Micha Drukker

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi The immunogenicity of human embryonic stem-derived cells
    Micha Drukker
    Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, 91904 Jerusalem, Israel
    Trends Biotechnol 22:136-41. 2004
  2. ncbi Immunogenicity of embryonic stem cells and their progeny
    Micha Drukker
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Methods Enzymol 420:391-409. 2006
  3. ncbi Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation
    Feng Cao
    The Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5344, USA
    Cloning Stem Cells 9:107-17. 2007
  4. ncbi Integration and differentiation of human embryonic stem cells transplanted to the chick embryo
    Ronald S Goldstein
    Gonda Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Dev Dyn 225:80-6. 2002
  5. pmc Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells
    Micha Drukker
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA
    Nat Biotechnol 30:531-42. 2012
  6. ncbi Recent advancements towards the derivation of immune-compatible patient-specific human embryonic stem cell lines
    Micha Drukker
    Institute for Stem Cell Biology and Regenerative Medicine, Beckman Center B261, Stanford, CA 94305 5323, USA
    Semin Immunol 20:123-9. 2008
  7. pmc An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells
    Chad Tang
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA
    Nat Biotechnol 29:829-34. 2011
  8. pmc Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes
    Feng Cao
    Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 3:e3474. 2008
  9. doi Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells
    Stephen L Hendry
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
    J Thorac Cardiovasc Surg 136:1028-1037.e1. 2008
  10. pmc Immunogenicity of in vitro maintained and matured populations: potential barriers to engraftment of human pluripotent stem cell derivatives
    Chad Tang
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 1029:17-31. 2013

Collaborators

Detail Information

Publications20

  1. ncbi The immunogenicity of human embryonic stem-derived cells
    Micha Drukker
    Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, 91904 Jerusalem, Israel
    Trends Biotechnol 22:136-41. 2004
    ..Here, we propose ways of overcoming the rejection of human embryonic stem cells after transplantation...
  2. ncbi Immunogenicity of embryonic stem cells and their progeny
    Micha Drukker
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Methods Enzymol 420:391-409. 2006
    ..In this chapter, I will discuss the utility of the humanized mouse Trimera model as an in vivo experimental system to study the immunological properties of hESCs and their differentiated derivatives...
  3. ncbi Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation
    Feng Cao
    The Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5344, USA
    Cloning Stem Cells 9:107-17. 2007
    ....
  4. ncbi Integration and differentiation of human embryonic stem cells transplanted to the chick embryo
    Ronald S Goldstein
    Gonda Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Dev Dyn 225:80-6. 2002
    ..The chick embryo, therefore, may serve as an accessible and unique experimental system for the study of in vivo development of human ES cells...
  5. pmc Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells
    Micha Drukker
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA
    Nat Biotechnol 30:531-42. 2012
    ..These markers and progenitors provide tools for purifying human tissue-regenerating progenitors and for studying the commitment of pluripotent stem cells to lineage progenitors...
  6. ncbi Recent advancements towards the derivation of immune-compatible patient-specific human embryonic stem cell lines
    Micha Drukker
    Institute for Stem Cell Biology and Regenerative Medicine, Beckman Center B261, Stanford, CA 94305 5323, USA
    Semin Immunol 20:123-9. 2008
    ..Importantly, if these techniques can be harnessed for generating patient-specific pluripotent cell lines, then immunological processes are expected to be low or completely absent...
  7. pmc An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells
    Chad Tang
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA
    Nat Biotechnol 29:829-34. 2011
    ..Immunodepletion with antibodies against SSEA-5 and two additional PSMs completely removed teratoma-formation potential from incompletely differentiated hESC cultures...
  8. pmc Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes
    Feng Cao
    Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 3:e3474. 2008
    ....
  9. doi Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells
    Stephen L Hendry
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
    J Thorac Cardiovasc Surg 136:1028-1037.e1. 2008
    ..Multimodal comparison of the restorative effects of mouse embryonic stem cells and mouse embryonic fibroblasts was performed to validate magnetic resonance imaging data and provide mechanistic insight...
  10. pmc Immunogenicity of in vitro maintained and matured populations: potential barriers to engraftment of human pluripotent stem cell derivatives
    Chad Tang
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 1029:17-31. 2013
    ..Finally, we discuss immunosuppressive approaches that could potentially address these immunological concerns...
  11. pmc Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors
    Reza Ardehali
    Department of Internal Medicine, Division of Cardiovascular Medicine, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:3282-7. 2011
    ....
  12. doi Potential barriers to therapeutics utilizing pluripotent cell derivatives: intrinsic immunogenicity of in vitro maintained and matured populations
    Chad Tang
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Semin Immunopathol 33:563-72. 2011
    ..In addition, we highlight immunosuppressive approaches that could potentially address the immunogenicity of these proposed mechanisms...
  13. doi Manganese-guided cellular MRI of human embryonic stem cell and human bone marrow stromal cell viability
    Mayumi Yamada
    Department of Medicine, Stanford University, Stanford, California 94305 5233, USA
    Magn Reson Med 62:1047-54. 2009
    ..Finally, in vivo Mn(2+)-guided MRI of the transplanted hESC was successfully achieved and validated by bioluminescence imaging...
  14. pmc Distinguishing mast cell and granulocyte differentiation at the single-cell level
    Christopher B Franco
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stem Cell 6:361-8. 2010
    ..Our data provide criteria for the prospective isolation of SL-CMP and SL-GMP and support the conclusion that mast cells are specified during hematopoiesis earlier than and independently from granulocytes...
  15. ncbi In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery
    Feng Cao
    Department of Radiology, Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5344, USA
    Circulation 113:1005-14. 2006
    ..Recent studies have shown that stem cell therapy can promote tissue regeneration; however, monitoring stem cells in vivo remains problematic owing to limitations of conventional histological assays and imaging modalities...
  16. ncbi Generation of a monoclonal antibody library against human embryonic stem cells
    Micha Drukker
    Department of Pathology, Stanford University School of Medicine, CA, USA
    Methods Mol Biol 407:63-81. 2007
    ..This method may have profound implications for many aspects of hESC research and therapeutics...
  17. ncbi Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells
    Micha Drukker
    Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, 91904 Jerusalem, Israel
    Stem Cells 24:221-9. 2006
    ..Thus, immunosuppressive regimens for hESC-based therapeutics could be highly reduced compared with conventional organ transplantation because direct allorejection processes of hESCs and their derivatives are considerably weaker...
  18. ncbi Immunogenicity of human embryonic stem cells: can we achieve tolerance?
    Micha Drukker
    Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, 91904 Jerusalem, Israel
    Springer Semin Immunopathol 26:201-13. 2004
    ..Here we describe the routes of immune recognition that can identify these antigens and the proposed ways for overcoming the rejection of human embryonic stem cell derivatives...
  19. pmc Characterization of the expression of MHC proteins in human embryonic stem cells
    Micha Drukker
    Department of Genetics, Silberman Institute of Life Sciences, Hebrew University, 91904 Jerusalem, Israel
    Proc Natl Acad Sci U S A 99:9864-9. 2002
    ..In conclusion, our results demonstrate that human ES cells can express high levels of MHC-I proteins and thus may be rejected on transplantation...