J Domen

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fate
    J Domen
    Dept of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5428, USA
    Mol Med Today 5:201-8. 1999
  2. pmc The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential
    J Domen
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 5428, USA
    J Exp Med 191:253-64. 2000
  3. ncbi request reprint Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:155-62. 1997
  4. ncbi request reprint CD8+TCR+ and CD8+TCR- cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers
    K L Gandy
    Department of Pathology and Developmental Biology, Stanford University Medical Center, Stanford University, California 94305, USA
    Immunity 11:579-90. 1999

Detail Information

Publications4

  1. ncbi request reprint Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fate
    J Domen
    Dept of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5428, USA
    Mol Med Today 5:201-8. 1999
    ..This review focuses on recent approaches towards understanding how the HSC compartment is regulated in vivo and discusses how this knowledge might be applied to manipulating HSC numbers...
  2. pmc The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential
    J Domen
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 5428, USA
    J Exp Med 191:253-64. 2000
    ..6x wild type). Their HSC have an increased plating efficiency in vitro, engraft at least as well as wild-type HSC in vivo, and have an advantage following competitive reconstitution with wild-type HSC...
  3. ncbi request reprint Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:155-62. 1997
    ..Therefore, the development of T, B, and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated by coupling of gamma(c)-related receptors...
  4. ncbi request reprint CD8+TCR+ and CD8+TCR- cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers
    K L Gandy
    Department of Pathology and Developmental Biology, Stanford University Medical Center, Stanford University, California 94305, USA
    Immunity 11:579-90. 1999
    ..We also demonstrate that lytic function is nqt necessary for facilitation and that the CD8alpha molecule is either important for facilitation or in the development of facilitators...