Michael Greicius

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 100:253-8. 2003
  2. pmc Dissociable intrinsic connectivity networks for salience processing and executive control
    William W Seeley
    Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:2349-56. 2007
  3. doi request reprint Neuroimaging insights into network-based neurodegeneration
    Michael D Greicius
    Functional Imaging in Neuropsychiatric Disorders Laboratory, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5235, USA
    Curr Opin Neurol 25:727-34. 2012
  4. doi request reprint Resting-state functional connectivity in neuropsychiatric disorders
    Michael Greicius
    Stanford University School of Medicine, Neurology and Neurological Sciences, Stanford, California 64305 5235, USA
    Curr Opin Neurol 21:424-30. 2008
  5. pmc Resting-state functional connectivity reflects structural connectivity in the default mode network
    Michael D Greicius
    Department of Neurology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Cereb Cortex 19:72-8. 2009
  6. pmc Persistent default-mode network connectivity during light sedation
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5235, USA
    Hum Brain Mapp 29:839-47. 2008
  7. pmc Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
    Biol Psychiatry 62:429-37. 2007
  8. ncbi request reprint Default-mode activity during a passive sensory task: uncoupled from deactivation but impacting activation
    Michael D Greicius
    Department of Neurology, Stanford University School of Medicine, CA 94301 5719, USA
    J Cogn Neurosci 16:1484-92. 2004
  9. pmc Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 101:4637-42. 2004
  10. ncbi request reprint Regional analysis of hippocampal activation during memory encoding and retrieval: fMRI study
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5719, USA
    Hippocampus 13:164-74. 2003

Research Grants

Detail Information

Publications27

  1. pmc Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 100:253-8. 2003
    ..Our findings also provide insight into how this network is modulated by task demands and what functions it might subserve...
  2. pmc Dissociable intrinsic connectivity networks for salience processing and executive control
    William W Seeley
    Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:2349-56. 2007
    ..Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior...
  3. doi request reprint Neuroimaging insights into network-based neurodegeneration
    Michael D Greicius
    Functional Imaging in Neuropsychiatric Disorders Laboratory, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5235, USA
    Curr Opin Neurol 25:727-34. 2012
    ..This review considers the role of neuroimaging in strengthening the case for network-based neurodegeneration and elucidating potential mechanisms...
  4. doi request reprint Resting-state functional connectivity in neuropsychiatric disorders
    Michael Greicius
    Stanford University School of Medicine, Neurology and Neurological Sciences, Stanford, California 64305 5235, USA
    Curr Opin Neurol 21:424-30. 2008
    ..This review considers recent advances in the application of resting-state functional magnetic resonance imaging to the study of neuropsychiatric disorders...
  5. pmc Resting-state functional connectivity reflects structural connectivity in the default mode network
    Michael D Greicius
    Department of Neurology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Cereb Cortex 19:72-8. 2009
    ..The results demonstrate that resting-state functional connectivity reflects structural connectivity and that combining modalities can enrich our understanding of these canonical brain networks...
  6. pmc Persistent default-mode network connectivity during light sedation
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5235, USA
    Hum Brain Mapp 29:839-47. 2008
    ..We hypothesize that focal reductions in DMN connectivity, as shown here in the posterior cingulate cortex, may represent a stable correlate of reduced consciousness...
  7. pmc Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
    Biol Psychiatry 62:429-37. 2007
    ..The goal of this study was to examine resting-state, default-mode network functional connectivity in subjects with major depression and in healthy controls...
  8. ncbi request reprint Default-mode activity during a passive sensory task: uncoupled from deactivation but impacting activation
    Michael D Greicius
    Department of Neurology, Stanford University School of Medicine, CA 94301 5719, USA
    J Cogn Neurosci 16:1484-92. 2004
    ....
  9. pmc Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 101:4637-42. 2004
    ..Finally, a goodness-of-fit analysis applied at the individual subject level suggests that activity in the default-mode network may ultimately prove a sensitive and specific biomarker for incipient AD...
  10. ncbi request reprint Regional analysis of hippocampal activation during memory encoding and retrieval: fMRI study
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5719, USA
    Hippocampus 13:164-74. 2003
    ..Finally, this study is the first to quantify the effects of susceptibility-induced signal loss on hippocampal activation and suggests that this artifact has significantly biased the interpretation of earlier fMRI studies...
  11. ncbi request reprint Neuroimaging in developmental disorders
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5719, USA
    Curr Opin Neurol 16:143-6. 2003
    ..This review considers the role of neuroimaging in developmental disorders by highlighting recent studies in two distinct, but overlapping, developmental disorders: autism and fragile X syndrome...
  12. ncbi request reprint Reduced basal forebrain and hippocampal activation during memory encoding in girls with fragile X syndrome
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford Brain Research Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuroreport 15:1579-83. 2004
    ..This is the first study, to our knowledge, demonstrating functional deficits in FraX subjects in brain regions known to have the highest FMR1 transcription...
  13. pmc Neurodegenerative diseases target large-scale human brain networks
    William W Seeley
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 62:42-52. 2009
    ..Future studies may clarify how these complex systems are assembled during development and undermined by disease...
  14. pmc Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Arch Neurol 67:1370-8. 2010
    ....
  15. ncbi request reprint Non-fluent progressive aphasia, depression, and OCD in a woman with progressive supranuclear palsy: neuroanatomical and neuropathological correlations
    Niranjan S Karnik
    Department of Anthropology, History and Social Medicine, University of California School of Medicine, San Francisco, CA, USA
    Neurocase 12:332-8. 2006
    ....
  16. ncbi request reprint Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: reciprocal networks and neuronal evolution
    William W Seeley
    Department of Neurology, University of California at San Francisco, CA 94143 1207, USA
    Alzheimer Dis Assoc Disord 21:S50-7. 2007
    ..We suggest that the regional and neuronal vulnerability patterns seen in bvFTD and AD underlie the divergent impact of these disorders on recently evolved social-emotional functions...
  17. pmc Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease
    Juan Zhou
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Brain 133:1352-67. 2010
    ..Further developed, intrinsic connectivity network signatures may provide simple, inexpensive, and non-invasive biomarkers for dementia differential diagnosis and disease monitoring...
  18. pmc Development of functional and structural connectivity within the default mode network in young children
    Kaustubh Supekar
    Graduate Program in Biomedical Informatics, Stanford University School of Medicine, Stanford, CA 94304, USA
    Neuroimage 52:290-301. 2010
    ..More generally, our study demonstrates how quantitative multimodal analysis of anatomy and connectivity allows us to better characterize the heterogeneous development and maturation of brain networks...
  19. pmc Dissociable connectivity within human angular gyrus and intraparietal sulcus: evidence from functional and structural connectivity
    Lucina Q Uddin
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA
    Cereb Cortex 20:2636-46. 2010
    ....
  20. doi request reprint Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder
    Amit Etkin
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Arch Gen Psychiatry 66:1361-72. 2009
    ..A functional connectivity approach at the subregional level may therefore yield novel insights into GAD...
  21. doi request reprint Episodic encephalopathy due to an occult spinal vascular malformation complicated by superficial siderosis
    Marie C Gonella
    Stanford University Medical Center, Department of Neurology, Room A 343, 300 Pasteur Drive, Stanford, CA 94305 5235, USA
    Clin Neurol Neurosurg 112:82-4. 2010
    ..When no source of hemorrhage is identified intracranially, then total spinal cord imaging is indicated to assess for an occult source of hemorrhage as occurred in our case...
  22. doi request reprint Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity
    Jessica S Damoiseaux
    Stanford University School of Medicine, Stanford, CA 94305, USA
    Brain Struct Funct 213:525-33. 2009
    ....
  23. pmc Default-mode function and task-induced deactivation have overlapping brain substrates in children
    Moriah E Thomason
    Department of Psychology, Stanford University, Jordan Hall, Building 420, Stanford, CA 94305 2130, USA
    Neuroimage 41:1493-503. 2008
    ..We describe how future studies assessing the development of these systems would benefit from examining these constructs as part of one continuous system...
  24. pmc Network analysis of intrinsic functional brain connectivity in Alzheimer's disease
    Kaustubh Supekar
    Graduate Program in Biomedical Informatics, Stanford University School of Medicine, Stanford, California, USA
    PLoS Comput Biol 4:e1000100. 2008
    ..Small-world metrics can characterize the functional organization of the brain in AD, and our findings further suggest that these network measures may be useful as an imaging-based biomarker to distinguish AD from healthy aging...
  25. ncbi request reprint Humor modulates the mesolimbic reward centers
    Dean Mobbs
    Stanford Psychiatry Neuroimaging Laboratory, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 40:1041-8. 2003
    ..Further, the degree of humor intensity was positively correlated with BOLD signal intensity in these regions. Together, these findings offer new insight into the neural basis of salutary aspects of humor...
  26. pmc A cross-modal system linking primary auditory and visual cortices: evidence from intrinsic fMRI connectivity analysis
    Mark A Eckert
    Department of Otolaryngology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Hum Brain Mapp 29:848-57. 2008
    ..Our study provides novel, fcMRI-based, support for a neural system involving low-level auditory and visual cortices...
  27. ncbi request reprint Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associate memory task
    Alireza Atri
    Boston University, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02215, USA
    Behav Neurosci 118:223-36. 2004
    ....

Research Grants3

  1. A Novel MRI Biomarker for Incipient Alzheimer's Disease
    Michael Greicius; Fiscal Year: 2007
    ..Greicius plans to become an independent investigator in the fields of dementia and neuroimaging and contribute to the early detection and treatment of AD and other dementing diseases of the elderly. ..
  2. Development of Resting-State fMRI as a Biomarker for Alzheimers Disease
    Michael D Greicius; Fiscal Year: 2010
    ..Such a test would help determine whether experimental drugs were working and would allow drugs to be started early in the course of the illness when they are more likely to be effective. ..