, Suite 3301 A, 401 Quarry Road, Stanford, CA 94305, USA
J Psychosom Res 53:611-5. 2002..SDB)? Which type of SDB (upper airway resistance syndrome [UARS] or obstructive sleep apnea syndrome [OSAS]) is the most frequent? Is there a specific upper airway anatomical abnormality in SDB patients predisposing to the syndrome?..
Pregnancy, sleep disordered breathing and treatment with nasal continuous positive airway pressureChristian Guilleminault
Stanford University Sleep Disorders Clinic, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA
Sleep Med 5:43-51. 2004..To investigate the tolerance, compliance and problems associated with usage of nasal continuous positive airway pressure (CPAP) by pregnant women with sleep disordered breathing (SDB)...
A prospective study on the surgical outcomes of children with sleep-disordered breathingChristian Guilleminault
Stanford University Sleep Disorders Clinic, CA 94305, USA
Sleep 27:95-100. 2004..To prospectively evaluate the outcome of surgical treatment decisions made by a multidisciplinary team for children aged 18 months to 12 years with sleep-disordered breathing (SDB)...
A prospective study of nocturia and the quality of life of elderly patients with obstructive sleep apnea or sleep onset insomniaC Guilleminault
Stanford University Sleep Disorders Clinic, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA
J Psychosom Res 56:511-5. 2004..To prospectively evaluate the relationship between obstructive sleep apnea syndrome (OSAS), nocturia and quality of life in elderly patients free of the urologic and medical conditions that lead to increased nocturia...
Breathing patterns in prepubertal children with sleep-related breathing disordersChristian Guilleminault
Stanford University Sleep Disorders Clinic, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA
Arch Pediatr Adolesc Med 158:153-61. 2004..To investigate abnormal breathing patterns during sleep in prepubertal children using nonstandard polysomnographic patterns in association with an apnea-hypopnea scoring technique...
Comparison of the results of the Epworth Sleepiness Scale and the Multiple Sleep Latency TestR D Chervin
Sleep Disorders Center, University of Michigan, Ann Arbor, USA
J Psychosom Res 42:145-55. 1997..The ESS score correlated with the degree to which patients complained of sleepiness and may be useful as an otherwise elusive link between patients' complaints and their objective findings on MSLT...
Morbidly obese patients with severe obstructive sleep apnea: is airway reconstructive surgery a viable treatment option?K K Li
Stanford University Sleep Disorders and Research Center, California, USA
Laryngoscope 110:982-7. 2000..To evaluate the outcomes of airway reconstructive surgery for the treatment of severe obstructive sleep apnea in the morbidly obese patient...
Sleep fragmentation in normals: a model for sleepiness associated with upper airway resistance syndromeP Philip
Stanford Sleep Disorders Clinic and Research Center, Stanford University School of Medicine, Palo Alto, California
Sleep 17:242-7. 1994..There was a significant relationship between percent nocturnal SWS and mean sleep latencies. The selected performance tests were not affected by 1 night of sleep fragmentation, despite the obvious sleepiness...
Forensic sleep medicine: nocturnal wandering and violenceC Guilleminault
Stanford University Sleep Disorders Center, California 94304, USA
Sleep 18:740-8. 1995..In both groups, the frequency of nocturnal wandering increased with an increase in daytime stressors. Pharmacological and psychiatric treatment approaches were beneficial in both groups...
Uvulopalatopharyngoplasty, maxillomandibular advancement, and the velopharynxK K Li
Stanford University Sleep Disorders and Research Center, Stanford, California, USA
Laryngoscope 111:1075-8. 2001....
A comparison of Asian and white patients with obstructive sleep apnea syndromeK K Li
Stanford University Sleep Disorders and Research Center, California, USA
Laryngoscope 109:1937-40. 1999..To evaluate the possible differences between Asian and white patients with obstructive sleep apnea syndrome...
Should everyone be monitored for upper-airway resistance and how?C Guilleminault
Stanford University Sleep Disorders Clinic, California 94305, USA
Sleep 19:S260-2. 1996..This eliminates the need for many sleep recordings...
The road to danger: the comparative risks of driving while sleepyN B Powell
Stanford Sleep Disorders and Research Center, Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, California, USA
Laryngoscope 111:887-93. 2001..CONCLUSION: This comparative model suggests that the potential risks of driving while sleepy are at least as dangerous as the risks of driving illegally under the influence of alcohol...
Postoperative airway findings after maxillomandibular advancement for obstructive sleep apnea syndromeK K Li
Stanford University Sleep Disorders and Research Center, California, USA
Laryngoscope 110:325-7. 2000..To evaluate the upper airway characteristics in the early postoperative period after maxilomandibular advancement for obstructive sleep apnea syndrome...
Maxillomandibular advancement for persistent obstructive sleep apnea after phase I surgery in patients without maxillomandibular deficiencyK K Li
Stanford University Sleep Disorders and Research Center, California, USA
Laryngoscope 110:1684-8. 2000..To assess the outcomes of maxillomandibular advancement (MMA) for the treatment of persistent obstructive sleep apnea syndrome (OSA) after phase I reconstruction in patients who do not have maxillomandibular deficiency...
Is sleep-disordered breathing an independent risk factor for hypertension in the general population (13,057 subjects)?M M Ohayon
Sleep Disorders Center, Stanford University School of Medicine, 401 Quarry Road Suite 3301, Stanford, CA 94305, USA
J Psychosom Res 48:593-601. 2000..This is an important health issue that requires further clarification because of the potential impact on the prevention and control of hypertension...
Upper airway resistance syndrome and its treatmentC Guilleminault
Stanford University Sleep Disorders Clinic and Research Center, CA 94305, USA
Sleep 23:S197-200. 2000....
Sleep-disordered breathing and upper-airway anomalies in first-degree relatives of ALTE childrenC Guilleminault
Stanford University Sleep Disorders Center, 401 Quarry Road, Suite 330, Stanford, CA 94305, USA
Pediatr Res 50:14-22. 2001..Naso-oro-maxillomandibular anatomic traits that may lead to small upper airways in parents may be risk factors for abnormal breathing during sleep in their infants...
Upper airway resistance syndrome in children: a clinical reviewC Guilleminault
Stanford University Sleep Disorders Clinic, CA 94305-5547, USA
Semin Pediatr Neurol 8:207-15. 2001..Children with sleep-disordered breathing should have a maxillomandibular examination to assess the need for orthodontic treatment to expand the oral cavity...
The diurnal variability of ventricular premature depolarizations: influence of heart rate, sleep, and wakefulnessA M Gillis
Division of Cardiology, Stanford University, CA 94305
Sleep 12:391-9. 1989..These observations suggest that HR is a major determinant of the diurnal variation of VPD frequency in a subset of patients with frequent VPDs...
Excessive daytime sleepiness: a challenge for the practising neurologistC Guilleminault
Stanford Sleep Disorders Clinic, Stanford Hospital and Clinics, Stanford University and Medical Centre, Stanford, California 94305, USA
Brain 124:1482-91. 2001..As our understanding of the neurological underpinnings of alertness and sleepiness deepens, improved treatment methods are bound to emerge...
[Cyclic alternating pattern as a sign of brain instability during sleep]A Ferre
Departamento de Neurofisiologia Clinica, Hospital Vall d Hebron, Barcelona, Spain, and Sleep Disorders Clinic, Stanford University, California, USA
Neurologia 21:304-11. 2006..This study aims to explain the concept of CAP and its pathophysiology studied up to the present...
Problems associated with switch to modafinil - a novel alerting agent in narcolepsyC Guilleminault
Stanford Sleep Disorders Clinic and Research Center, CA 94605, USA
Eur J Neurol 7:381-4. 2000..Venlafaxine hydrochloride combined well with modafinil to control cataplectic attacks. Usage of a progressive withdrawal protocol may ease the difficulties observed...
Sleep-disordered breathing in childrenC Guilleminault
Stanford Sleep Disorders Center, CA 94305, USA
Ann Med 30:350-6. 1998..Excessive daytime sleepiness and obesity are not always present. Untreated children may develop cardiovascular complications. The condition is treatable with continuous or bilevel positive airway pressure, and may be cured with surgery...
Tiredness and somnolence despite initial treatment of obstructive sleep apnea syndrome (what to do when an OSAS patient stays hypersomnolent despite treatment)C Guilleminault
Stanford University Sleep Disorders Center, Palo Alto, California 94304, USA
Sleep 19:S117-22. 1996..These treatments were not effective in specific cases, and stimulant medications had to be prescribed...
Blood pressure "dipping" and "non-dipping" in obstructive sleep apnea syndrome patientsM Suzuki
Stanford University Sleep Disorders Center, California, USA
Sleep 19:382-7. 1996..We found a relationship between increasing respiratory disturbance index and increasing average 24-hour systolic blood pressure only when OSAS subjects were non-dippers and hypertensive...
Arousal, EEG spectral power and pulse transit time in UARS and mild OSAS subjectsD Poyares
Stanford University Sleep Disorders Center, 401 Quarry Road, Suite 3301, CA 94305, USA
Clin Neurophysiol 113:1598-1606. 2002..This PTT response, however, is much slower than that occurring with arousal. UARS and mild OSAS do not respond in the same way to SRREs, particularly during rapid eye movement sleep...
Comparison of hypopnea definitions in lean patients with known obstructive sleep apnea hypopnea syndrome (OSAHS)C Guilleminault
Sleep Medicine Clinic, Stanford University, CA, USA
Sleep Breath 13:341-7. 2009..We sought to determine whether these changes would affect detection and treatment of OSAHS in lean patients-a group known to desaturate less-than-obese patients...
Cervical positional effects on snoring and apneasC A Kushida
Stanford University Sleep Disorders Clinic and Research Center, Stanford, California, 94305, USA
Sleep Res Online 2:7-10. 1999..Subjects with severe OSAS cases showed slight improvement in some measures of their abnormal respiratory events during the experimental period...
Radiofrequency treatment of turbinate hypertrophy in subjects using continuous positive airway pressure: a randomized, double-blind, placebo-controlled clinical pilot trialN B Powell
Stanford Sleep Disorders and Research Center, Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, California, USA
Laryngoscope 111:1783-90. 2001..Placebo control and double blinding are critical for establishing the true treatment effect. A future definitive trial is feasible to establish statistical significance of these findings...
DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black AmericansE Mignot
Stanford University, School of Medicine, Sleep Disorders Center, Palo Alto, California
Sleep 17:S60-7. 1994..These results demonstrate that DQB1*0602/DQA1*0102 is the best marker for narcolepsy across all ethnic groups...
Radiofrequency (pacing and thermic effects) in the treatment of sleep-disordered breathingC Guilleminault
Stanford University Sleep Disorders Clinic and Research Center, CA 94305, USA
Sleep 23:S182-6. 2000..Too high a level of radiofrequency will cause pain or otherwise avoidable complications. The determination of which patients will benefit most from these procedures will require further multi-center, placebo-controlled studies...
A reversible uvulopalatal flap for snoring and sleep apnea syndromeN Powell
Stanford University Sleep Disorders Center, California, USA
Sleep 19:593-9. 1996..The new reported procedure is reversible and conservative and reduces the risk of VPI. Snoring is improved, which is consistent with a decrease in airway resistance or obstruction...
Risk factors for sleep bruxism in the general populationM M Ohayon
Stanford University School of Medicine, Sleep Disorders Center, Stanford, CA 94305, USA
Chest 119:53-61. 2001..It may also be associated with a number of disorders. However, little is known about the epidemiology of sleep bruxism and its risk factors in the general population...
Sleep-disordered breathing and hypertension: past lessons, future directionsC Guilleminault
Stanford University Sleep Disorders Center, California, USA
Sleep 20:806-11. 1997..These findings are supportive fo the role of sleep-disordered breathing in the development of hypertension in man...
Stroke and treatment with nasal CPAPL Palombini
Stanford University Sleep Disorders Clinic, Stanford, CA 94305, USA
Eur J Neurol 13:198-200. 2006..The majority of OSA stroke patients rejected CPAP treatment. Better education and support of patients and families, and special training sessions in rehabilitation services, will be needed to improve compliance...
Validation of a cataplexy questionnaire in 983 sleep-disorders patientsS Anic-Labat
Stanford University, Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, CA 94305, USA
Sleep 22:77-87. 1999..7%) and low-(0.6%) risk groups for cataplexy. This questionnaire will be used to increase diagnostic consistency across clinical centers, thus providing more homogenous subject pools for clinical and basic research studies...
How age and daytime activities are related to insomnia in the general population: consequences for older peopleM M Ohayon
Stanford University School of Medicine, Sleep Disorder Center, California 94305, USA
J Am Geriatr Soc 49:360-6. 2001..e., without organic or mental pathologies) have a prevalence of insomnia symptoms similar to that observed in younger people. Moreover, being active and satisfied with social life are protective factors against insomnia at any age...
Controversies in the diagnosis of narcolepsyC Guilleminault
Sleep Disorders Clinic, School of Medicine, Stanford University, Palo Alto, California
Sleep 17:S1-6. 1994..History of daytime sleepiness and presence of more than one SOREMP during MSLT, however, is a poorer discriminant of narcolepsy than history of cataplexy, particularly in an aging population...
Circadian rhythms and enhanced athletic performance in the National Football LeagueR S Smith
Stanford University Sleep Disorders Clinic, CA 94305, USA
Sleep 20:362-5. 1997..These results support the presence of an enhancement of athletic performance at certain circadian times of the day...
Twenty minutes versus forty-five minutes morning bright light treatment on sleep onset insomnia in elderly subjectsC Kirisoglu
Stanford University Sleep Disorders Clinic, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA
J Psychosom Res 56:537-42. 2004..To compare the efficacy of 20 min versus 45 min light exposure for relieving psychophysiological insomnia in the elderly...
New insights into the pathogenesis and treatment of narcolepsyS N Brooks
Stanford Sleep Disorders Clinic, Stanford, California 94305, USA
Curr Opin Pulm Med 7:407-10. 2001..Fortunately, recent advances in the understanding of narcolepsy offer the promise of improved treatments in the foreseeable future...
DQB1-0602 (DQw1) is not present in most nonDR2 Caucasian narcolepticsE Mignot
Stanford University, School of Medicine, Sleep Disorders Center, Palo Alto, California 94304
Sleep 15:415-22. 1992..Further studies with more patients are warranted to exclude the possibility that a few caucasian patients carry rare haplotypes with DQB1-0602 independently of DR2...
Effect of atrial overdrive pacing on obstructive sleep apnea in patients with systolic heart failureAmir Sharafkhaneh
Department of Medicine at Baylor College of Medicine, Houston, TX, USA
Sleep Med 8:31-6. 2007..To further investigate this relationship, we conducted a randomized clinical trial evaluating the effect of atrial overdrive pacing on sleep-related breathing events in subjects with OSA and systolic heart failure...
Attention-deficit/hyperactivity disorder with obstructive sleep apnea: a treatment outcome studyYu Shu Huang
Department of Child Psychiatry, Chang Gung Memorial University Hospital, Tao Yuan, Taipei, Taiwan
Sleep Med 8:18-30. 2007....
A double-blind, placebo-controlled, crossover study of sildenafil in obstructive sleep apneaSuely Roizenblatt
Department of Psychobiology, Federal University of Sao Paulo, Sao Paulo, Brazil
Arch Intern Med 166:1763-7. 2006....
Chronic snoring and sleep in children: a demonstration of sleep disruptionM Cecilia Lopes
Stanford University Sleep Medicine Program, Stanford, California, USA
Pediatrics 118:e741-6. 2006....
Chronic fatigue, unrefreshing sleep and nocturnal polysomnographyChristian Guilleminault
Stanford University Sleep Disorders Clinic, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA
Sleep Med 7:513-20. 2006..To investigate the complaint of unrefreshing sleep with study of sleep electroencephalogram (EEG) in patients with chronic fatigue...
Maintenance of wakefulness test as a predictor of driving performance in patients with untreated obstructive sleep apneaPatricia Sagaspe
Clinique du Sommeil, CHU Pellegrin, Bordeaux, France
Sleep 30:327-30. 2007..To determine the ability of Maintenance of Wakefulness Test (MWT) to predict simulated driving performance in patients suffering from sleep apnea syndrome...
Antihypertensive treatment and endothelium-dependent venodilation in sleep-disordered breathingHans-Werner Duchna
Medical Clinic III, Pulmonary Medicine, Allergology, Sleep and Respiratory Medicine, University Hospital Bergmannsheil, Ruhr-University Bochum, , 44789, Bochum, Germany
Sleep Breath 10:115-22. 2006..Hypertensive patients with SDB present a normal nitric oxide-mediated endothelial function under antihypertensive treatment...
Upper airway resistance syndrome: a long-term outcome studyChristian Guilleminault
Stanford Sleep Disorders Clinic, Stanford, CA 94305, USA
J Psychiatr Res 40:273-9. 2006..CONCLUSIONS: Many UARS patients remained untreated following initial evaluation. Worsening of symptoms of insomnia, fatigue and depressive mood were seen with absence of treatment of UARS...
Sleepwalking, a disorder of NREM sleep instabilityChristian Guilleminault
Stanford University Sleep Disorders Clinic, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA
Sleep Med 7:163-70. 2006..In the current study, all records were blindly scored to perform a cyclic alternating pattern (CAP) analysis...
Vascular endothelial dysfunction in patients with mild obstructive sleep apnea syndromeHans Werner Duchna
University Hospital Bergmannsheil, Ruhr University Bochum, Medical Clinic III, Pulmonary Medicine, Allergology, Sleep and Ventilatory Medicine, Bochum, Germany
Wien Med Wochenschr 156:596-604. 2006..We investigated endothelial dysfunction, an early manifestation of atherosclerosis, in patients with mild obstructive sleep apnea syndrome (OSAS) (5/h < AHI < 15/h)...
Rapid maxillary expansion in children with obstructive sleep apnea syndrome: 12-month follow-upMaria Pia Villa
Pediatric Clinic, Sant Andrea Hospital, II Faculty of Medicine, University La Sapienza, Rome, Italy
Sleep Med 8:128-34. 2007..6+/-2.0; 9 males) with dental malocclusion, a body mass index < or =85 percentile, and OSAS confirmed by polysomnography...
Polysomnography in Kleine-Levin syndromeYu Shu Huang
Sleep Center and Child Psychiatry Department, Chang Gung Memorial Hospital Taipei, Taiwan
Neurology 70:795-801. 2008..We describe findings obtained with polysomnography (PSG) and Multiple Sleep Latency Test (MSLT) and correlation obtained between clinical and PSG findings from different episodes...
Catathrenia: parasomnia or uncommon feature of sleep disordered breathing?Christian Guilleminault
Stanford University Sleep Medicine Program, Stanford, CA 94305, USA
Sleep 31:132-9. 2008..We report a series of seven consecutive cases of catathrenia (sleep related groaning) that differ from limited previous reports in the literature with regard to sleep stage and response to treatment...
Placebo and modafinil effect on sleepiness in obstructive sleep apneaLia Rita A Bittencourt
Sleep Medicine and Biology Discipline, Psychobiology Department, Universidade Federal de Sao Paulo, Napoleão de Barros 925, Sao Paulo 04024 002, SP Brazil
Prog Neuropsychopharmacol Biol Psychiatry 32:552-9. 2008..Even though those trials also used placebo groups, we suppose that the placebo effect might influence the patients' response to modafinil...
Cyanotic breath-holding spells in children respond to adenotonsillectomy for sleep-disordered breathingChristian Guilleminault
Stanford University Sleep Disorders Program, 401 Quarry Road, Stanford, CA 94305, USA
J Sleep Res 16:406-13. 2007..In conclusion, the presence of cyanotic BH should prompt investigation and polysomnography for possible SDB. Independent treatment of SDB may hasten resolution of BH spells in these cases...
Pre-eclampsia and nasal CPAP: part 2. Hypertension during pregnancy, chronic snoring, and early nasal CPAP interventionDalva Poyares
Federal University of Sao Paulo Sleep Disorders Center, Brazil
Sleep Med 9:15-21. 2007..To evaluate the potential benefit of nasal continuous positive airway pressure (CPAP) administration in pregnant women recognized to have hypertension early in pregnancy...
Pre-eclampsia and nasal CPAP: part 1. Early intervention with nasal CPAP in pregnant women with risk-factors for pre-eclampsia: preliminary findingsChristian Guilleminault
Stanford University Sleep Disorders Program, Department of Obstetric Gynecology, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA
Sleep Med 9:9-14. 2007..This prospective, longitudinal study was designed to characterize sleep-related breathing patterns in pregnant women with pre-eclampsia risk factors, and to describe the effects of early nasal CPAP therapy in these patients...
The Apnea Positive Pressure Long-term Efficacy Study (APPLES): rationale, design, methods, and proceduresClete A Kushida
Stanford Universit y, Stanfbrd, CA, USA
J Clin Sleep Med 2:288-300. 2006..To assess the size, time course, and durability of the effects of long-term continuous positive airway pressure (CPAP) therapy on neurocognitive function, mood, sleepiness, and quality of life in patients with obstructive sleep apnea...
The cyclic alternating pattern demonstrates increased sleep instability and correlates with fatigue and sleepiness in adults with upper airway resistance syndromeChristian Guilleminault
Stanford University Sleep Medicine Program, Stanford, CA 94305, USA
Sleep 30:641-7. 2007..To clarify the relationship between sleep instability and subjective complaints in patients with upper airway resistance syndrome (UARS)...
Major depressive disorder, sleep EEG and agomelatine: an open-label studyMaria Antonia Quera Salva
Sleep Unit, Raymond Poincare Hospital, Garches, France
Int J Neuropsychopharmacol 10:691-6. 2007..In conclusion agomelatine improved sleep continuity and quality. It normalized the distribution of SWS sleep and delta power throughout the night...
Sleepy driver near-misses may predict accident risksNelson B Powell
Department of Otolaryngology Head and Neck Surgery and Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, CA, USA
Sleep 30:331-42. 2007..To quantify the prevalence of self-reported near-miss sleepy driving accidents and their association with self-reported actual driving accidents...
Adenotonsillectomy and obstructive sleep apnea in children: a prospective surveyChristian Guilleminault
Stanford University Sleep Medicine Program, Stanford, CA 94305, USA
Otolaryngol Head Neck Surg 136:169-75. 2007..Prospective survey of children up to 14 years of age with OSA submitted to adenotonsillectomy...
The effect of CNS activation versus EEG arousal during sleep on heart rate response and daytime testsChristian Guilleminault
Stanford Sleep Disorders Center, Stanford University, 401 Quarry Road Suite 3301, Stanford, CA 94305 5730, USA
Clin Neurophysiol 117:731-9. 2006..To induce a heart rate change in normal subjects using auditory stimulation without inducing EEG arousals and to assess the effects on daytime functioning and compare results to auditory stimulation leading to short EEG arousals...
Hypersynchronous slow delta, cyclic alternating pattern and sleepwalkingChristian Guilleminault
Sleep 29:14-5. 2006
Pediatric sleep pharmacology: you want to give my kid sleeping pills?Rafael Pelayo
Department of Pediatrics, Psychiatry, and Behavioral Science, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
Pediatr Clin North Am 51:117-34. 2004..Training programs should play the lead role in enhancing pediatricians' knowledge of the pharmacologic treatment of sleep disorders in children...
The effects of trazodone on sleep in patients treated with stimulant antidepressantsHakan Kaynak
Department of Neurology, Sleep Disorders Unit, Cerrahpasa Medical School, University of Istanbul, Cerrahpasa, 34303 Istanbul, Turkey
Sleep Med 5:15-20. 2004..SSRIs can exacerbate or cause new insomnia while alleviating other symptoms of depression. Trazodone has been reported to be an effective hypnotic for patients with antidepressant-associated insomnia...
Sleep disordered breathing: surgical outcomes in prepubertal childrenChristian Guilleminault
Stanford University Sleep Disorders Clinic, CA 94305, USA
Laryngoscope 114:132-7. 2004..To evaluate the treatment outcomes of sleep disordered breathing (SDB) in prepubertal children 3 months following surgical intervention...
Abnormal blood pressure in prepubertal children with sleep-disordered breathingChristian Guilleminault
Stanford University Sleep Disorders Center, Stanford, CA 94305, USA
Pediatr Res 55:76-84. 2004....
Sleep and respiratory stimulus specific dampening of cortical responsiveness in OSASLamia Afifi
Department of Neurology, Cairo University, Cairo, Egypt
Respir Physiol Neurobiol 136:221-34. 2003..The absence of significant group differences in the responses to auditory stimuli highlight that the sleep-related differences seen in OSAS patients are specific to the processing of inspiratory effort related stimuli...
Anterior cervical spine fusion and sleep disordered breathingChristian Guilleminault
Stanford University Sleep Disorders Center, CA 94305, USA
Neurology 61:97-9. 2003..The authors found that placement of the anterior cervical plates reduced the size of the upper airway. Symptoms and objective findings were controlled with nasal continuous positive airway pressure...
Fatigue, sleep restriction, and performance in automobile drivers: a controlled study in a natural environmentPierre Philip
Clinique du Sommeil, CHU Pellegrin, 33076 Bordeaux, France
Sleep 26:277-80. 2003..To test the neurobehavioral consequences of sleep restriction combined with fatigue from long-distance driving (1000 Km/600 miles)...
Sleep/wake cycles in the dark: sleep recorded by polysomnography in 26 totally blind subjects compared to controlsDamien Leger
Centre du Sommeil, Hotel Dieu de Paris, France
Clin Neurophysiol 113:1607-14. 2002..To evaluate subjective sleep difficulties and nocturnal sleep with polysomnography in 26 completely blind subjects, living in normal social environments and to compare the findings with those of matched controls...
Temperature-controlled radiofrequency tongue base reduction for sleep-disordered breathing: Long-term outcomesKasey K Li
Stanford University Sleep Disorders and Research Center, California, USA
Otolaryngol Head Neck Surg 127:230-4. 2002..Our goal was to evaluate the long-term outcomes of temperature-controlled radiofrequency reduction of the tongue base in sleep-disordered breathing...
Two-point palatal discrimination in patients with upper airway resistance syndrome, obstructive sleep apnea syndrome, and normal control subjectsChristian Guilleminault
Stanford University Sleep Disorders Clinic, CA 94305, USA
Chest 122:866-70. 2002....
Can valerian improve the sleep of insomniacs after benzodiazepine withdrawal?Dalva R Poyares
Sleep Laboratory of the Department of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 26:539-45. 2002..Sleep of control subjects was monitored in parallel...
Obstructive sleep apnea syndromesChristian Guilleminault
Sleep Disorders Program, Stanford University School of Medicine, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA
Med Clin North Am 88:611-30, viii. 2004
Maxillomandibular expansion for the treatment of sleep-disordered breathing: preliminary resultChristian Guilleminault
Stanford University Sleep Disorders and Research Center, Stanford, CA 94305, USA
Laryngoscope 114:893-6. 2004..6 cm H2O. No complications were encountered, and the follow-up period was 18.1 +/- 9.8 months. CONCLUSION:: The result suggests that MME improves SDB in patients with maxillary and mandibular constriction and can be a valid treatment...
Obstructive sleep apnea syndrome, sleepiness, and quality of lifeMarta A Goncalves
Instituto do Sono, Chronobiologia, e Telemedecina Porto, Porto, Portugal
Chest 125:2091-6. 2004..Other unrelated factors have a greater impact. To relate sleepiness while driving only to the usually studied variables in OSA patients is an oversimplification...
Heart rate variability during sleep in patients with vasovagal syncopeFatima Cintra
Clinical Electrophysiology and Sleep Medicine and Biology Divisions, , Brazil
Pacing Clin Electrophysiol 28:1310-6. 2005..Syncope patients also showed an increase in slow wave sleep (28.2 +/- 10.5, 19.7 +/- 7.8, P = 0.01). CONCLUSIONS: VVS patients exhibited sympathetic suppression during REM sleep. Possible mechanisms are discussed in this article...
Is obstructive sleep apnea syndrome a neurological disorder? A continuous positive airway pressure follow-up studyChristian Guilleminault
Stanford University Sleep Disorders Clinic, Suite 3301, 401 Quarry Road, Stanford, CA 94117, USA
Ann Neurol 58:880-7. 2005..Obstructive sleep apnea syndrome involves abnormal upper airway sensory input, which may be responsible for the development of apneas and hypopneas. These neurological lesions are persistent despite nasal CPAP treatment...
[Violent behavior during sleep]Dalva Poyares
Universidade Federal de Sao Paulo
Rev Bras Psiquiatr 27:22-6. 2005..The most frequently diagnosed sleep disorders are REM behavior disorder and somnambulism. Violent behavior might be precipitated by stress, use of alcohol or drugs, sleep deprivation or fever...
Pediatric obstructive sleep apnea syndromeChristian Guilleminault
Stanford University Sleep Disorders Program, Stanford, CA 94305, USA
Arch Pediatr Adolesc Med 159:775-85. 2005..To review evidence-based knowledge of pediatric obstructive sleep apnea syndrome (OSAS)...
Adult chronic sleepwalking and its treatment based on polysomnographyChristian Guilleminault
Stanford University Sleep Disorders Program, Stanford, CA, USA
Brain 128:1062-9. 2005..Those successfully treated with surgery also had complete resolution of sleepwalking. Successful treatment of SDB, which is frequently associated with chronic sleepwalking, controlled the syndrome in young adults...
C-reactive protein and sleep-disordered breathingChristian Guilleminault
Sleep Disorders Clinic, Stanford University, Stanford, CA 94305, USA
Sleep 27:1507-11. 2004....
Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespanMaurice M Ohayon
Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, Palo Alto, CA 94303, USA
Sleep 27:1255-73. 2004....
Periodic leg movements in prepubertal children with sleep disturbanceSandra Martinez
Stanford University Sleep Disorders Clinic, Stanford, California 94305, USA
Dev Med Child Neurol 46:765-70. 2004..Isolated treatment of SDB might help eliminate some, but not all, PLMs...
Upper airway resistance syndrome--one decade laterGang Bao
Stanford University Sleep Disorders Clinic, Stanford, California 94305, USA
Curr Opin Pulm Med 10:461-7. 2004..SUMMARY: The clinical presentation of patients with UARS is similar to the presentation of subjects with functional somatic syndrome. To diagnose UARS, nocturnal polysomnography should include additional measurement channels...
