Research Topics
| MIRIAM GOODMANSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
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Publications
Transducing touch in Caenorhabditis elegansMiriam B Goodman
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
Annu Rev Physiol 65:429-52. 2003..elegans, with an emphasis on insights into their function derived from mutation. We also review the neuronal cell types in which these channels might be expressed and mediate mechanotransduction...- Eppendorf essay winner. Deconstructing C. elegans sensory mechanotransductionMiriam B Goodman
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 306:427-8. 2004 
Bidirectional temperature-sensing by a single thermosensory neuron in C. elegansDaniel Ramot
Program in Neuroscience, Stanford University, 279 Campus Dr, Stanford, California 94305, USA
Nat Neurosci 11:908-15. 2008....- The C. elegans EMAP-like protein, ELP-1 is required for touch sensation and associates with microtubules and adhesion complexesJennifer L Hueston
Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA
BMC Dev Biol 8:110. 2008..elegans (ELP-1). Biochemical studies of sea urchin EMAP and vertebrate EMLs implicate these proteins in the regulation of microtubule stability. So far, however, the physiological function of this protein family remains unknown... - Sensation is painlessMiriam B Goodman
Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
Trends Neurosci 26:643-5. 2003..Painless thus joins an elite group of TRPs implicated in sensory transduction in insects, nematodes, mammals and fish... - Molecules and mechanisms of mechanotransductionMiriam B Goodman
Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305, USA
J Neurosci 24:9220-2. 2004 - Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neuronsJuan G Cueva
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurosci 27:14089-98. 2007..We speculate that the microtubule bundle converts external point loads into membrane stretch which, in turn, facilitates MeT channel activation... - MEC-2 and MEC-6 in the Caenorhabditis elegans sensory mechanotransduction complex: auxiliary subunits that enable channel activityAustin L Brown
Biophysics Program, Stanford University, Stanford, CA 94305, USA
J Gen Physiol 131:605-16. 2008..We suggest that MEC-2 and MEC-6 play essential roles in modulating both the local membrane environment of MEC-4/MEC-10 channels and the availability of such channels to be gated by force in vivo... 
Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockadeAustin L Brown
Biophysics Program, Stanford University School of Medicine, CA 94305, USA
J Gen Physiol 129:161-73. 2007..We conclude that the d position is part of a key region in the channel functionally and structurally, possibly representing the beginning of a pore-forming domain...- An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregationMatthew P Klassen
Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
Neuron 66:710-23. 2010..Together, these results suggest that arl-8 promotes a trafficking identity for presynaptic cargoes, facilitating their efficient transport by repressing premature self-association... - SU-8 force sensing pillar arrays for biological measurementsJoseph C Doll
Department of Mechanical Engineering, Stanford University, Stanford, CA, USA
Lab Chip 9:1449-54. 2009..elegans in probing and responding to their environment during locomotion. The device features sub-microN force resolution from 1 Hz to 1 kHz, >25 microN range, kHz acquisition rates and biocompatibility... - Analysis of nematode mechanics by piezoresistive displacement clampSung Jin Park
Department of Mechanical Engineering and Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 104:17376-81. 2007..This initial analysis of C. elegans body mechanics suggests that shell mechanics dominates stiffness and is a first step in understanding how body mechanics affect locomotion and force sensing... 
Thermotaxis is a robust mechanism for thermoregulation in Caenorhabditis elegans nematodesDaniel Ramot
Program in Neuroscience, Stanford University, Stanford, California 94305, USA
J Neurosci 28:12546-57. 2008..We suggest that, similar to biochemical networks, animals evolve behavioral strategies that are robust, rather than strategies that rely on fine tuning of specific behavioral parameters...- The Parallel Worm Tracker: a platform for measuring average speed and drug-induced paralysis in nematodesDaniel Ramot
Program in Neuroscience, Stanford University, Stanford, California, United States of America
PLoS ONE 3:e2208. 2008..elegans locomotion rely on qualitative experimenter observation. Here we report the implementation of an automated tracking system developed to quantify the locomotion of multiple individual worms in parallel... - MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensationMiriam B Goodman
Department of Biological Sciences, Columbia University, New York 10027, USA
Nature 415:1039-42. 2002..Some of these channels may mediate mechanosensory responses... - The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signalsMartin Chalfie
Department of Biological Sciences, Columbia University, New York, New York 10027, USA
Nat Neurosci 8:43-50. 2005..Our findings link the application of external force to the activation of a molecularly defined metazoan sensory transduction channel... - The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channelDattananda S Chelur
Department of Biological Sciences, Columbia University, New York, New York 10027, USA
Nature 420:669-73. 2002..In vivo, MEC-6 co-localizes with MEC-4, and is required for punctate MEC-4 expression along touch-neuron processes. We propose that MEC-6 is a part of the degenerin channel complex that may mediate mechanotransduction in touch cells... - Physiology: Keeping it regular with protonsLaura M Prolo
Nature 452:35-6. 2008 - Dissecting a circuit for olfactory behaviour in Caenorhabditis elegansSreekanth H Chalasani
Howard Hughes Medical Institute, Laboratory of Neural Circuits and Behaviour, The Rockefeller University, New York, New York 10065, USA
Nature 450:63-70. 2007..Information processing by this circuit resembles information flow from vertebrate photoreceptors to 'OFF' bipolar and 'ON' bipolar neurons, indicating a conserved or convergent strategy for sensory information processing...
Research Grants
- Molecular Basis of Sensory Transduction in C elegansMIRIAM GOODMAN; Fiscal Year: 2007..What is learned from these studies will clarify basic mechanisms of mechanotransduction and could improve the diagnosis and treatment of sensory neuropathies associated with both inherited and acquired diseases. ..
- Temperature Sensation and Its Behavioral ConsequencesMIRIAM GOODMAN; Fiscal Year: 2007....
- Molecular Basis of Sensory Transduction in C. elegansMiriam B Goodman; Fiscal Year: 2010..What is learned from this research has the potential to provide new insight into possible diagnostic tools and treatments for the degradation of touch sensation. ..
- Molecular Basis of Sensory Transduction in C. elegansMIRIAM GOODMAN; Fiscal Year: 2009..What is learned from this research has the potential to provide new insight into possible diagnostic tools and treatments for the degradation of touch sensation. ..