Rona Giffard

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Astrocyte proliferation following stroke in the mouse depends on distance from the infarct
    George E Barreto
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 6:e27881. 2011
  2. pmc The future of molecular chaperones and beyond
    Rona G Giffard
    Stanford University School of Medicine, 300 Pasteur Drive, Grant Building S272A, Stanford, California 94305 5117, USA
    J Clin Invest 123:3206-8. 2013
  3. pmc Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways
    Rachid Kacimi
    Dept, Neurology, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco 94121 USA
    J Inflamm (Lond) 8:7. 2011
  4. pmc Quantitative characterization and analysis of the dynamic NF-κB response in microglia
    Patrick W Sheppard
    Department of Mechanical Engineering, University of California, Santa Barbara, Engineering II Bldg, Santa Barbara, CA 93106 5070, USA
    BMC Bioinformatics 12:276. 2011
  5. ncbi request reprint Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury
    Rona G Giffard
    Department of Anesthesia, Stanford University, Stanford, CA 94305, USA
    J Exp Biol 207:3213-20. 2004
  6. pmc Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia: the complex roles of heat shock protein 70
    Rona G Giffard
    Department of Anesthesia, 300 Pasteur Drive, Grant Building S272, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesthesiology 109:339-48. 2008
  7. pmc Astrocytes: targets for neuroprotection in stroke
    George Barreto
    Department of Anesthesia, Stanford University School of Medicine, S272, Stanford, CA 94305, USA
    Cent Nerv Syst Agents Med Chem 11:164-73. 2011
  8. ncbi request reprint Two variants of the rat brain sodium-driven chloride bicarbonate exchanger (NCBE): developmental expression and addition of a PDZ motif
    Rona G Giffard
    Department of Anesthesia, S272, Stanford University, Stanford, CA 94305 5117, USA
    Eur J Neurosci 18:2935-45. 2003
  9. ncbi request reprint Effect of overexpression of protective genes on mitochondrial function of stressed astrocytes
    Rona Giffard
    Department of Anesthesia, Grant Building S272, Stanford University School of Medicine, Stanford, California 94305, USA
    J Bioenerg Biomembr 36:313-5. 2004
  10. ncbi request reprint Geldanamycin treatment reduces delayed CA1 damage in mouse hippocampal organotypic cultures subjected to oxygen glucose deprivation
    Yi Bing Ouyang
    Department of Anesthesia, Grant Building S272, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Neurosci Lett 380:229-33. 2005

Collaborators

Detail Information

Publications53

  1. pmc Astrocyte proliferation following stroke in the mouse depends on distance from the infarct
    George E Barreto
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 6:e27881. 2011
    ..Despite extensive cell proliferation primarily of microglia and neutrophils/monocytes in the week following stroke, few mature astrocytes re-enter cell cycle, and these are concentrated close to the infarct boundary...
  2. pmc The future of molecular chaperones and beyond
    Rona G Giffard
    Stanford University School of Medicine, 300 Pasteur Drive, Grant Building S272A, Stanford, California 94305 5117, USA
    J Clin Invest 123:3206-8. 2013
    ..The work also suggests that defective chaperones could cause ear disease and supports the potential use of chaperone therapeutics...
  3. pmc Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways
    Rachid Kacimi
    Dept, Neurology, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco 94121 USA
    J Inflamm (Lond) 8:7. 2011
    ..LPS is a classic TLR4 agonist, and is used here to model aspects of brain conditions where TLR4 stimulation occurs...
  4. pmc Quantitative characterization and analysis of the dynamic NF-κB response in microglia
    Patrick W Sheppard
    Department of Mechanical Engineering, University of California, Santa Barbara, Engineering II Bldg, Santa Barbara, CA 93106 5070, USA
    BMC Bioinformatics 12:276. 2011
    ..Mathematical modeling, which has been instrumental for understanding the NF-κB response in other cell types, offers a valuable tool to investigate the regulation of NF-κB activation in microglia at a systems level...
  5. ncbi request reprint Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury
    Rona G Giffard
    Department of Anesthesia, Stanford University, Stanford, CA 94305, USA
    J Exp Biol 207:3213-20. 2004
    ..Protection from ischemia and ischemia-like injury by chaperones thus involves at least anti-apoptotic, anti-necrotic and anti-protein aggregation mechanisms...
  6. pmc Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia: the complex roles of heat shock protein 70
    Rona G Giffard
    Department of Anesthesia, 300 Pasteur Drive, Grant Building S272, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesthesiology 109:339-48. 2008
    ..Intracellular effects are often antiinflammatory with inhibition of nuclear factor-kappaB signaling. Extracellular effects can lead to inflammatory cytokine production or induction of regulatory immune cells and reduced inflammation...
  7. pmc Astrocytes: targets for neuroprotection in stroke
    George Barreto
    Department of Anesthesia, Stanford University School of Medicine, S272, Stanford, CA 94305, USA
    Cent Nerv Syst Agents Med Chem 11:164-73. 2011
    ....
  8. ncbi request reprint Two variants of the rat brain sodium-driven chloride bicarbonate exchanger (NCBE): developmental expression and addition of a PDZ motif
    Rona G Giffard
    Department of Anesthesia, S272, Stanford University, Stanford, CA 94305 5117, USA
    Eur J Neurosci 18:2935-45. 2003
    ..These results are a first step towards understanding the regulation of expression and activity of this transporter in the brain...
  9. ncbi request reprint Effect of overexpression of protective genes on mitochondrial function of stressed astrocytes
    Rona Giffard
    Department of Anesthesia, Grant Building S272, Stanford University School of Medicine, Stanford, California 94305, USA
    J Bioenerg Biomembr 36:313-5. 2004
    ..Overexpression of Bcl-x(L) improves mitochondrial respiratory function, normalizes mitochondrial membrane potential, and reduces production of free radicals early after the imposition of a stress in primary cultured murine astrocytes...
  10. ncbi request reprint Geldanamycin treatment reduces delayed CA1 damage in mouse hippocampal organotypic cultures subjected to oxygen glucose deprivation
    Yi Bing Ouyang
    Department of Anesthesia, Grant Building S272, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Neurosci Lett 380:229-33. 2005
    ..Staining with ubiquitin to identify protein aggregates revealed reduced redistribution of ubiquitin, consistent with reduced protein aggregation likely due at least in part to induction of Hsp70 by GA...
  11. ncbi request reprint Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro
    Lijun Xu
    Department of Anesthesia, Stanford University, Stanford, CA 94305, USA
    Neurobiol Aging 27:562-9. 2006
    ..This suggests that strategies to maintain protein solubility and inhibit aggregation in the face of acute insults such as stroke may be a useful protective strategy...
  12. ncbi request reprint The carboxyl-terminal domain of inducible Hsp70 protects from ischemic injury in vivo and in vitro
    Yunjuan Sun
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    J Cereb Blood Flow Metab 26:937-50. 2006
    ..This indicates that neither the ability to fold denatured proteins nor interactions with cochaperones or other proteins that bind the amino-terminal half of Hsp70 are essential to ischemic protection...
  13. pmc Inhibition of mitochondrial function in astrocytes: implications for neuroprotection
    Ludmila A Voloboueva
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurochem 102:1383-94. 2007
    ....
  14. ncbi request reprint Changes in astrocyte mitochondrial function with stress: effects of Bcl-2 family proteins
    Yi Bing Ouyang
    Department of Anesthesia, Grant Building S272, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neurochem Int 45:371-9. 2004
    ..This mini-review summarizes current knowledge regarding mitochondrial control of cell survival and death in astrocytes and the effects of anti-apoptotic Bcl-2 proteins on astrocyte mitochondrial function...
  15. ncbi request reprint Effect of Bcl-x(L) overexpression on reactive oxygen species, intracellular calcium, and mitochondrial membrane potential following injury in astrocytes
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Free Radic Biol Med 33:544-51. 2002
    ..There was no increase in [Ca(2+)](i) with 5 h of GD. These data thus dissociate the effect of Bcl-x(L) on calcium homeostasis from effects on ROS, DeltaPsi(m,) and for H(2)O(2) exposure, cell survival...
  16. pmc Age-related defects in sensorimotor activity, spatial learning, and memory in C57BL/6 mice
    George Barreto
    Department of Anesthesia, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5117, USA
    J Neurosurg Anesthesiol 22:214-9. 2010
    ..These tests will be useful to assess outcome in neurodegenerative disease and postoperative cognitive dysfunction models carried out in aged mice...
  17. pmc Overexpression of inducible heat shock protein 70 and its mutants in astrocytes is associated with maintenance of mitochondrial physiology during glucose deprivation stress
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stress Chaperones 11:180-6. 2006
    ....
  18. ncbi request reprint Regulation of the rat brain Na+ -driven Cl-/HCO3 - exchanger involves protein kinase A and a multiprotein signaling complex
    Yong Sun Lee
    Department of Anesthesia, S272 Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    FEBS Lett 580:4865-71. 2006
    ..It is concluded that NCBE activity is inhibited by PKA and depends on the integrity of the actin cytoskeleton within a multiprotein complex at the plasma membrane...
  19. ncbi request reprint Ischemia-induced programmed cell death in astrocytes
    Rona G Giffard
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    Glia 50:299-306. 2005
    ..Since most protoplasmic astrocytes are poorly immunoreactive for GFAP, the extent of ischemia-induced programmed cell death in this cell type remains uncertain...
  20. ncbi request reprint Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2
    Stephen Kelly
    Department of Neurosurgery, Stanford University, Stanford, CA 94305 5327, USA
    Ann Neurol 52:160-7. 2002
    ..We show that HSP72 overexpression protects cornu ammonis 1 region of the hippocampus neurons from global cerebral ischemia, and that this protection may be mediated in part by increased Bcl-2 expression...
  21. ncbi request reprint Overexpression of HDJ-2 protects astrocytes from ischemia-like injury and reduces redistribution of ubiquitin staining in vitro
    Yanli Qiao
    Department of Anesthesia, Stanford University School of Medicine, California 94305, USA
    J Cereb Blood Flow Metab 23:1113-6. 2003
    ..When HDJ-2 was overexpressed, the number of cells with evidence of protein aggregation was significantly reduced. Thus, blocking protein aggregation may be an important mechanism by which HDJ-2 protects cells from damage...
  22. ncbi request reprint Geldanamycin reduces necrotic and apoptotic injury due to oxygen-glucose deprivation in astrocytes
    Lijun Xu
    Department of Anesthesia, Grant Building S272, Stanford University School of Medicine, Stanford, California 94305, USA
    Neurol Res 25:697-700. 2003
    ..Geldanamycin protection of astrocytes against in vitro ischemia is likely due to upregulation of heat shock protein 70...
  23. pmc Overexpression of mitochondrial Hsp70/Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia
    Lijun Xu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    J Cereb Blood Flow Metab 29:365-74. 2009
    ..This suggests that targeting mitochondria for protection may be a useful strategy to reduce ischemic brain injury...
  24. ncbi request reprint Many mechanisms for hsp70 protection from cerebral ischemia
    Rona G Giffard
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosurg Anesthesiol 16:53-61. 2004
    ..Despite these new insights into the ways in which Hsp70 functions as an anti-death protein, further surprises are likely as we continue to gain insight into the functioning of this multifaceted protein...
  25. ncbi request reprint Antegrade cerebral perfusion reduces apoptotic neuronal injury in a neonatal piglet model of cardiopulmonary bypass
    Valerie Y Chock
    Department of Neonatology, Stanford University School of Medicine, Stanford, Calif, USA
    J Thorac Cardiovasc Surg 131:659-65. 2006
    ..We sought to evaluate and compare the extent of neurologic injury in a neonatal piglet model of deep hypothermic circulatory arrest and antegrade cerebral perfusion...
  26. pmc microRNAs: innovative targets for cerebral ischemia and stroke
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, S272A and S290, Stanford, CA 94305 5117, USA
    Curr Drug Targets 14:90-101. 2013
    ....
  27. pmc Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury
    Mathieu Lafargue
    Department of Anesthesia, University of California, San Francisco, California, USA
    FASEB J 26:2919-29. 2012
    ..In summary, the α7 nicotinic cholinergic pathway plays an important role in mediating the systemic immunosuppression observed after stroke and directly contributes to more severe lung damage induced by P. aeruginosa...
  28. pmc Overexpression of mitochondrial Hsp70/Hsp75 protects astrocytes against ischemic injury in vitro
    Ludmila A Voloboueva
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    J Cereb Blood Flow Metab 28:1009-16. 2008
    ..These findings indicate that Hsp75 can provide protection against ischemia-like in vitro injury and suggest that it should be further studied as a potential candidate for protection against ischemic injury...
  29. pmc Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 27:4253-60. 2007
    ..We suggest that greater oxidative stress and loss of GLT-1 function selectively in CA1 astrocytes is central to the well known delayed death of CA1 neurons...
  30. ncbi request reprint Bcl-XL maintains mitochondrial function in murine astrocytes deprived of glucose
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cereb Blood Flow Metab 23:275-9. 2003
    ..When Bcl-XL was overexpressed normal state III respiration and mitochondrial morphology were maintained and cytochrome c release was inhibited in the face of glucose deprivation stress...
  31. ncbi request reprint Biphasic role of nuclear factor-kappa B on cell survival and COX-2 expression in SOD1 Tg astrocytes after oxygen glucose deprivation
    Yong Sun Lee
    Department of Neurosurgery, Department of Neurology and Neurological Sciences, and Program in Neurosciences, Stanford University School of Medicine, Stanford, California 94305 5487, USA
    J Cereb Blood Flow Metab 26:1076-88. 2006
    ..This biphasic role of NF-kappaB might be coordinately regulated by reactive oxygen species levels in astrocytes, thereby functioning as a regulator of cell death/survival...
  32. pmc Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia
    Lijun Xu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Glia 58:1042-9. 2010
    ..Targeting astrocytes is a promising strategy for neuronal preservation following cardiac arrest and resuscitation...
  33. ncbi request reprint Development of neonatal murine microglia in vitro: changes in response to lipopolysaccharide and ischemia-like injury
    Valerie Y Chock
    Department of Neonatology, Stanford University School of Medicine, Stanford, California 94305, USA
    Pediatr Res 57:475-80. 2005
    ..Inhibition of microglial activation and decreasing proinflammatory cytokine release may be targets for reduction of neonatal hypoxic/ischemic brain injury...
  34. ncbi request reprint Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury
    Jian Wang
    Department of Anesthesia, School of Medicine, Stanford University, Stanford, CA 94305 5117, USA
    Neuropharmacology 47:136-45. 2004
    ..Our data demonstrate protection of neurons by selective activation of epsilonPKC but enhanced astrocyte cell death with selective inhibition of betaIPKC. Thus PKC isozymes exhibit cell type-specific effects on ischemia-like injury...
  35. pmc Heat shock protein 72 (Hsp72) improves long term recovery after focal cerebral ischemia in mice
    Lijun Xu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, United States
    Neurosci Lett 488:279-82. 2011
    ..Hsp72 reduced infarct area lost and improved behavioral outcome on rotarod and foot fault at one month. Thus protection by Hsp72 overexpression is long lasting, and includes improved recovery of motor function over one month...
  36. ncbi request reprint Caspase inhibitors reduce the apoptotic but not necrotic component of kainate injury in primary murine cortical neuronal cultures
    Alexander Glassford
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Neurol Res 24:796-800. 2002
    ..Kainate injury causes both apoptosis and necrosis, with the injury depending on both the dose of kainate and the age of the culture. The apoptotic component can be selectively reduced by caspase inhibition or cycloheximide...
  37. pmc Mitochondrial protection attenuates inflammation-induced impairment of neurogenesis in vitro and in vivo
    Ludmila A Voloboueva
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 30:12242-51. 2010
    ..Our findings highlight mitochondrial mechanisms involved in neurogenesis and indicate mitochondria as a potential target for protective strategies to prevent the impairment of neurogenesis by inflammation...
  38. ncbi request reprint Neuroprotective effects of bcl-2 overexpression in hippocampal cultures: interactions with pathways of oxidative damage
    Sarah Howard
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    J Neurochem 83:914-23. 2002
    ..Thus, the antioxidant actions of Bcl-2 are neither necessary nor sufficient to explain its protective actions against these insults in hippocampal neurons...
  39. pmc Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor
    Ru Quan Han
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesth Analg 108:280-7. 2009
    ..We used beta(2)AR knockout mice and a beta(2) selective antagonist to test the effect of loss of beta(2)ARs on outcome from transient focal cerebral ischemia...
  40. ncbi request reprint Susceptibility to apoptosis varies with time in culture for murine neurons and astrocytes: changes in gene expression and activity
    Lijun Xu
    Department of Anesthesia, Stanford University School of Medicine, Stanford CA 94305 5123, USA
    Neurol Res 26:632-43. 2004
    ..However, caspase inhibitors, but not MAP kinase inhibitors reduced cell death. Our findings demonstrate that apoptosis regulatory proteins display cell type and developmentally specific expression and activation...
  41. ncbi request reprint Cellular neuroprotective mechanisms in cerebral ischemia: Bcl-2 family proteins and protection of mitochondrial function
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Grant Building S272, Stanford, CA 94305, USA
    Cell Calcium 36:303-11. 2004
    ....
  42. ncbi request reprint Overexpression of copper/zinc superoxide dismutase decreases ischemia-like astrocyte injury
    Jian Wang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Free Radic Biol Med 38:1112-8. 2005
    ....
  43. ncbi request reprint Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade
    Lijun Xu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    J Cereb Blood Flow Metab 22:21-8. 2002
    ....
  44. ncbi request reprint Gene therapy and hypothermia for stroke treatment
    Midori A Yenari
    Department of Neurosurgery, Stanford University, California 94305, USA
    Ann N Y Acad Sci 993:54-68; discussion 79-81. 2003
    ....
  45. pmc NOx and ADMA changes with focal ischemia, amelioration with the chaperonin GroEL
    Lijun Xu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Neurosci Lett 418:201-4. 2007
    ..Rats protected by expression of the chaperonin GroEL or its folding deficient mutant D87K had lower plasma NOx levels at 24h reperfusion. ADMA, NO, and their ratio in CSF merit further study as biomarkers for ischemic brain injury...
  46. pmc Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia
    Xiaoxing Xiong
    Department of Anesthesia, Stanford University School of Medicine, S272, Stanford, CA 94305, USA
    Stroke 42:2026-32. 2011
    ..We tested the hypothesis that the anti-inflammatory cytokine interleukin-4 (IL-4) reduces injury after stroke using IL-4 knockout (KO) adult male mice...
  47. ncbi request reprint Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation
    Hyung Soo Han
    Department of Neurology, Stanford University Medical Center, Stanford, California 94305, USA
    J Neurosci 22:3921-8. 2002
    ..We conclude that mild hypothermia significantly inhibits the inflammatory response by affecting microglial iNOS-NO generation. Therapies directed against microglia or their activation may be useful in treating stroke...
  48. ncbi request reprint UV-vulnerability of human papilloma virus type-16 E7-expressing astrocytes is associated with mitochondrial membrane depolarization and caspase-3 activation
    Won Taek Lee
    Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea
    Mol Cells 14:288-94. 2002
    ..E6 overexpression decreased while E7 overexpression increased UV-induced astrocyte apoptosis...
  49. ncbi request reprint The 70 kDa heat shock protein suppresses matrix metalloproteinases in astrocytes
    Jong Eun Lee
    Department of Anatomy, College of Medicine, Room 136 A, Yonsei University, 134 Shinchon dong, Seodaemun Ku, Seoul 120 752, Korea
    Neuroreport 15:499-502. 2004
    ..Zymograms and Western blots showed that Hsp70 over-expression suppressed MMP-2 and MMP-9. These findings suggest that Hsp70 may protect by regulating MMPs...
  50. ncbi request reprint Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro
    Midori A Yenari
    Department of Neurology, University of California, San Francisco Veterans Affairs Medical Center, California 94121, USA
    Stroke 37:1087-93. 2006
    ..We determined the effect of microglia on the BBB and its primary constituents, endothelial cells (ECs) and astrocytes, after ischemia using in vivo and in vitro models...
  51. ncbi request reprint Perinatal brain injury: the role of development in vulnerability
    Rona G Giffard
    Anesthesiology 98:1039-41. 2003
  52. ncbi request reprint Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection
    Midori A Yenari
    Department of Neurology, University of California, San Francisco, Caifornia 94121, USA
    Ann N Y Acad Sci 1053:74-83. 2005
    ..We suggest that HSPs are capable of protecting brain cells from lethal insults through a variety of mechanisms and should be explored as a potential therapy against stroke and other neurodegenerative diseases...

Research Grants27

  1. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 2009
    ..The goal of this research is to identify new ways to reduce the brain injury caused by stroke which when translated to clinical use could improve the lives of stroke victims by reducing the damage caused by stroke. ..
  2. Astrocytes and Ischemic Brain Injury
    Rona Giffard; Fiscal Year: 2007
    ..Maintaining and improving astrocyte function provides a novel target for developing therapies to improve neurological function following cardiac arrest. ..
  3. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 2005
    ..These studies will identify new therapeutic strategies and lay the foundation for the development of Hsp70 mimetics for neuroprotection. ..
  4. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 2001
    ..With improving ability to deliver peptide therapeutics it is possible that a subdomain of HSP70 could be developed into a useful pharmaceutical to improve outcome from stroke. ..
  5. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 1999
    ..The knowledge gained from this project has direct implications for the treatment of ischemic stroke in both surgical and medical patients. ..
  6. Astrocytes and Ischemic Brain Injury
    Rona Giffard; Fiscal Year: 2009
    ..Maintaining and improving astrocyte function provides a novel target for developing therapies to improve neurological function following cardiac arrest. ..
  7. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 2007
    ..These studies will identify new therapeutic strategies and lay the foundation for the development of Hsp70 mimetics for neuroprotection. ..
  8. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 2005
    ..These studies will identify new therapeutic strategies and lay the foundation for the development of Hsp70 mimetics for neuroprotection. ..
  9. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 2006
    ..These studies will identify new therapeutic strategies and lay the foundation for the development of Hsp70 mimetics for neuroprotection. ..
  10. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 2003
    ..With improving ability to deliver peptide therapeutics it is possible that a subdomain of HSP70 could be developed into a useful pharmaceutical to improve outcome from stroke. ..
  11. Astrocytes and Ischemic Brain Injury
    Rona G Giffard; Fiscal Year: 2010
    ..Maintaining and improving astrocyte function provides a novel target for developing therapies to improve neurological function following cardiac arrest. ..
  12. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 2002
    ..With improving ability to deliver peptide therapeutics it is possible that a subdomain of HSP70 could be developed into a useful pharmaceutical to improve outcome from stroke. ..
  13. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona G Giffard; Fiscal Year: 2010
    ..The goal of this research is to identify new ways to reduce the brain injury caused by stroke which when translated to clinical use could improve the lives of stroke victims by reducing the damage caused by stroke. ..
  14. Astrocytes and Ischemic Brain Injury
    Rona Giffard; Fiscal Year: 2007
    ..Maintaining and improving astrocyte function provides a novel target for developing therapies to improve neurological function following cardiac arrest. ..
  15. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 2000
    ..With improving ability to deliver peptide therapeutics it is possible that a subdomain of HSP70 could be developed into a useful pharmaceutical to improve outcome from stroke. ..
  16. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 2004
    ..These studies will identify new therapeutic strategies and lay the foundation for the development of Hsp70 mimetics for neuroprotection. ..
  17. Astrocytes and Ischemic Brain Injury
    Rona Giffard; Fiscal Year: 2009
    ..Maintaining and improving astrocyte function provides a novel target for developing therapies to improve neurological function following cardiac arrest. ..
  18. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 2003
    ..With improving ability to deliver peptide therapeutics it is possible that a subdomain of HSP70 could be developed into a useful pharmaceutical to improve outcome from stroke. ..
  19. ANESTHETICS AND STRESS PROTEINS IN BRAIN CELL INJURY
    Rona Giffard; Fiscal Year: 1993
    ..These studies will help define the mechanism of induction of hsp70 and its possible importance in protecting neurons and astrocytes from OGD injury...