Jorg Goronzy

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Regulation of T cell receptor signaling by activation-induced zinc influx
    Mingcan Yu
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 208:775-85. 2011
  2. pmc The janus head of T cell aging - autoimmunity and immunodeficiency
    Jorg J Goronzy
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA Department of Medicine, Palo Alto Veteran Administration Health Care System, Palo Alto, CA, USA
    Front Immunol 4:131. 2013
  3. doi request reprint Understanding immunosenescence to improve responses to vaccines
    Jorg J Goronzy
    The Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA
    Nat Immunol 14:428-36. 2013
  4. pmc Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment
    Jorg J Goronzy
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States
    Semin Immunol 24:365-72. 2012
  5. pmc Giant cell arteritis: immune and vascular aging as disease risk factors
    Shalini V Mohan
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305 5166, USA
    Arthritis Res Ther 13:231. 2011
  6. doi request reprint Immune aging and autoimmunity
    Jorg J Goronzy
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive West, Stanford, CA, 94305 5166, USA
    Cell Mol Life Sci 69:1615-23. 2012

Research Grants

  1. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2006
  2. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2005
  3. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 2005
  4. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2004
  5. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2002
  6. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 2002
  7. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 2000
  8. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2000
  9. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 1999
  10. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2007

Collaborators

  • Mingcan Yu
  • Shalini V Mohan
  • Cornelia M Weyand
  • Lu Tian
  • Won Woo Lee
  • David L Lamar
  • Jonathan W Kim
  • Karnail Singh
  • Sergey Pryshchep
  • Marta Czesnikiewicz-Guzik
  • Guangjin Li
  • Y Joyce Liao
  • Deepak Tomar

Detail Information

Publications6

  1. pmc Regulation of T cell receptor signaling by activation-induced zinc influx
    Mingcan Yu
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 208:775-85. 2011
    ..By calibrating TCR activation thresholds, increased extracellular zinc bioavailability facilitated the induction of T cell proliferative responses to suboptimal stimuli...
  2. pmc The janus head of T cell aging - autoimmunity and immunodeficiency
    Jorg J Goronzy
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA Department of Medicine, Palo Alto Veteran Administration Health Care System, Palo Alto, CA, USA
    Front Immunol 4:131. 2013
    ..In this review, we will discuss age-associated deviations in the immune repertoire and the regulation of signaling pathways that may shed light on this conundrum...
  3. doi request reprint Understanding immunosenescence to improve responses to vaccines
    Jorg J Goronzy
    The Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA
    Nat Immunol 14:428-36. 2013
    ....
  4. pmc Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment
    Jorg J Goronzy
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States
    Semin Immunol 24:365-72. 2012
    ..Prominent examples are the expression of negative regulatory receptors of the CD28 and the TNF receptor superfamilies as well the expression of various cytoplasmic and nuclear dual-specific phosphatases...
  5. pmc Giant cell arteritis: immune and vascular aging as disease risk factors
    Shalini V Mohan
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305 5166, USA
    Arthritis Res Ther 13:231. 2011
    ..Thus, the aging process impacts the two major biologic systems that liaise to promote giant cell arteritis; the immune system and the vessel wall niche...
  6. doi request reprint Immune aging and autoimmunity
    Jorg J Goronzy
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive West, Stanford, CA, 94305 5166, USA
    Cell Mol Life Sci 69:1615-23. 2012
    ....

Research Grants23

  1. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2006
    ..The promise of this concept is that targeting these active mechanisms can, in part, restore immunocompetence. ..
  2. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2005
    ..The promise of this concept is that targeting these active mechanisms can, in part, restore immunocompetence. ..
  3. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 2005
    ..The long-term goal of this proposal is to determine whether this novel regulatory system of stimulatory and inhibitory receptors can be exploited for therapeutic interventions to control disease-relevant T-cell responses in RA. ..
  4. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2004
    ..The promise of this concept is that targeting these active mechanisms can, in part, restore immunocompetence. ..
  5. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2002
    ..Preventing the accumulation of CD4+ CD28null T cells might be a primary target for immune therapy in aging individuals. ..
  6. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 2002
    ..The long-term goal of this proposal is to determine whether this novel regulatory system of stimulatory and inhibitory receptors can be exploited for therapeutic interventions to control disease-relevant T-cell responses in RA. ..
  7. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 2000
    ..In combination, these approaches will allow us to determine how autoreactive CD4+ CD28- T cells are clonally expanded in RA patients and how they function in the rheumatoid inflammation. ..
  8. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2000
    ..Preventing the accumulation of CD4+ CD28null T cells might be a primary target for immune therapy in aging individuals. ..
  9. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 1999
    ..In combination, these approaches will allow us to determine how autoreactive CD4+ CD28- T cells are clonally expanded in RA patients and how they function in the rheumatoid inflammation. ..
  10. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2007
    ..The promise of this concept is that targeting these active mechanisms can, in part, restore immunocompetence. ..
  11. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 2006
    ..The long-term goal of this proposal is to determine whether this novel regulatory system of stimulatory and inhibitory receptors can be exploited for therapeutic interventions to control disease-relevant T-cell responses in RA. ..
  12. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 2001
    ..Preventing the accumulation of CD4+ CD28null T cells might be a primary target for immune therapy in aging individuals. ..
  13. T CELLS AND AGING
    Jorg Goronzy; Fiscal Year: 1999
    ..Preventing the accumulation of CD4+ CD28null T cells might be a primary target for immune therapy in aging individuals. ..
  14. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 2004
    ..The long-term goal of this proposal is to determine whether this novel regulatory system of stimulatory and inhibitory receptors can be exploited for therapeutic interventions to control disease-relevant T-cell responses in RA. ..
  15. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 2003
    ..The long-term goal of this proposal is to determine whether this novel regulatory system of stimulatory and inhibitory receptors can be exploited for therapeutic interventions to control disease-relevant T-cell responses in RA. ..
  16. DIVERSITY OF T LYMPHOCYTES IN RHEUMATOID ARTHRITIS
    Jorg Goronzy; Fiscal Year: 2001
    ..In combination, these approaches will allow us to determine how autoreactive CD4+ CD28- T cells are clonally expanded in RA patients and how they function in the rheumatoid inflammation. ..