David Feldman

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint The development of androgen-independent prostate cancer
    B J Feldman
    Department of Medicine, Stanford University School of Medicine, California 94305 5103, USA
    Nat Rev Cancer 1:34-45. 2001
  2. ncbi request reprint Identification of a functional vitamin D response element in the human insulin-like growth factor binding protein-3 promoter
    Lihong Peng
    Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103
    Mol Endocrinol 18:1109-19. 2004
  3. ncbi request reprint Vitamin D inhibition of the prostaglandin pathway as therapy for prostate cancer
    David Feldman
    Department of Medicine Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Room S 025, Stanford, CA 94305 5103, USA
    Nutr Rev 65:S113-5. 2007
  4. doi request reprint Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients
    Srilatha Swami
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Int J Cancer 124:2050-9. 2009
  5. pmc Dietary vitamin D₃ and 1,25-dihydroxyvitamin D₃ (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer
    Srilatha Swami
    Department of Medicine Endocrinology, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Endocrinology 153:2576-87. 2012
  6. ncbi request reprint The role of insulin-like growth factor binding protein-3 in the growth inhibitory actions of androgens in LNCaP human prostate cancer cells
    Lihong Peng
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Int J Cancer 122:558-66. 2008
  7. pmc Hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from a novel missense mutation in the DNA-binding domain of the vitamin D receptor
    Peter J Malloy
    Department of Medicine, Stanford University School of Medicine, Room S025, Stanford, CA 94305, USA
    Mol Genet Metab 99:72-9. 2010
  8. ncbi request reprint Two new unrelated cases of hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from the same novel nonsense mutation in the vitamin D receptor gene
    Nikta Forghani
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Pediatr Endocrinol Metab 23:843-50. 2010
  9. pmc Inhibitory effects of calcitriol on the growth of MCF-7 breast cancer xenografts in nude mice: selective modulation of aromatase expression in vivo
    Srilatha Swami
    Department of Medicine Endocrinology, Stanford University School of Medicine, Room S025, 300 Pasteur Drive, Stanford, CA 94305 5103, USA
    Horm Cancer 2:190-202. 2011
  10. pmc Modulation of vitamin d receptor activity by the corepressor hairless: differential effects of hairless isoforms
    Peter J Malloy
    S025 Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5103, USA
    Endocrinology 150:4950-7. 2009

Research Grants

  1. DIABETES, ENDOCRINOLOGY AND METABOLISM
    David Feldman; Fiscal Year: 2007

Collaborators

Detail Information

Publications70

  1. ncbi request reprint The development of androgen-independent prostate cancer
    B J Feldman
    Department of Medicine, Stanford University School of Medicine, California 94305 5103, USA
    Nat Rev Cancer 1:34-45. 2001
    ....
  2. ncbi request reprint Identification of a functional vitamin D response element in the human insulin-like growth factor binding protein-3 promoter
    Lihong Peng
    Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103
    Mol Endocrinol 18:1109-19. 2004
    ..In conclusion, we have identified a functional VDRE in the distal region of the human IGFBP-3 promoter. The induction of IGFBP-3 by 1,25-(OH)2D3 appears to be directly mediated via VDR interaction with this VDRE...
  3. ncbi request reprint Vitamin D inhibition of the prostaglandin pathway as therapy for prostate cancer
    David Feldman
    Department of Medicine Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Room S 025, Stanford, CA 94305 5103, USA
    Nutr Rev 65:S113-5. 2007
  4. doi request reprint Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients
    Srilatha Swami
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Int J Cancer 124:2050-9. 2009
    ..We propose that the inhibition of the PG pathway contributes to the beneficial effect of soy isoflavones in PCa chemoprevention and/or treatment...
  5. pmc Dietary vitamin D₃ and 1,25-dihydroxyvitamin D₃ (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer
    Srilatha Swami
    Department of Medicine Endocrinology, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Endocrinology 153:2576-87. 2012
    ..These preclinical data demonstrate the potential utility of dietary vitamin D(3) supplementation in cancer prevention and therapy...
  6. ncbi request reprint The role of insulin-like growth factor binding protein-3 in the growth inhibitory actions of androgens in LNCaP human prostate cancer cells
    Lihong Peng
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Int J Cancer 122:558-66. 2008
    ....
  7. pmc Hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from a novel missense mutation in the DNA-binding domain of the vitamin D receptor
    Peter J Malloy
    Department of Medicine, Stanford University School of Medicine, Room S025, Stanford, CA 94305, USA
    Mol Genet Metab 99:72-9. 2010
    ..In summary, we have identified a novel V26M mutation in the VDR DBD as the molecular defect in a patient with HVDRR and an unusual pattern of alopecia...
  8. ncbi request reprint Two new unrelated cases of hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from the same novel nonsense mutation in the vitamin D receptor gene
    Nikta Forghani
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Pediatr Endocrinol Metab 23:843-50. 2010
    ..In conclusion, we identified a novel nonsense mutation in the VDR gene in two patients with HVDRR and alopecia. The mutation truncates the VDR protein and causes 1,25(OH)2D3 resistance...
  9. pmc Inhibitory effects of calcitriol on the growth of MCF-7 breast cancer xenografts in nude mice: selective modulation of aromatase expression in vivo
    Srilatha Swami
    Department of Medicine Endocrinology, Stanford University School of Medicine, Room S025, 300 Pasteur Drive, Stanford, CA 94305 5103, USA
    Horm Cancer 2:190-202. 2011
    ..We hypothesize that cumulatively these calcitriol actions would contribute to a beneficial effect when calcitriol is combined with an AI in the treatment of BCa...
  10. pmc Modulation of vitamin d receptor activity by the corepressor hairless: differential effects of hairless isoforms
    Peter J Malloy
    S025 Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5103, USA
    Endocrinology 150:4950-7. 2009
    ..HRDelta1072-1126 may function as a coactivator in some settings by inhibiting HDAC recruitment to the VDR transcriptional complex...
  11. doi request reprint Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment
    Aruna V Krishnan
    Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5103, USA
    Endocr Relat Cancer 17:R19-38. 2010
    ..Calcitriol or its analogs may have utility as chemopreventive agents and should be evaluated in clinical trials in PCa patients with early or precancerous disease...
  12. ncbi request reprint Molecular activity of 1,25-dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cDNA microarray analysis
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Steroid Biochem Mol Biol 92:131-41. 2004
    ..The functions of other regulated genes suggest protection by 1,25(OH)(2)D(3) from oxidative stress. Overall, these results provide new insights into the molecular basis of antitumor activities of Vitamin D in prostate cells...
  13. ncbi request reprint Potentiation of the growth-inhibitory effects of vitamin D in prostate cancer by genistein
    Aruna V Krishnan
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Grant Building, S 025, Stanford, CA 94305, USA
    Nutr Rev 65:S121-3. 2007
  14. pmc Combination of calcitriol and dietary soy exhibits enhanced anticancer activity and increased hypercalcemic toxicity in a mouse xenograft model of prostate cancer
    Jennifer Y Wang
    Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Prostate 72:1628-37. 2012
    ..In this study, we evaluated the anticancer activity of calcitriol, the active form of vitamin D, dietary soy, and their combinations in a mouse model of PCa...
  15. pmc Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy
    Aruna V Krishnan
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5103, USA
    Endocrinology 151:32-42. 2010
    ....
  16. ncbi request reprint Hereditary 1,25-dihydroxyvitamin D resistant rickets due to a mutation causing multiple defects in vitamin D receptor function
    Peter J Malloy
    Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford University Medical Center, Room S025, Stanford, California 94305 5103, USA
    Endocrinology 145:5106-14. 2004
    ..These combined defects in VDR function cause resistance to 1,25(OH)(2)D(3) action and result in the syndrome of HVDRR...
  17. ncbi request reprint Interactions of the vitamin D receptor with the corepressor hairless: analysis of hairless mutants in atrichia with papular lesions
    Jining Wang
    Division of Endocrinology, Gerontology, and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    J Biol Chem 282:25231-9. 2007
    ..This study of HR mutations provides evidence for the molecular basis of APL...
  18. ncbi request reprint Fulvestrant (ICI 182,780) down-regulates androgen receptor expression and diminishes androgenic responses in LNCaP human prostate cancer cells
    Rumi S Bhattacharyya
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Mol Cancer Ther 5:1539-49. 2006
    ..Our study suggests that AR down-regulation by ICI would be an effective strategy for the treatment of all prostate cancer, especially AR-dependent androgen-independent prostate cancer...
  19. pmc Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian-inhibiting substance (MIS) promoter: regulation of MIS expression by calcitriol in prostate cancer cells
    Peter J Malloy
    S025 Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5103
    Endocrinology 150:1580-7. 2009
    ..MIS is up-regulated by calcitriol via a functional VDRE that binds the VDR. Up-regulation of MIS by calcitriol may be an important component of the antiproliferative actions of calcitriol in some cancers...
  20. doi request reprint Selenite treatment inhibits LAPC-4 tumor growth and prostate-specific antigen secretion in a xenograft model of human prostate cancer
    Rumi S Bhattacharyya
    Department of Endocrinology, Stanford University, Stanford, CA, USA
    Int J Radiat Oncol Biol Phys 72:935-40. 2008
    ..In this study, we investigated the in vivo effects of selenite as a therapy to treat mice with established LAPC-4 tumors...
  21. pmc The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer
    Aruna V Krishnan
    Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States
    Steroids 77:1107-12. 2012
    ..Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention and/or treatment of ER+BCa in women...
  22. ncbi request reprint Growth inhibitory concentrations of androgens up-regulate insulin-like growth factor binding protein-3 expression via an androgen response element in LNCaP human prostate cancer cells
    Lihong Peng
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, California 94305 5103, USA
    Endocrinology 147:4599-607. 2006
    ....
  23. ncbi request reprint Phase II study evaluating oral triamcinolone in patients with androgen-independent prostate cancer
    Sandy Srinivas
    Division of Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Urology 67:1001-6. 2006
    ..To assess the effect of triamcinolone administration on the serum prostate-specific antigen (PSA) response and the time to progression in patients with androgen-independent prostate cancer (AIPC)...
  24. ncbi request reprint Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells
    Jacqueline Moreno
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Cancer Res 65:7917-25. 2005
    ....
  25. pmc Compound heterozygous mutations in the vitamin D receptor in a patient with hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia
    Yulin Zhou
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    J Bone Miner Res 24:643-51. 2009
    ..The R30X mutation truncates the VDR, whereas the DeltaK246 mutation prevents heterodimerization with RXR and disrupts coactivator interactions...
  26. ncbi request reprint Genistein potentiates the growth inhibitory effects of 1,25-dihydroxyvitamin D3 in DU145 human prostate cancer cells: role of the direct inhibition of CYP24 enzyme activity
    Srilatha Swami
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305, USA
    Mol Cell Endocrinol 241:49-61. 2005
    ..Together these two effects lead to a substantial enhancement of the cellular responses to the growth inhibitory and pro-apoptotic signaling by 1,25(OH)2D3...
  27. ncbi request reprint Analysis of vitamin D-regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays
    Aruna V Krishnan
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Prostate 59:243-51. 2004
    ..To better understand the molecular mechanisms underlying these actions, we employed cDNA microarrays to study 1,25(OH)2D3-regulated gene expression in the LNCaP human prostate cancer cells...
  28. doi request reprint Hereditary vitamin D-resistant rickets (HVDRR) owing to a heterozygous mutation in the vitamin D receptor
    Peter J Malloy
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    J Bone Miner Res 26:2710-8. 2011
    ..The E420A mutant appears to act in a dominant-negative fashion, silencing the wild-type VDR and resulting in an attenuated response to 1,25(OH)(2)D(3)...
  29. ncbi request reprint Inhibition of prostate cancer growth by vitamin D: Regulation of target gene expression
    Aruna V Krishnan
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    J Cell Biochem 88:363-71. 2003
    ..Further investigation of the role of calcitriol and its analogs for the therapy or chemoprevention of PCa is currently being pursued...
  30. ncbi request reprint A low-calcemic vitamin D analog (Ro 25-4020) inhibits the growth of LNCaP human prostate cancer cells with increased potency by producing an active 24-oxo metabolite (Ro 29-9970)
    Srilatha Swami
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Recent Results Cancer Res 164:349-52. 2003
    ..These results suggest that conversion of Ro 25-4020 into an active and more stable 24-oxo metabolite with longer half-life contributes significantly to its potent antiproliferative actions on the LNCaP cells...
  31. ncbi request reprint Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer
    Aruna V Krishnan
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Steroid Biochem Mol Biol 103:694-702. 2007
    ..Thus, we conclude that calcitriol regulates myriad pathways that contribute to the potential chemopreventive and therapeutic utility of calcitriol in PCa...
  32. pmc A unique insertion/duplication in the VDR gene that truncates the VDR causing hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia
    Peter J Malloy
    Division of Endocrinology, Gerontology and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Arch Biochem Biophys 460:285-92. 2007
    ....
  33. ncbi request reprint Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D
    Larisa Nonn
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    Cancer Res 66:4516-24. 2006
    ....
  34. pmc Vitamin D metabolism and action in the prostate: implications for health and disease
    Srilatha Swami
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell Endocrinol 347:61-9. 2011
    ..The current paper is an overview addressing some of the key factors that influence the biological actions of vitamin D and its metabolites in the treatment and/or prevention of PCa...
  35. ncbi request reprint Sex steroid hormones in young manhood and the risk of subsequent prostate cancer: a longitudinal study in African-Americans and Caucasians (United States)
    Chiaojung J Tsai
    Department of Health Research and Policy, Stanford University School of Medicine, HRP Redwood Building, Room T204, Stanford, CA 94305 5405, USA
    Cancer Causes Control 17:1237-44. 2006
    ..To investigate the relation of sex hormone levels in young adults to subsequent prostate cancer risk...
  36. ncbi request reprint Calcitriol as a chemopreventive and therapeutic agent in prostate cancer: role of anti-inflammatory activity
    Aruna V Krishnan
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, California, USA
    J Bone Miner Res 22:V74-80. 2007
    ..We conclude that calcitriol exerts several anti-inflammatory actions in prostate cells, which contribute to its potential as a chemopreventive and therapeutic agent in PCa...
  37. pmc Inactivation of the human vitamin D receptor by caspase-3
    Peter J Malloy
    Division of Endocrinology, Gerontology, and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Endocrinology 150:679-86. 2009
    ..In conclusion, our results demonstrate that the human VDR is a target of caspase-3 and suggest that activation of caspase-3 may limit VDR activity...
  38. ncbi request reprint Interaction of nuclear receptor ligands with the Vitamin D signaling pathway in prostate cancer
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Steroid Biochem Mol Biol 92:307-15. 2004
    ..In order to design the most effective strategies to use calcitriol to prevent or treat prostate cancer, the interactions of other nuclear receptors and their ligands with the Vitamin D signaling pathway need to be considered...
  39. doi request reprint Vitamin D and breast cancer: inhibition of estrogen synthesis and signaling
    Aruna V Krishnan
    Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States
    J Steroid Biochem Mol Biol 121:343-8. 2010
    ..We hypothesize that the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in the use of calcitriol for the prevention and/or treatment of BCa...
  40. ncbi request reprint Mechanisms of vitamin D-mediated growth inhibition in prostate cancer cells: inhibition of the prostaglandin pathway
    Jacqueline Moreno
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Anticancer Res 26:2525-30. 2006
    ..We also propose that calcitriol can be combined with non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit COX enzyme activity, as a potential therapeutic strategy in PCa...
  41. ncbi request reprint Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells
    Jian Feng Ma
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell Endocrinol 221:67-74. 2004
    ..We conclude that diminished 1alpha(OH)ase activity in prostate cancer cell lines is through decreased gene expression, whereas decreased activity in primary cultures and tissues is post-translational...
  42. doi request reprint The role of vitamin D in cancer prevention and treatment
    Aruna V Krishnan
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Endocrinol Metab Clin North Am 39:401-18, table of contents. 2010
    ..The reasons for the lack of impressive beneficial effects in clinical trials compared with the substantial efficacy seen in preclinical models are discussed...
  43. ncbi request reprint Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer
    Srilatha Swami
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Nutr 137:205S-210S. 2007
    ..Both calcitriol and genistein are relatively safe and have little toxicity associated with their intake. We postulate that the combination of calcitriol and genistein is an attractive therapeutic option for the treatment of PCa...
  44. ncbi request reprint Pathways mediating the growth-inhibitory actions of vitamin D in prostate cancer
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Nutr 133:2461S-2469S. 2003
    ..Our research is directed at understanding the mechanisms of vitamin D action in prostate cells with the goal of developing chemoprevention and treatment strategies to improve prostate cancer therapy...
  45. pmc Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: importance of mammary CYP27B1 for treatment and prevention
    Aruna V Krishnan
    Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States
    J Steroid Biochem Mol Biol 136:289-95. 2013
    ..These findings warrant clinical trials in BCa patients and in women at high risk for BCa to evaluate the benefits of dietary vitamin D3 supplementation. This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  46. ncbi request reprint A unique insertion/substitution in helix H1 of the vitamin D receptor ligand binding domain in a patient with hereditary 1,25-dihydroxyvitamin D-resistant rickets
    Peter J Malloy
    Department of Medicine, Stanford University School of Medicine, California 94305 5103, USA
    J Bone Miner Res 19:1018-24. 2004
    ..In this study, we examined the VDR in a young boy who exhibited the typical clinical features of HVDRR but without alopecia...
  47. pmc Genetic disorders and defects in vitamin d action
    Peter J Malloy
    Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford University, S 025 Endocrinology, Stanford, CA 94305 5103, USA
    Endocrinol Metab Clin North Am 39:333-46, table of contents. 2010
    ..In this article, these 2 genetic childhood diseases, which present similarly with hypocalcemia and rickets in infancy, are discussed and compared...
  48. ncbi request reprint Molecular mechanisms mediating the anti-proliferative effects of Vitamin D in prostate cancer
    Jacqueline Moreno
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Steroid Biochem Mol Biol 97:31-6. 2005
    ..In addition, we propose that calcitriol can be combined with non-steroidal anti-inflammatory drugs that inhibit COX activity, as a potential therapeutic strategy to improve the potency and efficacy of both drugs in the treatment of PCa...
  49. ncbi request reprint Hereditary 1,25-Dihydroxyvitamin D-resistant rickets
    Peter J Malloy
    Department of Medicine, Stanford University School of Medicine, Stanford, Calif, USA
    Endocr Dev 6:175-99. 2003
  50. ncbi request reprint Inhibition of androgen receptor signaling by selenite and methylseleninic acid in prostate cancer cells: two distinct mechanisms of action
    Bryan Husbeck
    Department of Radiation Oncology, Stanford University Medical Center, 300 Pasteur Drive, CA 94305, USA
    Mol Cancer Ther 5:2078-85. 2006
    ..In conclusion, we have found that selenite and MSeA disrupt AR signaling by distinct mechanisms. The inhibition of AR expression and activity by selenite occurs via a redox mechanism involving GSH, superoxide, and Sp1...
  51. ncbi request reprint A novel nonsense mutation in the ligand binding domain of the vitamin D receptor causes hereditary 1,25-dihydroxyvitamin D-resistant rickets
    Peter J Malloy
    Division of Endocrinology, Gerontology, and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford University Medical Center, Room S005, Stanford, CA 94305 5103, USA
    Mol Genet Metab 77:314-8. 2002
    ..The Q317X mutation deletes 110 amino acids of the ligand-binding domain of the VDR and results in the loss of [3H]1,25(OH)(2)D(3) binding and target gene transactivation...
  52. ncbi request reprint A novel mutation in helix 12 of the vitamin D receptor impairs coactivator interaction and causes hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia
    Peter J Malloy
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Endocrinol 16:2538-46. 2002
    ..In conclusion, we have identified the first case of a naturally occurring mutation in the VDR (E420K) that disrupts coactivator binding to the VDR and causes HVDRR...
  53. pmc The role of vitamin D receptor mutations in the development of alopecia
    Peter J Malloy
    Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Mol Cell Endocrinol 347:90-6. 2011
    ..The cumulative findings indicate that hair follicle cycling is dependent on unliganded actions of the VDR. Further research is ongoing to elucidate the role of the VDR in hair growth and differentiation...
  54. ncbi request reprint Risk of early-onset prostate cancer in relation to germ line polymorphisms of the vitamin D receptor
    Ingrid Oakley-Girvan
    Department of Health Research and Policy, Stanford University School of Medicine, HRP Redwood Building, T204, Stanford, CA 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 13:1325-30. 2004
    ..S. Whites. If the FokI association noted here were causal, this difference could account for some of the disease burden among African Americans and some of the excess risk in African Americans compared with Whites...
  55. ncbi request reprint Vitamin D receptor start codon polymorphism (FokI) and prostate cancer progression
    Yue Xu
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cancer Epidemiol Biomarkers Prev 12:23-7. 2003
    ..Additional studies with a larger sample size and investigation of the functional significance of the FokI polymorphism in prostate cancer cells are warranted...
  56. pmc Calcium plus vitamin D supplementation and the risk of nonmelanoma and melanoma skin cancer: post hoc analyses of the women's health initiative randomized controlled trial
    Jean Y Tang
    Department of Dermatology, Stanford University School of Medicine, 450 Broadway, Pavilion C, MC 5334, Redwood City, CA, USA
    J Clin Oncol 29:3078-84. 2011
    ....
  57. doi request reprint Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D
    Aruna V Krishnan
    Department of Medicine, Stanford University School of Medicine, California 94305, USA
    Annu Rev Pharmacol Toxicol 51:311-36. 2011
    ..These calcitriol actions provide a basis for its potential use in cancer therapy and chemoprevention. We summarize the status of trials involving calcitriol and its analogs, used alone or in combination with known anti-cancer agents...
  58. pmc Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation
    Christopher D Gardner
    Department of Medicine, Stanford Prevention Research Center, Stanford University Medical School, Stanford, California 94305, USA
    Prostate 69:719-26. 2009
    ..The effects of soy isoflavones on prostate cancer may be concentration-dependent. The impact of soy supplementation on isoflavone concentrations in prostate tissues and serum remain unclear...
  59. ncbi request reprint A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer
    Aruna V Krishnan
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Endocrinology 143:1889-900. 2002
    ..Triamcinolone, by itself, would not activate the AR(ccr) or promote tumor growth but would provide glucocorticoid activity essential for survival...
  60. ncbi request reprint The role of vitamin D in prostate cancer
    Aruna V Krishnan
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Recent Results Cancer Res 164:205-21. 2003
    ..Current research involves further investigation of the role of 1,25(OH)2D3 and its analogs for the therapy or chemoprevention of PCa...
  61. ncbi request reprint Prostate specific antigen levels in young adulthood predict prostate cancer risk: results from a cohort of Black and White Americans
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, California 94305 5405, USA
    J Urol 174:872-6; discussion 876. 2005
    ..Little is known about PSA distribution in young adulthood, when benign and malignant prostatic diseases are rare, or about how PSA within the normal range in youth relates to subsequent prostate cancer risk...
  62. ncbi request reprint A phase II trial of calcitriol and naproxen in recurrent prostate cancer
    Sandy Srinivas
    Stanford University School of Medicine, Stanford, CA 94305, USA
    Anticancer Res 29:3605-10. 2009
    ..The objective of the study was to determine whether treatment with calcitriol and naproxen is effective in safely delaying the growth and progression of PCa in men with early recurrent disease...
  63. ncbi request reprint Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells
    Donna M Peehl
    Department of Urology, Stanford University School of Medicine, California 94305 5118, USA
    J Urol 168:1583-8. 2002
    ..We tested the growth inhibitory activity of ketoconazole combined with 1,25-dihydroxyvitamin D3 (calcitriol) and with the vitamin D analogue EB 1089 in a preclinical model of prostate cancer...
  64. ncbi request reprint The role of vitamin D in cancer prevention and treatment
    Aruna V Krishnan
    Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Rheum Dis Clin North Am 38:161-78. 2012
    ..Such studies may finally provide compelling data to prove whether or not there is a role for vitamin D analogues in cancer therapy...
  65. ncbi request reprint Vitamin D growth inhibition of breast cancer cells: gene expression patterns assessed by cDNA microarray
    Srilatha Swami
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Breast Cancer Res Treat 80:49-62. 2003
    ....
  66. pmc Hereditary vitamin D resistant rickets: identification of a novel splice site mutation in the vitamin D receptor gene and successful treatment with oral calcium therapy
    Nina S Ma
    Division of Endocrinology, Diabetes and Metabolism, Department of Pediatrics, Childrens Hospital Los Angeles and Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027, USA
    Bone 45:743-6. 2009
    ....
  67. ncbi request reprint Genetic disorders and defects in vitamin D action
    Peter J Malloy
    Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5103, USA
    Rheum Dis Clin North Am 38:93-106. 2012
    ..These studies have been essential to promote the well-being of the families with HVDRR and in improving the diagnostic and clinical management of this rare genetic disease...
  68. ncbi request reprint Enhanced coactivator binding and transcriptional activation of mutant vitamin D receptors from patients with hereditary 1,25-dihydroxyvitamin D-resistant rickets by phosphorylation and vitamin D analogs
    Yan Liu
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School and the Graduate School for Biomedical Sciences, Newark, New Jersey 07103, USA
    J Bone Miner Res 20:1680-91. 2005
    ..Our study provides new insights into mechanisms involved in enhancement of mutant VDR function...
  69. pmc Adoption of exercise and readiness to change differ between Whites and African-Americans with hypertension: a report from the Ohio State University Primary Care Practice-Based Research Network (OSU-PCPBRN)
    Randy Wexler
    Department of Family Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Am Board Fam Med 21:358-60. 2008
    ..A cornerstone to treatment is nonpharmacologic lifestyle modifications. Despite such recommendations, many patients fail to exercise...
  70. ncbi request reprint The fundamental cellular mechanisms underlying cardiac resynchronization remain poorly differentiated
    David Feldman
    Heart Failure and Cardiac Transplant Program, Department of Medicine Cardiology, The Ohio State University, Columbus, OH 43210 1252, USA
    Congest Heart Fail 13:53-4. 2007

Research Grants1

  1. DIABETES, ENDOCRINOLOGY AND METABOLISM
    David Feldman; Fiscal Year: 2007
    ..Programs in the ethics of responsible research, grant writing, critical evaluation of the literature as well as many other courses and seminars enrich the training program. ..