MIRIAM GOODMAN

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Transducing touch in Caenorhabditis elegans
    Miriam B Goodman
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Physiol 65:429-52. 2003
  2. ncbi request reprint Eppendorf essay winner. Deconstructing C. elegans sensory mechanotransduction
    Miriam B Goodman
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 306:427-8. 2004
  3. pmc Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans
    Daniel Ramot
    Program in Neuroscience, Stanford University, 279 Campus Dr, Stanford, California 94305, USA
    Nat Neurosci 11:908-15. 2008
  4. pmc MEC-2 and MEC-6 in the Caenorhabditis elegans sensory mechanotransduction complex: auxiliary subunits that enable channel activity
    Austin L Brown
    Biophysics Program, Stanford University, Stanford, CA 94305, USA
    J Gen Physiol 131:605-16. 2008
  5. pmc The Parallel Worm Tracker: a platform for measuring average speed and drug-induced paralysis in nematodes
    Daniel Ramot
    Program in Neuroscience, Stanford University, Stanford, California, United States of America
    PLoS ONE 3:e2208. 2008
  6. pmc GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis
    Dong Wang
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305
    J Gen Physiol 142:437-49. 2013
  7. pmc The C. elegans EMAP-like protein, ELP-1 is required for touch sensation and associates with microtubules and adhesion complexes
    Jennifer L Hueston
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA
    BMC Dev Biol 8:110. 2008
  8. ncbi request reprint Sensation is painless
    Miriam B Goodman
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Trends Neurosci 26:643-5. 2003
  9. ncbi request reprint Molecules and mechanisms of mechanotransduction
    Miriam B Goodman
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305, USA
    J Neurosci 24:9220-2. 2004
  10. ncbi request reprint Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neurons
    Juan G Cueva
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 27:14089-98. 2007

Research Grants

Collaborators

  • Minoru Tada
  • Kang Shen
  • Ellen A Lumpkin
  • Erich M Schwarz
  • Maurice Kernan
  • TERESA A NICOLSON
  • W D Tracey
  • Anthony J Ricci
  • Daniel Ramot
  • Juan G Cueva
  • Austin L Brown
  • Dong Wang
  • Matthew P Klassen
  • Joseph C Doll
  • BETH L PRUITT
  • Bronwyn L MacInnis
  • Laura M Prolo
  • Jennifer L Hueston
  • Zhiwen Liao
  • Sreekanth H Chalasani
  • Sung Jin Park
  • ROBERT O'HAGAN
  • Martin Chalfie
  • Dattananda S Chelur
  • Damien O'Halloran
  • Ye E Wu
  • Isei Nakae
  • Celine I Maeder
  • George J Wang
  • Emily K Lehrman
  • Shohei Mitani
  • Toshiaki Katada
  • Keiko Gengyo-Ando
  • Kenji Kontani
  • Ronald Kwon
  • Nathan Klejwa
  • Nahid Harjee
  • Bryan Petzold
  • Sarah M Coulthard
  • Kathy A Suprenant
  • Gina Purinton Herren
  • Erik A Lundquist
  • Brandon E Johnson
  • Lucinda Carnell
  • Matthew Buechner
  • Tommie L Berry
  • Hau Chen Lee
  • Silvia M Fernandez-Illescas
  • Nikos Chronis
  • Cornelia I Bargmann
  • Jesse M Gray
  • Atticus Mulholland
  • Makoto Tsunozaki
  • Glen G Ernstrom
  • Robert O' Hagan
  • Lei Chen
  • C Andrea Yao

Detail Information

Publications20

  1. ncbi request reprint Transducing touch in Caenorhabditis elegans
    Miriam B Goodman
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Physiol 65:429-52. 2003
    ..elegans, with an emphasis on insights into their function derived from mutation. We also review the neuronal cell types in which these channels might be expressed and mediate mechanotransduction...
  2. ncbi request reprint Eppendorf essay winner. Deconstructing C. elegans sensory mechanotransduction
    Miriam B Goodman
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 306:427-8. 2004
  3. pmc Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans
    Daniel Ramot
    Program in Neuroscience, Stanford University, 279 Campus Dr, Stanford, California 94305, USA
    Nat Neurosci 11:908-15. 2008
    ....
  4. pmc MEC-2 and MEC-6 in the Caenorhabditis elegans sensory mechanotransduction complex: auxiliary subunits that enable channel activity
    Austin L Brown
    Biophysics Program, Stanford University, Stanford, CA 94305, USA
    J Gen Physiol 131:605-16. 2008
    ..We suggest that MEC-2 and MEC-6 play essential roles in modulating both the local membrane environment of MEC-4/MEC-10 channels and the availability of such channels to be gated by force in vivo...
  5. pmc The Parallel Worm Tracker: a platform for measuring average speed and drug-induced paralysis in nematodes
    Daniel Ramot
    Program in Neuroscience, Stanford University, Stanford, California, United States of America
    PLoS ONE 3:e2208. 2008
    ..elegans locomotion rely on qualitative experimenter observation. Here we report the implementation of an automated tracking system developed to quantify the locomotion of multiple individual worms in parallel...
  6. pmc GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis
    Dong Wang
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305
    J Gen Physiol 142:437-49. 2013
    ....
  7. pmc The C. elegans EMAP-like protein, ELP-1 is required for touch sensation and associates with microtubules and adhesion complexes
    Jennifer L Hueston
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA
    BMC Dev Biol 8:110. 2008
    ..elegans (ELP-1). Biochemical studies of sea urchin EMAP and vertebrate EMLs implicate these proteins in the regulation of microtubule stability. So far, however, the physiological function of this protein family remains unknown...
  8. ncbi request reprint Sensation is painless
    Miriam B Goodman
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Trends Neurosci 26:643-5. 2003
    ..Painless thus joins an elite group of TRPs implicated in sensory transduction in insects, nematodes, mammals and fish...
  9. ncbi request reprint Molecules and mechanisms of mechanotransduction
    Miriam B Goodman
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305, USA
    J Neurosci 24:9220-2. 2004
  10. ncbi request reprint Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neurons
    Juan G Cueva
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 27:14089-98. 2007
    ..We speculate that the microtubule bundle converts external point loads into membrane stretch which, in turn, facilitates MeT channel activation...
  11. pmc Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade
    Austin L Brown
    Biophysics Program, Stanford University School of Medicine, CA 94305, USA
    J Gen Physiol 129:161-73. 2007
    ..We conclude that the d position is part of a key region in the channel functionally and structurally, possibly representing the beginning of a pore-forming domain...
  12. pmc An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation
    Matthew P Klassen
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 66:710-23. 2010
    ..Together, these results suggest that arl-8 promotes a trafficking identity for presynaptic cargoes, facilitating their efficient transport by repressing premature self-association...
  13. pmc SU-8 force sensing pillar arrays for biological measurements
    Joseph C Doll
    Department of Mechanical Engineering, Stanford University, Stanford, CA, USA
    Lab Chip 9:1449-54. 2009
    ..elegans in probing and responding to their environment during locomotion. The device features sub-microN force resolution from 1 Hz to 1 kHz, >25 microN range, kHz acquisition rates and biocompatibility...
  14. pmc Analysis of nematode mechanics by piezoresistive displacement clamp
    Sung Jin Park
    Department of Mechanical Engineering and Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:17376-81. 2007
    ..This initial analysis of C. elegans body mechanics suggests that shell mechanics dominates stiffness and is a first step in understanding how body mechanics affect locomotion and force sensing...
  15. pmc Thermotaxis is a robust mechanism for thermoregulation in Caenorhabditis elegans nematodes
    Daniel Ramot
    Program in Neuroscience, Stanford University, Stanford, California 94305, USA
    J Neurosci 28:12546-57. 2008
    ..We suggest that, similar to biochemical networks, animals evolve behavioral strategies that are robust, rather than strategies that rely on fine tuning of specific behavioral parameters...
  16. ncbi request reprint The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
    Dattananda S Chelur
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nature 420:669-73. 2002
    ..In vivo, MEC-6 co-localizes with MEC-4, and is required for punctate MEC-4 expression along touch-neuron processes. We propose that MEC-6 is a part of the degenerin channel complex that may mediate mechanotransduction in touch cells...
  17. ncbi request reprint MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation
    Miriam B Goodman
    Department of Biological Sciences, Columbia University, New York 10027, USA
    Nature 415:1039-42. 2002
    ..Some of these channels may mediate mechanosensory responses...
  18. ncbi request reprint The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals
    ROBERT O'HAGAN
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nat Neurosci 8:43-50. 2005
    ..Our findings link the application of external force to the activation of a molecularly defined metazoan sensory transduction channel...
  19. doi request reprint Physiology: Keeping it regular with protons
    Laura M Prolo
    Nature 452:35-6. 2008
  20. ncbi request reprint Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans
    Sreekanth H Chalasani
    Howard Hughes Medical Institute, Laboratory of Neural Circuits and Behaviour, The Rockefeller University, New York, New York 10065, USA
    Nature 450:63-70. 2007
    ..Information processing by this circuit resembles information flow from vertebrate photoreceptors to 'OFF' bipolar and 'ON' bipolar neurons, indicating a conserved or convergent strategy for sensory information processing...

Research Grants9

  1. Molecular Basis of Sensory Transduction in C elegans
    MIRIAM GOODMAN; Fiscal Year: 2004
    ..What is learned from these studies will clarify basic mechanisms of mechanotransduction and could improve the diagnosis and treatment of sensory neuropathies associated with both inherited and acquired diseases. ..
  2. Molecular Basis of Sensory Transduction in C elegans
    MIRIAM GOODMAN; Fiscal Year: 2005
    ..What is learned from these studies will clarify basic mechanisms of mechanotransduction and could improve the diagnosis and treatment of sensory neuropathies associated with both inherited and acquired diseases. ..
  3. Molecular Basis of Sensory Transduction in C elegans
    MIRIAM GOODMAN; Fiscal Year: 2006
    ..What is learned from these studies will clarify basic mechanisms of mechanotransduction and could improve the diagnosis and treatment of sensory neuropathies associated with both inherited and acquired diseases. ..
  4. Molecular Basis of Sensory Transduction in C elegans
    MIRIAM GOODMAN; Fiscal Year: 2007
    ..What is learned from these studies will clarify basic mechanisms of mechanotransduction and could improve the diagnosis and treatment of sensory neuropathies associated with both inherited and acquired diseases. ..
  5. Temperature Sensation and Its Behavioral Consequences
    MIRIAM GOODMAN; Fiscal Year: 2007
    ....
  6. Molecular Basis of Sensory Transduction in C. elegans
    MIRIAM GOODMAN; Fiscal Year: 2009
    ..What is learned from this research has the potential to provide new insight into possible diagnostic tools and treatments for the degradation of touch sensation. ..
  7. Molecular Basis of Sensory Transduction in C. elegans
    Miriam B Goodman; Fiscal Year: 2010
    ..What is learned from this research has the potential to provide new insight into possible diagnostic tools and treatments for the degradation of touch sensation. ..
  8. Molecular Basis of Sensory Transduction in C. elegans
    MIRIAM GOODMAN; Fiscal Year: 2009
    ..What is learned from this research has the potential to provide new insight into possible diagnostic tools and treatments for the degradation of touch sensation. ..