Gerald R Crabtree

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint NFAT signaling: choreographing the social lives of cells
    Gerald R Crabtree
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 109:S67-79. 2002
  2. ncbi request reprint Cell signaling. Nuclear actin as choreographer of cell morphology and transcription
    Jiang I Wu
    Howared Hughes Medical Institute and Stanford University School of Medicine, Stanford, CA 94305 5323, USA
    Science 316:1710-1. 2007
  3. pmc An essential switch in subunit composition of a chromatin remodeling complex during neural development
    Julie Lessard
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 55:201-15. 2007
  4. ncbi request reprint A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis
    Ching Pin Chang
    Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
    Cell 118:649-63. 2004
  5. pmc Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development
    Hai Wu
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:30673-9. 2007
  6. ncbi request reprint Regulation of dendritic development by neuron-specific chromatin remodeling complexes
    Jiang I Wu
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 56:94-108. 2007
  7. pmc MicroRNA-mediated switching of chromatin-remodelling complexes in neural development
    Andrew S Yoo
    Howard Hughes Medical Institute, and Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
    Nature 460:642-6. 2009
  8. ncbi request reprint Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulation
    Minggui Pan
    Division of Oncology, Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    J Immunol 178:4315-21. 2007
  9. ncbi request reprint Calcineurin sets the bandwidth for discrimination of signals during thymocyte development
    Elena M Gallo
    Howard Hughes Medical Institute and the Department of Pathology, Stanford University, Stanford, California 94305, USA
    Nature 450:731-5. 2007
  10. pmc BAF complexes facilitate decatenation of DNA by topoisomerase IIα
    Emily C Dykhuizen
    Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 497:624-7. 2013

Collaborators

Detail Information

Publications97

  1. ncbi request reprint NFAT signaling: choreographing the social lives of cells
    Gerald R Crabtree
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 109:S67-79. 2002
    ..Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell-cell interactions...
  2. ncbi request reprint Cell signaling. Nuclear actin as choreographer of cell morphology and transcription
    Jiang I Wu
    Howared Hughes Medical Institute and Stanford University School of Medicine, Stanford, CA 94305 5323, USA
    Science 316:1710-1. 2007
  3. pmc An essential switch in subunit composition of a chromatin remodeling complex during neural development
    Julie Lessard
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 55:201-15. 2007
    ..More broadly, these studies suggest that SWI/SNF-like complexes in vertebrates achieve biological specificity by combinatorial assembly of their subunits...
  4. ncbi request reprint A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis
    Ching Pin Chang
    Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
    Cell 118:649-63. 2004
    ..This mechanism also operates in zebrafish, indicating a conserved role for calcineurin/NFAT signaling in vertebrate heart valve morphogenesis...
  5. pmc Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development
    Hai Wu
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:30673-9. 2007
    ..Thus, our studies indicate that the DSCR1 gene is a direct transcriptional target of NFATc1 proteins within the endocardium during a critical window of heart valve formation...
  6. ncbi request reprint Regulation of dendritic development by neuron-specific chromatin remodeling complexes
    Jiang I Wu
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 56:94-108. 2007
    ....
  7. pmc MicroRNA-mediated switching of chromatin-remodelling complexes in neural development
    Andrew S Yoo
    Howard Hughes Medical Institute, and Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
    Nature 460:642-6. 2009
    ..Indeed, expression of REST in post-mitotic neurons led to derepression of BAF53a, indicating that REST-mediated repression of microRNAs directs the essential switch of chromatin regulatory complexes...
  8. ncbi request reprint Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulation
    Minggui Pan
    Division of Oncology, Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    J Immunol 178:4315-21. 2007
    ..In addition, NFATc1(nuc) destabilizes a positive feedback loop in which NFATc1 activates its own transcription as well as its targets, such as CD40 ligand and Th1/Th2 cytokines...
  9. ncbi request reprint Calcineurin sets the bandwidth for discrimination of signals during thymocyte development
    Elena M Gallo
    Howard Hughes Medical Institute and the Department of Pathology, Stanford University, Stanford, California 94305, USA
    Nature 450:731-5. 2007
    ..This mechanism might be generally useful in the discrimination of graded signals that induce different cell fates...
  10. pmc BAF complexes facilitate decatenation of DNA by topoisomerase IIα
    Emily C Dykhuizen
    Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 497:624-7. 2013
    ..These studies indicate that the ability of TOP2A to prevent DNA entanglement at mitosis requires BAF complexes and suggest that this activity contributes to the role of BAF subunits as tumour suppressors...
  11. pmc Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation
    Shih Chu Kao
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Science 323:651-4. 2009
    ..Our studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells...
  12. pmc An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency
    Lena Ho
    Program in Immunology, Stanford University, Stanford, CA, USA
    Proc Natl Acad Sci U S A 106:5181-6. 2009
    ....
  13. ncbi request reprint Selective role of NFATc3 in positive selection of thymocytes
    Kirsten Canté-Barrett
    Departments of Developmental Biology and Pathology, Howard Hughes Medical Institute, Stanford University, 279 Campus Drive, Stanford, CA 94305, USA
    J Immunol 179:103-10. 2007
    ..In addition to NFATc3, this suggests a role for NFATc1 in T cell development. Our studies indicate that the signals that direct positive selection likely use both NFATc1 and NFATc3 downstream of calcineurin...
  14. ncbi request reprint Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development
    Tian H Chi
    Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
    Immunity 19:169-82. 2003
    ..Our studies indicate that BAF complexes dynamically remodel chromatin to propel sequential developmental transitions in response to external signals...
  15. pmc esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function
    Lena Ho
    Program in Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Cell Biol 13:903-13. 2011
    ..Therefore, esBAF does not simply antagonize PcG. Rather, the two chromatin regulators act both antagonistically and synergistically with the common goal of supporting pluripotency...
  16. ncbi request reprint Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function
    Jeremy J Heit
    Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
    Nature 443:345-9. 2006
    ..Thus, calcineurin/NFAT signalling regulates multiple factors that control growth and hallmark beta-cell functions, revealing unique models for the pathogenesis and therapy of diabetes...
  17. ncbi request reprint NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
    Joseph R Arron
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 441:595-600. 2006
    ..More generally, these observations suggest that the destabilization of regulatory circuits can underlie human disease...
  18. ncbi request reprint Immunology. Decoding calcium signaling
    Monte M Winslow
    Immunology Program, Stanford University, Stanford, CA 94305, USA
    Science 307:56-7. 2005
  19. ncbi request reprint Conditional protein alleles using knockin mice and a chemical inducer of dimerization
    Kryn Stankunas
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 12:1615-24. 2003
    ..Inducible stabilization could be valuable for many developmental and physiological studies and for drug target validation...
  20. pmc Identification of a polymorphic, neuron-specific chromatin remodeling complex
    Ivan Olave
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Genes Dev 16:2509-17. 2002
    ..We speculate that bBAF complexes create neuronal-specific patterns of chromatin accessibility, thereby imparting new regulatory characteristics to ubiquitous sequence-specific transcription factors in neurons...
  21. pmc Selective role of calcineurin in haematopoiesis and lymphopoiesis
    Elena M Gallo
    Multidisciplinary Program in Immunology, Stanford University, Stanford, California, USA
    EMBO Rep 9:1141-8. 2008
    ..The requirement for calcineurin/NFAT in the development of the adaptive but not of the innate immune system is consistent with the idea that the evolutionary appearance of this pathway was involved in the emergence of vertebrates...
  22. pmc Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT
    William R Goodyer
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 23:21-34. 2012
    ..Discovery of conserved pathways regulating β cell maturation and proliferation suggests new strategies for controlling β cell growth or replacement in human islet diseases...
  23. ncbi request reprint Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim [corrected]
    Kirsten Canté-Barrett
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, CA 94305, USA
    J Immunol 176:2299-306. 2006
    ..These results localize the decision point in positive vs negative selection to a step downstream of Ca(2+) signaling and suggest that negative selection signals induce Ca(2+)-dependent bim transcription through PKC...
  24. ncbi request reprint The calcineurin phosphatase complex modulates immunogenic B cell responses
    Monte M Winslow
    Program in Immunology, Stanford University, Stanford, California 94305, USA
    Immunity 24:141-52. 2006
    ..By several different criteria, calcineurin is dispensable for B cell tolerance, indicating that this phosphatase complex modulates immunogenic, but not tolerogenic, responses in vivo...
  25. ncbi request reprint Nuclear actin and actin-related proteins in chromatin remodeling
    Ivan A Olave
    Department of Developmental Biology and Department of Pathology, Howard Hughes Medical Institute at Stanford University, Stanford, California 94305, USA
    Annu Rev Biochem 71:755-81. 2002
    ....
  26. ncbi request reprint Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
    Tian H Chi
    Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 418:195-9. 2002
    ..These results indicate that BAF complexes contribute to lineage bifurcation by reciprocally regulating lineage-specific genes, reminiscent of the role of the yeast SWI/SNF complex in mediating mating-type switching...
  27. ncbi request reprint Calcineurin B1 is essential for positive but not negative selection during thymocyte development
    Joel R Neilson
    Department of Microbiology and Immunology, Beckman Center, Room B211, Stanford, CA 94305, USA
    Immunity 20:255-66. 2004
    ....
  28. pmc Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways
    Brett T Staahl
    Department of Developmental Biology and Pathology, Stanford University Medical School, Stanford, California 94305, USA
    J Neurosci 33:10348-61. 2013
    ....
  29. pmc Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
    Cigall Kadoch
    Howard Hughes Medical Institute, Chevy Chase, Maryland, USA
    Nat Genet 45:592-601. 2013
    ..Thus, proper functioning of polymorphic BAF complexes may constitute a major mechanism of tumor suppression...
  30. pmc An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
    Lena Ho
    Programs in Immunology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:5187-91. 2009
    ....
  31. doi request reprint From neural development to cognition: unexpected roles for chromatin
    Jehnna L Ronan
    Stanford University, Stanford, California 94305, USA
    Nat Rev Genet 14:347-59. 2013
    ..We speculate on the contribution of these similar mutations to disparate disorders...
  32. ncbi request reprint Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands
    Kryn Stankunas
    Department of Pathology, Stanford University, 279 Campus Drive, Beckman Building, Stanford, CA 94305, USA
    Chembiochem 8:1162-9. 2007
    ..Further, these results provide a collection of conditionally stable fusion partners for use in controlling protein stability...
  33. ncbi request reprint NFAT signaling and the invention of vertebrates
    Hai Wu
    Stanford University and the Howard Hughes Medical Institute, Department of Pathology, Beckman Center, Stanford, CA 94305, USA
    Trends Cell Biol 17:251-60. 2007
    ..We review recent evidence supporting this prediction and propose a systematic approach to explore aspects of vertebrate morphogenesis...
  34. pmc Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery
    Ching Pin Chang
    Division of Cardiovascular Medicine, Department of Medicine, Howard Hughes Medical Institute, Stanford University Medical Center, California, USA
    J Clin Invest 113:1051-8. 2004
    ..These studies also emphasize the importance of functional obstruction, resulting from developmental abnormality, in causing congenital obstructive nephropathy...
  35. ncbi request reprint Calcineurin/NFAT signaling in osteoblasts regulates bone mass
    Monte M Winslow
    Program in Immunology, Stanford University, Stanford, California 94305, USA
    Dev Cell 10:771-82. 2006
    ..Our results indicate that NFATc1 regulates bone mass by functioning in both osteoblasts and osteoclasts...
  36. pmc Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation
    Maximilian Diehn
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:11796-801. 2002
    ....
  37. ncbi request reprint Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons
    Isabella A Graef
    Department of Developmental Biology, 300 Pasteur Drive, Stanford, CA 94305, USA
    Cell 113:657-70. 2003
    ..The precise parsing of signals for elongation turning and survival could allow independent control of these processes during development...
  38. pmc An EZ mark to miss
    Lena Ho
    Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stem Cell 3:577-8. 2008
    ..Recently in Molecular Cell, Shen and colleagues (2008) revealed that EZH2 is dispensable for ESC derivation and self-renewal, and that EZH1 may unexpectedly compensate for its loss...
  39. pmc MicroRNA-mediated conversion of human fibroblasts to neurons
    Andrew S Yoo
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
    Nature 476:228-31. 2011
    ..These studies indicate that the genetic circuitry involving miR-9/9*-124 can have an instructive role in neural fate determination...
  40. doi request reprint MicroRNAs: regulators of neuronal fate
    Alfred X Sun
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Curr Opin Cell Biol 25:215-21. 2013
    ..Here we discuss some of the recent findings about microRNAs' activity in regulating various developmental stages of neurons...
  41. pmc Chromatin remodelling during development
    Lena Ho
    Stanford University Medical School, Room B211, Beckman Center, 279 Campus Drive, Stanford, California 94305, USA
    Nature 463:474-84. 2010
    ..Particularly intriguing are the findings that specialized assemblies of ATP-dependent remodellers are essential for establishing and maintaining pluripotent and multipotent states in cells...
  42. pmc Understanding the words of chromatin regulation
    Jiang I Wu
    Howard Hughes Medical Institute, Departments of Pathology and Developmental Biology, Stanford University, Stanford, CA 94062, USA
    Cell 136:200-6. 2009
    ..Combinatorial assembly of chromatin regulatory complexes may be critical for maximizing the information content provided by arrays of histone modifications...
  43. ncbi request reprint Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3
    Colleen M Sheridan
    Program in Immunology, Department of Molecular Pharmacology, Howard Hughes Medical Institute, California 94305, USA
    J Biol Chem 277:48664-76. 2002
    ....
  44. pmc ATP-dependent chromatin remodeling in neural development
    Andrew S Yoo
    Departments of Developmental Biology and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Curr Opin Neurobiol 19:120-6. 2009
    ..This remodeling complex has dedicated functions at different stages of neural development that appear to arise by combinatorial assembly of its subunits...
  45. pmc ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4
    Xiaomin Bao
    Program in Epithelial Biology, Stanford University, Stanford, CA 94305, USA
    Cell Stem Cell 12:193-203. 2013
    ..Thus, ACTL6a controls the epidermal progenitor state by sequestering SWI/SNF to prevent activation of differentiation programs...
  46. ncbi request reprint Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation
    Jason E Gestwicki
    Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
    Science 306:865-9. 2004
    ..This strategy yields potent inhibitors of Abeta aggregation and could lead to therapeutics for Alzheimer's disease and other forms of neurodegeneration...
  47. pmc Bursting into the nucleus
    Gerald R Crabtree
    Stanford University Medical School, Stanford, CA 94305, USA
    Sci Signal 1:pe54. 2008
    ..The frequency but not the amplitude of the bursts is controlled by Ca(2+). Modulation of the frequency of the burst coordinates aspects of expression of Crz target genes...
  48. ncbi request reprint Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH gene
    J Henri Bayle
    Howard Hughes Medical Institute and the Department Pathology, Beckman Center for Molecular and Genetic Medicine, Stanford University, Stanford, California 94305, USA
    J Biol Chem 277:28884-91. 2002
    ..DCoH function as it pertains to HNF1 activity appears to be partially complemented by a newly identified homolog, DCoH2...
  49. pmc Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma
    Cigall Kadoch
    Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 153:71-85. 2013
    ..This mechanism of transformation depends on only two amino acids of SSX, providing a potential foundation for therapeutic intervention...
  50. pmc Dynamics and memory of heterochromatin in living cells
    Nathaniel A Hathaway
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 149:1447-60. 2012
    ..This framework predicts the steady-state dynamics and spatial features of the majority of euchromatic H3K9me3 domains over the genome...
  51. pmc Dynamics of inherently bounded histone modification domains
    Courtney Hodges
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:13296-301. 2012
    ..Additionally, we find that to establish such domains, propagation of the histone marks must occur primarily through local contacts...
  52. doi request reprint Monster protein controls calcium entry and fights infection
    Amy N Radermacher
    Howard Hughes Medical Institute, Department of Pathology, Stanford University, Stanford, CA 94305, USA
    Immunity 28:13-4. 2008
    ..In this issue of Immunity, Matza et al. (2007) demonstrate that the huge scaffold protein, AHNAK1, interacts with L-type calcium channels, regulates Ca2+ influx, and defends against Leishmania major infection...
  53. ncbi request reprint Lymphocyte calcium signaling from membrane to nucleus
    Elena M Gallo
    Program in Immunology, Stanford University, Stanford, California 94305, USA
    Nat Immunol 7:25-32. 2006
    ..Here we review studies of the pathways that allow Ca(2+) entry, the function of Ca(2+) in the regulation of cell polarity and motility and the principles by which Ca(2+)-dependent transcription regulates lymphocyte function...
  54. pmc ATP-dependent chromatin remodeling: genetics, genomics and mechanisms
    Diana C Hargreaves
    Howard Hughes Medical Institute, Beckman Center B211, 279 Campus Drive, Mailcode 5323, Stanford University School of Medicine, Stanford, CA 94305 5323, USA
    Cell Res 21:396-420. 2011
    ..The mechanistic bases underlying the genetic requirements for BAF and other chromatin remodelers in development and cancer are relatively unexplored and will be a focus of this review...
  55. pmc Engineering the ABA plant stress pathway for regulation of induced proximity
    Fu Sen Liang
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Sci Signal 4:rs2. 2011
    ..These properties, along with its lack of toxicity and low cost, suggest that ABA may be well suited for therapeutic applications and as an experimental tool to control diverse cellular activities in vivo...
  56. ncbi request reprint Three-part inventions: intracellular signaling and induced proximity
    G R Crabtree
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, CA 94305 5428, USA
    Trends Biochem Sci 21:418-22. 1996
    ..We discuss natural molecules that appear to have arisen to bring two proteins together and illustrate how this simple mechanism can be used to control a wide variety of biological processes...
  57. ncbi request reprint Specific triggering of the Fas signal transduction pathway in normal human keratinocytes
    R A Freiberg
    Veterans Administration Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Biol Chem 271:31666-9. 1996
    ..These findings reveal that the Fas signal transduction pathway is active in keratinocytes, requires no induction, and dominantly overrides growth stimuli...
  58. pmc Exome sequencing to identify de novo mutations in sporadic ALS trios
    Alessandra Chesi
    Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
    Nat Neurosci 16:851-5. 2013
    ..These findings expand our understanding of the ALS genetic landscape and provide a resource for future studies into the pathogenic mechanisms contributing to sporadic ALS. ..
  59. ncbi request reprint Screening for inhibitors of an essential chromatin remodeler in mouse embryonic stem cells by monitoring transcriptional regulation
    Emily C Dykhuizen
    Department of Pathology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Biomol Screen 17:1221-30. 2012
    ..Together these data indicate that expression-based screening using qRT-PCR is a successful approach to identify compounds targeting the regulation of key developmental genes in ES cells...
  60. pmc Exploiting protein destruction for constructive use
    Kryn Stankunas
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:11511-2. 2007
  61. pmc Modulation of peripheral B cell tolerance by CD72 in a murine model
    Daniel Hsieh Hsin Li
    Stanford University School of Medicine, Stanford, California 94305, USA
    Arthritis Rheum 58:3192-204. 2008
    ..The goal of this study was to elucidate the role of CD72 in modulating B cell receptor (BCR)-mediated tolerogenic signaling and peripheral B cell tolerance...
  62. ncbi request reprint Calcium signalling in lymphocytes
    Monte M Winslow
    Program in Immunology and the Howard Hughes Medical Institute, Stanford University, Stanford CA 94305, USA
    Curr Opin Immunol 15:299-307. 2003
    ..In addition, recent gene profiling of T lymphocytes has identified the genes that are controlled by [Ca(2+)](i) and the Ca(2+)-dependent phosphatase calcineurin...
  63. ncbi request reprint Controlling programmed cell death with a cyclophilin-cyclosporin-based chemical inducer of dimerization
    P J Belshaw
    Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Chem Biol 3:731-8. 1996
    ..We use this CID to deliver a death signal to cells expressing a fusion protein containing cyclophilin (CyP, the protein receptor for cyclosporin) and the cytoplasmic signaling domain of Fas...
  64. doi request reprint Reprogramming human fibroblasts to neurons by recapitulating an essential microRNA-chromatin switch
    Jiong Tang
    Howard Hughes Medical Institute, Department of Pathology and Developmental Biology, Stanford University Medical School, Stanford, CA 94305, USA
    Curr Opin Genet Dev 23:591-8. 2013
    ..We review how this switch in ATP-dependent chromatin complexes might interface with traditional ideas about neural determination and reprogramming. ..
  65. pmc Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex
    Oliver J Rando
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:2824-9. 2002
    ..Based on these findings, we propose a model for PIP2 activation of actin binding by relief of intramolecular capping of actin by Brg1...
  66. pmc Engineering small molecule specificity in nearly identical cellular environments
    Mark A Sellmyer
    Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA
    Bioorg Med Chem Lett 17:2703-5. 2007
    ..These studies demonstrate that non-target proteins in an otherwise identical genetic background can be used to predictably regulate the biological activity of synthetic molecules...
  67. ncbi request reprint Sonographic staging of the developmental status of mouse embryos in utero
    Ching Pin Chang
    Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA
    Genesis 36:7-11. 2003
    ..Empirically, this approach is applicable to mice of various genetic backgrounds and significantly enhances the efficiency of studying murine embryogenesis...
  68. ncbi request reprint Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization
    D M Spencer
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical School, California 94305, USA
    Curr Biol 6:839-47. 1996
    ..Although Fas is normally expressed on most thymocytes, negative selection seems to be unperturbed in Fas-deficient (lpr) mice. This suggests that Fas has an important function in peripheral, but not thymic, T cells...
  69. ncbi request reprint Chemically regulated transcription factors reveal the persistence of repressor-resistant transcription after disrupting activator function
    S R Biggar
    Department of Developmental Biology, Stanford University Medical School, CA 94305, USA
    J Biol Chem 275:25381-90. 2000
    ....
  70. ncbi request reprint BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription
    P A Khavari
    Howard Hughes Medical Institute, Stanford University, California 94305
    Nature 366:170-4. 1993
    ..These results show that the SWI2 family DNA-dependent ATPase domain has functional conservation between yeast and humans and suggest that a SWI/SNF protein complex is required for the activation of selective mammalian genes...
  71. pmc Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes
    W Wang
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, CA 94305 5323, USA
    Proc Natl Acad Sci U S A 95:492-8. 1998
    ....
  72. ncbi request reprint HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF
    S Baumhueter
    Howard Hughes Medical Institute, Stanford University, California 94305 5428
    Genes Dev 4:372-9. 1990
    ..These data indicate that HNF-1 is a more broadly acting transcription factor than has been indicated by previous work...
  73. pmc Cell signaling can direct either binary or graded transcriptional responses
    S R Biggar
    Department of Developmental Biology, Howard Hughes Medical Institute, Room B211, Beckman Center, 279 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305-5323, USA
    EMBO J 20:3167-76. 2001
    ..Our studies demonstrate that a given promoter can adapt either binary or graded behavior, and identify the Mig1 and Gal80 genes as necessary for binary versus graded behavior of the Gal1 promoter...
  74. ncbi request reprint Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling
    J Neilson
    Department of Microbiology and Immunology, Stanford University Medical School, 279 Campus Drive, 94305, Stanford, CA, USA
    Curr Opin Immunol 13:346-50. 2001
    ..We summarize evidence that the cytoplasmic-to-nuclear shuttling of NF-ATc family members monitors the duration of receptor occupancy...
  75. pmc Evolutionary relationships among Rel domains indicate functional diversification by recombination
    I A Graef
    Department of Genetics, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305 5323, USA
    Proc Natl Acad Sci U S A 98:5740-5. 2001
    ....
  76. pmc The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface
    C Wulfing
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 97:10150-5. 2000
    ..These data indicate that vav is an essential regulator of cytoskeletal rearrangements during T cell activation...
  77. ncbi request reprint Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling
    K Zhao
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, California 94305 5323, USA
    Cell 95:625-36. 1998
    ..This work indicates that membrane signals control the activity of the mammalian SWI/SNF or BAF complex and demonstrates a direct interface between signaling and chromatin regulation...
  78. ncbi request reprint Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
    L J Holsinger
    Department of Pathology, Howard Hughes Medical Institute, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, California 94305, USA
    Curr Biol 8:563-72. 1998
    ..We have studied the events underlying cap formation using mice bearing a null mutation in vav (vav-/-), a gene that encodes a guanine-nucleotide exchange factor for the GTPase Rac...
  79. ncbi request reprint Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
    C R Beals
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Science 275:1930-4. 1997
    ..Because GSK-3 responds to signals initiated by Wnt and other ligands, NF-AT family members could be effectors of these pathways...
  80. pmc Purification and biochemical heterogeneity of the mammalian SWI-SNF complex
    W Wang
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, CA 94305 5428, USA
    EMBO J 15:5370-82. 1996
    ..Certain cell lines completely lack BRG1 and hbrm, indicating that they are not essential for cell viability and that the mammalian SWI-SNF complex may be tailored to the needs of a differentiated cell type...
  81. ncbi request reprint NF-AT components define a family of transcription factors targeted in T-cell activation
    J P Northrop
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, California 94305
    Nature 369:497-502. 1994
    ..Agents that increase intracellular Ca2+ or activate protein kinase C independently modify NF-ATc, indicating that distinct signalling pathways converge on NF-ATc to regulate its function...
  82. ncbi request reprint NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity
    S N Ho
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, California 94305, USA
    J Biol Chem 270:19898-907. 1995
    ..Given the preferential expression of NFATc3 in the thymus, NFATc family members may regulate distinct subsets of genes during T cell development...
  83. ncbi request reprint Identification of a putative regulator of early T cell activation genes
    J P Shaw
    Howard Hughes Medical Institute, Stanford University, CA 94305
    Science 241:202-5. 1988
    ..These characteristics suggest that NFAT-1 transmits signals initiated at the T cell antigen receptor...
  84. ncbi request reprint Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature
    I A Graef
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 105:863-75. 2001
    ..We show that calcineurin function is transiently required between E7.5 and E8.5. Hence, early calcineurin/NFAT signaling initiates the later cross-talk between vessels and surrounding tissues that pattern the vasculature...
  85. ncbi request reprint NFAT signaling in vertebrate development
    I A Graef
    Department of Developmental Biology, Stanford University Medical School, Stanford, CA 94305, USA
    Curr Opin Genet Dev 11:505-12. 2001
    ..These speculations are borne out by studies of mice with null mutations in the different family members...
  86. ncbi request reprint Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein
    D B Mendel
    Howard Hughes Medical Institute, Stanford University, CA 94305
    Science 254:1762-7. 1991
    ..These results indicate that DCoH regulates formation of transcriptionally active tetrameric complexes and may contribute to the developmental specificity of the complex...
  87. ncbi request reprint 'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation
    M Bose
    Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
    Biochem Soc Trans 33:543-7. 2005
    ....
  88. ncbi request reprint Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics
    Marjorie Brand
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nat Struct Mol Biol 11:73-80. 2004
    ....
  89. pmc Calcineurin: a central controller of signalling in eukaryotes
    Jose Aramburu
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Carrer Dr Aiguader 80, 08003 Barcelona, Spain
    EMBO Rep 5:343-8. 2004
  90. pmc Calcineurin/Nfat signaling is required for perinatal lung maturation and function
    Vrushank Dave
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:2597-609. 2006
    ..The calcineurin/Nfat pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing...
  91. ncbi request reprint Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2
    Robert B Rose
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3206, USA
    Biochemistry 43:7345-55. 2004
    ..We propose that HNF1alpha binding kinetics may distinguish regulation by DCoH2, under thermodynamic control, from regulation by DCoH, under kinetic control...
  92. pmc Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complex
    Teddy T C Yang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 25:907-20. 2005
    ..Ser(676) is also targeted by the ERK MAP kinase, which interacts with NFAT at a distinct region than RSK. Thus, integration of the ERK/RSK signaling pathway provides a mechanism to modulate NFATc4 transcription activity...
  93. ncbi request reprint Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control
    Cristina Mammucari
    Department of Biochemistry, Lausanne University, Epalinges, Switzerland
    Dev Cell 8:665-76. 2005
    ..Thus, an important interconnection exists between Notch 1 and Calcineurin-NFAT pathways in keratinocyte growth/differentiation control...
  94. ncbi request reprint Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim
    Adrian Liston
    Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, 2601, Australia
    Immunity 21:817-30. 2004
    ..These findings establish defects in thymic deletion and Bim induction as a key mechanism in the pathogenesis of autoimmunity...
  95. ncbi request reprint Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy
    Stephanie A Parsons
    Department of Pediatrics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 279:26192-200. 2004
    ..We conclude that calcineurin expression is important during myogenesis and fiber-type switching, but not for muscle growth in response to hypertrophic stimuli...
  96. ncbi request reprint Second messenger control of chromatin remodeling
    Oliver J Rando
    Nat Struct Biol 10:81-3. 2003
  97. ncbi request reprint Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin
    Kelvin J A Davies
    Ethel Percy Andrus Gerontology Center, and Division of Molecular and Computational Biology, The University of Southern California, Los Angeles, CA 90089 0191, USA
    FASEB J 21:3023-8. 2007