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Genomes and Genes | Mark M DavisSummaryAffiliation: Stanford University Country: USA Publications
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Publications
T cells as a self-referential, sensory organMark M Davis
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Annu Rev Immunol 25:681-95. 2007..With the multitude of specificities available to most T cells, they can thus be considered as a sensory organ, trained on self-peptide-MHCs and primed to detect nonself...
Evidence for a functional sidedness to the alphabetaTCRMichael S Kuhns
Department of Microbiology and Immunology, Graduate Program in Immunology, The Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
Proc Natl Acad Sci U S A 107:5094-9. 2010..These data reveal a "functional-sidedness" to the alphabetaTCR constant region, with dimerization occurring on the side of the TCR opposite from where the CD3 heterodimers are located...- TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinityJohannes B Huppa
Department of Microbiology and Immunology, Stanford School of Medicine, California 94305 5323, USA
Nature 463:963-7. 2010..However, CD4 blockade had no effect on the synaptic TCR affinity, nor did it destabilize TCR-pMHC complexes, indicating that the TCR binds pMHC independently of CD4... - TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activationBjörn F Lillemeier
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
Nat Immunol 11:90-6. 2010..This separation versus physical juxtapositioning of receptor domains and domains containing downstream signaling molecules in quiescent versus activated T cells may be a general feature of plasma membrane-associated signal transduction... - Quantitative imaging of lymphocyte membrane protein reorganization and signalingPeter M Kasson
Biophysics Program, Stanford University School of Medicine, Stanford, California, USA
Biophys J 88:579-89. 2005..Our methods can be generalized to a range of cell-signaling phenomena and enable novel applications not feasible with single-particle studies, such as analysis of subcellular protein localization in live organ culture... - Detection and characterization of cellular immune responses using peptide-MHC microarraysYoav Soen
Department of Biochemistry, Stanford University, Stanford, California, USA
PLoS Biol 1:E65. 2003.... - Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivityMichelle Krogsgaard
The Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 434:238-43. 2005.... - T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formationCenk Sumen
Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA
J Cell Biol 166:579-90. 2004..Hence, antagonist peptides selectively disable MHC clustering and the stop signal, whereas LFA-1 valency up-regulation occurs normally... - Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarizationMichelle R Kuhne
Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Center for Medical Research in Arthritis, University of California, San Francisco, CA 94143, USA
J Immunol 171:860-6. 2003..Moreover, our studies revealed that a calcium-dependent event not requiring calcineurin or calcium/calmodulin-dependent kinase is required for TCR-induced polarization of the MTOC... - Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonistMorgan Huse
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 27:76-88. 2007..These results establish the speed and localization of early signaling steps, and have important implications regarding the overall structure of the network... - CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapseQi-Jing Li
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 5:791-9. 2004..We also discuss broader implications for T cell biology, including thymic selection, diversity of the repertoire of self pMHC molecules and serial triggering... - Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activationMichelle Krogsgaard
Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Mol Cell 12:1367-78. 2003..Structural analysis shows significant changes in the central TCR contact residue of the peptide-MHC, indicating that structural rearrangements within the TCR-peptide-MHC interface can contribute to T cell activation... - miR-181a is an intrinsic modulator of T cell sensitivity and selectionQi jing Li
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 129:147-61. 2007..Importantly, higher miR-181a expression correlates with greater T cell sensitivity in immature T cells, suggesting that miR-181a acts as an intrinsic antigen sensitivity "rheostat" during T cell development... - Linking molecular and cellular events in T-cell activation and synapse formationMichelle Krogsgaard
Howard Hughes Medical Institute and the Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305-5323, USA
Semin Immunol 15:307-15. 2003..Ultimately, we want to integrate these cellular aspects of T-cell recognition with key features of the molecular interactions that drive specific events... 
An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181aPeter J R Ebert
The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA
Nat Immunol 10:1162-9. 2009..Therefore, miR-181a helps to guarantee the clonal deletion of particular moderate-affinity clones by modulating the TCR signaling threshold of thymocytes...- Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selectionJeremy Juang
The Department of Microbiology and Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
J Exp Med 207:1223-34. 2010..Thus, both positive and negative selection can be driven by dimeric but not monomeric ligands. In addition, positive selection has much more stringent requirements for the partner self-pMHC... - Dynamics of cell surface molecules during T cell recognitionMark M Davis
Howard Hughes Medical Institute and the Department of Microbiology and Immunology, Stanford University, Stanford, California 94305 5323, USA
Annu Rev Biochem 72:717-42. 2003.... - Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formationWilliam C Moss
Department of Microbiology and Immunology, Stanford University School of Medicine and Howard Hughes Medical Institute, CA 94305, USA
Proc Natl Acad Sci U S A 99:15024-9. 2002..This method should permit the quantitation of other dynamic membrane events and the associated movement of cell-surface molecules... - Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarrayDaniel S Chen
Department of Internal Medicine/Division of Oncology, Stanford University, Stanford, California, United States of America
PLoS Med 2:e265. 2005.... - Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k)Evan W Newell
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA
J Immunol 186:5823-32. 2011..These and other data illustrate the ability of TCRs to accommodate large variations in CDR3 structure and peptide contacts within the constraints of highly conserved TCR-MHC interactions... - γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 responseXun Zeng
Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA 94305, USA
Immunity 37:524-34. 2012..These results underscore the adaptability of lymphocyte antigen receptors and suggest an antigen-driven rapid response in protective immunity prior to the maturation of classical adaptive immunity... - Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMACJianming Xie
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
Nat Immunol 13:674-80. 2012.... - Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturationPeter J R Ebert
Howard Hughes Medical Institute and the Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 29:734-45. 2008.... - Functional development of the T cell receptor for antigenPeter J R Ebert
The Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
Prog Mol Biol Transl Sci 92:65-100. 2010..Here, we discuss our recent findings relating to T cell antigen recognition and how this leads to the thymic development of foreign-antigen-responsive alphabetaT cells... - Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulationLauren I Richie Ehrlich
Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 17:809-22. 2002..Most surprisingly, we find an intracellular pool of lck associated with recycling endosomes that translocates to mature synapses within 10 min of calcium flux. This bolus of lck may contribute to intermediate-late signal transduction... - The safety on the TCR triggerMichael S Kuhns
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 135:594-6. 2008..Prior to activation, basic residues in the cytoplasmic domain of the signaling subunits of the T cell receptor associate with the plasma membrane such that the key signaling tyrosines are sequestered in the bilayer... - A hybrid machine-learning approach for segmentation of protein localization dataPeter M Kasson
Biophysics Program, Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94305, USA
Bioinformatics 21:3778-86. 2005..We also demonstrate accurate automated learning utilizing additional experimental data... - A blood-borne antigen induces rapid T-B cell contact: a potential mechanism for tolerance inductionInes Gütgemann
Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
Immunology 107:420-5. 2002..In addition, B cells gain the ability to present antigen. Our results suggest a way for T cells to be stimulated by blood-borne antigen presented by naïve B cells, a potential mechanism of tolerance induction... - Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper deviceAmirAli H Talasaz
Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 106:3970-5. 2009..In contrast, we could not find any circulating epithelial cells in samples from 5 healthy donors. The isolated CEpCs are all stored individually for further molecular analysis... - Simultaneous detection of many T-cell specificities using combinatorial tetramer stainingEvan W Newell
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
Nat Methods 6:497-9. 2009..Here we describe and validate a method using combinations of fluorescent pMHC tetramers to simultaneously detect and enrich for many (>or=15) T-cell specificities in a single human blood sample... - Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysisMark M Davis
Department of Microbiology and Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA
Nat Rev Immunol 11:551-8. 2011..Furthermore, enrichment techniques have provided a greatly increased sensitivity that allows the analysis of the naive T cell repertoire directly. Thus, we can expect a flood of new information to emerge in the coming years... - Blimp-1 over BudapestMark M Davis
Howard Hughes Medical Institute and the Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 8:445-7. 2007..Recent work confirmed its role in the maturation of B cells into immunoglobulin-secreting plasmablasts, as well as in the control of T cell homeostasis and tolerance. What follows is a short history of how Blimp-1 was discovered... - Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signalingMichael S Kuhns
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 26:357-69. 2007..These data demonstrate that extracellular TCR-CD3 subunit interactions contribute to the structural integrity and function of this multisubunit receptor... - Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gammaKirk D C Jensen
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
Immunity 29:90-100. 2008..The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens... - How T cells 'see' antigenMichelle Krogsgaard
The Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 6:239-45. 2005..Here we summarize some of the more recent work on alphabeta T cell receptor recognition and discuss the implications for activation... - T cell killing does not require the formation of a stable mature immunological synapseMarco A Purbhoo
Department of Microbiology and Immunology and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 5:524-30. 2004..Furthermore, only three pMHC complexes were required for killing, showing that stable synapse formation and complete signaling are not required for cytotoxicity... - Continuous T cell receptor signaling required for synapse maintenance and full effector potentialJohannes B Huppa
Stanford University School of Medicine, Department of Microbiology and Immunology, and Howard Hughes Medical Institute, Beckman Center B221, 279 Campus Drive, Stanford, California 94305, USA
Nat Immunol 4:749-55. 2003..Thus TCR signaling persists for hours, has a cumulative effect and is necessary for the maintenance of the immunological synapse... - Direct observation of ligand recognition by T cellsDarrell J Irvine
Department of Microbiology and Immunology and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 419:845-9. 2002..This sensitivity is highly dependent on CD4, because blocking this molecule with antibodies renders T cells unable to detect less than about 30 ligands... - T-cell-antigen recognition and the immunological synapseJohannes B Huppa
The Howard Hughes Medical Institute and The Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Rev Immunol 3:973-83. 2003 - Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cellsJeremy I Pearl
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell Stem Cell 8:309-17. 2011.... - Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenograftsRutger Jan Swijnenburg
Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 105:12991-6. 2008..This process can be mitigated by a combined immunosuppressive regimen as assessed by molecular imaging approaches... - Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodiesSanae Sasaki
Department of Immunology and Microbiology, Stanford University School of Medicine, Stanford, California, USA
J Clin Invest 121:3109-19. 2011..They also suggest that exposure history affects the cross-reactivity of vaccination-induced antibodies... - Deconstructing the form and function of the TCR/CD3 complexMichael S Kuhns
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Immunity 24:133-9. 2006..Here, we review the current state of our understanding of the structure and organization of the TCR/CD3 complex... - T cells use two directionally distinct pathways for cytokine secretionMorgan Huse
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 7:247-55. 2006..These data suggest that T helper cells release some cytokines into the immunological synapse to impart specific communication and others multidirectionally to promote inflammation and to establish chemokine gradients... - Lineage structure of the human antibody repertoire in response to influenza vaccinationNing Jiang
Department of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, USA
Sci Transl Med 5:171ra19. 2013..We have thus shown that global analysis of the immune system's clonal structure provides direct insight into the effects of vaccination and provides a detailed molecular portrait of age-related effects... - Plasma membrane-associated proteins are clustered into islands attached to the cytoskeletonBjörn F Lillemeier
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 103:18992-7. 2006..Abundant actin staining and inhibitor studies show that these structures are connected to the cytoskeleton and at least partially depend on it for their formation and/or maintenance... - A new trigger for T cellsMark M Davis
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 110:285-7. 2002..A recent study has described a new trigger for T cell activation, involving a TCR-ligand-induced conformational change in CD3epsilon that permits binding of the adaptor protein Nck... - Cell type-specific gene expression differences in complex tissuesShai S Shen-Orr
Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
Nat Methods 7:287-9. 2010.... - Plasmablast-derived polyclonal antibody response after influenza vaccinationXiao Song He
Stanford University School of Medicine, Stanford, CA, USA
J Immunol Methods 365:67-75. 2011.... - Modular nature of Blimp-1 in the regulation of gene expression during B cell maturationRoger Sciammas
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 172:5427-40. 2004..Furthermore, mutagenesis of Blimp-1 reveals multiple effector domains, which regulate distinct genes. This indicates that Blimp-1 subdivides the maturation program into select and tunable pathways... - T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cellsKeishi Adachi
The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 108:1549-54. 2011..Thus, there are distinct signaling pathways triggered by TCR ligation that impair signaling in naïve cells and facilitate it in antigen-experienced cells... - Molecular and functional analysis using live cell microarraysDaniel S Chen
Department of Microbiology and Immunology and the Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Curr Opin Chem Biol 10:28-34. 2006..This review focuses on the use of cellular microarrays to detect antigen-specific T cells and their responsiveness, analyze cancer cell types and behavior and to investigate the control of stem cell differentiation... - Two-step binding mechanism for T-cell receptor recognition of peptide MHCLawren C Wu
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, B221 Beckman Center, Stanford, California 94305, USA
Nature 418:552-6. 2002.... - Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypesEvan W Newell
Department of Microbiology and Immunology, Stanford University, CA 94305, USA
Immunity 36:142-52. 2012..This large degree of functional diversity even between cells with the same specificity gives CD8(+) T cells a remarkable degree of flexibility in responding to pathogens... - Structural insight into pre-B cell receptor functionAlexander J Bankovich
Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 316:291-4. 2007.... - Pluripotent stem cells: immune to the immune system?Jeremy I Pearl
Department of Medicine and Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Sci Transl Med 4:164ps25. 2012..With clinical trials on the horizon, it is imperative that the immunogenicity of hESCs and iPSCs be definitively understood... - Significance analysis of xMap cytokine bead arraysJoong Ho Won
Division of Biostatistics, Department of Health Research and Policy, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 109:2848-53. 2012..We show that SAxCyB outperforms conventional analysis schemes in both sensitivity (low fluorescence) and robustness (high variability) and has enabled us to find many new differentially expressed cytokines in published studies... - Probing the plasma membrane structure of immune cells through the analysis of membrane sheets by electron microscopyBjörn F Lillemeier
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA
Methods Mol Biol 748:169-82. 2011..The exposed inner membrane surfaces can then be visualized with electron dense stains and specific proteins can be detected with gold conjugated probes... - Cellular immunotherapy: antigen recognition is just the beginningDaniel S Chen
Department of Internal Medicine, Division of Oncology, Stanford University, Stanford, California 94305-5124, USA
Springer Semin Immunopathol 27:119-27. 2005..Such understanding will lead to more sophisticated clinical trials, earlier determination of efficacy and individualized protocols... - The alphabeta T cell repertoire comes into focusMark M Davis
The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 27:179-80. 2007..Moon et al. (2007) report the enumeration and isolation of naive CD4(+) T cells and show their numbers could predict the size and diversity of the primary immune response... - A prescription for human immunologyMark M Davis
The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 29:835-8. 2008..Thus, to maximize the use of immunologic approaches to improve human health, we need more strategically directed efforts in human immunology. This would also open up new opportunities for basic research... - Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adultsLaura F Su
Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94304, USA
Immunity 38:373-83. 2013..Thus, the presence of these memory-phenotype T cells has significant implications for immunity to novel pathogens, child and adult health, and the influence of pathogen-rich versus hygienic environments... - Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selectionLauren I Richie
Program in Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 16:595-606. 2002..This implicates differences in synapse geometry in initiation of alternate signals downstream of the TCR... - Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD miceFelix J Baker
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:9374-9. 2002..Thus, autoimmune diabetes in NOD may be initiated by a limited number of antigens distinct from GAD65 and insulin... - Identification of Epstein-Barr virus-specific CD8+ T lymphocytes in the circulation of pediatric transplant recipientsDaniel A Falco
Department of Pediatrics, Stanford University School of Medicine, CA 94305, USA
Transplantation 74:501-10. 2002..Phenotypic and functional analysis of tetramer cells may prove useful in defining and monitoring EBV infection in the posttransplant patient... - Costimulation and endogenous MHC ligands contribute to T cell recognitionChristoph Wulfing
The Howard Hughes Medical Institute and The Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Nat Immunol 3:42-7. 2002..Thus, low-affinity ligands can contribute to synapse formation and T cell signaling... - CD4+ T-cell synapses involve multiple distinct stagesHironori Ueda
The Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305 5323, USA
Proc Natl Acad Sci U S A 108:17099-104. 2011.... - The evolutionary and structural 'logic' of antigen receptor diversityMark M Davis
The Department of Microbiology and Immunology, Stanford University School of Medicine, The Howard Hughes Medical Institute, 279 Campus Drive, Stanford, CA 94305 5323, USA
Semin Immunol 16:239-43. 2004..Thus, the wide variations seen in V region repertoires amongst vertebrates is likely to be of lesser importance than the preservation of one or more diverse CDR3 regions... - Shouts, whispers and the kiss of death: directional secretion in T cellsMorgan Huse
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Nat Immunol 9:1105-11. 2008..Thus, the mode of secretion seems to be tailored to the intended function of the secreted molecule... - MHC-peptide tetramers to visualize antigen-specific T cellsJohn D Altman
Emory University School of Medicine, Atlanta, Georgia, USA
Curr Protoc Immunol . 2003.... - A role for "self" in T-cell activationMichelle Krogsgaard
Department of Pathology and NYU Cancer Institute, NYU School of Medicine, New York, NY 10016, USA
Semin Immunol 19:236-44. 2007..Here, we highlight recent experimental data that provides insights into the initiation of T-cell activation and also discuss the main controversies and uncertainties in this area... - A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapseKentner Singleton
Center for Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Immunol 177:4402-13. 2006..Based on this characterization, we speculate that the T cell invagination, aided by CD2 enrichment, internalizes parts of the TCR signaling machinery to reset T cell signaling upon agonist-mediated, stable APC contact... - Distinct molecular mechanisms account for the specificity of two different T-cell receptorsNadja Anikeeva
Department of Microbiology and Immunology and Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Biochemistry 42:4709-16. 2003..The use of these different mechanisms by TCRs to recognize ligands might be an important means augmenting their inherent cross-reactivity... - Dynamics of the immunological synapse: finding, establishing and solidifying a connectionMatthew F Krummel
Department of Pathology, University of California at San Francisco, San Francisco, CA 94143 0511, USA
Curr Opin Immunol 14:66-74. 2002..This unexpected level of complexity of co-clustering and exclusion in the interface has generated much interest in the functional consequences of signaling and/or immune effector function... - The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouseStephane D Vincent
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Development 132:1315-25. 2005..Thus Blimp1 probably acts to turn off the default pathway that allows epiblast cells to adopt a somatic cell fate, and shifts the transcriptional program so that they become exclusively allocated into the germ cell lineage... - Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctionsShuyan Qi
Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 103:4416-21. 2006.... - A single class II myosin modulates T cell motility and stopping, but not synapse formationJordan Jacobelli
Department of Pathology, University of California at San Francisco, 513 Parnassus Ave, San Francisco, California 93143, USA
Nat Immunol 5:531-8. 2004..Phosphorylation of MyH9 in its multimerization domain by T cell receptor-generated signals indicates that inactivation of this motor may be a key step in the 'stop' response during antigen recognition...