Research Topics
| MICHAEL FAYERSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
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Detail Information
Publications
Water in a crowdMichael D Fayer
Department of Chemistry, Stanford University, Stanford, California, USA
Physiology (Bethesda) 26:381-92. 2011..Here, the results of ultrafast infrared experiments are described that shed light on the influences of nanoconfinement, interfaces, ions, and organic molecules on water hydrogen bond dynamics...- Analysis of water in confined geometries and at interfacesMichael D Fayer
Department of Chemistry, Stanford University, California 94305, USA
Annu Rev Anal Chem (Palo Alto Calif) 3:89-107. 2010..These experiments can be applied to water in reverse micelles (spherical nanopools). The results provide quantitative determination of the dynamics of water as a function of the size and nature of the confining structure... 
Water dynamics in salt solutions studied with ultrafast two-dimensional infrared (2D IR) vibrational echo spectroscopyMichael D Fayer
Department of Chemistry, Stanford University, Stanford, California 94305, USA
Acc Chem Res 42:1210-9. 2009..The results demonstrate that water interacting with ions has slower hydrogen-bond dynamics than pure water, but the slowing is a factor of 3 or 4 rather than orders of magnitude...- Dynamics of liquids, molecules, and proteins measured with ultrafast 2D IR vibrational echo chemical exchange spectroscopyM D Fayer
Department of Chemistry, Stanford University, Stanford, California 94305, USA
Annu Rev Phys Chem 60:21-38. 2009..The results are used to obtain an approximate isomerization rate for ethane. Finally, the time dependence of a well-defined single structural transformation of a protein is measured... 
Orientational dynamics of water confined on a nanometer length scale in reverse micellesHowe Siang Tan
Department of Chemistry, Stanford University, California 94305, USA
J Chem Phys 122:174501. 2005..The angle over which the inertial orientational motion occurs is determined. The results are in semiquantitative agreement with the molecular-dynamics simulations...- Dynamics of water confined on a nanometer length scale in reverse micelles: ultrafast infrared vibrational echo spectroscopyHowe-Siang Tan
Department of Chemistry, Stanford University, Stanford, California 94305, USA
Phys Rev Lett 94:057405. 2005..The fastest dynamics (approximately 50 fs) is more similar to bulk water, while the slowest time scale dynamics is much slower than water, and, in analogy to bulk water, reflects the making and breaking of hydrogen bonds... - Confinement or the nature of the interface? Dynamics of nanoscopic waterDavid E Moilanen
Department of Chemistry, Stanford University, Palo Alto, California 94305, USA
J Am Chem Soc 129:14311-8. 2007..The results demonstrate that confinement by an interface to form a nanoscopic water pool is a primary factor governing the dynamics of nanoscopic water rather than the presence of charged groups at the interface... - Fast protein dynamics probed with infrared vibrational echo experimentsM D Fayer
Department of Chemistry, Stanford University, Stanford, California 94305, USA
Annu Rev Phys Chem 52:315-56. 2001..The dynamic electric field-coupling mechanism is tested by observing differences in the temperature dependence of the pure dephasing of Mb-CO mutations... - Viscosity-dependent protein dynamicsIlya J Finkelstein
Department of Chemistry, Stanford University, Stanford, California, USA
Biophys J 92:3652-62. 2007..A calibration method based on the near-infrared spectrum of water overtones was constructed to accurately determine the viscosity of small volumes of protein solutions... - Fifth-order contributions to ultrafast spectrally resolved vibrational echoes: heme-CO proteinsIlya J Finkelstein
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Chem Phys 121:877-85. 2004..Finally, it is shown that the anharmonic oscillations in vibrational echo data of Hb-CO that previous work had attributed strictly to fifth order effects arise even without fifth order contributions... - Ion-water hydrogen-bond switching observed with 2D IR vibrational echo chemical exchange spectroscopyDavid E Moilanen
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 106:375-80. 2009..Pump-probe measurements of the orientational relaxation rates and vibrational lifetimes are used in the CES data analysis. The pump-probe measurements are shown to have the correct functional form for a system undergoing exchange... - Dynamics of nanoscopic water: vibrational echo and infrared pump-probe studies of reverse micellesIvan R Piletic
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Phys Chem B 109:21273-84. 2005..The vibrational echo data for the smallest reverse micelle displays a dependence on the detection wavelength, which may indicate that multiple ensembles of water molecules are being observed... - Myoglobin-CO substate structures and dynamics: multidimensional vibrational echoes and molecular dynamics simulationsKusai A Merchant
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Am Chem Soc 125:13804-18. 2003..Dephasing in the A(1) state is controlled by His64 on femtosecond time scales, and by the rest of the protein and the water solvent on longer time scales... - Dynamics around solutes and solute-solvent complexes in mixed solventsKyungwon Kwak
Department of Chemistry, Stanford University, Stanford CA 94305, USA
Proc Natl Acad Sci U S A 104:14221-6. 2007..The experimental results and recent MD simulations indicate that the solvent structure around the solute may be different from the mixed solvent's mole fraction... - Dynamics of hemoglobin in human erythrocytes and in solution: influence of viscosity studied by ultrafast vibrational echo experimentsBrian L McClain
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Am Chem Soc 126:15702-10. 2004.... - Dynamics of water probed with vibrational echo correlation spectroscopyJohn B Asbury
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Chem Phys 121:12431-46. 2004..The SPC-FQ derived FTCF is much closer to the experimental results than previously tested nonpolarizable water models which are also presented for comparison... - Water dynamics at neutral and ionic interfacesEmily E Fenn
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 106:15243-8. 2009.... - Geometry and nanolength scales versus interface interactions: water dynamics in AOT lamellar structures and reverse micellesDavid E Moilanen
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Am Chem Soc 131:8318-28. 2009.... - Water dynamics at the interface in AOT reverse micellesDavid E Moilanen
Department of Chemistry, Stanford University, California 94305, USA
J Phys Chem B 113:8560-8. 2009..The orientational relaxation of interfacial water molecules occurs in 18 +/- 3 ps, in contrast to the bulk water value of 2.6 ps... - Hydrogen bond dynamics probed with ultrafast infrared heterodyne-detected multidimensional vibrational stimulated echoesJohn B Asbury
Department of Chemistry, Stanford University, Stanford, California 94305, USA
Phys Rev Lett 91:237402. 2003.... - Hydrogen bond migration between molecular sites observed with ultrafast 2D IR chemical exchange spectroscopyDaniel E Rosenfeld
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Phys Chem B 114:2383-9. 2010..The observation of direct hydrogen bond migration can have implications for macromolecular systems... - Water dynamics--the effects of ions and nanoconfinementSungnam Park
Department of Chemistry Stanford University, Stanford, California 94305, USA
J Phys Chem B 112:5279-90. 2008.... - Two-dimensional time-frequency ultrafast infrared vibrational echo spectroscopyK A Merchant
Department of Chemistry, Stanford University, Stanford, California 94305, USA
Phys Rev Lett 86:3899-902. 2001..A new explanation is given for these "anharmonic" oscillations. Calculations show that spectral resolution enables the 0-1 and 1-2 dephasing to be measured independently... - Substrate binding and protein conformational dynamics measured by 2D-IR vibrational echo spectroscopyIlya J Finkelstein
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 104:2637-42. 2007..It is suggested that dynamic quenching caused by substrate binding can cause the protein to be locked into a conformation suitable for downstream steps in the enzymatic cycle of HRP... - Photoinduced electron transfer and geminate recombination in the group head region of micellesKsenija Glusac
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Chem Phys 125:054712. 2006..The theory includes important aspects of the topology of the micelle and the diffusion of the donor-acceptors in the micelle head group region. A semiquantitative but nonquantitative agreement between theory and experiments is achieved... - Proton transport and the water environment in nafion fuel cell membranes and AOT reverse micellesD B Spry
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
J Am Chem Soc 129:8122-30. 2007..The effective size of the Nafion water channels at various hydration levels are estimated by the known size of the AOT reverse micelles that display the corresponding proton-transfer kinetics and orientational relaxation... - Native and unfolded cytochrome c--comparison of dynamics using 2D-IR vibrational echo spectroscopySeongheun Kim
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Phys Chem B 112:10054-63. 2008..The results suggest the denatured protein may be in a glassy-like state involving hydrophobic collapse around the heme... - Charge transfer in photoacids observed by stark spectroscopyLisa N Silverman
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Phys Chem A 112:10244-9. 2008..Conversely, for the cationic (ammonium) photoacid studied, photoexcitation of a particular electronic state results in much smaller charge transfer for the protonated state than for the deprotonated state... - Ultrafast dynamics of myoglobin without the distal histidine: stimulated vibrational echo experiments and molecular dynamics simulationsIlya J Finkelstein
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Phys Chem B 109:16959-66. 2005..However, vibrational echoes calculated for H64V do not show the quantitative agreement with measurements demonstrated previously for the native protein... - The influence of aqueous versus glassy solvents on protein dynamics: vibrational echo experiments and molecular dynamics simulationsAaron M Massari
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
J Am Chem Soc 127:14279-89. 2005.... - Hydrogen bond lifetimes and energetics for solute/solvent complexes studied with 2D-IR vibrational echo spectroscopyJunrong Zheng
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Am Chem Soc 129:4328-35. 2007..The correlation can be described with an equation similar to the Arrhenius equation. The results are discussed in terms of transition state theory... - Water inertial reorientation: hydrogen bond strength and the angular potentialDavid E Moilanen
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 105:5295-300. 2008....
Research Grants
- Biodynamics: Vibrational Echo Correlation SpectroscopyMICHAEL FAYER; Fiscal Year: 2007..In addition, water-protein dynamical interactions and water-protein hydrogen bond dynamics in nanoscopic water environments will be examined. ..
- PROTEIN DYNAMICS AND INTERACTIONS: VIBRATIONAL ECHOESMICHAEL FAYER; Fiscal Year: 2003..abstract_text> ..
- Protein, Enzyme, and Biological Water Dynamics: 2D Vibrational Echo SpectroscopyMichael D Fayer; Fiscal Year: 2010..The methodology builds on previous successful applications and developments of state-of-the-art ultrafast infrared laser experiments. ..