W F Fearon

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Does elevated cardiac troponin I in patients with unstable angina predict ischemia on stress testing?
    W F Fearon
    Stanford University Medical Center, California 94305 5406, USA
    Am J Cardiol 84:1440-2, A6, A8. 1999
  2. doi request reprint Prognostic value of the Index of Microcirculatory Resistance measured after primary percutaneous coronary intervention
    William F Fearon
    Stanford University Medical Center, Stanford, CA 94305, USA
    Circulation 127:2436-41. 2013
  3. pmc Physiologic approach for coronary intervention
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Korean J Intern Med 28:1-7. 2013
  4. ncbi request reprint Comparison of coronary thermodilution and Doppler velocity for assessing coronary flow reserve
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, H3554, 300 Pasteur Dr, Stanford, Calif 94305, USA
    Circulation 108:2198-200. 2003
  5. ncbi request reprint Evaluation of high-pressure retrograde coronary venous delivery of FGF-2 protein
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California 94305, USA
    Catheter Cardiovasc Interv 61:422-8. 2004
  6. ncbi request reprint Microvascular resistance is not influenced by epicardial coronary artery stenosis severity: experimental validation
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif, USA
    Circulation 109:2269-72. 2004
  7. doi request reprint Economic evaluation of fractional flow reserve-guided percutaneous coronary intervention in patients with multivessel disease
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, 300 Pasteur Dr, H2103, Stanford, CA 94305, USA
    Circulation 122:2545-50. 2010
  8. ncbi request reprint Discordant changes in epicardial and microvascular coronary physiology after cardiac transplantation: Physiologic Investigation for Transplant Arteriopathy II (PITA II) study
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California 94305 5637, USA
    J Heart Lung Transplant 25:765-71. 2006
  9. doi request reprint Predictive value of the index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California 94305, USA
    J Am Coll Cardiol 51:560-5. 2008
  10. ncbi request reprint Rationale and design of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) study
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Am Heart J 154:632-6. 2007

Research Grants

  1. Invasive Assessment of the Coronary Microcirculation
    William Fearon; Fiscal Year: 2007
  2. ACE Inhibition and Cardiac Allograft Vasculopathy
    William F Fearon; Fiscal Year: 2010

Detail Information

Publications46

  1. ncbi request reprint Does elevated cardiac troponin I in patients with unstable angina predict ischemia on stress testing?
    W F Fearon
    Stanford University Medical Center, California 94305 5406, USA
    Am J Cardiol 84:1440-2, A6, A8. 1999
    ..Elevated cardiac troponin I in patients who present with chest pain and normal creatine kinase levels is associated with ischemia on stress testing, as well as with future cardiac events...
  2. doi request reprint Prognostic value of the Index of Microcirculatory Resistance measured after primary percutaneous coronary intervention
    William F Fearon
    Stanford University Medical Center, Stanford, CA 94305, USA
    Circulation 127:2436-41. 2013
    ..The aim of this study is to determine whether the Index of Microcirculatory Resistance (IMR), measured at the time of primary percutaneous coronary intervention, is predictive of death and rehospitalization for heart failure...
  3. pmc Physiologic approach for coronary intervention
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Korean J Intern Med 28:1-7. 2013
    ..FFR-guided percutaneous coronary intervention of these lesions results in improved outcomes and saves resources. Non-hemodynamically significant lesions can be safely managed medically with a low rate of subsequent cardiac events...
  4. ncbi request reprint Comparison of coronary thermodilution and Doppler velocity for assessing coronary flow reserve
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, H3554, 300 Pasteur Dr, Stanford, Calif 94305, USA
    Circulation 108:2198-200. 2003
    ..Whether CFRthermo correlates well enough with absolute flow-derived CFR (CFRflow) to replace Doppler wire-derived CFR (CFRDoppler) remains unclear...
  5. ncbi request reprint Evaluation of high-pressure retrograde coronary venous delivery of FGF-2 protein
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California 94305, USA
    Catheter Cardiovasc Interv 61:422-8. 2004
    ..30-1.23; P < 0.05), but did not change significantly in the other three arms. High-pressure retrograde injection into the AIV may represent an efficient and effective means for delivering angiogenic factors to ischemic myocardium...
  6. ncbi request reprint Microvascular resistance is not influenced by epicardial coronary artery stenosis severity: experimental validation
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif, USA
    Circulation 109:2269-72. 2004
    ..The effect of epicardial artery stenosis on myocardial microvascular resistance remains controversial. Recruitable collateral flow, which may affect resistance, was not incorporated into previous measurements...
  7. doi request reprint Economic evaluation of fractional flow reserve-guided percutaneous coronary intervention in patients with multivessel disease
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, 300 Pasteur Dr, H2103, Stanford, CA 94305, USA
    Circulation 122:2545-50. 2010
    ..The economic impact of routine measurement of FFR in this setting is not known...
  8. ncbi request reprint Discordant changes in epicardial and microvascular coronary physiology after cardiac transplantation: Physiologic Investigation for Transplant Arteriopathy II (PITA II) study
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California 94305 5637, USA
    J Heart Lung Transplant 25:765-71. 2006
    ....
  9. doi request reprint Predictive value of the index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California 94305, USA
    J Am Coll Cardiol 51:560-5. 2008
    ....
  10. ncbi request reprint Rationale and design of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) study
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Am Heart J 154:632-6. 2007
    ..However, some have suggested that invasive physiologic guidance may improve decision making...
  11. ncbi request reprint Changes in coronary arterial dimensions early after cardiac transplantation
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305 5637, USA
    Transplantation 83:700-5. 2007
    ..The degree to which these changes compromise coronary lumen dimensions, and the clinical factors that affect these changes, remain controversial...
  12. ncbi request reprint Simultaneous assessment of fractional and coronary flow reserves in cardiac transplant recipients: Physiologic Investigation for Transplant Arteriopathy (PITA Study)
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, Calif 94305, USA
    Circulation 108:1605-10. 2003
    ..We evaluated a new method for simultaneously measuring FFR and CFR with a single wire to investigate transplant arteriopathy...
  13. ncbi request reprint Novel index for invasively assessing the coronary microcirculation
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Circulation 107:3129-32. 2003
    ..A relatively simple, invasive method for quantitatively assessing the status of the coronary microcirculation independent of the epicardial artery is lacking...
  14. ncbi request reprint Cost-effectiveness of measuring fractional flow reserve to guide coronary interventions
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Calif 94305 5406, USA
    Am Heart J 145:882-7. 2003
    ..Most patients come to the catheterization laboratory without prior functional tests, which makes the cost-effective treatment of patients with intermediate coronary lesions a practical challenge...
  15. ncbi request reprint The effect of resting ST segment depression on the diagnostic characteristics of the exercise treadmill test
    W F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, Palo Alto, USA
    J Am Coll Cardiol 35:1206-11. 2000
    ..The aim of this study is to demonstrate the effect of resting ST segment depression on the diagnostic characteristics of the exercise treadmill test...
  16. ncbi request reprint A comparison of treadmill scores to diagnose coronary artery disease
    William F Fearon
    Divisions of Cardiovascular Medicine, Stanford University Medical Center, California 94305 5406, USA
    Clin Cardiol 25:117-22. 2002
    ....
  17. ncbi request reprint Fractional flow reserve compared with intravascular ultrasound guidance for optimizing stent deployment
    W F Fearon
    Stanford University Medical Center, Stanford, CA, USA
    Circulation 104:1917-22. 2001
    ..In this prospective, multicenter trial, we evaluate the use of FFR to optimize stenting by comparing it with standard intravascular ultrasound (IVUS) criteria...
  18. ncbi request reprint Use of fractional myocardial flow reserve to assess the functional significance of intermediate coronary stenoses
    W F Fearon
    Division of Cardiovascular Medicine, Stanford University Medical Center, California 94305 5406, USA
    Am J Cardiol 86:1013-4, A10. 2000
    ..We demonstrated that myocardial fractional flow reserve detects ischemia in intermediate coronary lesions accurately when compared with nuclear stress imaging...
  19. ncbi request reprint Changes in coronary anatomy and physiology after heart transplantation
    Atsushi Hirohata
    Center for Research in Cardiovascular Interventions, Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California, USA
    Am J Cardiol 99:1603-7. 2007
    ..5 +/- 10.5%, p = NS). In conclusion, early after HT, anatomic and physiologic evidence of epicardial CAV was found. Later after HT, the physiologic effect of epicardial CAV may be less, because of increased microvascular dysfunction...
  20. ncbi request reprint Clinical utility of the exercise ECG in patients with diabetes and chest pain
    D P Lee
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford 94305 5406, USA
    Chest 119:1576-81. 2001
    ..The purpose of this study was to determine the characteristics of exercise treadmill testing in diabetic patients presenting with chest pain...
  21. ncbi request reprint T-cell immunity to subclinical cytomegalovirus infection reduces cardiac allograft disease
    Wenwei Tu
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5164, USA
    Circulation 114:1608-15. 2006
    ..How subclinical viral replication influences cardiac allograft disease remains poorly understood, as does the importance of T-cell immunity in controlling such replication...
  22. doi request reprint In vivo comparison between optical coherence tomography and intravascular ultrasound for detecting small degrees of in-stent neointima after stent implantation
    Yoriyasu Suzuki
    Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA
    JACC Cardiovasc Interv 1:168-73. 2008
    ..The purpose of this study was to evaluate optical coherence tomography (OCT) for detecting small degrees of in-stent neointima (ISN) after stent implantation compared with intravascular ultrasound (IVUS)...
  23. doi request reprint ST-elevation myocardial infarction following heart transplantation as an unusual presentation of coronary allograft vasculopathy: a case report
    S Peter
    Stanford University Hospital, Stanford, Calif 94305 5110, USA
    Transplant Proc 45:787-91. 2013
    ..Herein, we present a unique case of STEMI years after heart transplantation with a focus on the salient features of its diagnosis and interventions. We also provide a review of the epidemiology of this phenomenon...
  24. ncbi request reprint Effects of chronotropic incompetence and beta-blocker use on the exercise treadmill test in men
    A J Gauri
    Division of Cardiovascular Medicine, Stanford University Medical Center, Palo Alto, CA, USA
    Am Heart J 142:136-41. 2001
    ..In those who fail to reach target heart rate and are not beta-blocked, sensitivity and predictive accuracy are maintained...
  25. doi request reprint Granulocyte colony-stimulating factor therapy is associated with a reduced incidence of acute rejection episodes or allograft vasculopathy in heart transplant recipients
    B Vrtovec
    Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA
    Transplant Proc 45:2406-9. 2013
    ..We evaluated the potential effects of granulocyte colony-simulating factor (G- CSF) on the incidence of rejection and allograft vasculopathy in heart transplant recipients...
  26. ncbi request reprint Invasive assessment of the coronary microcirculation: superior reproducibility and less hemodynamic dependence of index of microcirculatory resistance compared with coronary flow reserve
    Martin K C Ng
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Circulation 113:2054-61. 2006
    ..We sought to compare the reproducibility and hemodynamic dependence of IMR with CFR in humans...
  27. ncbi request reprint Adjunctive platelet glycoprotein IIb/IIIa receptor inhibition with tirofiban before primary angioplasty improves angiographic outcomes: results of the TIrofiban Given in the Emergency Room before Primary Angioplasty (TIGER-PA) pilot trial
    David P Lee
    Stanford University Medical Center, Division of Cardiovascular Medicine, Stanford, Calif 94305, USA
    Circulation 107:1497-501. 2003
    ..The TIGER-PA pilot trial was a single-center randomized study to evaluate the safety, feasibility, and utility of early tirofiban administration before planned primary angioplasty in patients presenting with acute myocardial infarction...
  28. ncbi request reprint "Tako-tsubo-like left ventricular dysfunction": a clinical entity mimicking acute myocardial infarction with a favorable prognosis
    H M Omar Farouque
    Stanford University Medical Center, Interventional Cardiology, Room H2103, 300 Pasteur Drive, Stanford, CA 94305, USA
    Am J Geriatr Cardiol 13:323-6. 2004
    ..One month later, the left ventricular wall motion abnormality had improved. In this report, the authors discuss this compilation of findings known as tako-tsubo-like left ventricular dysfunction...
  29. ncbi request reprint Determinants of lumen loss between years 1 and 2 after cardiac transplantation
    Ryota Sakurai
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA, USA
    Transplantation 84:1097-102. 2007
    ..Whether these findings persist between years 1 and 2 after transplantation is unknown...
  30. ncbi request reprint Intriguing peri-strut low-intensity area detected by optical coherence tomography after coronary stent deployment
    Tomohiko Teramoto
    Department of Cardiovascular Medicine, Stanford University, Stanford, CA, USA
    Circ J 74:1257-9. 2010
    ..Although peri-strut low-intensity area (PLIA) is frequently observed on post-stenting optical coherence tomography (OCT) images, the histology associated with PLIA is undocumented...
  31. ncbi request reprint Evaluating intermediate coronary lesions in the cardiac catheterization laboratory
    William F Fearon
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Rev Cardiovasc Med 4:1-7. 2003
    ..Ultimately, FFR appears to be the ideal method for interrogating intermediate coronary lesions...
  32. doi request reprint Anatomic and functional evaluation of bifurcation lesions undergoing percutaneous coronary intervention
    Bon Kwon Koo
    Division of Cardiovascular Medicine, Interventional Cardiology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
    Circ Cardiovasc Interv 3:113-9. 2010
    ..We sought to investigate the mechanism of geometric changes after main branch (MB) stent implantation and to identify the predictors of functionally significant "jailed" side branch (SB) lesions...
  33. doi request reprint Effect of rapamycin therapy on coronary artery physiology early after cardiac transplantation
    Seema S Sinha
    Department of Internal Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Am Heart J 155:889.e1-6. 2008
    ..Rapamycin has been shown to reduce anatomical evidence of cardiac allograft vasculopathy, but its effect on coronary artery physiology is unknown...
  34. doi request reprint Asymmetric dimethylarginine and cardiac allograft vasculopathy progression: modulation by sirolimus
    Luciano Potena
    Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Transplantation 85:827-33. 2008
    ..It was hypothesized that ADMA concentrations may influence CAV progression during the first postoperative year...
  35. ncbi request reprint Acute rejection and cardiac allograft vascular disease is reduced by suppression of subclinical cytomegalovirus infection
    Luciano Potena
    Division of Cardiovascular Medicine, Stanford University School of Medicine, CA, USA
    Transplantation 82:398-405. 2006
    ..We sought to determine whether CMV prophylaxis administered for three months after heart transplant would improve patient outcomes...
  36. ncbi request reprint Prognostic significance of PVCs and resting heart rate
    Gregory Engel
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA, USA
    Ann Noninvasive Electrocardiol 12:121-9. 2007
    ..We sought to evaluate the prognostic significance of premature ventricular contractions (PVCs) on a routine electrocardiogram (ECG) and to evaluate the relationship between heart rate and PVCs...
  37. ncbi request reprint Selective renal arterial infusion of fenoldopam for the prevention of contrast-induced nephropathy
    Martin K C Ng
    Stanford University Medical Center, Stanford, CA 94305 5637, USA
    J Interv Cardiol 19:75-9. 2006
    ..Further studies are warranted to evaluate the efficacy of intrarenal administration of vasodilator therapies such as fenoldopam for the prevention of CIN...
  38. ncbi request reprint Interplay between systemic inflammation and markers of insulin resistance in cardiovascular prognosis after heart transplantation
    Ombretta Biadi
    Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA
    J Heart Lung Transplant 26:324-30. 2007
    ..Although systemic inflammation, as detected by C-reactive protein (CRP), predicts CAV development, the relationship between CRP and markers of metabolic abnormalities remains unexplored...
  39. ncbi request reprint Risk factors for the development of retroperitoneal hematoma after percutaneous coronary intervention in the era of glycoprotein IIb/IIIa inhibitors and vascular closure devices
    H M Omar Farouque
    Division of Cardiovascular Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94304, USA
    J Am Coll Cardiol 45:363-8. 2005
    ..We sought to determine the incidence, clinical features, and risk factors for retroperitoneal hematoma (RPH) after percutaneous coronary intervention (PCI)...
  40. ncbi request reprint The current and future role of percutaneous coronary intervention in patients with coronary artery disease
    Michael J Lipinski
    Division of Cardiology, Virginia Commonwealth University Health System, Richmond, VA 23298, USA
    J Interv Cardiol 17:283-94. 2004
    ..Providing an evidence-based understanding of lesion morphology and clinical variables that influence outcome enables the interventional cardiologist to determine which atherosclerotic plaques require PCI...
  41. ncbi request reprint Coronary pressure measurement after stenting predicts adverse events at follow-up: a multicenter registry
    Nico H J Pijls
    Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands
    Circulation 105:2950-4. 2002
    ..In this multicenter registry, we investigated the relation between optimum physiological stent implantation as assessed by poststent fractional flow reserve (FFR) and outcome at 6 months...
  42. ncbi request reprint Epicardial stenosis severity does not affect minimal microcirculatory resistance
    Wilbert Aarnoudse
    Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    Circulation 110:2137-42. 2004
    ..We investigated the feasibility of determining IMR in humans and tested the hypothesis that microvascular resistance is independent of epicardial stenosis...
  43. ncbi request reprint Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology
    Morton J Kern
    University of California, Irvine, USA
    Circulation 114:1321-41. 2006
    ..The goal of this statement is to provide a logical approach to the use of coronary physiological measurements in the catheterization lab to assist both clinicians and investigators in improving patient care...
  44. ncbi request reprint Physiologic assessment of renal artery stenosis: will history repeat itself?
    William F Fearon
    J Am Coll Cardiol 48:1856-8. 2006
  45. ncbi request reprint The pathophysiology and clinical course of the normal coronary angina syndrome (cardiac syndrome X)
    Narbeh Melikian
    Division of Cardiovascular Medicine, King s College London School of Medicine at Guy s Hospital, London, United Kingdom
    Prog Cardiovasc Dis 50:294-310. 2008
  46. ncbi request reprint Pioglitazone-induced heart failure despite normal left ventricular function
    Maulik Shah
    Am J Med 117:973-4. 2004

Research Grants4

  1. Invasive Assessment of the Coronary Microcirculation
    William Fearon; Fiscal Year: 2007
    ..abstract_text> ..
  2. ACE Inhibition and Cardiac Allograft Vasculopathy
    William F Fearon; Fiscal Year: 2010
    ..The goal of this project is to investigate the ability of a drug called ramipril to prevent this significant complication. ..