Research Topics
| Guri GiaeverSummaryAffiliation: Stanford University Country: USA Publications
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Detail Information
Publications
A chemical genomics approach to understanding drug actionGuri Giaever
Stanford Genome Technology Center, 855 California Avenue, Palo Alto, CA 94304, USA
Trends Pharmacol Sci 24:444-6. 2003..In this article, some of the recent results generated from experiments that exploit the yeast deletion collection to understand mechanisms of drug action are discussed...
Chemogenomic profiling: identifying the functional interactions of small molecules in yeastGuri Giaever
Stanford Genome Technology Center, 855 California Avenue, Palo Alto, CA 94304 1103, USA
Proc Natl Acad Sci U S A 101:793-8. 2004..The ability to identify on-and-off target effects in vivo is fundamental to understanding the cellular response to small-molecule perturbants...- The chemical genomic portrait of yeast: uncovering a phenotype for all genesMaureen E Hillenmeyer
Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA
Science 320:362-5. 2008..We found that 97% of gene deletions exhibited a measurable growth phenotype, suggesting that nearly all genes are essential for optimal growth in at least one condition... 
Yeast chemical genomics and drug discovery: an updateShawn Hoon
Department of Genetics, Stanford University, Palo Alto, CA 94305, USA
Trends Pharmacol Sci 29:499-504. 2008..In this update of an earlier review, we present a snapshot of the current state of chemical genomic approaches in yeast, propose a set of integrated chemical genomic assays to move the field forward and consider its near-term future...- An integrated platform of genomic assays reveals small-molecule bioactivitiesShawn Hoon
Department of Genetics, Stanford University, Mail Stop 5120, Palo Alto, California 94305, USA
Nat Chem Biol 4:498-506. 2008..Finally, we applied this platform to 188 novel synthetic chemical compounds and identified both potential targets and structure-activity relationships... - The automated cell: compound and environment screening system (ACCESS) for chemogenomic screeningMichael Proctor
Stanford Genome Technology Center, Palo Alto, CA, USA
Methods Mol Biol 759:239-69. 2011..The ACCESS system also has a diverse set of software tools to enable users to set up, run, annotate, and evaluate complex screens with minimal training... - A universal TagModule collection for parallel genetic analysis of microorganismsJulia Oh
Department of Genetics, Stanford University, Palo Alto, CA 94305, USA
Nucleic Acids Res 38:e146. 2010..The publicly available TagModule collection is a platform-independent resource for the functional genomics of a wide range of microbial systems in the post-genome era... - Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled culturesSarah E Pierce
Department of Genetics, Stanford Genome Technology Center, 855 S California Ave, Palo Alto, CA 94304, USA
Nat Protoc 2:2958-74. 2007.... - Functional profiling of the Saccharomyces cerevisiae genomeGuri Giaever
Stanford Genome Technology Center, Stanford University, Palo Alto, California 94304, USA
Nature 418:387-91. 2002..Our results validate the yeast gene-deletion collection as a valuable resource for functional genomics... - Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug actionMaureen E Hillenmeyer
Biomedical Informatics, 251 Campus Drive, MSOB, Stanford University, Stanford, CA 94305, USA
Genome Biol 11:R30. 2010..We developed an algorithm predicting protein targets of chemical compounds and verified its accuracy with experimental testing. Fitness data provide a novel, systems-level perspective on the cell... - Systematic screen for human disease genes in yeastLars M Steinmetz
Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Genet 31:400-4. 2002..To apply these advantages to human disorders involving mitochondria, human orthologs were identified and linked to heritable diseases using genomic map positions... - "Chemogenomics: tools for protein families" and "Chemical genomics: chemical and biological integration"Corey Nislow
Stanford Genome Technology Center, 855 California Avenue, Palo Alto, CA 94304, USA
Pharmacogenomics 4:15-8. 2003 - Off-target effects of psychoactive drugs revealed by genome-wide assays in yeastElke Ericson
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
PLoS Genet 4:e1000151. 2008.... - Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiersZhun Yan
Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
Nat Methods 5:719-25. 2008..1% of all essential yeast genes. These experiments validate both the Barcoders and the DAmP strain collection as useful tools for genome-wide chemical-genetic assays... - Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screenAnthony Arnoldo
Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada
PLoS Genet 4:e1000005. 2008..Taken together, our integrated cell-based, chemical-genetic approach demonstrates that such screens can augment traditional drug screening approaches and facilitate the discovery of new compounds against a broad range of human pathogens... - Chemical-genetic approaches for exploring the mode of action of natural productsAndres Lopez
Banting and Best Department of Medical Research and Department of Medical Genetics and Microbiology, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Canada
Prog Drug Res 66:237, 239-71. 2008..Extensive application of chemical genetics in yeast has the potential to develop a small molecule inhibitor for the majority of all approximately 6000 yeast genes... - Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutantsWilliam J Jo
Department of Nutritional Sciences and Toxicology, Superfund Basic Research Program corrected University of California Berkeley, Berkeley, California 94720, USA
Toxicol Sci 101:140-51. 2008.... - Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assayNadine C Gassner
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
J Nat Prod 70:383-90. 2007..There were 46 active compounds among the NCI set. One very active extract was selected for bioactivity-guided fractionation, resulting in the identification of crambescidin 800 as a potent antifungal agent... - Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeastAdam M Deutschbauer
Department of Genetics, Stanford University School of Medicine, California 94305, USA
Genetics 169:1915-25. 2005..Overall, our results suggest that the primary mechanism of haploinsufficiency in yeast is due to insufficient protein production. We discuss the relevance of our findings in yeast to human haploinsufficiency disorders... - Functional genomic analysis of the rates of protein evolutionDennis P Wall
Department of Biological Sciences, and Stanford Genome Technology Center, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 102:5483-8. 2005.... - A latent variable model for chemogenomic profilingPatrick Flaherty
Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA 94720, USA
Bioinformatics 21:3286-93. 2005..The model also incorporates the functional annotation of known genes to guide the clustering procedure... - Genome-wide requirements for resistance to functionally distinct DNA-damaging agentsWilliam Lee
Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
PLoS Genet 1:e24. 2005..Further genetic analysis allowed determination of epistasis for one of these functional groups... - Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture systemBernhard Suter
Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 3E1, Canada
Genome Res 17:1774-82. 2007..Our studies establish the "Cross-and-Capture" assay as a novel, versatile tool that provides a valuable complement for the next generation of yeast proteomic studies... - Noise minimization in eukaryotic gene expressionHunter B Fraser
Department of Molecular and Cell Biology, University of California, Berkeley, USA
PLoS Biol 2:e137. 2004..Our results support the hypothesis that noise in gene expression is a biologically important variable, is generally detrimental to organismal fitness, and is subject to natural selection... - Experimental approaches to identify genetic networksMichael Costanzo
Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
Curr Opin Biotechnol 17:472-80. 2006..Many of these experimental approaches have been adopted and adapted to study other systems, including worm, fly, fish and mammalian cultured cells, using an ingenious set of molecular tools... - The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeastGabriel Musso
Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
Genome Res 18:1092-9. 2008.... - Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletionsRobert P St Onge
Department of Biochemistry, Stanford University, Stanford, California 94305, USA
Nat Genet 39:199-206. 2007..Our results emphasize the utility of small molecules and multifactorial deletion mutants in uncovering functional relationships and pathway order... - Defining genetic interactionRamamurthy Mani
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:3461-6. 2008..Additionally, we show that the Additive and Log definitions, each commonly used in population genetics, lead to differing conclusions related to the selective advantages of sexual reproduction... - Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agentsGeoff W Birrell
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:8778-83. 2002..The data also suggest that the nature of the lesions produced by DNA-damaging agents cannot easily be deduced from gene expression profiling...