M S Cyert

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p
    R S Polizotto
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 154:951-60. 2001
  2. pmc Alpha-arrestins Aly1 and Aly2 regulate intracellular trafficking in response to nutrient signaling
    Allyson F O'Donnell
    Department of Biology, Stanford University, Stanford, CA 94305 5020, USA
    Mol Biol Cell 21:3552-66. 2010
  3. pmc Whi3, an S. cerevisiae RNA-Binding Protein, Is a Component of Stress Granules That Regulates Levels of Its Target mRNAs
    Kristen J Holmes
    Department of Biology, Stanford University, Stanford, California, United States of America
    PLoS ONE 8:e84060. 2013
  4. pmc Regulation of cation balance in Saccharomyces cerevisiae
    Martha S Cyert
    Department of Biology, Stanford University, Stanford, CA 94305 5020, USA
    Genetics 193:677-713. 2013
  5. ncbi request reprint Genetic analysis of calmodulin and its targets in Saccharomyces cerevisiae
    M S Cyert
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Annu Rev Genet 35:647-72. 2001
  6. ncbi request reprint Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress
    Martha S Cyert
    Department of Biological Sciences, Stanford University, Stanford, CA 94306, USA
    Biochem Biophys Res Commun 311:1143-50. 2003
  7. pmc Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast
    A M Stathopoulos
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Genes Dev 11:3432-44. 1997
  8. pmc The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers
    T C Pozos
    Department of Biological Sciences, Stanford University, California 94305 5020, USA
    Mol Cell Biol 16:3730-41. 1996
  9. pmc Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation
    A Stathopoulos-Gerontides
    Deptartment of Biological Sciences, Stanford University, Stanford, California 94305 5020 USA
    Genes Dev 13:798-803. 1999
  10. pmc The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p
    K E Williams
    Department of Biological Science, Stanford University, Stanford, CA 94305 5020, USA
    EMBO J 20:3473-83. 2001

Collaborators

  • Caroline C Philpott
  • Patrick G Hogan
  • Audrey Gasch
  • Michael Snyder
  • David Botstein
  • KELVIN J DAVIES
  • Rhonda Bassel-Duby
  • Gerald R Crabtree
  • JOSEPH B HEITMAN
  • Jeffery Molkentin
  • Allyson F O'Donnell
  • Valerie Denis
  • Kimberly A Kafadar
  • Kristen J Holmes
  • Victoria L Heath
  • Steven Minear
  • Francisco J Piña
  • Jagoree Roy
  • Geert Bultynck
  • Leila M Boustany
  • Hiroyuki Yoshimoto
  • Daniel M Klass
  • Evan L Guiney
  • K E Williams
  • R S Polizotto
  • Anna Ballew
  • Tim Stearns
  • Guri Giaever
  • Silvere Pagant
  • Corey Nislow
  • Stanley Fields
  • Hai Lan Piao
  • Elizabeth A Miller
  • John P Miller
  • Alex Apffel
  • M J Conboy
  • Richard G Gardner
  • A Stathopoulos-Gerontides
  • B Jiang
  • Huiming Li
  • Rosine Haguenauer-Tsapis
  • J L Withee
  • Alia P Majeed
  • Jean Marc Galan
  • Sidney L Shaw
  • Sharmili Roy
  • A M Stathopoulos
  • Heng Zhu
  • Nobuo Ogawa
  • Hong Xia Li
  • T C Pozos
  • Patrick O Brown
  • Kirstie Saltsman
  • P Garrett-Engele
  • J J Guo
  • R Sen
  • I Sekler
  • B Moilanen

Detail Information

Publications26

  1. pmc Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p
    R S Polizotto
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 154:951-60. 2001
    ..Finally, we demonstrate that residues in both the NH2- and COOH-terminal portions of Crz1p are required for regulated Crz1p binding to Nmd5p, supporting a model of NLS masking for regulating Crz1p nuclear import...
  2. pmc Alpha-arrestins Aly1 and Aly2 regulate intracellular trafficking in response to nutrient signaling
    Allyson F O'Donnell
    Department of Biology, Stanford University, Stanford, CA 94305 5020, USA
    Mol Biol Cell 21:3552-66. 2010
    ..This work defines a new role for arrestins in membrane trafficking and offers insight into how α-arrestins coordinate signaling events with protein trafficking...
  3. pmc Whi3, an S. cerevisiae RNA-Binding Protein, Is a Component of Stress Granules That Regulates Levels of Its Target mRNAs
    Kristen J Holmes
    Department of Biology, Stanford University, Stanford, California, United States of America
    PLoS ONE 8:e84060. 2013
    ..Together our results suggest an expanded model for Whi3 function: in addition to its role as a regulator of the cell cycle, Whi3 may have a role in stress-dependent RNA processing and responses to a variety of stress conditions. ..
  4. pmc Regulation of cation balance in Saccharomyces cerevisiae
    Martha S Cyert
    Department of Biology, Stanford University, Stanford, CA 94305 5020, USA
    Genetics 193:677-713. 2013
    ..e., either limited availability or toxic levels in the environment...
  5. ncbi request reprint Genetic analysis of calmodulin and its targets in Saccharomyces cerevisiae
    M S Cyert
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Annu Rev Genet 35:647-72. 2001
    ..Thus, calmodulin performs important physiological functions in yeast cells in both its Ca2+-bound and Ca2+-free form...
  6. ncbi request reprint Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress
    Martha S Cyert
    Department of Biological Sciences, Stanford University, Stanford, CA 94306, USA
    Biochem Biophys Res Commun 311:1143-50. 2003
    ..Recent studies concerning the regulation of Crz1p by calcineurin are discussed in this review and the mechanisms by which calcineurin controls gene expression in yeast and mammalian cells are compared...
  7. pmc Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast
    A M Stathopoulos
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Genes Dev 11:3432-44. 1997
    ..Thus, in response to multiple signals, calcineurin acts through the Crz1p transcription factor to differentially regulate the expression of several target genes in yeast...
  8. pmc The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers
    T C Pozos
    Department of Biological Sciences, Stanford University, California 94305 5020, USA
    Mol Cell Biol 16:3730-41. 1996
    ..Vacuolar membrane vesicles from hum1 mutants lack all Ca2+/H+ antiport activity, demonstrating that Hum1p catalyzes the exchange of Ca2+ for H+ across the yeast vacuolar membrane...
  9. pmc Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation
    A Stathopoulos-Gerontides
    Deptartment of Biological Sciences, Stanford University, Stanford, California 94305 5020 USA
    Genes Dev 13:798-803. 1999
    ..Thus, the mechanism of Ca2+/calcineurin-dependent signaling shows remarkable conservation between yeast and mammalian cells...
  10. pmc The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p
    K E Williams
    Department of Biological Science, Stanford University, Stanford, CA 94305 5020, USA
    EMBO J 20:3473-83. 2001
    ..The DNA-binding domain of Skn7p is also required for binding to Crz1p and calcineurin in vitro. Thus, we propose that Skn7p protects Crz1p from degradation by binding to it and calcineurin through its DNA-binding domain...
  11. pmc Ion tolerance of Saccharomyces cerevisiae lacking the Ca2+/CaM-dependent phosphatase (calcineurin) is improved by mutations in URE2 or PMA1
    J L Withee
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Genetics 149:865-78. 1998
    ..These studies further characterize the roles that URE2 and PMA1 play in regulating intracellular ion homeostasis...
  12. ncbi request reprint Identification of a novel region critical for calcineurin function in vivo and in vitro
    B Jiang
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Biol Chem 274:18543-51. 1999
    ....
  13. pmc Luv1p/Rki1p/Tcs3p/Vps54p, a yeast protein that localizes to the late Golgi and early endosome, is required for normal vacuolar morphology
    M J Conboy
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Mol Biol Cell 11:2429-43. 2000
    ..Computer analysis predicts a short coiled-coil domain in Luv1p. We propose that this protein maintains traffic through or the integrity of the early endosome and that this function is required for proper vacuolar morphology...
  14. pmc Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae
    Victoria L Heath
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Eukaryot Cell 3:695-704. 2004
    ..Thus, Hph1p and Hph2p are components of a novel Ca2+- and calcineurin-regulated response required to promote growth under conditions of high Na+, alkaline pH, and cell wall stress...
  15. pmc A conserved docking site modulates substrate affinity for calcineurin, signaling output, and in vivo function
    Jagoree Roy
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA
    Mol Cell 25:889-901. 2007
    ..Thus, calcineurin-substrate affinity determines the Ca(2+) concentration dependence and output of signaling in vivo as well as the balance between different branches of calcineurin signaling in an overall biological response...
  16. pmc Integration of stress responses: modulation of calcineurin signaling in Saccharomyces cerevisiae by protein kinase A
    Kimberly A Kafadar
    Department of Biological Sciences, Stanford University, 337 Campus Dr, Lokey Building, Stanford, CA 94305 5020, USA
    Eukaryot Cell 3:1147-53. 2004
    ..Thus, these studies identify a specific biochemical mechanism through which the activities of multiple stress-activated signaling pathways are integrated in vivo...
  17. pmc Negative regulation of calcineurin signaling by Hrr25p, a yeast homolog of casein kinase I
    Kimberly A Kafadar
    Department of Biological Sciences Stanford University, Stanford, California, 94305 5020, USA
    Genes Dev 17:2698-708. 2003
    ..These findings represent the first identification of a negative regulator for Crz1p, and establish a novel physiological role for Hrr25p in antagonizing calcineurin signaling...
  18. pmc Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site
    Leila M Boustany
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Genes Dev 16:608-19. 2002
    ..Therefore, in yeast as in mammals, a docking site is required to target calcineurin to its substrate such that it can dephosphorylate it efficiently...
  19. pmc Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase
    P Garrett-Engele
    Department of Biological Sciences, Stanford University, California 94305 5020
    Mol Cell Biol 15:4103-14. 1995
    ..We discuss possible roles for calcineurin in regulating intracellular ion homeostasis and in maintaining cell integrity...
  20. ncbi request reprint Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae
    Hiroyuki Yoshimoto
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305 5020, USA
    J Biol Chem 277:31079-88. 2002
    ..A similar sequence, 5'-GAGGCTG-3', was identified as a common sequence motif in the upstream regions of calcineurin/ Crz1p-dependent genes. This finding is consistent with direct regulation of these genes by Crz1p...
  21. pmc Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease
    Geert Bultynck
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Mol Cell Biol 26:4729-45. 2006
    ....
  22. pmc Molecular analysis reveals localization of Saccharomyces cerevisiae protein kinase C to sites of polarized growth and Pkc1p targeting to the nucleus and mitotic spindle
    Valerie Denis
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Eukaryot Cell 4:36-45. 2005
    ..This novel nuclear and spindle localization of Pkc1p may provide a molecular explanation for previous observations that suggest a role for Pkc1p in regulating microtubule function...
  23. pmc Internal Ca(2+) release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue
    Valerie Denis
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 156:29-34. 2002
    ..These studies reveal a novel mechanism of internal Ca(2+) release and establish a new function for TRP channels...
  24. pmc Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation
    Steven Minear
    Department of Biology, Stanford University, Stanford, CA 94305 5020, USA
    Eukaryot Cell 10:1574-81. 2011
    ..These findings suggest that curcumin-induced iron starvation is conserved from yeast to humans and underlies curcumin's medicinal properties...
  25. pmc Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis
    Francisco J Piña
    Department of Biology, 371 Serra Drive, Stanford University, Stanford, CA 94305 5020, USA
    Eukaryot Cell 10:63-71. 2011
    ..We propose that Hph1 and Hph2 aid Sec63/Sec62-mediated translocation of specific proteins, including factors that promote efficient biogenesis of V-ATPase, to support yeast cell survival during environmental stress...
  26. ncbi request reprint Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin
    Kelvin J A Davies
    Ethel Percy Andrus Gerontology Center, and Division of Molecular and Computational Biology, The University of Southern California, Los Angeles, CA 90089 0191, USA
    FASEB J 21:3023-8. 2007

Research Grants19

  1. Role of Ca2+/Calcineurin Signaling in S.Cerevisiae
    Martha Cyert; Fiscal Year: 2009
    ..3) Identify the role of calcineurin interacting proteins in calcineurin signaling pathways. 4) Identify additional calcineurin substrates using novel proteomic and genomic screening methods. ..
  2. Role of Ca2+/Calcineurin Signaling in S.Cerevisiae
    Martha Cyert; Fiscal Year: 2009
    ..3) Identify the role of calcineurin interacting proteins in calcineurin signaling pathways. 4) Identify additional calcineurin substrates using novel proteomic and genomic screening methods. ..
  3. Role of Ca2+/Calcineurin Signaling in S.Cerevisiae
    Martha Cyert; Fiscal Year: 2007
    ..3) Identify the role of calcineurin interacting proteins in calcineurin signaling pathways. 4) Identify additional calcineurin substrates using novel proteomic and genomic screening methods. ..
  4. Role of Ca2+/Calcineurin Signaling in S.Cerevisiae
    Martha Cyert; Fiscal Year: 2006
    ..3) Identify the role of calcineurin interacting proteins in calcineurin signaling pathways. 4) Identify additional calcineurin substrates using novel proteomic and genomic screening methods. ..
  5. Role of Ca2+/Calcineurin Signaling in S. cerevisiae
    Martha Cyert; Fiscal Year: 2005
    ..cerevisiae, because of the many experimental advantages offered by this organism. However, we believe our findings will establish general principles that will apply to calcineurin-dependent signaling in all cells. ..
  6. Role of Ca2+/Calcineurin Signaling in S. cerevisiae
    Martha Cyert; Fiscal Year: 2005
    ..cerevisiae, because of the many experimental advantages offered by this organism. However, we believe our findings will establish general principles that will apply to calcineurin-dependent signaling in all cells. ..
  7. Role of Ca2+/Calcineurin Signaling in S. cerevisiae
    Martha Cyert; Fiscal Year: 2004
    ..cerevisiae, because of the many experimental advantages offered by this organism. However, we believe our findings will establish general principles that will apply to calcineurin-dependent signaling in all cells. ..
  8. Role of Ca2+/Calcineurin Signaling in S. cerevisiae
    Martha Cyert; Fiscal Year: 2003
    ..cerevisiae, because of the many experimental advantages offered by this organism. However, we believe our findings will establish general principles that will apply to calcineurin-dependent signaling in all cells. ..
  9. Role of Ca2+/Calcineurin Signaling in S. cerevisiae
    Martha Cyert; Fiscal Year: 2002
    ..cerevisiae, because of the many experimental advantages offered by this organism. However, we believe our findings will establish general principles that will apply to calcineurin-dependent signaling in all cells. ..
  10. YEAST PP2B PHOSPHATASES--ROLE IN PHEROMONE ADAPTATION
    Martha Cyert; Fiscal Year: 2001
    ..4) Identify substrates of calcineurin by identifying gene products that physically interact with calcineurin in vivo and by testing specific candidate proteins in vitro for calcineurin-dependent dephosphorylation. ..
  11. YEAST PP2B PHOSPHATASES--ROLE IN PHEROMONE ADAPTATION
    Martha Cyert; Fiscal Year: 2000
    ..4) Identify substrates of calcineurin by identifying gene products that physically interact with calcineurin in vivo and by testing specific candidate proteins in vitro for calcineurin-dependent dephosphorylation. ..
  12. YEAST PP2B PHOSPHATASES--ROLE IN PHEROMONE ADAPTATION
    Martha Cyert; Fiscal Year: 1999
    ..4) Identify substrates of calcineurin by identifying gene products that physically interact with calcineurin in vivo and by testing specific candidate proteins in vitro for calcineurin-dependent dephosphorylation. ..
  13. Role of Ca2+/Calcineurin Signaling in S. cerevisiae
    Martha S Cyert; Fiscal Year: 2010
    ..This research studies, at the biochemical level, the functions of calcineurin in a simple, experimentally tractable organism, i.e. yeast, and will serve as a model for understanding the actions of calcineurin in human cells. ..