Affiliation: Stanford University
- p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C geneShanthi Adimoolam
Departments of Medicine Oncology and Genetics, Stanford University School of Medicine, 1115 CCSR Building, 269 Campus Drive, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:12985-90. 2002..These results provide strong evidence that the NER gene XPC is a DNA damage-inducible and p53-regulated gene and likely plays a role in the p53-dependent NER pathway...
- p53 responsive nucleotide excision repair gene products p48 and XPC, but not p53, localize to sites of UV-irradiation-induced DNA damage, in vivoMaureen E Fitch
Department of Medicine, Division of Oncology, 1115 CCSR Bldg, 269 Campus Drive, Stanford University Medical School, CA 94305 5151, USA
Carcinogenesis 24:843-50. 2003..We propose that p53 functions to transcriptionally regulate the DDB2 and XPC NER genes, but does not activate the NER pathway through direct interactions with UV-induced damaged DNA or other repair factors...
- CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancerJeffrey A Norton
Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94035, USA
Ann Surg 245:873-9. 2007....
- Microsatellite instability and mismatch repair protein defects in ovarian epithelial neoplasms in patients 50 years of age and youngerKristin C Jensen
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Am J Surg Pathol 32:1029-37. 2008..The occurrence of MMR inactivation in a significant proportion of ovarian clear cell carcinomas (17% in this study) suggests that this tumor may warrant targeted testing in women <or=50 years of age...
- Lupus antibody tops cancer cellsJames M Ford
Departments of Medicine and Genetics, Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Sci Transl Med 4:157fs38. 2012..A lupus causing anti-DNA antibody penetrates living cells and targets DNA repair for therapeutic advantage in human cancer cells...
- Identification of a biomarker panel using a multiplex proximity ligation assay improves accuracy of pancreatic cancer diagnosisStephanie T Chang
Department of Radiation Oncology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA
J Transl Med 7:105. 2009..Proximity ligation assay (PLA) is a highly sensitive technique for multiplex detection of biomarkers in plasma with little or no interfering background signal...
- Enhanced sensitivity to cisplatin and gemcitabine in Brca1-deficient murine mammary epithelial cellsElizabeth Alli
Department of Medicine, Division of Oncology, Stanford University School of Medicine, Center for Clinical Sciences Research, Stanford, CA 94305, USA
BMC Pharmacol 11:7. 2011..BRCA1 plays a role in multiple DNA repair pathways, and thus, when mutated, results in sensitivity to certain DNA damaging drugs...
- Regulation of DNA damage recognition and nucleotide excision repair: another role for p53James M Ford
Department of Medicine Oncology, Stanford University School of Medicine, 1115 CCSR Bldg, 269 Campus Drive Stanford, CA 94305, USA
Mutat Res 577:195-202. 2005..A historical review of this work is presented...
- Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinomaAnne Renee Hartman
Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5458, USA
Cancer 100:479-89. 2004....
- Strategies to identify the Lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysisUri Ladabaum
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA
Ann Intern Med 155:69-79. 2011..Testing has been advocated for all persons with newly diagnosed colorectal cancer to identify families with the Lynch syndrome, an autosomal dominant cancer-predisposition syndrome that is a paradigm for personalized medicine...
- Ductal lavage of fluid-yielding and non-fluid-yielding ducts in BRCA1 and BRCA2 mutation carriers and other women at high inherited breast cancer riskAllison W Kurian
Division of Oncology, Department of Medicine, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA 94305 5820
Cancer Epidemiol Biomarkers Prev 14:1082-9. 2005..Most publications on ductal lavage for cell collection report cannulating fluid-yielding ducts only. We report lavage of fluid-yielding and non-fluid-yielding ducts in women at high inherited breast cancer risk...
- Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinomaHanlee Ji
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5151, USA
Cancer Res 66:7910-9. 2006..This finding has potential clinical ramifications given the application of 18q loss of heterozygosity events as a potential indicator for adjuvant treatment in stage II colorectal carcinoma...
- Cancer risk reduction and reproductive concerns in female BRCA1/2 mutation carriersAshley D Staton
Department of Medicine, Stanford University School of Medicine, CCSR Building, Room 1115, 269 Campus Drive, Stanford, CA 94305 5151, USA
Fam Cancer 7:179-86. 2008..In order to explore women's preferences for management of elevated cancer risk, we evaluated the decisions of BRCA1/2 mutation carriers about contraception, prophylactic surgery, and family planning...
- Performance of BRCA1/2 mutation prediction models in Asian AmericansAllison W Kurian
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
J Clin Oncol 26:4752-8. 2008..We compared the performance in Asian and white individuals of two widely used BRCA1/2 mutation prediction models, BRCAPRO and Myriad II...
- Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancerDevin Schellenberg
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA
Int J Radiat Oncol Biol Phys 72:678-86. 2008..This prospective trial evaluated the efficacy of a single fraction of 25 Gy stereotactic body radiotherapy (SBRT) delivered between Cycle 1 and 2 of gemcitabine chemotherapy...
- Novel treatment approaches for triple-negative breast cancerMelinda L Telli
Department of Medicine, Stanford University School of Medicine, CA 94305 5820, USA
Clin Breast Cancer 10:E16-22. 2010..Ongoing studies, including those investigating the role of antiangiogenic therapies, are also reviewed...
- Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancerAlbert C Koong
Department of Radiation Oncology, Stanford University School of Medicine, 269 Campus Drive West, Stanford, CA 94305
Int J Radiat Oncol Biol Phys 63:320-3. 2005..To determine the efficacy of concurrent 5-fluorouracil (5-FU) and intensity-modulated radiotherapy (IMRT) followed by body stereotactic radiosurgery (SRS) in patients with locally advanced pancreatic cancer...
- Risk-reducing total gastrectomy for germline mutations in E-cadherin (CDH1): pathologic findings with clinical implicationsWilliam M Rogers
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Am J Surg Pathol 32:799-809. 2008..The observed site predilection suggests a possible role for geographically targeted endoscopic surveillance biopsy in patients who elect to delay surgical intervention...
- Expression of p16(INK4A) but not hypoxia markers or poly adenosine diphosphate-ribose polymerase is associated with improved survival in patients with pancreatic adenocarcinomaDaniel T Chang
Department of Radiation Oncology, Stanford University, Stanford, CA, USA
Cancer 116:5179-87. 2010..This study investigates whether immunohistochemical expression of p16(INK4A) as well as hypoxia markers and poly adenosine diphosphate-ribose polymerase (PARP) correlates with survival in patients with resected pancreatic adenocarcinoma...
- Opinions of women with high inherited breast cancer risk about prophylactic mastectomy: an initial evaluation from a screening trial including magnetic resonance imaging and ductal lavageAllison W Kurian
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5820, USA
Health Expect 8:221-33. 2005....
- Functional characterization of global genomic DNA repair and its implications for cancerPhilip C Hanawalt
Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
Mutat Res 544:107-14. 2003..Since rodents are used as surrogates for humans in environmental cancer risk assessment it is very important that we determine how they differ from humans with respect to DNA repair and oncogenic responses to environmental genotoxins...
- p53 and regulation of DNA damage recognition during nucleotide excision repairShanthi Adimoolam
Department of Medicine Oncology, Stanford University School of Medicine, 1115 CCSR Building, 269 Campus Drive, Stanford, CA 94305, USA
DNA Repair (Amst) 2:947-54. 2003..These advances have greatly enhanced our understanding of the role of p53 in DNA repair and this review comprehensively summarizes current opinions on the mechanisms of p53-dependent DNA repair...
- BRCA1 and p53: compensatory roles in DNA repairAnne Renee Hartman
Department of Medicine, School of Medicine, Stanford University, 269 Campus Drive, Stanford, CA 94305, USA
J Mol Med (Berl) 81:700-7. 2003..Here we discuss the role of BRCA1 and NER in breast cancer and the interactions of BRCA1 with p53 in breast tumorigenesis and suggest approaches for risk assessment and chemotherapeutic management of BRCA1-related breast cancer...
- Defective repair of oxidative dna damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymeraseElizabeth Alli
Department of Medicine Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
Cancer Res 69:3589-96. 2009..The defect may be attributed, at least in part, to a novel role for BRCA1 in the BER pathway. Overall, these data offer preventive, prognostic, and therapeutic usefulness...
- Phase II study of gefitinib, fluorouracil, leucovorin, and oxaliplatin therapy in previously treated patients with metastatic colorectal cancerTimothy Kuo
Oncology Division, Department of Medicine, Stanford University School of Medicine, 269 Campus Dr, CCSR 1105, Stanford, CA 94305 5151, USA
J Clin Oncol 23:5613-9. 2005..To investigate the gefitinib, fluorouracil (FU), leucovorin, and oxaliplatin regimen (IFOX) in previously treated patients with metastatic colorectal cancer...
- Ductal pattern enhancement on magnetic resonance imaging of the breast due to ductal lavagePejman Ghanouni
Department of Radiology, Division of Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
Breast J 13:281-6. 2007..Knowledge of the potential for breast MRI enhancement subsequent to DL, which can mimic the appearance of a pathologic lesion, is critical to the care of patients who undergo breast MRI and DL or other intraductal cannulation procedures...
- Hereditary diffuse gastric cancer: implications of genetic testing for screening and prophylactic surgeryRobin M Cisco
Department of Surgery, Stanford University School of Medicine, Stanford, California, USA
Cancer 113:1850-6. 2008..Because of the emergence of gene-directed gastrectomy for HDGC, today, a previously lethal disease is detected by molecular techniques, allowing curative surgery at an early stage...
- Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-Ribose) polymerase inhibition, gemcitabine, and cisplatinKedar Hastak
Division of Oncology, Stanford University School of Medicine, Stanford, California, USA
Cancer Res 70:7970-80. 2010..Our results suggest a novel therapeutic strategy to treat women with TN breast cancer, an aggressive disease that presently lacks effective treatment options...
- Hereditary diffuse gastric cancer due to a previously undescribed CDH1 splice site mutationKaren E Matsukuma
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Hum Pathol 41:1200-3. 2010..In summary, we have identified a novel CDH1 mutation in a large hereditary diffuse gastric cancer kindred and identified its pathogenic mechanism...
- The DDB2 nucleotide excision repair gene product p48 enhances global genomic repair in p53 deficient human fibroblastsMaureen E Fitch
Departments of Medicine and Genetics, Stanford University Medical Center, Stanford, CA 94305, USA
DNA Repair (Amst) 2:819-26. 2003..The regulation of p48 at both the transcriptional level by p53, and post-translationally by the proteasome suggests that p48 may be a rate limiting component of NER...
- Identification of a novel p53 in-frame deletion in a Li-Fraumeni-like familyJoshua D Schiffman
Division of Pediatric Hematology Oncology, Stanford University School of Medicine, Stanford, California 94304, USA
Pediatr Blood Cancer 50:914-6. 2008..The in-frame deletion we describe has not previously been reported and adds to our understanding of the biologic effects of p53 gene mutation in Li-Fraumeni syndrome (LFS)...
- In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene productMaureen E Fitch
Departments of Medicine and Genetics, Division of Oncology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA
J Biol Chem 278:46906-10. 2003..XPC did localize to CPDs when p48 was overexpressed in the same cell, signifying that p48 activates the recruitment of XPC to CPDs and may be the initial recognition factor in the NER pathway...
- Magnetic resonance galactography: a feasibility study in women with prior atypical breast duct cytologyAllison W Kurian
Breast J 14:211-4. 2008
- BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repairAnne Renee Hartman
Department of Internal Medicine Oncology, Stanford University Medical Center, Stanford, California 94305 5151, USA
Nat Genet 32:180-4. 2002..Defects in the NER pathway in BRCA1-associated breast cancers may be causal in tumor development, suggesting a multistep model of carcinogenesis...
- Characterization of a recurrent germ line mutation of the E-cadherin gene: implications for genetic testing and clinical managementGianpaolo Suriano
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Clin Cancer Res 11:5401-9. 2005..To identify germ line CDH1 mutations in hereditary diffuse gastric cancer (HDGC) families and develop guidelines for management of at risk individuals...
- Genetic/familial high-risk assessment: breast and ovarianMary B Daly
Fox Chase Cancer Center, Philadelphia, PA, USA
J Natl Compr Canc Netw 4:156-76. 2006
- Colorectal Cancer Screening Clinical Practice GuidelinesBernard Levin
J Natl Compr Canc Netw 4:384-420. 2006
- Phase II trial of preoperative 3D conformal radiotherapy, protracted venous infusion 5-fluorouracil, and weekly CPT-11, followed by surgery for ultrasound-staged T3 rectal cancerVivek K Mehta
Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA, USA
Int J Radiat Oncol Biol Phys 55:132-7. 2003..We report the results from a Phase II trial of preoperative radiotherapy (RT), CPT-11, and 5-FU for patients with ultrasound-staged T3 rectal cancer...
- A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteinsXiaoai Chen
Department of Pathology and Laboratory Medicine, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
Mol Cell 22:489-99. 2006..These results revealed a kinase-independent function of c-Abl in a ubiquitin-proteolytic pathway that regulates the damage recognition step of nucleotide excision repair...
- A carrier of both MEN1 and BRCA2 mutations: case report and review of the literaturePavandeep Ghataorhe
School of Medicine, Oxford University, South Parks Road, Oxford OX1 3PL, UK
Cancer Genet Cytogenet 179:89-92. 2007..To our knowledge, this is the first report of a patient with both MEN1 and BRCA2 mutations and with a personal history of hyperparathyroidism and pancreatic neuroendocrine tumors...
- Reversal of stathmin-mediated resistance to paclitaxel and vinblastine in human breast carcinoma cellsElizabeth Alli
The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Department of Pharmacology, New Brunswick, NJ 08901, USA
Mol Pharmacol 71:1233-40. 2007..Therefore, these data suggest a novel approach to improving the efficacy of certain antimicrotubule agents against breast cancer by regulating the function of stathmin...
- HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombinationShanthi Adimoolam
Pharmacyclics, Inc, Sunnyvale, CA 94085 4521, USA
Proc Natl Acad Sci U S A 104:19482-7. 2007..Together these results demonstrate that HDAC enzymes are critically important to enable functional HR by controlling the expression of HR-related genes and promoting the proper assembly of HR-directed subnuclear foci...
- Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signalingRyan D Bomgarden
Department of Molecular Pharmacology, Stanford University, Stanford, CA 94305 5174, USA
EMBO J 25:2605-14. 2006..Taken together, these results suggest that lesion bypass and not lesion repair may raise the level of UV damage that can be tolerated before checkpoint activation, and that XPA plays a critical role in this activation...
- MECHANISM FOR P53-DEPENDENT DNA EXCISION REPAIRJames Ford; Fiscal Year: 2002..Genes identified as candidates for p53- dependent DNA repair will be transfected and expressed in p53 null cells, and DNA repair activity determined following UV-irradiation. ..
- Genome-Wide Allelic Imbalances in Colon CancerJames Ford; Fiscal Year: 2006..The cancer MIP probes will be used to analyze clinical colorectal cancer sample and identify particular gene copy number or allelic imbalance events that can distinguish different types of genomic instability. ..
- Ubiquitin-Mediated Regulation of DNA RepairJames Ford; Fiscal Year: 2007..2. To determine whether ubiquitination of these NER proteins is required for DNA damage binding activity, in vivo. 3. To determine the functional consequences of ubiquitination on NER activity in human cells. ..