Genomes and Genes
Jean Dominique Delcroix
Affiliation: Stanford University
- NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signalsJean Dominique Delcroix
Department of Neurology and Neurological Sciences, Stanford University, Stanford 94305, USA
Neuron 39:69-84. 2003..Our results are evidence that signaling endosomes, with the characteristics of early endosomes, convey NGF signals from the target of nociceptive neurons to their cell bodies...
- Peripheral axon crush elevates transport of p75NTR in the central projection of sensory neurones of ratsJean Dominique Delcroix
School of Biological Sciences, University of Manchester, Manchester, UK
Neurosci Lett 351:181-5. 2003..Sciatic nerve crush induced a 2-fold increase (P<0.05) in the bidirectional axonal transport of p75(NTR) in the dorsal root while trkA transport remained below detectable levels...
- Trafficking the NGF signal: implications for normal and degenerating neuronsJean Dominique Delcroix
Department of Neurology and Neurological Sciences and of Pediatrics, Program in Neuroscience, Stanford University, Stanford, CA 94305, USA
Prog Brain Res 146:3-23. 2004..It is important to define further the significance of signaling endosomes in the biology of both normal and degenerating neurons...
- Traffic at the intersection of neurotrophic factor signaling and neurodegenerationAhmad Salehi
Department of Neurology and Neurological Sciences, Stanford University Medical Center, 1201Welch Rd, MSLS Building, Stanford, CA 94305 5489, USA
Trends Neurosci 26:73-80. 2003....
- Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degenerationAhmad Salehi
Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305, USA
Neuron 51:29-42. 2006..Our study thus provides evidence for a pathogenic mechanism for DS in which increased expression of App, in the context of trisomy, causes abnormal transport of NGF and cholinergic neurodegeneration...
- BPAG1n4 is essential for retrograde axonal transport in sensory neuronsJia Jia Liu
Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305 5489, USA
J Cell Biol 163:223-9. 2003..We conclude that BPAG1n4 plays an essential role in retrograde axonal transport in sensory neurons. These findings might advance our understanding of pathogenesis of axonal degeneration and neuronal death...
- Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathyNigel A Calcutt
Department of Pathology, University of California at San Diego, La Jolla, California 92093 0612, USA
J Clin Invest 111:507-14. 2003....