Anthony G Doufas
Affiliation: Stanford University
- Experimental pain and opioid analgesia in volunteers at high risk for obstructive sleep apneaAnthony G Doufas
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA
PLoS ONE 8:e54807. 2013..Using accepted experimental pain models, we characterized pain processing and opioid analgesia in male volunteers recruited based on their risk for OSA...
- Bispectral index dynamics during propofol hypnosis is similar in red-haired and dark-haired subjectsAnthony G Doufas
Department of Anesthesia, University of Louisville, Louisville, KY, USA
Anesth Analg 116:319-26. 2013..We tested the hypothesis that the propofol concentration in the effect site associated with half maximal electroencephalogram response, Ce50, is at least 50% higher in subjects with red hair...
- Neuromuscular block differentially affects immobility and cortical activation at near-minimum alveolar concentration anesthesiaAnthony G Doufas
Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, H3590, Stanford, CA 94305 5640, USA
Anesth Analg 109:1097-104. 2009....
- Automated responsiveness monitor to titrate propofol sedationAnthony G Doufas
Department of Anesthesia, Stanford University School of Medicine, Palo Alto, California, USA
Anesth Analg 109:778-86. 2009..We hypothesized that loss and return of response to the ARM occur at similar sedation levels in individual subjects, independent of the propofol effect titration scheme...
- Lower-body warming mimics the normal epidural-induced reduction in the shivering thresholdAnthony G Doufas
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
Anesth Analg 106:252-6, table of contents. 2008..We tested the hypothesis that increasing leg skin temperature to 38 degrees C mimics the normal approximately 0.6 degrees C reduction in the shivering threshold during epidural anesthesia...
- Induction speed is not a determinant of propofol pharmacodynamicsAnthony G Doufas
Department of Anesthesiology and Perioperative Medicine, and Outcomes Research Institute, University of Louisville, Kentucky, USA
Anesthesiology 101:1112-21. 2004..The authors concurrently evaluated the automated responsiveness monitor (ARM) against other sedation measures and the propofol effect site concentration...
- Neither arm nor face warming reduces the shivering threshold in unanesthetized humansAnthony G Doufas
Outcomes Research Institute, Department of Anesthesiology, University of Louisville, Louisville, KY, USA
Stroke 34:1736-40. 2003..We tested the hypothesis that focal arm (forearm and hand) warming or lower facial warming, combined with inhalation of heated and humidified gas, only minimally reduces the shivering threshold (triggering core temperature)...
- The timing of acupuncture stimulation does not influence anesthetic requirementGrigory Chernyak
Outcomes Research Institute, 501 East Broadway, Louisville, KY 40202, USA
Anesth Analg 100:387-92. 2005..2% +/- 0.6%), Preinduction (5.0% +/- 0.8%), and At-induction (4.7% +/- 0.3%; P = 0.125) days. This type of acupuncture is thus unlikely to facilitate general anesthesia or decrease the requirement for anesthetic drugs...
- Dantrolene reduces the threshold and gain for shiveringChun Ming Lin
Outcomes Research Institute, University of Louisville, Louisville, Kentucky 40202, USA
Anesth Analg 98:1318-24, table of contents. 2004..It thus seems unlikely to prove more effective than conventional muscle relaxants for treatment of life-threatening hyperthermia...
- Dexmedetomidine and meperidine additively reduce the shivering threshold in humansAnthony G Doufas
Outcomes Research Institute and the Department of Anesthesiology, Louisville, KY, USA
Stroke 34:1218-23. 2003..We tested the hypothesis that meperidine and dexmedetomidine synergistically reduce the shivering threshold without producing substantial sedation or respiratory depression...
- Anesthetic requirement is increased in redheadsEdwin B Liem
Outcomes Research Institute, University of Louisville, Louisville, Kentucky USA
Anesthesiology 101:279-83. 2004..Therefore, the authors tested the hypothesis that the requirement for the volatile anesthetic desflurane is greater in natural redheaded than in dark-haired women...
- Electro-acupuncture at the Zusanli, Yanglingquan, and Kunlun points does not reduce anesthetic requirementNobutada Morioka
Department of Anesthesiology, University of Louisville, 501 East Broadway, Louisville, KY 40202, USA
Anesth Analg 95:98-102, table of contents. 2002..6% +/- 0.6%, mean +/- SD) and control (4.6% +/- 0.8%) days (P = 0.8). These data provided an 80% power for detecting a difference of 0.35 volume-percent between the groups...
- The new perilaryngeal airway (CobraPLA) is as efficient as the laryngeal mask airway (LMA) but provides better airway sealing pressuresOzan Akca
Outcomes Research Institute, Louisville, Kentucky 40202, USA
Anesth Analg 99:272-8. 2004..Airway sealing pressure was significantly greater with CobraPLA (23 +/- 6 cm H2O) than LMA (18 +/- 5 cm H2O, P < 0.001). The CobraPLA has insertion characteristics similar to the LMA but better airway sealing capabilities...
- Women have the same desflurane minimum alveolar concentration as men: a prospective studyAnupama Wadhwa
Department of Anesthesiology, University of Louisville, Kentucky, USA
Anesthesiology 99:1062-5. 2003..The authors therefore tested the hypothesis that the desflurane concentration required to prevent movement in response to skin incision (MAC) differs between men and women...
- Midazolam causes less sedation in volunteers with red hairMarlene V Chua
Department of Anesthesiology and the Outcomes Research Institute, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Can J Anaesth 51:25-30. 2004..We studied sedation, cognition, and mood during midazolam infusion in volunteers with red and non-red (blond or brown) hair, to test the hypothesis that patients with red hair may require more drugs to attain desired levels of sedation...
- Hypercapnia improves tissue oxygenationOzan Akca
Outcomes Research Institute and Department of Anesthesiology, University of Louisville, KY 40202, USA
Anesthesiology 97:801-6. 2002..Since hypercapnia improves cardiac output and peripheral tissue perfusion, we tested the hypothesis that peripheral tissue oxygenation increases as a function of arterial carbon dioxide tension (PaCO(2)) in anesthetized humans...
- Physiology and clinical relevance of induced hypothermiaAnthony G Doufas
Outcomes Research Institute, Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY, USA
Neurocrit Care 1:489-98. 2004..However, pharmacological induction of thermoregulatory tolerance to cold without excessive sedation, respiratory depression, or other serious toxicity remains a major focus of current therapeutic hypothermia research...
- Initial experience with a novel heat-exchanging catheter in neurosurgical patientsAnthony G Doufas
Outcomes Research Institute and Department of Anesthesiology, University of Louisville, KY 40202, USA
Anesth Analg 95:1752-6, table of contents. 2002..No thrombus or other particulate material was identified on the extracted catheters. None of the patients suffered any complications that could be attributed to the SetPoint system or thermal management...
- Transcutaneous electrical stimulation of an auricular acupuncture point decreases anesthetic requirementRobert Greif
Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA
Anesthesiology 96:306-12. 2002..This is known as auricular electrically stimulated analgesia. The authors therefore tested the hypothesis that auricular electrically stimulated analgesia reduces anesthetic requirement...
- Insufficiency in a new temporal-artery thermometer for adult and pediatric patientsMohammad Irfan Suleman
Outcomes Research Institute and Department of Anesthesiology, University of Louisville, 501 East Broadway, Louisville, KY 40202, USA
Anesth Analg 95:67-71, table of contents. 2002..6. Infrared and bladder temperatures in children differed by only 0.3 degrees C, but the SD of the difference was 0.5 degrees C. Thus, 31% of the values in the infants and children differed by more than 0.5 degrees C...
- Concordance of sleep and pain outcomes of diverse interventions: an umbrella reviewAnthony G Doufas
Department of Anesthesia, Stanford University School of Medicine, Stanford, California, United States of America
PLoS ONE 7:e40891. 2012..We performed an umbrella review of meta-analyses on treatments for diverse conditions in order to examine whether diverse medical treatments for different conditions have similar or divergent effects on pain and sleep...
- Ventilator-associated pneumonia in critically ill stroke patients: frequency, risk factors, and outcomesYusuke Kasuya
Department of Anesthesiology and Perioperative Medicine, University of Louisville, KY 40202, USA
J Crit Care 26:273-9. 2011..Our main objective was to assess incidence, risk factors, and outcomes of ventilator-associated pneumonia (VAP) in stroke patients...
- Consequences of inadvertent perioperative hypothermiaAnthony G Doufas
Department of Anesthesiology Neuroscience and Anesthesia ICU, and Outcomes Research Institute, University of Louisville Hospital, 530 South Jackson Street, Louisville, KY 40202, USA
Best Pract Res Clin Anaesthesiol 17:535-49. 2003..Finally, mild core hypothermia influences pulse oximetry monitoring and various electrophysiological indices of the nervous system, with questionable clinical significance, as yet...
- The threshold and gain of thermoregulatory vasoconstriction differs during anesthesia in the dependent and upper arms in the lateral positionRobert Greif
Department of Anesthesiology and Intensive Care Medicine, Donauspital SMZO, Vienna, Austria
Anesth Analg 94:1019-22, table of contents. 2002..The thermoregulatory system may thus recognize that hydrostatic forces reduce the vasoconstriction threshold and may compensate by sufficiently augmenting gain...