Affiliation: Stanford University
- Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fateJ Domen
Dept of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5428, USA
Mol Med Today 5:201-8. 1999..This review focuses on recent approaches towards understanding how the HSC compartment is regulated in vivo and discusses how this knowledge might be applied to manipulating HSC numbers...
- The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potentialJ Domen
Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 5428, USA
J Exp Med 191:253-64. 2000..6x wild type). Their HSC have an increased plating efficiency in vitro, engraft at least as well as wild-type HSC in vivo, and have an advantage following competitive reconstitution with wild-type HSC...
- Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient miceM Kondo
Department of Pathology, Stanford University School of Medicine, California 94305, USA
Immunity 7:155-62. 1997..Therefore, the development of T, B, and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated by coupling of gamma(c)-related receptors...
- CD8+TCR+ and CD8+TCR- cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriersK L Gandy
Department of Pathology and Developmental Biology, Stanford University Medical Center, Stanford University, California 94305, USA
Immunity 11:579-90. 1999..We also demonstrate that lytic function is nqt necessary for facilitation and that the CD8alpha molecule is either important for facilitation or in the development of facilitators...