Research Topics
Genomes and Genes | M M DavisSummaryAffiliation: Stanford University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Dynamics of cell surface molecules during T cell recognitionMark M Davis
Howard Hughes Medical Institute and the Department of Microbiology and Immunology, Stanford University, Stanford, California 94305 5323, USA
Annu Rev Biochem 72:717-42. 2003....- A new trigger for T cellsMark M Davis
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 110:285-7. 2002..A recent study has described a new trigger for T cell activation, involving a TCR-ligand-induced conformational change in CD3epsilon that permits binding of the adaptor protein Nck... - Blimp-1 over BudapestMark M Davis
Howard Hughes Medical Institute and the Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 8:445-7. 2007..Recent work confirmed its role in the maturation of B cells into immunoglobulin-secreting plasmablasts, as well as in the control of T cell homeostasis and tolerance. What follows is a short history of how Blimp-1 was discovered... - The evolutionary and structural 'logic' of antigen receptor diversityMark M Davis
The Department of Microbiology and Immunology, Stanford University School of Medicine, The Howard Hughes Medical Institute, 279 Campus Drive, Stanford, CA 94305 5323, USA
Semin Immunol 16:239-43. 2004..Thus, the wide variations seen in V region repertoires amongst vertebrates is likely to be of lesser importance than the preservation of one or more diverse CDR3 regions... - Ligand recognition by alpha beta T cell receptorsM M Davis
Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA
Annu Rev Immunol 16:523-44. 1998..We conclude with an analysis of the highly diverse CDR3 loops found in all antigen receptor molecules and suggest that such regions form the core of both TCR and antibody specificity... 
Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramersX S He
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 96:5692-7. 1999..Direct quantitation and characterization of HCV-specific CTLs should extend our understanding of the immunopathogenesis and the mechanism of clearance or persistence of HCV...- The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interfaceC Wulfing
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 97:10150-5. 2000..These data indicate that vav is an essential regulator of cytoskeletal rearrangements during T cell activation... - The nature of major histocompatibility complex recognition by gamma delta T cellsH Schild
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305
Cell 76:29-37. 1994..These results suggest that the molecular nature of gamma delta T cell recognition is fundamentally different than that of alpha beta T cells... - Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART)C M Gray
Center for AIDS Research, Division of Infectious Diseases and Geographic Medicine, Stanford University Medical Center, Stanford, CA 94305
J Immunol 162:1780-8. 1999..In conclusion, this study provides evidence that persistently replicating viral populations are probably required to maintain high frequencies of HIV-1 epitope-specific CD8+ T cells in asymptomatic chronically infected individuals.. - Attributes of gammadelta intraepithelial lymphocytes as suggested by their transcriptional profileA M Fahrer
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 98:10261-6. 2001..This study provides a strong basis for further investigations of the roles of these cells as well as mucosal immune defense in general... - Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cellsC A Turner
Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5428
Cell 77:297-306. 1994..Thus, Blimp-1 appears to be a pleiotropic regulatory factor capable of at least partially driving the terminal differentiation of B cells... - A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitisS Akkaraju
Department of Microbiology and Immunology, Beckman Center, Stanford University School of Medicine, California 94305 5428, USA
Immunity 7:255-71. 1997.... - Direct functional analysis of epitope-specific CD8+ T cells in peripheral bloodX S He
Department of Medicine, Stanford University School of Medicine, California 94305 5187, USA
Viral Immunol 14:59-69. 2001.... - Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodiesP A Reay
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
J Immunol 164:5626-34. 2000..The analysis indicates that T cell activation is a stochastic process... 
Detection and characterization of cellular immune responses using peptide-MHC microarraysYoav Soen
Department of Biochemistry, Stanford University, Stanford, California, USA
PLoS Biol 1:E65. 2003....- Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activationMichelle Krogsgaard
Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Mol Cell 12:1367-78. 2003..Structural analysis shows significant changes in the central TCR contact residue of the peptide-MHC, indicating that structural rearrangements within the TCR-peptide-MHC interface can contribute to T cell activation... - A kinetic window constricts the T cell receptor repertoire in the thymusP A Savage
Program in Cancer Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 14:243-52. 2001..These studies provide direct evidence that thymic selection biases the naive peripheral T cell repertoire toward TCR-ligand interactions that fall within a moderate half-life "window.".. - The adult T-cell receptor delta-chain is diverse and distinct from that of fetal thymocytesJ F Elliott
Department of Medical Microbiology, Stanford University, California 94305
Nature 331:627-31. 1988.... - CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapseQi-Jing Li
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 5:791-9. 2004..We also discuss broader implications for T cell biology, including thymic selection, diversity of the repertoire of self pMHC molecules and serial triggering... - Modular nature of Blimp-1 in the regulation of gene expression during B cell maturationRoger Sciammas
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 172:5427-40. 2004..Furthermore, mutagenesis of Blimp-1 reveals multiple effector domains, which regulate distinct genes. This indicates that Blimp-1 subdivides the maturation program into select and tunable pathways... - T cells as a self-referential, sensory organMark M Davis
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Annu Rev Immunol 25:681-95. 2007..With the multitude of specificities available to most T cells, they can thus be considered as a sensory organ, trained on self-peptide-MHCs and primed to detect nonself... - miR-181a is an intrinsic modulator of T cell sensitivity and selectionQi jing Li
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 129:147-61. 2007..Importantly, higher miR-181a expression correlates with greater T cell sensitivity in immature T cells, suggesting that miR-181a acts as an intrinsic antigen sensitivity "rheostat" during T cell development... - The alphabeta T cell repertoire comes into focusMark M Davis
The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 27:179-80. 2007..Moon et al. (2007) report the enumeration and isolation of naive CD4(+) T cells and show their numbers could predict the size and diversity of the primary immune response... - A prescription for human immunologyMark M Davis
The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 29:835-8. 2008..Thus, to maximize the use of immunologic approaches to improve human health, we need more strategically directed efforts in human immunology. This would also open up new opportunities for basic research... 
An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181aPeter J R Ebert
The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA
Nat Immunol 10:1162-9. 2009..Therefore, miR-181a helps to guarantee the clonal deletion of particular moderate-affinity clones by modulating the TCR signaling threshold of thymocytes...- Identification and sequence of a fourth human T cell antigen receptor chainE Y Loh
Department of Medical Microbiology, Stanford University School of Medicine, California 94305
Nature 330:569-72. 1987.... - Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapyL Fong
Departments of Pathology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 98:8809-14. 2001..Clinical response correlated with the expansion of CD8 tetramer(+) T cells, confirming the role of CD8 T cells in this treatment strategy... - Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selectionJeremy Juang
The Department of Microbiology and Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
J Exp Med 207:1223-34. 2010..Thus, both positive and negative selection can be driven by dimeric but not monomeric ligands. In addition, positive selection has much more stringent requirements for the partner self-pMHC... - TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activationBjörn F Lillemeier
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
Nat Immunol 11:90-6. 2010..This separation versus physical juxtapositioning of receptor domains and domains containing downstream signaling molecules in quiescent versus activated T cells may be a general feature of plasma membrane-associated signal transduction... - T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formationCenk Sumen
Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA
J Cell Biol 166:579-90. 2004..Hence, antagonist peptides selectively disable MHC clustering and the stop signal, whereas LFA-1 valency up-regulation occurs normally... - How T cells 'see' antigenMichelle Krogsgaard
The Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 6:239-45. 2005..Here we summarize some of the more recent work on alphabeta T cell receptor recognition and discuss the implications for activation... - Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturationPeter J R Ebert
Howard Hughes Medical Institute and the Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 29:734-45. 2008.... - Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gammaKirk D C Jensen
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
Immunity 29:90-100. 2008..The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens... - Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarizationMichelle R Kuhne
Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Center for Medical Research in Arthritis, University of California, San Francisco, CA 94143, USA
J Immunol 171:860-6. 2003..Moreover, our studies revealed that a calcium-dependent event not requiring calcineurin or calcium/calmodulin-dependent kinase is required for TCR-induced polarization of the MTOC... - Direct observation of ligand recognition by T cellsDarrell J Irvine
Department of Microbiology and Immunology and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 419:845-9. 2002..This sensitivity is highly dependent on CD4, because blocking this molecule with antibodies renders T cells unable to detect less than about 30 ligands... - Two-step binding mechanism for T-cell receptor recognition of peptide MHCLawren C Wu
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, B221 Beckman Center, Stanford, California 94305, USA
Nature 418:552-6. 2002.... - Costimulation and endogenous MHC ligands contribute to T cell recognitionChristoph Wulfing
The Howard Hughes Medical Institute and The Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Nat Immunol 3:42-7. 2002..Thus, low-affinity ligands can contribute to synapse formation and T cell signaling... - Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selectionLauren I Richie
Program in Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 16:595-606. 2002..This implicates differences in synapse geometry in initiation of alternate signals downstream of the TCR... - Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formationWilliam C Moss
Department of Microbiology and Immunology, Stanford University School of Medicine and Howard Hughes Medical Institute, CA 94305, USA
Proc Natl Acad Sci U S A 99:15024-9. 2002..This method should permit the quantitation of other dynamic membrane events and the associated movement of cell-surface molecules... - Linking molecular and cellular events in T-cell activation and synapse formationMichelle Krogsgaard
Howard Hughes Medical Institute and the Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305-5323, USA
Semin Immunol 15:307-15. 2003..Ultimately, we want to integrate these cellular aspects of T-cell recognition with key features of the molecular interactions that drive specific events... - Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cellsW Y Ho
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305
J Exp Med 179:1539-49. 1994.... - Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonistMorgan Huse
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 27:76-88. 2007..These results establish the speed and localization of early signaling steps, and have important implications regarding the overall structure of the network... - A blood-borne antigen induces rapid T-B cell contact: a potential mechanism for tolerance inductionInes Gütgemann
Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
Immunology 107:420-5. 2002..In addition, B cells gain the ability to present antigen. Our results suggest a way for T cells to be stimulated by blood-borne antigen presented by naïve B cells, a potential mechanism of tolerance induction... - Molecular and functional analysis using live cell microarraysDaniel S Chen
Department of Microbiology and Immunology and the Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Curr Opin Chem Biol 10:28-34. 2006..This review focuses on the use of cellular microarrays to detect antigen-specific T cells and their responsiveness, analyze cancer cell types and behavior and to investigate the control of stem cell differentiation... - Evidence for a functional sidedness to the alphabetaTCRMichael S Kuhns
Department of Microbiology and Immunology, Graduate Program in Immunology, The Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
Proc Natl Acad Sci U S A 107:5094-9. 2010..These data reveal a "functional-sidedness" to the alphabetaTCR constant region, with dimerization occurring on the side of the TCR opposite from where the CD3 heterodimers are located... - Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivityMichelle Krogsgaard
The Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 434:238-43. 2005.... - Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulationLauren I Richie Ehrlich
Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 17:809-22. 2002..Most surprisingly, we find an intracellular pool of lck associated with recycling endosomes that translocates to mature synapses within 10 min of calcium flux. This bolus of lck may contribute to intermediate-late signal transduction... - TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinityJohannes B Huppa
Department of Microbiology and Immunology, Stanford School of Medicine, California 94305 5323, USA
Nature 463:963-7. 2010..However, CD4 blockade had no effect on the synaptic TCR affinity, nor did it destabilize TCR-pMHC complexes, indicating that the TCR binds pMHC independently of CD4... - Quantitative imaging of lymphocyte membrane protein reorganization and signalingPeter M Kasson
Biophysics Program, Stanford University School of Medicine, Stanford, California, USA
Biophys J 88:579-89. 2005..Our methods can be generalized to a range of cell-signaling phenomena and enable novel applications not feasible with single-particle studies, such as analysis of subcellular protein localization in live organ culture... - Continuous T cell receptor signaling required for synapse maintenance and full effector potentialJohannes B Huppa
Stanford University School of Medicine, Department of Microbiology and Immunology, and Howard Hughes Medical Institute, Beckman Center B221, 279 Campus Drive, Stanford, California 94305, USA
Nat Immunol 4:749-55. 2003..Thus TCR signaling persists for hours, has a cumulative effect and is necessary for the maintenance of the immunological synapse... - A human T cell-specific molecule is a member of a new gene familyT J Schall
Department of Pediatrics, Stanford University School of Medicine, CA 94305
J Immunol 141:1018-25. 1988..There is significant homology between the RANTES sequence and several other T cell genes, suggesting that they comprise a previously undescribed family of small T cell molecules... - Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper deviceAmirAli H Talasaz
Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 106:3970-5. 2009..In contrast, we could not find any circulating epithelial cells in samples from 5 healthy donors. The isolated CEpCs are all stored individually for further molecular analysis... - The safety on the TCR triggerMichael S Kuhns
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 135:594-6. 2008..Prior to activation, basic residues in the cytoplasmic domain of the signaling subunits of the T cell receptor associate with the plasma membrane such that the key signaling tyrosines are sequestered in the bilayer... - T cell killing does not require the formation of a stable mature immunological synapseMarco A Purbhoo
Department of Microbiology and Immunology and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 5:524-30. 2004..Furthermore, only three pMHC complexes were required for killing, showing that stable synapse formation and complete signaling are not required for cytotoxicity... - Functional development of the T cell receptor for antigenPeter J R Ebert
The Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
Prog Mol Biol Transl Sci 92:65-100. 2010..Here, we discuss our recent findings relating to T cell antigen recognition and how this leads to the thymic development of foreign-antigen-responsive alphabetaT cells... - Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signalingMichael S Kuhns
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 26:357-69. 2007..These data demonstrate that extracellular TCR-CD3 subunit interactions contribute to the structural integrity and function of this multisubunit receptor... - Plasma membrane-associated proteins are clustered into islands attached to the cytoskeletonBjörn F Lillemeier
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 103:18992-7. 2006..Abundant actin staining and inhibitor studies show that these structures are connected to the cytoskeleton and at least partially depend on it for their formation and/or maintenance... - T-cell-antigen recognition and the immunological synapseJohannes B Huppa
The Howard Hughes Medical Institute and The Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Rev Immunol 3:973-83. 2003 - A hybrid machine-learning approach for segmentation of protein localization dataPeter M Kasson
Biophysics Program, Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94305, USA
Bioinformatics 21:3778-86. 2005..We also demonstrate accurate automated learning utilizing additional experimental data... - Deconstructing the form and function of the TCR/CD3 complexMichael S Kuhns
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Immunity 24:133-9. 2006..Here, we review the current state of our understanding of the structure and organization of the TCR/CD3 complex... - Cell type-specific gene expression differences in complex tissuesShai S Shen-Orr
Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
Nat Methods 7:287-9. 2010.... - Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD miceFelix J Baker
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:9374-9. 2002..Thus, autoimmune diabetes in NOD may be initiated by a limited number of antigens distinct from GAD65 and insulin... - Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenograftsRutger Jan Swijnenburg
Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 105:12991-6. 2008..This process can be mitigated by a combined immunosuppressive regimen as assessed by molecular imaging approaches... - A role for "self" in T-cell activationMichelle Krogsgaard
Department of Pathology and NYU Cancer Institute, NYU School of Medicine, New York, NY 10016, USA
Semin Immunol 19:236-44. 2007..Here, we highlight recent experimental data that provides insights into the initiation of T-cell activation and also discuss the main controversies and uncertainties in this area... - A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapseKentner Singleton
Center for Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Immunol 177:4402-13. 2006..Based on this characterization, we speculate that the T cell invagination, aided by CD2 enrichment, internalizes parts of the TCR signaling machinery to reset T cell signaling upon agonist-mediated, stable APC contact... - Shouts, whispers and the kiss of death: directional secretion in T cellsMorgan Huse
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Nat Immunol 9:1105-11. 2008..Thus, the mode of secretion seems to be tailored to the intended function of the secreted molecule... - MHC-peptide tetramers to visualize antigen-specific T cellsJohn D Altman
Emory University School of Medicine, Atlanta, Georgia, USA
Curr Protoc Immunol . 2003.... - Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctionsShuyan Qi
Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 103:4416-21. 2006.... - The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouseStephane D Vincent
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Development 132:1315-25. 2005..Thus Blimp1 probably acts to turn off the default pathway that allows epiblast cells to adopt a somatic cell fate, and shifts the transcriptional program so that they become exclusively allocated into the germ cell lineage... - Distinct molecular mechanisms account for the specificity of two different T-cell receptorsNadja Anikeeva
Department of Microbiology and Immunology and Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Biochemistry 42:4709-16. 2003..The use of these different mechanisms by TCRs to recognize ligands might be an important means augmenting their inherent cross-reactivity... - A single class II myosin modulates T cell motility and stopping, but not synapse formationJordan Jacobelli
Department of Pathology, University of California at San Francisco, 513 Parnassus Ave, San Francisco, California 93143, USA
Nat Immunol 5:531-8. 2004..Phosphorylation of MyH9 in its multimerization domain by T cell receptor-generated signals indicates that inactivation of this motor may be a key step in the 'stop' response during antigen recognition... - Dynamics of the immunological synapse: finding, establishing and solidifying a connectionMatthew F Krummel
Department of Pathology, University of California at San Francisco, San Francisco, CA 94143 0511, USA
Curr Opin Immunol 14:66-74. 2002..This unexpected level of complexity of co-clustering and exclusion in the interface has generated much interest in the functional consequences of signaling and/or immune effector function...