John C Game
Affiliation: Stanford University
- The role of RAD6 in recombinational repair, checkpoints and meiosis via histone modificationJohn C Game
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
DNA Repair (Amst) 8:470-82. 2009..However, the specific histone modification pathways involved diverge in these different eukaryotes...
- Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instabilitySophia B Chernikova
Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
Cancer Res 72:2111-9. 2012....
- Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cellsSophia B Chernikova
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5152, USA
Radiat Res 174:558-65. 2010..Thus our data suggest that the observed defects in the radiation response of Bre1a/b-deficient cells are associated with reduced H3K79me2 and not with H4K20me2...
- Inhibiting homologous recombination for cancer therapySophia B Chernikova
Department of Radiation Oncology, Stanford University, Stanford, CA USA
Cancer Biol Ther 13:61-8. 2012..We review strategies for identifying HR inhibitors and discuss current progress...