- Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblastsD W Felsher
Division of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA 94305 5115, USA
Proc Natl Acad Sci U S A 97:10544-8. 2000..The loss of p53 function seems to be one mechanism by which this relaxation commonly occurs. These findings dramatize how multiple genetic events can collaborate to produce neoplastic cells...
- Reversible tumorigenesis by MYC in hematopoietic lineagesD W Felsher
Department of Medicine, G W Hooper Foundation, San Francisco, California, USA
Mol Cell 4:199-207. 1999..We conclude that even though tumorigenesis is a multistep process, remediation of a single genetic lesion may be sufficient to reverse malignancy...