STEPHEN JOSEPH GALLI

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Evidence that mast cells are not required for healing of splinted cutaneous excisional wounds in mice
    Allison C Nauta
    Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e59167. 2013
  2. pmc IgE and mast cells in allergic disease
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, California, USA
    Nat Med 18:693-704. 2012
  3. pmc Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11
    Koichi Sayama
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    BMC Immunol 3:5. 2002
  4. pmc Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus
    Rosetta Pedotti
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    BMC Immunol 4:2. 2003
  5. pmc Mast cells: versatile regulators of inflammation, tissue remodeling, host defense and homeostasis
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5176, United States
    J Dermatol Sci 49:7-19. 2008
  6. pmc Immunomodulatory mast cells: negative, as well as positive, regulators of immunity
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Rev Immunol 8:478-86. 2008
  7. pmc The development of allergic inflammation
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 454:445-54. 2008
  8. ncbi request reprint Mast cells in the development of adaptive immune responses
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Immunol 6:135-42. 2005
  9. pmc Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Immunol 40:1843-51. 2010
  10. ncbi request reprint Mast cells as "tunable" effector and immunoregulatory cells: recent advances
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Immunol 23:749-86. 2005

Research Grants

  1. REGULATION OF MAST CELL DEVELOPMENT AND FUNCTION
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
  2. Expression and Modulation of Mast Cell Function in Asthma
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
  3. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2006
  4. REGULATION OF MAST CELL DEVELOPMENT AND FUNCTION
    STEPHEN GALLI; Fiscal Year: 2007
  5. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2005
  6. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2002
  7. REGULATION OF MAST CELL DEVELOPMENT AND FUNCTION
    STEPHEN GALLI; Fiscal Year: 2009
  8. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2009
  9. Expression and Modulation of Mast Cell Function in Asthma
    STEPHEN GALLI; Fiscal Year: 2009
  10. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2004

Detail Information

Publications71

  1. pmc Evidence that mast cells are not required for healing of splinted cutaneous excisional wounds in mice
    Allison C Nauta
    Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e59167. 2013
    ..These data indicate that mast cells do not play a significant non-redundant role in these features of the healing of splinted full thickness excisional cutaneous wounds in mice...
  2. pmc IgE and mast cells in allergic disease
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, California, USA
    Nat Med 18:693-704. 2012
    ..In this review, we discuss findings supporting the conclusion that IgE and mast cells can have both interdependent and independent roles in the complex immune responses that manifest clinically as asthma and other allergic disorders...
  3. pmc Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11
    Koichi Sayama
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    BMC Immunol 3:5. 2002
    ..To search for new mast cell products, we used complementary DNA microarrays to analyze gene expression in human umbilical cord blood-derived mast cells stimulated via the high-affinity IgE receptor (Fc(epsilon)RI)...
  4. pmc Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus
    Rosetta Pedotti
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    BMC Immunol 4:2. 2003
    ....
  5. pmc Mast cells: versatile regulators of inflammation, tissue remodeling, host defense and homeostasis
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5176, United States
    J Dermatol Sci 49:7-19. 2008
    ..Through such functions, mast cells can significantly influence inflammation, tissue remodeling, host defense and homeostasis...
  6. pmc Immunomodulatory mast cells: negative, as well as positive, regulators of immunity
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Rev Immunol 8:478-86. 2008
    ..Here, we review the evidence that mast cells can have negative, as well as positive, immunomodulatory roles in vivo, and we propose that mast cells can both enhance and later suppress certain features of an immune response...
  7. pmc The development of allergic inflammation
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 454:445-54. 2008
    ....
  8. ncbi request reprint Mast cells in the development of adaptive immune responses
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Immunol 6:135-42. 2005
    ..Thus, mast cells may influence the development, intensity and duration of adaptive immune responses that contribute to host defense, allergy and autoimmunity, rather than simply functioning as effector cells in these settings...
  9. pmc Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Immunol 40:1843-51. 2010
    ....
  10. ncbi request reprint Mast cells as "tunable" effector and immunoregulatory cells: recent advances
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Immunol 23:749-86. 2005
    ....
  11. ncbi request reprint Basophils are back!
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Immunity 28:495-7. 2008
    ....
  12. pmc Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Nat Immunol 12:1035-44. 2011
    ....
  13. ncbi request reprint Analyzing the roles of mast cells and basophils in host defense and other biological responses
    Stephen J Galli
    Department of Pathology, Stanford University Medical Center, California 94305 5324, USA
    Int J Hematol 75:363-9. 2002
    ..We will also describe briefly some approaches to investigate mast cell and basophil functions in vivo, including the use of mast cells generated directly from embryonic stem cells in vitro...
  14. ncbi request reprint Using mast cell knock-in mice to analyze the roles of mast cells in allergic responses in vivo
    Mindy Tsai
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif 94305, USA edu
    Chem Immunol Allergy 87:179-97. 2005
    ....
  15. ncbi request reprint Mast cells promote homeostasis by limiting endothelin-1-induced toxicity
    Marcus Maurer
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 432:512-6. 2004
    ..These findings identify a new biological function for mast cells: promotion of homeostasis by limiting the toxicity associated with an endogenous mediator...
  16. pmc RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 103:2659-64. 2006
    ..Thus, RabGEF1 plays a critical role in the regulation of SCF/c-Kit-mediated signaling events and biological responses in mast cells...
  17. pmc Mast cells can promote the development of multiple features of chronic asthma in mice
    Mang Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Clin Invest 116:1633-41. 2006
    ....
  18. ncbi request reprint RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation
    See Ying Tam
    Departments of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Novartis Found Symp 271:115-24; discussion 124-30, 145-51. 2005
    ....
  19. ncbi request reprint Mast cell-associated TNF promotes dendritic cell migration
    Hajime Suto
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:4102-12. 2006
    ..Our findings indicate that mast cell-associated TNF can contribute significantly to the initial stages of FITC-induced migration of cutaneous or airway DCs...
  20. ncbi request reprint TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Allergy Clin Immunol 119:680-6. 2007
    ..However, studies with TNF-deficient or TNF receptor-deficient mice have not produced a clear picture of the role of TNF in the AHR associated with allergic inflammation in the mouse...
  21. pmc Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 176:926-38. 2010
    ..typhimurium...
  22. ncbi request reprint Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Allergy Clin Immunol 120:48-55. 2007
    ..However, it is not clear to what extent mast cells represent a significant source of TNF in this mouse model...
  23. pmc Mast cells enhance T cell activation: Importance of mast cell-derived TNF
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5176, USA
    Proc Natl Acad Sci U S A 102:6467-72. 2005
    ..Finally, mast cells also can promote T cell activation by means of soluble factors. These findings identify multiple mechanisms by which mast cells can influence T cell proliferation and cytokine production...
  24. pmc Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 205:2207-20. 2008
    ..Rather, CCRL2 is able to bind the chemoattractant and increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1...
  25. pmc Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 167:835-48. 2005
    ..Thus, Kit(W-sh/W-sh) mice represent a useful model for mast cell research, especially for analyzing mast cell function in vivo...
  26. pmc Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Med 14:392-8. 2008
    ....
  27. ncbi request reprint Adoptive transfer of mast cells does not enhance the impaired survival of Kit(W)/Kit(W-v) mice in a model of low dose intraperitoneal infection with bioluminescent Salmonella typhimurium
    Devavani Chatterjea
    Department of Pathology, Stanford University Medical Center, 300 Pasteur Ave, L 235, Stanford, CA 94305 5324, USA
    Immunol Lett 99:122-9. 2005
    ....
  28. ncbi request reprint Mast cells in the promotion and limitation of chronic inflammation
    Martin Metz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Immunol Rev 217:304-28. 2007
    ..Such work has confirmed that mast cells can significantly influence multiple features of chronic inflammatory responses, through diverse effects that can either promote or, perhaps more surprisingly, suppress aspects of these responses...
  29. ncbi request reprint Interleukin-3 and c-Kit/stem cell factor are required for normal eosinophil responses in mice infected with Strongyloides venezuelensis
    Koichi Kimura
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Lab Invest 86:987-96. 2006
    ..b.). However, in mice with markedly impaired SCF/c-Kit signaling, IL-3 contributed significantly to the increased numbers of eosinophils that were observed in multiple tissues during S.v. infection, but not during infection with N.b...
  30. ncbi request reprint Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:2238-48. 2006
    ..These results indicate that the secretion of soluble TNF and direct cell-cell interactions between mast cell OX40L and T cell OX40 contribute to the ability of IgE- and Ag-stimulated mouse mast cells to enhance T cell activation...
  31. pmc Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice
    Maki Kakurai
    Department of Pathology, L 235, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305 5324, USA
    Am J Pathol 169:1713-21. 2006
    ..These observations show that mast cells, and mast cell-derived TNF, can promote the elongation of cutaneous nerve fibers during contact hypersensitivity in the mouse...
  32. pmc New developments in mast cell biology
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 9:1215-23. 2008
    ....
  33. doi request reprint Antiinflammatory and immunosuppressive functions of mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 677:207-20. 2011
    ....
  34. ncbi request reprint Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17
    Susumu Nakae
    Department of Pathology, L 235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    J Leukoc Biol 81:1258-68. 2007
    ..We also confirmed that IL-12 or IFN-gamma can negatively regulate Th17 cell differentiation. However, these cytokines could not modulate such effects on T cell differentiation in the absence of APC...
  35. ncbi request reprint Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    Christopher Lock
    Department of Neurology and Neurological Sciences, Beckman Center, Stanford University, Stanford, California, USA
    Nat Med 8:500-8. 2002
    ..These results in EAE corroborate the microarray studies on MS lesions. Large-scale analysis of transcripts in MS lesions elucidates new aspects of pathology and opens possibilities for therapy...
  36. ncbi request reprint IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals
    Lien H Ho
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Leukoc Biol 82:1481-90. 2007
    ..These observations suggest potential roles for IL-33 in mast cell- and Th2 cytokine-associated immune responses and disorders...
  37. pmc Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice
    Mindy Tsai
    Stanford University School of Medicine, Department of Pathology, L 235, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Am J Pathol 177:2411-20. 2010
    ....
  38. ncbi request reprint Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5176, USA
    Nat Immunol 8:1095-104. 2007
    ....
  39. pmc Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation
    Jason Gotlib
    Department of Medicine, Division of Hematology, Stanford University, Stanford Cancer Center, 875 Blake Wilbur Dr, Rm 2327B, Stanford, CA 94305 5821, USA
    Blood 106:2865-70. 2005
    ..This case indicates that KIT tyrosine kinase inhibition is a feasible approach in SM, but single-agent clinical efficacy may be limited by clonal evolution in the advanced leukemic phase of this disease...
  40. ncbi request reprint RabGEF1 is a negative regulator of mast cell activation and skin inflammation
    See Ying Tam
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 5:844-52. 2004
    ..Thus, RabGEF1 is a negative regulator of Fc epsilon RI-dependent mast cell activation, and a lack of RabGEF1 results in the development of skin inflammation in vivo...
  41. pmc Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice
    Susumu Nakae
    Department of Pathology L 235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Blood 109:3640-8. 2007
    ....
  42. ncbi request reprint Chair's introduction. Anaphylaxis
    Stephen J Galli
    Department of Pathology, L 235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Novartis Found Symp 257:1-5. 2004
  43. ncbi request reprint Anaphylaxis: mechanisms of mast cell activation
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Chem Immunol Allergy 95:45-66. 2010
    ..We will also discuss the use of mouse models to investigate the mechanisms that can contribute to anaphylaxis in that species in vivo, and the relevance of such mouse studies to human anaphylaxis...
  44. pmc Rabaptin-5 regulates receptor expression and functional activation in mast cells
    Eon J Rios
    Department of Pathology, Stanford University School of Medicine, CA, USA
    Blood 112:4148-57. 2008
    ..These findings show that, although dispensable for canonical Rab5 processes in mast cells, Rabaptin-5 importantly contributes to mast cell IgE-dependent immunologic function by enhancing mast cell receptor surface stability...
  45. pmc Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Blood 109:5308-17. 2007
    ..By contrast, correction of these -/- phenotypes required a functional Vps9 domain. Thus, Fc epsilon RI-mediated mast cell functional activation is dependent on RabGEF1's GEF activity...
  46. pmc Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination
    Rosetta Pedotti
    Department of Neurology and Neurological Science, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:1867-72. 2003
    ..The pathogenesis of demyelination must now be viewed as encompassing elements of both Th1 responses and "allergic" responses...
  47. ncbi request reprint Mast cells can enhance resistance to snake and honeybee venoms
    Martin Metz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Science 313:526-30. 2006
    ..These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms...
  48. pmc Identification of mast cell progenitors in adult mice
    Ching Cheng Chen
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 102:11408-13. 2005
    ....
  49. ncbi request reprint Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Curr Opin Immunol 18:751-60. 2006
    ....
  50. ncbi request reprint IL-33 can promote survival, adhesion and cytokine production in human mast cells
    Motoyasu Iikura
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Lab Invest 87:971-8. 2007
    ..Our findings thus support the hypothesis that IL-33 may enhance mast cell function in allergic disorders and other settings, either in the presence or absence of co-stimulation of mast cells via IgE/antigen-FcepsilonRI signals...
  51. doi request reprint The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice
    Satoshi Itoh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Heart Lung Transplant 29:401-9. 2010
    ..We used C57BL/6-Kit(W-sh/W-sh) mast cell-deficient and corresponding wild-type mice to investigate possible contributions of recipient mast cells to acute or chronic cardiac allograft rejection...
  52. pmc Distinguishing mast cell and granulocyte differentiation at the single-cell level
    Christopher B Franco
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stem Cell 6:361-8. 2010
    ..Our data provide criteria for the prospective isolation of SL-CMP and SL-GMP and support the conclusion that mast cells are specified during hematopoiesis earlier than and independently from granulocytes...
  53. ncbi request reprint Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response
    Kentaro Matsuda
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    J Allergy Clin Immunol 116:1357-63. 2005
    ..Mouse monoclonal IgE antibodies can promote the survival of mouse bone marrow-derived cultured mast cells and induce the cells to secrete mediators in the absence of known specific antigen...
  54. ncbi request reprint Mast cells derived from embryonic stem cells: a model system for studying the effects of genetic manipulations on mast cell development, phenotype, and function in vitro and in vivo
    Mindy Tsai
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Int J Hematol 75:345-9. 2002
    ....
  55. pmc TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Blood 110:2565-8. 2007
    ..These observations suggest that TIM-1 and TIM-3 may be able to influence T-cell-mediated immune responses in part through effects on mast cells...
  56. pmc Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:12911-6. 2003
    ..In hybridoma-transplanted mice, mucosal mast cell numbers correlate with serum IgE levels. Therefore, survival effects of IgE could contribute to the pathogenesis of allergic disease...
  57. ncbi request reprint Immune sensitization in the skin is enhanced by antigen-independent effects of IgE
    Paul J Bryce
    Division of Immunology, Children s Hospital, Boston, MA 02115 USA
    Immunity 20:381-92. 2004
    ..We speculate that levels of IgE normally present in mice favor immune sensitization via antigen-independent but FcepsilonRI-dependent effects on mast cells...
  58. ncbi request reprint Regulation of mast-cell and basophil function and survival by IgE
    Toshiaki Kawakami
    Division of Allergy, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nat Rev Immunol 2:773-86. 2002
    ..So, the binding of IgE to Fc epsilon RI might influence mast-cell and basophil survival directly or indirectly, and can also regulate cellular function...
  59. ncbi request reprint Probing the roles of mast cells and basophils in natural and acquired immunity, physiology and disease
    Gianni Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Trends Immunol 23:425-7. 2002
  60. ncbi request reprint Lack of significant skin inflammation during elimination by apoptosis of large numbers of mouse cutaneous mast cells after cessation of treatment with stem cell factor
    Marcus Maurer
    Department of Dermatology and Allergy, University Hospital Charite, Berlin, Germany
    Lab Invest 84:1593-602. 2004
    ....
  61. ncbi request reprint Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 117:391-7. 2006
    ....
  62. ncbi request reprint A key regulatory role for histamine in experimental autoimmune encephalomyelitis: disease exacerbation in histidine decarboxylase-deficient mice
    Silvia Musio
    Immunology and Muscular Pathology Unit, National Neurological Institute C Besta, Milan, Italy
    J Immunol 176:17-26. 2006
    ..Understanding which receptor(s) for histamine is/are involved in regulating autoimmunity against the CNS might help in the development of new strategies of treatment for EAE and multiple sclerosis...
  63. ncbi request reprint Nipping cat allergy with fusion proteins
    Janet Kalesnikoff
    Nat Med 11:381-2. 2005
  64. ncbi request reprint Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v) mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors
    Jochen Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany
    Lab Invest 85:388-96. 2005
    ..Our findings also are consistent with the possibility that mast cells promote the development of DMH-induced colonic epithelial tumors in mice...
  65. ncbi request reprint Identification of A3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 171:331-7. 2003
    ..Finally, our findings indicate that adenosine exposure can result in A(3)-dependent airway inflammation, as reflected in neutrophil recruitment, as well as alterations in airway function...
  66. ncbi request reprint Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells
    Paul J Bryce
    Division of Immunology, Children s Hospital, Boston, MA 02115, USA
    Novartis Found Symp 271:15-24; discussion 24-38, 95-9. 2005
    ..wild-type skin after hapten exposure. We propose that levels of IgE normally present in mice favour immune sensitization via antigen-independent effects on mast cells...
  67. ncbi request reprint Pathogenesis and management of anaphylaxis: current status and future challenges
    Stephen J Galli
    J Allergy Clin Immunol 115:571-4. 2005
  68. ncbi request reprint Symposium on the definition and management of anaphylaxis: summary report
    Hugh A Sampson
    Mount Sinai School of Medicine, Department of Pediatrics, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 115:584-91. 2005
  69. ncbi request reprint Mast cells to the defense
    Stephen J Galli
    Nat Immunol 4:1160-2. 2003
  70. ncbi request reprint Involvement of both 'allergic' and 'autoimmune' mechanisms in EAE, MS and other autoimmune diseases
    Rosetta Pedotti
    Immunology and Muscular Pathology Unit, National Neurological Institute C Besta, Milan, 20133, Italy
    Trends Immunol 24:479-84. 2003
  71. ncbi request reprint Interleukin-4-triggered, STAT6-dependent production of a factor that induces mouse mast cell apoptosis
    Zhi Qing Hu
    Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo, Japan
    Eur J Immunol 36:1275-84. 2006
    ..These results demonstrate a novel mechanism whereby IL-4 and IL-13 can suppress mast cell development by inducing the production of an apoptosis-inducing factor from macrophages...

Research Grants25

  1. REGULATION OF MAST CELL DEVELOPMENT AND FUNCTION
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ..abstract_text> ..
  2. Expression and Modulation of Mast Cell Function in Asthma
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ....
  3. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2006
    ..This work promises to improve our understanding of the complex potential roles of MCs, and IgE, in health & disease, as well as to improve our understanding of the pathology of CHS, a common occupational illness. ..
  4. REGULATION OF MAST CELL DEVELOPMENT AND FUNCTION
    STEPHEN GALLI; Fiscal Year: 2007
    ....
  5. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2005
    ....
  6. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2002
    ....
  7. REGULATION OF MAST CELL DEVELOPMENT AND FUNCTION
    STEPHEN GALLI; Fiscal Year: 2009
    ..abstract_text> ..
  8. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2009
    ..This work promises to improve our understanding of the complex potential roles of MCs, and IgE, in health & disease, as well as to improve our understanding of the pathology of CHS, a common occupational illness. ..
  9. Expression and Modulation of Mast Cell Function in Asthma
    STEPHEN GALLI; Fiscal Year: 2009
    ....
  10. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2004
    ....
  11. Expression and Modulation of Mast Cell Function in Asthma
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ....
  12. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ..This work promises to improve our understanding of the complex potential roles of MCs, and IgE, in health &disease, as well as to improve our understanding of the pathology of CHS, a common occupational illness. ..
  13. REGULATION OF MAST CELL DEVELOPMENT AND FUNCTION
    STEPHEN GALLI; Fiscal Year: 2009
    ..abstract_text> ..
  14. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2007
    ..This work promises to improve our understanding of the complex potential roles of MCs, and IgE, in health & disease, as well as to improve our understanding of the pathology of CHS, a common occupational illness. ..
  15. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2001
    ....
  16. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN GALLI; Fiscal Year: 2003
    ....
  17. Expression and Modulation of Mast Cell Function in Asthma
    STEPHEN GALLI; Fiscal Year: 2006
    ....
  18. REGULATION OF MAST CELL DEVELOPMENT AND FUNCTION
    STEPHEN GALLI; Fiscal Year: 2006
    ....
  19. Mast Cells in Physiology, Host Defese and Disease;
    STEPHEN GALLI; Fiscal Year: 2004
    ..Elucidating, at the molecular level, the positive and negative regulation of mast cell development and function; and 7. The development of definitive models for analyzing mast cell function in vivo. ..
  20. Expression and Modulation of Mast Cell Function in Asthma
    STEPHEN GALLI; Fiscal Year: 2007
    ....