Stephen J Galli

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice
    C M Williams
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305 5324, USA
    J Exp Med 192:455-62. 2000
  2. ncbi request reprint Mast cells and basophils
    S J Galli
    Department of Pathology, Stanford University Medical Center, California 94305 5324, USA
    Curr Opin Hematol 7:32-9. 2000
  3. ncbi request reprint IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals
    Lien H Ho
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Leukoc Biol 82:1481-90. 2007
  4. pmc Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice
    Jennifer N Lilla
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    Blood 118:6930-8. 2011
  5. ncbi request reprint Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Allergy Clin Immunol 120:48-55. 2007
  6. ncbi request reprint Mast cell-associated TNF promotes dendritic cell migration
    Hajime Suto
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:4102-12. 2006
  7. pmc RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 103:2659-64. 2006
  8. pmc The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Am J Pathol 181:875-86. 2012
  9. pmc Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 176:926-38. 2010
  10. pmc Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma
    Mang Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5176, USA
    J Clin Invest 121:3133-43. 2011

Detail Information

Publications86

  1. pmc Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice
    C M Williams
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305 5324, USA
    J Exp Med 192:455-62. 2000
    ..These results show that, depending on the "asthma model" investigated, mast cells can either have a critical role in, or not be essential for, multiple features of allergic airway responses in mice...
  2. ncbi request reprint Mast cells and basophils
    S J Galli
    Department of Pathology, Stanford University Medical Center, California 94305 5324, USA
    Curr Opin Hematol 7:32-9. 2000
    ..This review discusses certain recent findings about the differentiation, phenotype, and function of basophils and mast cells, as well as briefly considering evolving concepts about the roles of these cells in health and disease...
  3. ncbi request reprint IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals
    Lien H Ho
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Leukoc Biol 82:1481-90. 2007
    ..These observations suggest potential roles for IL-33 in mast cell- and Th2 cytokine-associated immune responses and disorders...
  4. pmc Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice
    Jennifer N Lilla
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    Blood 118:6930-8. 2011
    ....
  5. ncbi request reprint Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Allergy Clin Immunol 120:48-55. 2007
    ..However, it is not clear to what extent mast cells represent a significant source of TNF in this mouse model...
  6. ncbi request reprint Mast cell-associated TNF promotes dendritic cell migration
    Hajime Suto
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:4102-12. 2006
    ..Our findings indicate that mast cell-associated TNF can contribute significantly to the initial stages of FITC-induced migration of cutaneous or airway DCs...
  7. pmc RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 103:2659-64. 2006
    ..Thus, RabGEF1 plays a critical role in the regulation of SCF/c-Kit-mediated signaling events and biological responses in mast cells...
  8. pmc The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, California 94305 5324, USA
    Am J Pathol 181:875-86. 2012
    ..Our findings support the conclusion that mMCP-4 can enhance survival after CLP at least in part by limiting detrimental effects of TNF, and suggest that mast cell chymase may represent an important negative regulator of TNF in vivo...
  9. pmc Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 176:926-38. 2010
    ..typhimurium...
  10. pmc Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma
    Mang Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5176, USA
    J Clin Invest 121:3133-43. 2011
    ..These findings identify a previously unsuspected IFN-γ/mast cell axis in the pathology of chronic allergic inflammation of the airways in mice...
  11. ncbi request reprint RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation
    See Ying Tam
    Departments of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Novartis Found Symp 271:115-24; discussion 124-30, 145-51. 2005
    ....
  12. doi request reprint A beneficial role for immunoglobulin E in host defense against honeybee venom
    Thomas Marichal
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 39:963-75. 2013
    ....
  13. ncbi request reprint Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:2238-48. 2006
    ..These results indicate that the secretion of soluble TNF and direct cell-cell interactions between mast cell OX40L and T cell OX40 contribute to the ability of IgE- and Ag-stimulated mouse mast cells to enhance T cell activation...
  14. ncbi request reprint TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Allergy Clin Immunol 119:680-6. 2007
    ..However, studies with TNF-deficient or TNF receptor-deficient mice have not produced a clear picture of the role of TNF in the AHR associated with allergic inflammation in the mouse...
  15. pmc Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Blood 109:5308-17. 2007
    ..By contrast, correction of these -/- phenotypes required a functional Vps9 domain. Thus, Fc epsilon RI-mediated mast cell functional activation is dependent on RabGEF1's GEF activity...
  16. pmc Mast cells can promote the development of multiple features of chronic asthma in mice
    Mang Yu
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Clin Invest 116:1633-41. 2006
    ....
  17. pmc Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice
    Laurent L Reber
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif
    J Allergy Clin Immunol 132:881-8.e1-11. 2013
    ....
  18. ncbi request reprint Using mast cell knock-in mice to analyze the roles of mast cells in allergic responses in vivo
    Mindy Tsai
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif 94305, USA edu
    Chem Immunol Allergy 87:179-97. 2005
    ....
  19. pmc Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice
    Susumu Nakae
    Department of Pathology L 235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Blood 109:3640-8. 2007
    ....
  20. pmc Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 167:835-48. 2005
    ..Thus, Kit(W-sh/W-sh) mice represent a useful model for mast cell research, especially for analyzing mast cell function in vivo...
  21. pmc Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Med 14:392-8. 2008
    ....
  22. ncbi request reprint Mast cells in the promotion and limitation of chronic inflammation
    Martin Metz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Immunol Rev 217:304-28. 2007
    ..Such work has confirmed that mast cells can significantly influence multiple features of chronic inflammatory responses, through diverse effects that can either promote or, perhaps more surprisingly, suppress aspects of these responses...
  23. ncbi request reprint Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17
    Susumu Nakae
    Department of Pathology, L 235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    J Leukoc Biol 81:1258-68. 2007
    ..We also confirmed that IL-12 or IFN-gamma can negatively regulate Th17 cell differentiation. However, these cytokines could not modulate such effects on T cell differentiation in the absence of APC...
  24. pmc Critical role of P1-Runx1 in mouse basophil development
    Kaori Mukai
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 120:76-85. 2012
    ..The results of the present study suggest that P1-Runx1 is critical for a stage of basophil development between SN-Flk2(+/-) cells and basophil progenitors...
  25. pmc Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice
    Maki Kakurai
    Department of Pathology, L 235, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305 5324, USA
    Am J Pathol 169:1713-21. 2006
    ..These observations show that mast cells, and mast cell-derived TNF, can promote the elongation of cutaneous nerve fibers during contact hypersensitivity in the mouse...
  26. ncbi request reprint Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5176, USA
    Nat Immunol 8:1095-104. 2007
    ....
  27. pmc Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells
    Tatsuya Oka
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif
    J Allergy Clin Immunol 132:922-32.e1-16. 2013
    ..However, the mechanisms underlying successful rapid desensitization are not fully understood...
  28. ncbi request reprint Mast cells as "tunable" effector and immunoregulatory cells: recent advances
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Immunol 23:749-86. 2005
    ....
  29. pmc Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice
    Beatrix Schäfer
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif 94305 5324, USA
    J Allergy Clin Immunol 131:541-8.e1-9. 2013
    ..However, it is not clear to what extent mast cell expression of C3aR or C5aR influences C3a- or C5a-induced cutaneous responses or IgE-dependent mast cell activation and passive cutaneous anaphylaxis (PCA) in vivo...
  30. pmc Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice
    Tatsuya Oka
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Lab Invest 92:1472-82. 2012
    ..These results question cromolyn's effectiveness and selectivity as an inhibitor of mast cell activation and mediator release in the mouse...
  31. pmc Rabaptin-5 regulates receptor expression and functional activation in mast cells
    Eon J Rios
    Department of Pathology, Stanford University School of Medicine, CA, USA
    Blood 112:4148-57. 2008
    ..These findings show that, although dispensable for canonical Rab5 processes in mast cells, Rabaptin-5 importantly contributes to mast cell IgE-dependent immunologic function by enhancing mast cell receptor surface stability...
  32. pmc Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice
    Mindy Tsai
    Stanford University School of Medicine, Department of Pathology, L 235, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Am J Pathol 177:2411-20. 2010
    ....
  33. ncbi request reprint IL-33 can promote survival, adhesion and cytokine production in human mast cells
    Motoyasu Iikura
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Lab Invest 87:971-8. 2007
    ..Our findings thus support the hypothesis that IL-33 may enhance mast cell function in allergic disorders and other settings, either in the presence or absence of co-stimulation of mast cells via IgE/antigen-FcepsilonRI signals...
  34. pmc Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 205:2207-20. 2008
    ..Rather, CCRL2 is able to bind the chemoattractant and increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1...
  35. doi request reprint Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients
    Yael Gernez
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Immunol 32:565-73. 2012
    ..Thus, basophil responses to offending allergens are associated with modulation of mTOR effector phosphoproteins...
  36. ncbi request reprint Mast cells promote homeostasis by limiting endothelin-1-induced toxicity
    Marcus Maurer
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 432:512-6. 2004
    ..These findings identify a new biological function for mast cells: promotion of homeostasis by limiting the toxicity associated with an endogenous mediator...
  37. ncbi request reprint Mast cells can enhance resistance to snake and honeybee venoms
    Martin Metz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Science 313:526-30. 2006
    ..These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms...
  38. pmc Distinguishing mast cell and granulocyte differentiation at the single-cell level
    Christopher B Franco
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stem Cell 6:361-8. 2010
    ..Our data provide criteria for the prospective isolation of SL-CMP and SL-GMP and support the conclusion that mast cells are specified during hematopoiesis earlier than and independently from granulocytes...
  39. pmc Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice
    Mitsuteru Akahoshi
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Clin Invest 121:4180-91. 2011
    ..Our findings support the notion that mast cells can enhance innate defense by degradation of diverse animal toxins and that release of MCPT4, in addition to CPA3, can contribute to this mast cell function...
  40. ncbi request reprint Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response
    Kentaro Matsuda
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    J Allergy Clin Immunol 116:1357-63. 2005
    ..Mouse monoclonal IgE antibodies can promote the survival of mouse bone marrow-derived cultured mast cells and induce the cells to secrete mediators in the absence of known specific antigen...
  41. pmc New developments in mast cell biology
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 9:1215-23. 2008
    ....
  42. pmc Mast cells enhance T cell activation: Importance of mast cell-derived TNF
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5176, USA
    Proc Natl Acad Sci U S A 102:6467-72. 2005
    ..Finally, mast cells also can promote T cell activation by means of soluble factors. These findings identify multiple mechanisms by which mast cells can influence T cell proliferation and cytokine production...
  43. pmc The development of allergic inflammation
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 454:445-54. 2008
    ....
  44. ncbi request reprint Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Curr Opin Immunol 18:751-60. 2006
    ....
  45. doi request reprint The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice
    Satoshi Itoh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Heart Lung Transplant 29:401-9. 2010
    ..We used C57BL/6-Kit(W-sh/W-sh) mast cell-deficient and corresponding wild-type mice to investigate possible contributions of recipient mast cells to acute or chronic cardiac allograft rejection...
  46. pmc Identification of mast cell progenitors in adult mice
    Ching Cheng Chen
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 102:11408-13. 2005
    ....
  47. ncbi request reprint Adoptive transfer of mast cells does not enhance the impaired survival of Kit(W)/Kit(W-v) mice in a model of low dose intraperitoneal infection with bioluminescent Salmonella typhimurium
    Devavani Chatterjea
    Department of Pathology, Stanford University Medical Center, 300 Pasteur Ave, L 235, Stanford, CA 94305 5324, USA
    Immunol Lett 99:122-9. 2005
    ....
  48. ncbi request reprint Interleukin-3 and c-Kit/stem cell factor are required for normal eosinophil responses in mice infected with Strongyloides venezuelensis
    Koichi Kimura
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Lab Invest 86:987-96. 2006
    ..b.). However, in mice with markedly impaired SCF/c-Kit signaling, IL-3 contributed significantly to the increased numbers of eosinophils that were observed in multiple tissues during S.v. infection, but not during infection with N.b...
  49. doi request reprint Anaphylaxis: mechanisms of mast cell activation
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Chem Immunol Allergy 95:45-66. 2010
    ..We will also discuss the use of mouse models to investigate the mechanisms that can contribute to anaphylaxis in that species in vivo, and the relevance of such mouse studies to human anaphylaxis...
  50. pmc TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Blood 110:2565-8. 2007
    ..These observations suggest that TIM-1 and TIM-3 may be able to influence T-cell-mediated immune responses in part through effects on mast cells...
  51. pmc Mast cells: versatile regulators of inflammation, tissue remodeling, host defense and homeostasis
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5176, United States
    J Dermatol Sci 49:7-19. 2008
    ..Through such functions, mast cells can significantly influence inflammation, tissue remodeling, host defense and homeostasis...
  52. pmc IgE and mast cells in allergic disease
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, California, USA
    Nat Med 18:693-704. 2012
    ..In this review, we discuss findings supporting the conclusion that IgE and mast cells can have both interdependent and independent roles in the complex immune responses that manifest clinically as asthma and other allergic disorders...
  53. doi request reprint Antiinflammatory and immunosuppressive functions of mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 677:207-20. 2011
    ....
  54. pmc Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Nat Immunol 12:1035-44. 2011
    ....
  55. pmc Immunomodulatory mast cells: negative, as well as positive, regulators of immunity
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Rev Immunol 8:478-86. 2008
    ..Here, we review the evidence that mast cells can have negative, as well as positive, immunomodulatory roles in vivo, and we propose that mast cells can both enhance and later suppress certain features of an immune response...
  56. pmc Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination
    Rosetta Pedotti
    Department of Neurology and Neurological Science, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:1867-72. 2003
    ..The pathogenesis of demyelination must now be viewed as encompassing elements of both Th1 responses and "allergic" responses...
  57. ncbi request reprint RabGEF1 is a negative regulator of mast cell activation and skin inflammation
    See Ying Tam
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 5:844-52. 2004
    ..Thus, RabGEF1 is a negative regulator of Fc epsilon RI-dependent mast cell activation, and a lack of RabGEF1 results in the development of skin inflammation in vivo...
  58. pmc Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Immunol 40:1843-51. 2010
    ....
  59. ncbi request reprint Chair's introduction. Anaphylaxis
    Stephen J Galli
    Department of Pathology, L 235, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Novartis Found Symp 257:1-5. 2004
  60. pmc Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy
    Yael Gernez
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int Arch Allergy Immunol 154:318-27. 2011
    ..Basophils contribute to anaphylaxis and allergies. We examined the utility of assessing basophil-associated surface antigens (CD11b/CD63/CD123/CD203c/CD294) in characterizing and monitoring subjects with nut allergy...
  61. pmc Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus
    Rosetta Pedotti
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    BMC Immunol 4:2. 2003
    ....
  62. doi request reprint Mast cells and immunoregulation/immunomodulation
    Mindy Tsai
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Adv Exp Med Biol 716:186-211. 2011
    ..We also briefly describe some of the mast-cell functions, products and surface receptors that have the potential to permit mast cells to promote or suppress immune responses that can either enhance host defense or contribute to disease...
  63. doi request reprint Basophils are back!
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Immunity 28:495-7. 2008
    ....
  64. pmc Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11
    Koichi Sayama
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    BMC Immunol 3:5. 2002
    ..To search for new mast cell products, we used complementary DNA microarrays to analyze gene expression in human umbilical cord blood-derived mast cells stimulated via the high-affinity IgE receptor (Fc(epsilon)RI)...
  65. ncbi request reprint Mast cells in the development of adaptive immune responses
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Immunol 6:135-42. 2005
    ..Thus, mast cells may influence the development, intensity and duration of adaptive immune responses that contribute to host defense, allergy and autoimmunity, rather than simply functioning as effector cells in these settings...
  66. pmc New models for analyzing mast cell functions in vivo
    Laurent L Reber
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Trends Immunol 33:613-25. 2012
    ....
  67. ncbi request reprint Analyzing the roles of mast cells and basophils in host defense and other biological responses
    Stephen J Galli
    Department of Pathology, Stanford University Medical Center, California 94305 5324, USA
    Int J Hematol 75:363-9. 2002
    ..We will also describe briefly some approaches to investigate mast cell and basophil functions in vivo, including the use of mast cells generated directly from embryonic stem cells in vitro...
  68. ncbi request reprint A key regulatory role for histamine in experimental autoimmune encephalomyelitis: disease exacerbation in histidine decarboxylase-deficient mice
    Silvia Musio
    Immunology and Muscular Pathology Unit, National Neurological Institute C Besta, Milan, Italy
    J Immunol 176:17-26. 2006
    ..Understanding which receptor(s) for histamine is/are involved in regulating autoimmunity against the CNS might help in the development of new strategies of treatment for EAE and multiple sclerosis...
  69. ncbi request reprint Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 117:391-7. 2006
    ....
  70. ncbi request reprint Regulation of mast-cell and basophil function and survival by IgE
    Toshiaki Kawakami
    Division of Allergy, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nat Rev Immunol 2:773-86. 2002
    ..So, the binding of IgE to Fc epsilon RI might influence mast-cell and basophil survival directly or indirectly, and can also regulate cellular function...
  71. ncbi request reprint Probing the roles of mast cells and basophils in natural and acquired immunity, physiology and disease
    Gianni Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Trends Immunol 23:425-7. 2002
  72. ncbi request reprint Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells
    Paul J Bryce
    Division of Immunology, Children s Hospital, Boston, MA 02115, USA
    Novartis Found Symp 271:15-24; discussion 24-38, 95-9. 2005
    ..wild-type skin after hapten exposure. We propose that levels of IgE normally present in mice favour immune sensitization via antigen-independent effects on mast cells...
  73. ncbi request reprint Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    Christopher Lock
    Department of Neurology and Neurological Sciences, Beckman Center, Stanford University, Stanford, California, USA
    Nat Med 8:500-8. 2002
    ..These results in EAE corroborate the microarray studies on MS lesions. Large-scale analysis of transcripts in MS lesions elucidates new aspects of pathology and opens possibilities for therapy...
  74. pmc Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation
    Jason Gotlib
    Department of Medicine, Division of Hematology, Stanford University, Stanford Cancer Center, 875 Blake Wilbur Dr, Rm 2327B, Stanford, CA 94305 5821, USA
    Blood 106:2865-70. 2005
    ..This case indicates that KIT tyrosine kinase inhibition is a feasible approach in SM, but single-agent clinical efficacy may be limited by clonal evolution in the advanced leukemic phase of this disease...
  75. ncbi request reprint Identification of A3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 171:331-7. 2003
    ..Finally, our findings indicate that adenosine exposure can result in A(3)-dependent airway inflammation, as reflected in neutrophil recruitment, as well as alterations in airway function...
  76. pmc Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:12911-6. 2003
    ..In hybridoma-transplanted mice, mucosal mast cell numbers correlate with serum IgE levels. Therefore, survival effects of IgE could contribute to the pathogenesis of allergic disease...
  77. ncbi request reprint Nipping cat allergy with fusion proteins
    Janet Kalesnikoff
    Nat Med 11:381-2. 2005
  78. ncbi request reprint Immune sensitization in the skin is enhanced by antigen-independent effects of IgE
    Paul J Bryce
    Division of Immunology, Children s Hospital, Boston, MA 02115 USA
    Immunity 20:381-92. 2004
    ..We speculate that levels of IgE normally present in mice favor immune sensitization via antigen-independent but FcepsilonRI-dependent effects on mast cells...
  79. ncbi request reprint Lack of significant skin inflammation during elimination by apoptosis of large numbers of mouse cutaneous mast cells after cessation of treatment with stem cell factor
    Marcus Maurer
    Department of Dermatology and Allergy, University Hospital Charite, Berlin, Germany
    Lab Invest 84:1593-602. 2004
    ....
  80. ncbi request reprint Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v) mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors
    Jochen Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany
    Lab Invest 85:388-96. 2005
    ..Our findings also are consistent with the possibility that mast cells promote the development of DMH-induced colonic epithelial tumors in mice...
  81. ncbi request reprint Mast cells derived from embryonic stem cells: a model system for studying the effects of genetic manipulations on mast cell development, phenotype, and function in vitro and in vivo
    Mindy Tsai
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Int J Hematol 75:345-9. 2002
    ....
  82. ncbi request reprint Mast cells to the defense
    Stephen J Galli
    Nat Immunol 4:1160-2. 2003
  83. ncbi request reprint Pathogenesis and management of anaphylaxis: current status and future challenges
    Stephen J Galli
    J Allergy Clin Immunol 115:571-4. 2005
  84. ncbi request reprint Symposium on the definition and management of anaphylaxis: summary report
    Hugh A Sampson
    Mount Sinai School of Medicine, Department of Pediatrics, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 115:584-91. 2005
  85. ncbi request reprint Interleukin-4-triggered, STAT6-dependent production of a factor that induces mouse mast cell apoptosis
    Zhi Qing Hu
    Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo, Japan
    Eur J Immunol 36:1275-84. 2006
    ..These results demonstrate a novel mechanism whereby IL-4 and IL-13 can suppress mast cell development by inducing the production of an apoptosis-inducing factor from macrophages...
  86. ncbi request reprint Involvement of both 'allergic' and 'autoimmune' mechanisms in EAE, MS and other autoimmune diseases
    Rosetta Pedotti
    Immunology and Muscular Pathology Unit, National Neurological Institute C Besta, Milan, 20133, Italy
    Trends Immunol 24:479-84. 2003