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Genomes and Genes | L C GiudiceSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantationL C Giudice
Department of Gynecology and Obstetrics, Stanford University Medical Center, Stanford, California 94305, USA
J Clin Endocrinol Metab 87:2359-66. 2002..Overall, the data underscore potential roles for a complex family of enzyme (PAPP-A), substrate (IGFBP-4), inhibitor (proMBP), and cofactor (IGF-II) in the placental bed during human implantation...- EndometriosisLinda C Giudice
Division of Reproductive Endocrinology and Infertility, Center for Research on Women s Health and Reproduction, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
Lancet 364:1789-99. 2004..Clinicians should assess and follow up affected women for these and other associated disorders. There will probably be a new repertoire of approaches for treatment and perhaps cure of this enigmatic disorder in the near future... - Elucidating endometrial function in the post-genomic eraLinda C Giudice
Stanford University School of Medicine, Stanford, CA 94305 5317, USA
Hum Reprod Update 9:223-35. 2003..This monograph reviews some of the salient features of the new technologies and summarizes current information on endometrial biology derived from these approaches... - Insulin-like growth factor family in Graafian follicle development and functionL C Giudice
Division of Reproductive Endocrinology and Infertility, Center for Research on Women s Health and Reproductive Medicine, Department of Gynecology and Obstetrics, Stanford University Medical Center, Stanford, California 94305 5317, USA
J Soc Gynecol Investig 8:S26-9. 2001..In the Graafian follicle, IGF-II bioavailability is increased to act as a mediator of FSH action, by increased synthesis of this peptide and concomitant decrease in an inhibitor of its actions by proteolysis of IGFBP-4... - The molecular basis for implantation failure in endometriosis: on the road to discoveryLinda C Giudice
Center for Research on Women s Health and Reproductive Medicine, Department of Gynecology and Obstetrics, Stanford University Medical Center, California 94305, USA
Ann N Y Acad Sci 955:252-64; discussion 293-5, 396-406. 2002.... 
Maternal-fetal conflict--lessons from a transgeneLinda C Giudice
Center for Research on Women's Health and Reproductive Medicine, 300 Pasteur Drive, Stanford University, Stanford, California 94305-5317, USA
J Clin Invest 110:307-9. 2002- Microarray expression profiling reveals candidate genes for human uterine receptivityLinda C Giudice
Department of Gynecology and Obstetrics, Center for Research on Women s Health and Reproduction, Stanford University School of Medicine, Stanford, California, USA
Am J Pharmacogenomics 4:299-312. 2004..Global profiling of genes in the endometrium, decidua, and at the interface between the trophoblast and the decidua, has provided remarkable in sight into endometrial maturation and implantation... - Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertilityL C Kao
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305-5317, USA
Endocrinology 144:2870-81. 2003.... - Identification, characterization, and regulation of the canonical Wnt signaling pathway in human endometriumS Tulac
Department of Gynecology and Obstetrics, Stanford University, Stanford, California 94305-5317, USA
J Clin Endocrinol Metab 88:3860-6. 2003..Also, they underscore the likely importance of this family during endometrial development, differentiation and implantation... - Insulin-like growth factor (IGF)-II inhibition of endometrial stromal cell tissue inhibitor of metalloproteinase-3 and IGF-binding protein-1 suggests paracrine interactions at the decidua:trophoblast interface during human implantationJ C Irwin
Division of Reproductive Endocrinology and Infertility, Center for Research on Women's Health and Reproductive Medicine, Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305-5317, USA
J Clin Endocrinol Metab 86:2060-4. 2001..2-0.4 nM. These data suggest that the invading trophoblast has the capacity, via IGF-II, to inhibit maternal restraints on trophoblast invasiveness by regulating decidual TIMP-3 and IGFBP-1... - Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human developmentG A Ulaner
Department of Gynecology and Obstetrics, Stanford University School of Medicine, Palo Alto, CA, USA
Int J Cancer 91:644-9. 2001..The specific pattern of hTERT mRNA variants in human development provides evidence that alternative splicing is non-random and participates in the regulation of telomerase activity... - Global gene profiling in human endometrium during the window of implantationL C Kao
Department of Gynecology and Obstetrics, Stanford University, Stanford, California 94305, USA
Endocrinology 143:2119-38. 2002..In addition, the current study validates using high density oligonucleotide microarray technology to investigate global changes in gene expression in human endometrium... - Dose-dependent insulin regulation of insulin-like growth factor binding protein-1 in human endometrial stromal cells is mediated by distinct signaling pathwaysR B Lathi
Center for Research on Women s Health and Reproduction, Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Stanford University, Stanford, California 94305 5317, USA
J Clin Endocrinol Metab 90:1599-606. 2005.... - Comparative biology of the IGF system in endometrium, decidua, and placenta, and clinical implications for foetal growth and implantation disordersN R Nayak
Department of Gynecology and Obstetrics, Center for Research on Women's Health and Reproductive Medicine, Stanford University Medical Center, Stanford, CA 94305-5317, USA
Placenta 24:281-96. 2003.... - MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosisR O Burney
Division of Reproductive Endocrinology and Infertility, Madigan Army Medical Center, Tacoma, WA, USA
Mol Hum Reprod 15:625-31. 2009.... - A longitudinal analysis of maternal serum insulin-like growth factor I (IGF-I) and total and nonphosphorylated IGF-binding protein-1 in human pregnancies complicated by intrauterine growth restrictionS Bhatia
Department of Gynecology and Obstetrics, Stanford University Medical Center, Stanford, California 94305, USA
J Clin Endocrinol Metab 87:1864-70. 2002..Our results do not support the use of maternal serum IGF-I or IGFBP-1 or amniotic fluid IGFBP-1 or npIGFBP-1 early in gestation to predict later fetal growth restriction... - Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasmaP Cohen
Department of Pediatrics, Stanford University Medical Center, California 94305
J Clin Endocrinol Metab 75:1046-53. 1992..We speculate that PSA may serve to modulate IGF function within the reproductive system or in prostate cancer by altering IGF-IGFBP-3 interactions... 
Expression of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesteroneC Dosiou
Division of Endocrinology and Metabolism, Department of Medicine, Stanford University, Stanford, California 94305, USA
J Endocrinol 196:67-77. 2008..Progesterone activated an inhibitory G-protein (G(i)), suggesting that mPRs are coupled to G(i) in Jurkat cells. These results suggest a potential novel mechanism for progesterone's immunoregulatory function through activation of mPRs...- Angiopoietin-1 and -2 mRNA and protein expression in mouse preimplantation embryos and uteri suggests a role in angiogenesis during implantationA P Hess
Department of Gynecology and Obstetrics, Stanford University Medical School, 300 Pasteur Drive, Stanford, CA 94305 5317, USA
Reprod Fertil Dev 18:509-16. 2006.... - Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiencyR M Popovici
Department of Gynecology and Obstetrics, Stanford University Medical School, Stanford, California 94305, USA
J Clin Endocrinol Metab 86:2653-9. 2001..The data support a role for the fetal liver as a source of elevated circulating levels of IGFBP-1 in fetuses with in utero hypoxia and IUGR... - Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometriumG A Ulaner
Department of Gynecology and Obstetrics, Stanford University School of Medicine, Palo Alto, CA, USA
Int J Cancer 85:330-5. 2000.... - Identification of insulin-like growth factor binding proteins in human oviductL C Giudice
Department of Gynecology and Obstetrics, Stanford University Medical Center, California 94305
Fertil Steril 57:294-301. 1992.... - Measurement and characterization of insulin-like growth factor binding protein-3 in human biological fluids: discrepancies between radioimmunoassay and ligand blottingS E Gargosky
Department of Pediatrics, Stanford University School of Medicine, California 94305
Endocrinology 131:3051-60. 1992..Fluids with high proteolytic activity (pregnancy serum, CSF, seminal plasma, peritoneal fluid, and amniotic fluid) gave discrepant IGFBP-3 values between RIA and Western ligand blot.(ABSTRACT TRUNCATED AT 400 WORDS).. 
Application of functional genomics to primate endometrium: insights into biological processesLinda C Giudice
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 505 Parnassus, M1496, Box 0132, San Francisco, CA 94143 0132, USA
Reprod Biol Endocrinol 4:S4. 2006..It also highlights challenges encountered in using human endometrial tissue in translational research in this context...- The immune environment in human endometrium during the window of implantationShalini C Lobo
Department of Gynecology and Obstetrics, Stanford University Medical Center, Stanford, CA 94305-5317, USA
Am J Reprod Immunol 52:244-51. 2004..Upregulation of these immune-related genes in the window of implantation suggests their role during the process of implantation and in immune tolerance of the implanting conceptus... - Microbes on the human vaginal epitheliumRichard W Hyman
Stanford Genome Technology Center and Departments of Biochemistry, Genetics, and Obstetrics and Gynecology, Stanford University, 855 California Avenue, Palo Alto, CA 94304, USA
Proc Natl Acad Sci U S A 102:7952-7. 2005..Eight subjects presented complex mixtures of Lactobacillus and other microbes. The remaining eight subjects had no Lactobacillus. Instead, Bifidobacterium, Gardnerella, Prevotella, Pseudomonas, or Streptococcus predominated... - Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processingMeiyi Tang
Department of Obstetrics and Gynecology, Stony Brook University, New York 11794, USA
Endocrinology 146:5313-20. 2005..Taken together, the findings show that decidualized differentiation of stroma, which is a prerequisite for embryo implantation, leads to processing of lefty by PC5/6A... - The dilemma of endometriosis: is consensus possible with an enigma?Camran Nezhat
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University Medical Center, Stanford, California, USA
Fertil Steril 84:1587-8. 2005..The findings of our study add another dimension to management of endometriosis in the setting of infertility and emphasize the importance of keeping laparoscopy in the infertility management equation... - Expression, localization and hormonal control of angiopoietin-1 in the rhesus macaque endometrium: potential role in spiral artery growthNihar R Nayak
Department of Gynecology and Obstetrics, Stanford University, Stanford, CA 94305 5317, USA
Mol Hum Reprod 11:791-9. 2005..These data suggest, for the first time, that Ang-1 may play a key role in the P-dependent growth of the unique spiral arteries in the primate endometrium... - Dickkopf-1, an inhibitor of Wnt signaling, is regulated by progesterone in human endometrial stromal cellsSuzana Tulac
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California-San Francisco, 505 Parnassus Avenue M1496, San Francisco, CA 94143-0132, USA
J Clin Endocrinol Metab 91:1453-61. 2006.... - Endometrium in PCOS: Implantation and predisposition to endocrine CALinda C Giudice
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 505 Parnassus Avenue, M1496, Box 0132, San Francisco, CA 94143 0132, USA
Best Pract Res Clin Endocrinol Metab 20:235-44. 2006..The potential mechanisms underlying these disorders, specifically in women with PCOS, are complex and await additional transdisciplinary research for their complete elucidation... - Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosisRichard O Burney
Department of Obstetrics and Gynecology, Stanford University, Stanford, California 94305, USA
Endocrinology 148:3814-26. 2007..Collectively these findings provide a framework for further investigations on causality and mechanisms underlying attenuated progesterone response in endometrium of women with endometriosis... - Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeatsLisbeth S Laursen
Department of Molecular Biology, Science Park, University of Aarhus, Aarhus C, Denmark
J Biol Chem 277:47225-34. 2002..proMBP restores surface binding. We finally propose a model in which IGF bioactivity is regulated by reversible cell surface binding of PAPP-A, which in turn is regulated by proMBP... - VEGF blockade inhibits angiogenesis and reepithelialization of endometriumXiujun Fan
Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
FASEB J 22:3571-80. 2008..In summary, we provide novel experimental data indicating that VEGF is essential for endometrial neoangiogenesis during postmenstrual/postpartum repair... - The impact of ovarian stimulation with recombinant FSH in combination with GnRH antagonist on the endometrial transcriptome in the window of implantationNick S Macklon
Department of Reproductive Medicine and Gynecology, University Medical Center, Utrecht, Netherlands
Reprod Sci 15:357-65. 2008..These data suggest that dysregulation of the endometrial transcriptome in the stimulated cycle is not fully attributable to supraphysiological sex steroid levels at the folliculo-luteal transition... - Emerging role of genomics in endometriosis researchRobert N Taylor
Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco School of Medicine, 94143 0556, USA
Fertil Steril 78:694-8. 2002..In this report we briefly review some of the seminal technological advances that inspired the genomics revolution and describe their application in the field of endometriosis research... - Pregnancy-associated plasma protein A proteolytic activity is associated with the human placental trophoblast cell membraneIrene Y C Sun
Department of Gynecology and Obstetrics, Center for Research on Women s Health and Reproductive Medicine, Stanford University Medical Center, Stanford, CA 94305 5317, USA
J Clin Endocrinol Metab 87:5235-40. 2002.... - The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificityHenning B Boldt
Department of Molecular Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
J Biol Chem 279:38525-31. 2004..We propose a model in which LNR3 is spatially localized in proximity to LNR1 and -2, forming a single functional unit... - Developmental response to hypoxiaS-T Joseph Huang
Department of Obstetrics and Gynecology, Stanford University Medical Center, California 94305-5317, USA
FASEB J 18:1348-65. 2004..Furthermore, induction of inflammation-related genes in placentas exposed to long-term hypoxia (11 days) suggests a mechanism for placental dysfunction and impaired pregnancy outcome accompanying in utero hypoxia... - Activation of the protein kinase A pathway in human endometrial stromal cells reveals sequential categorical gene regulationEmily P Tierney
Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305-5317, USA
Physiol Genomics 16:47-66. 2003.... - Inhibition of proteolysis by the proform of eosinophil major basic protein (proMBP) requires covalent binding to its target proteinaseMichael T Overgaard
Department of Molecular Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
FEBS Lett 560:147-52. 2004.... - Role of activin A as a mediator of in vitro endometrial stromal cell decidualization via the cyclic adenosine monophosphate pathwayEmily P Tierney
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5317, USA
Fertil Steril 81:899-903. 2004.... - The influence of hydrosalpinx on markers of endometrial receptivityRicardo Francalacci Savaris
Departamento de Ginecologia e Obstetricia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Semin Reprod Med 25:476-82. 2007..In addition, the evidence for treatment options to improve pregnancy rates is also discussed... - Participation of mitogen-activated protein kinase in luteinizing hormone-induced differential regulation of steroidogenesis and steroidogenic gene expression in mural and cumulus granulosa cells of mouse preovulatory folliclesYou Qiang Su
Department of Obstetrics and Gynecology, Stanford University, Stanford, California 94305, USA
Biol Reprod 75:859-67. 2006.... - The science behind 25 years of ovarian stimulation for in vitro fertilizationNick S Macklon
Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
Endocr Rev 27:170-207. 2006..After a brief discussion of the relevant aspect of ovarian physiology, the development, application, and consequences of ovarian stimulation strategies are reviewed in detail... - Clomiphene, metformin, or both for infertility in the polycystic ovary syndromeRichard S Legro
Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, M S Hershey Medical Center, Hershey, PA 17033, USA
N Engl J Med 356:551-66. 2007..The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior... - Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome TrialPeter G McGovern
Department of Obstetrics, UMDNJ, New Jersey Medical School, Newark, New Jersey 07101 1709, USA
Fertil Steril 90:1283-6. 2008.... - Infertility and the environment: the medical contextLinda C Giudice
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143, USA
Semin Reprod Med 24:129-33. 2006.... - Utility of screening for other causes of infertility in women with "known" polycystic ovary syndromePeter G McGovern
Department of Obstetrics, Gynecology and Women s Health, UMDNJ New Jersey Medical School, Newark, New Jersey 07101 1709, USA
Fertil Steril 87:442-4. 2007..Other than failure to demonstrate laboratory evidence of hyperandrogenemia, the most common reasons for subject exclusion were persistent oligospermia and tubal factor infertility... - Developmental competence of immature and failed/abnormally fertilized human oocytes in nuclear transferSohyun Lee McElroy
Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, Palo Alto, CA 94304 5542, USA
Reprod Biomed Online 16:684-93. 2008..In light of these results, it is suggested that the discarded oocytes can be used to investigate new human nuclear transfer protocols for embryonic stem cell derivation... - Metabolic and ovarian effects of rosiglitazone treatment for 12 weeks in insulin-resistant women with polycystic ovary syndromeNicholas A Cataldo
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Hum Reprod 21:109-20. 2006..Insulin sensitizers have favourable metabolic and ovarian effects in polycystic ovary syndrome (PCOS). This study examined rosiglitazone, a thiazolidinedione, in PCOS... - Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysisLisbeth S Laursen
Department of Molecular and Structural Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
Biochem J 367:31-40. 2002.... - Prediction of the individual follicle-stimulating hormone threshold for gonadotropin induction of ovulation in normogonadotropic anovulatory infertility: an approach to increase safety and efficiencyBabak Imani
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
Fertil Steril 77:83-90. 2002..The prediction model developed in this study may increase the safety and efficiency of low-dose gonadotropin protocols (step-up and step-down) by correctly determining the appropriate starting dose for a given patient... - Regulation of insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetusesJohan Verhaeghe
Department of Obstetrics and Gynaecology, Katholieke Universiteit Leuven
Am J Obstet Gynecol 188:485-91. 2003..Insulin is a powerful determinant of insulin-like growth factor binding protein-1, but not insulin-like growth factor-I, concentrations in the preterm fetus... - Incidence of monozygotic twinning with blastocyst transfer compared to cleavage-stage transferAmin A Milki
Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305, USA
Fertil Steril 79:503-6. 2003..To evaluate the incidence of monozygotic twinning (MZT) in pregnancies conceived after blastocyst transfer compared to cleavage-stage transfer... - Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP moduleKathrin Weyer
Department of Molecular Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark
Eur J Biochem 271:1525-35. 2004..This explains, at least in part, why PAPP-A2 lacks the ability of cell surface adhesion, and further emphasizes the role of the basic clusters defined in PAPP-A... - Interferon-related and other immune genes are downregulated in peripheral blood leukocytes in the luteal phase of the menstrual cycleChrysoula Dosiou
Department of Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
J Clin Endocrinol Metab 89:2501-4. 2004..These results support significant hormonal regulation of the immune system and may have therapeutic implications in diseases of autoimmunity in women... - Genomics' role in understanding the pathogenesis of endometriosisLinda C Giudice
Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Stanford University School of Medicine, 300 Pasteur Drive, HH333, Stanford, CA 94305-5317, USA
Semin Reprod Med 21:119-24. 2003..Recent advances in molecular biology and genomics suggest an intrinsic abnormality in the eutopic endometrium of women with endometriosis that predisposes to these processes. These are discussed herein... - Silencing lamin A/C in human endometrial stromal cells: a model to investigate endometrial gene function and regulationSuzana Tulac
Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305, USA
Mol Hum Reprod 10:705-11. 2004.... - Absence of secretory endometrium after false-positive home urine luteinizing hormone testingPeter G McGovern
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
Fertil Steril 82:1273-7. 2004..To examine the proportion of cases with proliferative endometrium on biopsies performed after positive home urine LH testing... - Cellular expression and hormonal regulation of neuropilin-1 and -2 messenger ribonucleic Acid in the human and rhesus macaque endometriumAriane Germeyer
Department of Gynecology and Obstetrics, Stanford University School of Medicine, 300 Pasteur Drive, HH 333, Stanford, California 94305 5317, USA
J Clin Endocrinol Metab 90:1783-90. 2005..The findings extend our understanding of VEGF action in the primate endometrium... - Proteinase inhibition by proform of eosinophil major basic protein (pro-MBP) is a multistep process of intra- and intermolecular disulfide rearrangementsSimon Glerup
Department of Molecular Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
J Biol Chem 280:9823-32. 2005..It is therefore possible that the activity in vivo of PAPP-A is controlled by the redox potential, and it is further tempting to speculate that such mechanism operates under pathological conditions of altered redox potential... - Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectivesChrysoula Dosiou
Department of Endocrinology and Metabolism, Stanford University Medical Center, Stanford, California 94305, USA
Endocr Rev 26:44-62. 2005.... - Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activityRikke Søe
Department of Molecular and Structural Biology, Science Park, University of Aarhus, Denmark
Eur J Biochem 269:2247-56. 2002..Importantly, these data support the development of the mouse as a model organism for the study of PAPP-A, which must take into account the differences between the mouse and the human...