KARL ALEXANDER DEISSEROTH

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Dynamic multiphosphorylation passwords for activity-dependent gene expression
    Karl Deisseroth
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 34:179-82. 2002
  2. pmc Next-generation optical technologies for illuminating genetically targeted brain circuits
    Karl Deisseroth
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    J Neurosci 26:10380-6. 2006
  3. ncbi request reprint A role for circuit homeostasis in adult neurogenesis
    Leslie A Meltzer
    Department of Bioengineering, Neuroscience Program, Stanford University, W083 Clark Center, 318 Campus Drive West, Stanford, CA 94305, USA
    Trends Neurosci 28:653-60. 2005
  4. ncbi request reprint Multimodal fast optical interrogation of neural circuitry
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 446:633-9. 2007
  5. ncbi request reprint Excitation-neurogenesis coupling in adult neural stem/progenitor cells
    Karl Deisseroth
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 42:535-52. 2004
  6. ncbi request reprint Integration of light-controlled neuronal firing and fast circuit imaging
    Raag D Airan
    Department of Bioengineering, Stanford University, CA, United States
    Curr Opin Neurobiol 17:587-92. 2007
  7. ncbi request reprint Circuit-breakers: optical technologies for probing neural signals and systems
    Feng Zhang
    Department of Bioengineering, W083 Clark Center, 318 Campus Drive West, Stanford University, California, USA
    Nat Rev Neurosci 8:577-81. 2007
  8. pmc Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice
    Hong Hua Li
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
    EMBO Mol Med 1:50-65. 2009
  9. doi request reprint Temporally precise in vivo control of intracellular signalling
    Raag D Airan
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 458:1025-9. 2009
  10. ncbi request reprint High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
    Raag D Airan
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Science 317:819-23. 2007

Research Grants

Collaborators

  • Gero Miesenbock
  • Robert Malenka
  • Edward S Boyden
  • Anna K Majewska
  • Michael Ehlers
  • Raag D Airan
  • Feng Zhang
  • Leslie A Meltzer
  • Elbert S Hu
  • Madhuri Roy
  • Hong Hua Li
  • Luis de Lecea
  • Ragu Vijaykumar
  • Benjamin R Arenkiel
  • Viviana Gradinaru
  • Remy Durand
  • Antoine R Adamantidis
  • Birgit Halm
  • Uta Francke
  • Alessandra Splendore
  • Hannah Bernstein
  • Joseph H Bayle
  • Richard Paylor
  • Unsal Kuscuoglu
  • Lief E Fenno
  • Corinne M Spencer
  • Elena Wright
  • Katharine C Harrison
  • Kimberly R Thompson
  • Feng Ding
  • Natalie Watzke
  • Kenneth Kay
  • Antoine Adamantidis
  • Jana F Liewald
  • George J Augustine
  • Yuqing Gong
  • Ian G Davison
  • Phillip G Wood
  • Han Chen
  • Joao Peca
  • Ernst Bamberg
  • Georg Nagel
  • Li Ping Wang
  • Guoping Feng
  • Martin Brauner
  • Catia Feliciano
  • Alexander Gottschalk
  • Alexander M Aravanis
  • Raghu Yabaluri

Detail Information

Publications14

  1. ncbi request reprint Dynamic multiphosphorylation passwords for activity-dependent gene expression
    Karl Deisseroth
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 34:179-82. 2002
    ....
  2. pmc Next-generation optical technologies for illuminating genetically targeted brain circuits
    Karl Deisseroth
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    J Neurosci 26:10380-6. 2006
    ..Here we explore key recent advances that unite optical and genetic approaches, focusing on promising techniques that either allow novel studies of neural dynamics and behavior or provide fresh perspectives on classic model systems...
  3. ncbi request reprint A role for circuit homeostasis in adult neurogenesis
    Leslie A Meltzer
    Department of Bioengineering, Neuroscience Program, Stanford University, W083 Clark Center, 318 Campus Drive West, Stanford, CA 94305, USA
    Trends Neurosci 28:653-60. 2005
    ....
  4. ncbi request reprint Multimodal fast optical interrogation of neural circuitry
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 446:633-9. 2007
    ..NpHR and ChR2 form a complete system for multimodal, high-speed, genetically targeted, all-optical interrogation of living neural circuits...
  5. ncbi request reprint Excitation-neurogenesis coupling in adult neural stem/progenitor cells
    Karl Deisseroth
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 42:535-52. 2004
    ....
  6. ncbi request reprint Integration of light-controlled neuronal firing and fast circuit imaging
    Raag D Airan
    Department of Bioengineering, Stanford University, CA, United States
    Curr Opin Neurobiol 17:587-92. 2007
    ..Together these neuroengineering advances raise the exciting prospect of determining the role-specific cell types play in modulating neural activity flow in neuropsychiatric disease...
  7. ncbi request reprint Circuit-breakers: optical technologies for probing neural signals and systems
    Feng Zhang
    Department of Bioengineering, W083 Clark Center, 318 Campus Drive West, Stanford University, California, USA
    Nat Rev Neurosci 8:577-81. 2007
    ..These tools could lead to the development of precise neuromodulation technologies for animal models of disease and clinical neuropsychiatry...
  8. pmc Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice
    Hong Hua Li
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
    EMBO Mol Med 1:50-65. 2009
    ..Together, these partial deletion mice replicate crucial aspects of the human disorder and serve to identify genes and gene networks contributing to the neural substrates of complex behaviours and behavioural disorders...
  9. doi request reprint Temporally precise in vivo control of intracellular signalling
    Raag D Airan
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 458:1025-9. 2009
    ..The optoXR approach allows testing of hypotheses regarding the causal impact of biochemical signalling in behaving mammals, in a targetable and temporally precise manner...
  10. ncbi request reprint High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
    Raag D Airan
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Science 317:819-23. 2007
    ..Our results define a circuit-level neurophysiological endophenotype for affective behavior and suggest an approach to understanding circuit-level substrates underlying psychiatric disease symptoms...
  11. ncbi request reprint Millisecond-timescale, genetically targeted optical control of neural activity
    Edward S Boyden
    Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, California 94305, USA
    Nat Neurosci 8:1263-8. 2005
    ..This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers...
  12. doi request reprint Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California, USA
    Nat Protoc 5:439-56. 2010
    ..Together, these methods may help in providing circuit-level insight into the dynamics underlying complex mammalian behaviors in health and disease...
  13. doi request reprint Brain circuit dynamics
    Elbert S Hu
    Am J Psychiatry 165:800. 2008
  14. pmc In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2
    Benjamin R Arenkiel
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 54:205-18. 2007
    ....

Research Grants14

  1. OPTICAL NEUROMODULATION TECHNOLOGY FOR LONG TIMESCALES
    KARL ALEXANDER DEISSEROTH; Fiscal Year: 2010
    ..Achieving this new perspective could help change the landscape of our understanding of normal physiology and neuroplasticity, and help move toward insights into the etiology and treatment of neuropsychiatric disease. ..
  2. Technology development for fast optical interrogation of living neural circuitry
    KARL ALEXANDER DEISSEROTH; Fiscal Year: 2010
    ....
  3. Calcium channels, newborn neurons, and CNS circuit dynamics
    KARL ALEXANDER DEISSEROTH; Fiscal Year: 2010
    ..abstract_text> ..
  4. Excitatory Activity Control of Adult Neurogenesis
    Karl Deisseroth; Fiscal Year: 2007
    ..program that can be transitioned to a tenure-track position in a psychiatry department, where I look forward to continuing with 75-80% research and 20-25% patient care, and opportunities to teach and mentor others ..
  5. Technology development for fast optical interrogation of living neural circuitry
    KARL ALEXANDER DEISSEROTH; Fiscal Year: 2011
    ....