Les Dethlefsen

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint An ecological and evolutionary perspective on human-microbe mutualism and disease
    Les Dethlefsen
    Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA
    Nature 449:811-8. 2007
  2. pmc Differences in codon bias cannot explain differences in translational power among microbes
    Les Dethlefsen
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA
    BMC Bioinformatics 6:3. 2005
  3. pmc Diversity of the human intestinal microbial flora
    Paul B Eckburg
    Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Room S 169, 300 Pasteur Drive, Stanford CA 94305 5107, USA
    Science 308:1635-8. 2005
  4. ncbi request reprint Assembly of the human intestinal microbiota
    Les Dethlefsen
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Trends Ecol Evol 21:517-23. 2006
  5. pmc Distinct distal gut microbiome diversity and composition in healthy children from Bangladesh and the United States
    Audrie Lin
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e53838. 2013
  6. pmc Performance of the translational apparatus varies with the ecological strategies of bacteria
    Les Dethlefsen
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824 4320, USA
    J Bacteriol 189:3237-45. 2007
  7. doi request reprint The application of ecological theory toward an understanding of the human microbiome
    Elizabeth K Costello
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 336:1255-62. 2012
  8. pmc Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
    Les Dethlefsen
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:4554-61. 2011
  9. pmc The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
    Les Dethlefsen
    Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America
    PLoS Biol 6:e280. 2008
  10. ncbi request reprint The importance of individuals and scale: moving towards single cell microbiology
    Les Dethlefsen
    Department of Microbiology, Stanford University, Stanford, CA, USA
    Environ Microbiol 9:8-10. 2007

Detail Information

Publications10

  1. ncbi request reprint An ecological and evolutionary perspective on human-microbe mutualism and disease
    Les Dethlefsen
    Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA
    Nature 449:811-8. 2007
    ..In this way, looking to ecological and evolutionary principles might provide new strategies for restoring and maintaining human health...
  2. pmc Differences in codon bias cannot explain differences in translational power among microbes
    Les Dethlefsen
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA
    BMC Bioinformatics 6:3. 2005
    ..coli to the translation rate of a hypothetical strain which differs from E. coli only by lacking codon bias...
  3. pmc Diversity of the human intestinal microbial flora
    Paul B Eckburg
    Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Room S 169, 300 Pasteur Drive, Stanford CA 94305 5107, USA
    Science 308:1635-8. 2005
    ..We discovered significant intersubject variability and differences between stool and mucosa community composition. Characterization of this immensely diverse ecosystem is the first step in elucidating its role in health and disease...
  4. ncbi request reprint Assembly of the human intestinal microbiota
    Les Dethlefsen
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Trends Ecol Evol 21:517-23. 2006
    ..We argue here that the unique history of each community and intrinsic temporal dynamics also influence the structure of human intestinal communities...
  5. pmc Distinct distal gut microbiome diversity and composition in healthy children from Bangladesh and the United States
    Audrie Lin
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 8:e53838. 2013
    ..In contrast, little is known about the gut microbiota and its variation over time in older children and adolescents, especially in developing countries...
  6. pmc Performance of the translational apparatus varies with the ecological strategies of bacteria
    Les Dethlefsen
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824 4320, USA
    J Bacteriol 189:3237-45. 2007
    ....
  7. doi request reprint The application of ecological theory toward an understanding of the human microbiome
    Elizabeth K Costello
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 336:1255-62. 2012
    ..Judicious application of ecological theory may lead to improved strategies for restoring and maintaining the microbiota and the crucial health-associated ecosystem services that it provides...
  8. pmc Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
    Les Dethlefsen
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:4554-61. 2011
    ..Antibiotic perturbation may cause a shift to an alternative stable state, the full consequences of which remain unknown...
  9. pmc The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
    Les Dethlefsen
    Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America
    PLoS Biol 6:e280. 2008
    ..The rapid return to the pretreatment community composition is indicative of factors promoting community resilience, the nature of which deserves future investigation...
  10. ncbi request reprint The importance of individuals and scale: moving towards single cell microbiology
    Les Dethlefsen
    Department of Microbiology, Stanford University, Stanford, CA, USA
    Environ Microbiol 9:8-10. 2007