John C Game

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint The role of RAD6 in recombinational repair, checkpoints and meiosis via histone modification
    John C Game
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    DNA Repair (Amst) 8:470-82. 2009
  2. pmc Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability
    Sophia B Chernikova
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Cancer Res 72:2111-9. 2012
  3. pmc Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells
    Sophia B Chernikova
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5152, USA
    Radiat Res 174:558-65. 2010
  4. pmc Inhibiting homologous recombination for cancer therapy
    Sophia B Chernikova
    Department of Radiation Oncology, Stanford University, Stanford, CA USA
    Cancer Biol Ther 13:61-8. 2012

Detail Information

Publications4

  1. doi request reprint The role of RAD6 in recombinational repair, checkpoints and meiosis via histone modification
    John C Game
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    DNA Repair (Amst) 8:470-82. 2009
    ..However, the specific histone modification pathways involved diverge in these different eukaryotes...
  2. pmc Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability
    Sophia B Chernikova
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Cancer Res 72:2111-9. 2012
    ....
  3. pmc Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells
    Sophia B Chernikova
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5152, USA
    Radiat Res 174:558-65. 2010
    ..Thus our data suggest that the observed defects in the radiation response of Bre1a/b-deficient cells are associated with reduced H3K79me2 and not with H4K20me2...
  4. pmc Inhibiting homologous recombination for cancer therapy
    Sophia B Chernikova
    Department of Radiation Oncology, Stanford University, Stanford, CA USA
    Cancer Biol Ther 13:61-8. 2012
    ..We review strategies for identifying HR inhibitors and discuss current progress...