Research Topics
Genomes and Genes
| Gerald R CrabtreeSummaryAffiliation: Stanford University Country: USA Publications
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Detail Information
Publications
Cell signaling. Nuclear actin as choreographer of cell morphology and transcriptionJiang I Wu
Howared Hughes Medical Institute and Stanford University School of Medicine, Stanford, CA 94305-5323, USA
Science 316:1710-1. 2007- NFAT signaling: choreographing the social lives of cellsGerald R Crabtree
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Cell 109:S67-79. 2002..Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell-cell interactions... 
An essential switch in subunit composition of a chromatin remodeling complex during neural developmentJulie Lessard
Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
Neuron 55:201-15. 2007..More broadly, these studies suggest that SWI/SNF-like complexes in vertebrates achieve biological specificity by combinatorial assembly of their subunits...- A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesisChing Pin Chang
Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
Cell 118:649-63. 2004..This mechanism also operates in zebrafish, indicating a conserved role for calcineurin/NFAT signaling in vertebrate heart valve morphogenesis... - Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart developmentHai Wu
Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 282:30673-9. 2007..Thus, our studies indicate that the DSCR1 gene is a direct transcriptional target of NFATc1 proteins within the endocardium during a critical window of heart valve formation... - Regulation of dendritic development by neuron-specific chromatin remodeling complexesJiang I Wu
Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
Neuron 56:94-108. 2007.... - Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulationMinggui Pan
Division of Oncology, Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
J Immunol 178:4315-21. 2007..In addition, NFATc1(nuc) destabilizes a positive feedback loop in which NFATc1 activates its own transcription as well as its targets, such as CD40 ligand and Th1/Th2 cytokines... - MicroRNA-mediated switching of chromatin-remodelling complexes in neural developmentAndrew S Yoo
Howard Hughes Medical Institute, and Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
Nature 460:642-6. 2009..Indeed, expression of REST in post-mitotic neurons led to derepression of BAF53a, indicating that REST-mediated repression of microRNAs directs the essential switch of chromatin regulatory complexes... - Calcineurin sets the bandwidth for discrimination of signals during thymocyte developmentElena M Gallo
Howard Hughes Medical Institute and the Department of Pathology, Stanford University, Stanford, California 94305, USA
Nature 450:731-5. 2007..This mechanism might be generally useful in the discrimination of graded signals that induce different cell fates... - An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotencyLena Ho
Program in Immunology, Stanford University, Stanford, CA, USA
Proc Natl Acad Sci U S A 106:5181-6. 2009.... - Selective role of NFATc3 in positive selection of thymocytesKirsten Canté-Barrett
Departments of Developmental Biology and Pathology, Howard Hughes Medical Institute, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA
J Immunol 179:103-10. 2007..In addition to NFATc3, this suggests a role for NFATc1 in T cell development. Our studies indicate that the signals that direct positive selection likely use both NFATc1 and NFATc3 downstream of calcineurin... - Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiationShih Chu Kao
Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Science 323:651-4. 2009..Our studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells... - Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte developmentTian H Chi
Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
Immunity 19:169-82. 2003..Our studies indicate that BAF complexes dynamically remodel chromatin to propel sequential developmental transitions in response to external signals... - NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21Joseph R Arron
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 441:595-600. 2006..More generally, these observations suggest that the destabilization of regulatory circuits can underlie human disease... - esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb functionLena Ho
Program in Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Cell Biol 13:903-13. 2011..Therefore, esBAF does not simply antagonize PcG. Rather, the two chromatin regulators act both antagonistically and synergistically with the common goal of supporting pluripotency... - Immunology. Decoding calcium signalingMonte M Winslow
Immunology Program, Stanford University, Stanford, CA 94305, USA
Science 307:56-7. 2005 - Identification of a polymorphic, neuron-specific chromatin remodeling complexIvan Olave
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
Genes Dev 16:2509-17. 2002..We speculate that bBAF complexes create neuronal-specific patterns of chromatin accessibility, thereby imparting new regulatory characteristics to ubiquitous sequence-specific transcription factors in neurons... - Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and functionJeremy J Heit
Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
Nature 443:345-9. 2006..Thus, calcineurin/NFAT signalling regulates multiple factors that control growth and hallmark beta-cell functions, revealing unique models for the pathogenesis and therapy of diabetes... - Conditional protein alleles using knockin mice and a chemical inducer of dimerizationKryn Stankunas
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Mol Cell 12:1615-24. 2003..Inducible stabilization could be valuable for many developmental and physiological studies and for drug target validation... - Selective role of calcineurin in haematopoiesis and lymphopoiesisElena M Gallo
Multidisciplinary Program in Immunology, Stanford University, Stanford, California, USA
EMBO Rep 9:1141-8. 2008..The requirement for calcineurin/NFAT in the development of the adaptive but not of the innate immune system is consistent with the idea that the evolutionary appearance of this pathway was involved in the emergence of vertebrates... - Neonatal β cell development in mice and humans is regulated by calcineurin/NFATWilliam R Goodyer
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Dev Cell 23:21-34. 2012..Discovery of conserved pathways regulating β cell maturation and proliferation suggests new strategies for controlling β cell growth or replacement in human islet diseases... - The calcineurin phosphatase complex modulates immunogenic B cell responsesMonte M Winslow
Program in Immunology, Stanford University, Stanford, California 94305, USA
Immunity 24:141-52. 2006..By several different criteria, calcineurin is dispensable for B cell tolerance, indicating that this phosphatase complex modulates immunogenic, but not tolerogenic, responses in vivo... - Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim [corrected]Kirsten Canté-Barrett
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, CA 94305, USA
J Immunol 176:2299-306. 2006..These results localize the decision point in positive vs negative selection to a step downstream of Ca(2+) signaling and suggest that negative selection signals induce Ca(2+)-dependent bim transcription through PKC... - Calcineurin B1 is essential for positive but not negative selection during thymocyte developmentJoel R Neilson
Department of Microbiology and Immunology, Beckman Center, Room B211, Stanford, CA 94305, USA
Immunity 20:255-66. 2004.... - Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexesTian H Chi
Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
Nature 418:195-9. 2002..These results indicate that BAF complexes contribute to lineage bifurcation by reciprocally regulating lineage-specific genes, reminiscent of the role of the yeast SWI/SNF complex in mediating mating-type switching... - Nuclear actin and actin-related proteins in chromatin remodelingIvan A Olave
Department of Developmental Biology and Department of Pathology, Howard Hughes Medical Institute at Stanford University, Stanford, California 94305, USA
Annu Rev Biochem 71:755-81. 2002.... - An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional networkLena Ho
Programs in Immunology, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 106:5187-91. 2009.... - Calcineurin/NFAT signaling in osteoblasts regulates bone massMonte M Winslow
Program in Immunology, Stanford University, Stanford, California 94305, USA
Dev Cell 10:771-82. 2006..Our results indicate that NFATc1 regulates bone mass by functioning in both osteoblasts and osteoclasts... - Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machineryChing Pin Chang
Division of Cardiovascular Medicine, Department of Medicine, Howard Hughes Medical Institute, Stanford University Medical Center, California, USA
J Clin Invest 113:1051-8. 2004..These studies also emphasize the importance of functional obstruction, resulting from developmental abnormality, in causing congenital obstructive nephropathy... - An EZ mark to missLena Ho
Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell Stem Cell 3:577-8. 2008..Recently in Molecular Cell, Shen and colleagues (2008) revealed that EZH2 is dispensable for ESC derivation and self-renewal, and that EZH1 may unexpectedly compensate for its loss... - MicroRNA-mediated conversion of human fibroblasts to neuronsAndrew S Yoo
Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
Nature 476:228-31. 2011..These studies indicate that the genetic circuitry involving miR-9/9*-124 can have an instructive role in neural fate determination... - Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axonsIsabella A Graef
Department of Developmental Biology, 300 Pasteur Drive, Stanford, CA 94305, USA
Cell 113:657-70. 2003..The precise parsing of signals for elongation turning and survival could allow independent control of these processes during development... - NFAT signaling and the invention of vertebratesHai Wu
Stanford University and the Howard Hughes Medical Institute, Department of Pathology, Beckman Center, Stanford, CA 94305, USA
Trends Cell Biol 17:251-60. 2007..We review recent evidence supporting this prediction and propose a systematic approach to explore aspects of vertebrate morphogenesis... - Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligandsKryn Stankunas
Department of Pathology, Stanford University, 279 Campus Drive, Beckman Building, Stanford, CA 94305, USA
Chembiochem 8:1162-9. 2007..Further, these results provide a collection of conditionally stable fusion partners for use in controlling protein stability... - Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activationMaximilian Diehn
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:11796-801. 2002.... - Understanding the words of chromatin regulationJiang I Wu
Howard Hughes Medical Institute, Departments of Pathology and Developmental Biology, Stanford University, Stanford, CA 94062, USA
Cell 136:200-6. 2009..Combinatorial assembly of chromatin regulatory complexes may be critical for maximizing the information content provided by arrays of histone modifications... - ATP-dependent chromatin remodeling in neural developmentAndrew S Yoo
Departments of Developmental Biology and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Curr Opin Neurobiol 19:120-6. 2009..This remodeling complex has dedicated functions at different stages of neural development that appear to arise by combinatorial assembly of its subunits... - Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3Colleen M Sheridan
Program in Immunology, Department of Molecular Pharmacology, Howard Hughes Medical Institute, California 94305, USA
J Biol Chem 277:48664-76. 2002.... - Chromatin remodelling during developmentLena Ho
Stanford University Medical School, Room B211, Beckman Center, 279 Campus Drive, Stanford, California 94305, USA
Nature 463:474-84. 2010..Particularly intriguing are the findings that specialized assemblies of ATP-dependent remodellers are essential for establishing and maintaining pluripotent and multipotent states in cells... - Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregationJason E Gestwicki
Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
Science 306:865-9. 2004..This strategy yields potent inhibitors of Abeta aggregation and could lead to therapeutics for Alzheimer's disease and other forms of neurodegeneration... - Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH geneJ Henri Bayle
Howard Hughes Medical Institute and the Department Pathology, Beckman Center for Molecular and Genetic Medicine, Stanford University, Stanford, California 94305, USA
J Biol Chem 277:28884-91. 2002..DCoH function as it pertains to HNF1 activity appears to be partially complemented by a newly identified homolog, DCoH2... - Bursting into the nucleusGerald R Crabtree
Stanford University Medical School, Stanford, CA 94305, USA
Sci Signal 1:pe54. 2008..The frequency but not the amplitude of the bursts is controlled by Ca(2+). Modulation of the frequency of the burst coordinates aspects of expression of Crz target genes... - Dynamics of inherently bounded histone modification domainsCourtney Hodges
Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 109:13296-301. 2012..Additionally, we find that to establish such domains, propagation of the histone marks must occur primarily through local contacts... - Dynamics and memory of heterochromatin in living cellsNathaniel A Hathaway
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 149:1447-60. 2012..This framework predicts the steady-state dynamics and spatial features of the majority of euchromatic H3K9me3 domains over the genome... - ATP-dependent chromatin remodeling: genetics, genomics and mechanismsDiana C Hargreaves
Howard Hughes Medical Institute, Beckman Center B211, 279 Campus Drive, Mailcode 5323, Stanford University School of Medicine, Stanford, CA 94305 5323, USA
Cell Res 21:396-420. 2011..The mechanistic bases underlying the genetic requirements for BAF and other chromatin remodelers in development and cancer are relatively unexplored and will be a focus of this review... 
Monster protein controls calcium entry and fights infectionAmy N Radermacher
Howard Hughes Medical Institute, Department of Pathology, Stanford University, Stanford, CA 94305, USA
Immunity 28:13-4. 2008..In this issue of Immunity, Matza et al. (2007) demonstrate that the huge scaffold protein, AHNAK1, interacts with L-type calcium channels, regulates Ca2+ influx, and defends against Leishmania major infection...- Lymphocyte calcium signaling from membrane to nucleusElena M Gallo
Program in Immunology, Stanford University, Stanford, California 94305, USA
Nat Immunol 7:25-32. 2006..Here we review studies of the pathways that allow Ca(2+) entry, the function of Ca(2+) in the regulation of cell polarity and motility and the principles by which Ca(2+)-dependent transcription regulates lymphocyte function... - Engineering the ABA plant stress pathway for regulation of induced proximityFu Sen Liang
Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Sci Signal 4:rs2. 2011..These properties, along with its lack of toxicity and low cost, suggest that ABA may be well suited for therapeutic applications and as an experimental tool to control diverse cellular activities in vivo... - Specific triggering of the Fas signal transduction pathway in normal human keratinocytesR A Freiberg
Veterans Administration Palo Alto Health Care System, Palo Alto, California 94304, USA
J Biol Chem 271:31666-9. 1996..These findings reveal that the Fas signal transduction pathway is active in keratinocytes, requires no induction, and dominantly overrides growth stimuli... - Three-part inventions: intracellular signaling and induced proximityG R Crabtree
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, CA 94305 5428, USA
Trends Biochem Sci 21:418-22. 1996..We discuss natural molecules that appear to have arisen to bring two proteins together and illustrate how this simple mechanism can be used to control a wide variety of biological processes... - Screening for inhibitors of an essential chromatin remodeler in mouse embryonic stem cells by monitoring transcriptional regulationEmily C Dykhuizen
Department of Pathology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
J Biomol Screen 17:1221-30. 2012..Together these data indicate that expression-based screening using qRT-PCR is a successful approach to identify compounds targeting the regulation of key developmental genes in ES cells... - Modulation of peripheral B cell tolerance by CD72 in a murine modelDaniel Hsieh Hsin Li
Stanford University School of Medicine, Stanford, California 94305, USA
Arthritis Rheum 58:3192-204. 2008..The goal of this study was to elucidate the role of CD72 in modulating B cell receptor (BCR)-mediated tolerogenic signaling and peripheral B cell tolerance... - Calcium signalling in lymphocytesMonte M Winslow
Program in Immunology and the Howard Hughes Medical Institute, Stanford University, Stanford CA 94305, USA
Curr Opin Immunol 15:299-307. 2003..In addition, recent gene profiling of T lymphocytes has identified the genes that are controlled by [Ca(2+)](i) and the Ca(2+)-dependent phosphatase calcineurin... - Exploiting protein destruction for constructive useKryn Stankunas
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 104:11511-2. 2007 - Controlling programmed cell death with a cyclophilin-cyclosporin-based chemical inducer of dimerizationP J Belshaw
Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
Chem Biol 3:731-8. 1996..We use this CID to deliver a death signal to cells expressing a fusion protein containing cyclophilin (CyP, the protein receptor for cyclosporin) and the cytoplasmic signaling domain of Fas... - Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complexOliver J Rando
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:2824-9. 2002..Based on these findings, we propose a model for PIP2 activation of actin binding by relief of intramolecular capping of actin by Brg1... - Engineering small molecule specificity in nearly identical cellular environmentsMark A Sellmyer
Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA
Bioorg Med Chem Lett 17:2703-5. 2007..These studies demonstrate that non-target proteins in an otherwise identical genetic background can be used to predictably regulate the biological activity of synthetic molecules... - Sonographic staging of the developmental status of mouse embryos in uteroChing-Pin Chang
Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA
Genesis 36:7-11. 2003..Empirically, this approach is applicable to mice of various genetic backgrounds and significantly enhances the efficiency of studying murine embryogenesis... - BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcriptionP A Khavari
Howard Hughes Medical Institute, Stanford University, California 94305
Nature 366:170-4. 1993..These results show that the SWI2 family DNA-dependent ATPase domain has functional conservation between yeast and humans and suggest that a SWI/SNF protein complex is required for the activation of selective mammalian genes... - Functional analysis of Fas signaling in vivo using synthetic inducers of dimerizationD M Spencer
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical School, California 94305, USA
Curr Biol 6:839-47. 1996..Although Fas is normally expressed on most thymocytes, negative selection seems to be unperturbed in Fas-deficient (lpr) mice. This suggests that Fas has an important function in peripheral, but not thymic, T cells... - Chemically regulated transcription factors reveal the persistence of repressor-resistant transcription after disrupting activator functionS R Biggar
Department of Developmental Biology, Stanford University Medical School, CA 94305, USA
J Biol Chem 275:25381-90. 2000.... - HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APFS Baumhueter
Howard Hughes Medical Institute, Stanford University, California 94305 5428
Genes Dev 4:372-9. 1990..These data indicate that HNF-1 is a more broadly acting transcription factor than has been indicated by previous work... - Cell signaling can direct either binary or graded transcriptional responsesS R Biggar
Department of Developmental Biology, Howard Hughes Medical Institute, Room B211, Beckman Center, 279 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305-5323, USA
EMBO J 20:3167-76. 2001..Our studies demonstrate that a given promoter can adapt either binary or graded behavior, and identify the Mig1 and Gal80 genes as necessary for binary versus graded behavior of the Gal1 promoter... - Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttlingJ Neilson
Department of Microbiology and Immunology, Stanford University Medical School, 279 Campus Drive, 94305, Stanford, CA, USA
Curr Opin Immunol 13:346-50. 2001..We summarize evidence that the cytoplasmic-to-nuclear shuttling of NF-ATc family members monitors the duration of receptor occupancy... - Evolutionary relationships among Rel domains indicate functional diversification by recombinationI A Graef
Department of Genetics, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305 5323, USA
Proc Natl Acad Sci U S A 98:5740-5. 2001.... - The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interfaceC Wulfing
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 97:10150-5. 2000..These data indicate that vav is an essential regulator of cytoskeletal rearrangements during T cell activation... - Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signalingK Zhao
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, California 94305 5323, USA
Cell 95:625-36. 1998..This work indicates that membrane signals control the activity of the mammalian SWI/SNF or BAF complex and demonstrates a direct interface between signaling and chromatin regulation... - Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transductionL J Holsinger
Department of Pathology, Howard Hughes Medical Institute, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, California 94305, USA
Curr Biol 8:563-72. 1998..We have studied the events underlying cap formation using mice bearing a null mutation in vav (vav-/-), a gene that encodes a guanine-nucleotide exchange factor for the GTPase Rac... - Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexesW Wang
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, CA 94305 5323, USA
Proc Natl Acad Sci U S A 95:492-8. 1998.... - Purification and biochemical heterogeneity of the mammalian SWI-SNF complexW Wang
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, CA 94305 5428, USA
EMBO J 15:5370-82. 1996..Certain cell lines completely lack BRG1 and hbrm, indicating that they are not essential for cell viability and that the mammalian SWI-SNF complex may be tailored to the needs of a differentiated cell type... - NF-AT components define a family of transcription factors targeted in T-cell activationJ P Northrop
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, California 94305
Nature 369:497-502. 1994..Agents that increase intracellular Ca2+ or activate protein kinase C independently modify NF-ATc, indicating that distinct signalling pathways converge on NF-ATc to regulate its function... - NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificityS N Ho
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, California 94305, USA
J Biol Chem 270:19898-907. 1995..Given the preferential expression of NFATc3 in the thymus, NFATc family members may regulate distinct subsets of genes during T cell development... - Identification of a putative regulator of early T cell activation genesJ P Shaw
Howard Hughes Medical Institute, Stanford University, CA 94305
Science 241:202-5. 1988..These characteristics suggest that NFAT-1 transmits signals initiated at the T cell antigen receptor... - Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculatureI A Graef
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Cell 105:863-75. 2001..We show that calcineurin function is transiently required between E7.5 and E8.5. Hence, early calcineurin/NFAT signaling initiates the later cross-talk between vessels and surrounding tissues that pattern the vasculature... - NFAT signaling in vertebrate developmentI A Graef
Department of Developmental Biology, Stanford University Medical School, Stanford, CA 94305, USA
Curr Opin Genet Dev 11:505-12. 2001..These speculations are borne out by studies of mice with null mutations in the different family members... - Characterization of a cofactor that regulates dimerization of a mammalian homeodomain proteinD B Mendel
Howard Hughes Medical Institute, Stanford University, CA 94305
Science 254:1762-7. 1991..These results indicate that DCoH regulates formation of transcriptionally active tetrameric complexes and may contribute to the developmental specificity of the complex... - 'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregationM Bose
Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
Biochem Soc Trans 33:543-7. 2005.... - Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3C R Beals
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
Science 275:1930-4. 1997..Because GSK-3 responds to signals initiated by Wnt and other ligands, NF-AT family members could be effectors of these pathways... - Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation controlCristina Mammucari
Department of Biochemistry, Lausanne University, Epalinges, Switzerland
Dev Cell 8:665-76. 2005..Thus, an important interconnection exists between Notch 1 and Calcineurin-NFAT pathways in keratinocyte growth/differentiation control... - Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complexTeddy T C Yang
Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
Mol Cell Biol 25:907-20. 2005..Ser(676) is also targeted by the ERK MAP kinase, which interacts with NFAT at a distinct region than RSK. Thus, integration of the ERK/RSK signaling pathway provides a mechanism to modulate NFATc4 transcription activity... - Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2Robert B Rose
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3206, USA
Biochemistry 43:7345-55. 2004..We propose that HNF1alpha binding kinetics may distinguish regulation by DCoH2, under thermodynamic control, from regulation by DCoH, under kinetic control... - Calcineurin: a central controller of signalling in eukaryotesJose Aramburu
Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Carrer Dr Aiguader 80, 08003 Barcelona, Spain
EMBO Rep 5:343-8. 2004 - Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomicsMarjorie Brand
Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Nat Struct Mol Biol 11:73-80. 2004.... - Calcineurin/Nfat signaling is required for perinatal lung maturation and functionVrushank Dave
Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Clin Invest 116:2597-609. 2006..The calcineurin/Nfat pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing... - Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophyStephanie A Parsons
Department of Pediatrics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 279:26192-200. 2004..We conclude that calcineurin expression is important during myogenesis and fiber-type switching, but not for muscle growth in response to hypertrophic stimuli... - Second messenger control of chromatin remodelingOliver J Rando
Nat Struct Biol 10:81-3. 2003 - Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurinKelvin J A Davies
Ethel Percy Andrus Gerontology Center, and Division of Molecular and Computational Biology, The University of Southern California, Los Angeles, CA 90089-0191, USA
FASEB J 21:3023-8. 2007 - Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of BimAdrian Liston
Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, 2601, Australia
Immunity 21:817-30. 2004..These findings establish defects in thymic deletion and Bim induction as a key mechanism in the pathogenesis of autoimmunity...