Research Topics
| Gerald CrabtreeSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Our fragile intellect. Part IIGerald R Crabtree
Beckman Center, B211, Stanford University, Stanford, CA 94305, USA
Trends Genet 29:3-5. 2013..If so, how did we get them in the first place, and when did things begin to change?..- Our fragile intellect. Part IGerald R Crabtree
Beckman Center, B211, Stanford University, Stanford, CA 94305, USA
Trends Genet 29:1-3. 2013..New developments in genetics, anthropology, and neurobiology predict that a very large number of genes underlie our intellectual and emotional abilities, making these abilities genetically surprisingly fragile... 
Calcium signalling in lymphocytesMonte M Winslow
Program in Immunology and the Howard Hughes Medical Institute, Stanford University, Stanford CA 94305, USA
Curr Opin Immunol 15:299-307. 2003..In addition, recent gene profiling of T lymphocytes has identified the genes that are controlled by [Ca(2+)](i) and the Ca(2+)-dependent phosphatase calcineurin...- Cell signaling. Nuclear actin as choreographer of cell morphology and transcriptionJiang I Wu
Howared Hughes Medical Institute and Stanford University School of Medicine, Stanford, CA 94305-5323, USA
Science 316:1710-1. 2007 
ATP-dependent chromatin remodeling in neural developmentAndrew S Yoo
Departments of Developmental Biology and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Curr Opin Neurobiol 19:120-6. 2009..This remodeling complex has dedicated functions at different stages of neural development that appear to arise by combinatorial assembly of its subunits...- Nuclear actin and actin-related proteins in chromatin remodelingIvan A Olave
Department of Developmental Biology and Department of Pathology, Howard Hughes Medical Institute at Stanford University, Stanford, California 94305, USA
Annu Rev Biochem 71:755-81. 2002.... - NFAT signaling: choreographing the social lives of cellsGerald R Crabtree
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Cell 109:S67-79. 2002..Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell-cell interactions... - A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesisChing Pin Chang
Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
Cell 118:649-63. 2004..This mechanism also operates in zebrafish, indicating a conserved role for calcineurin/NFAT signaling in vertebrate heart valve morphogenesis... - Immunology. Decoding calcium signalingMonte M Winslow
Immunology Program, Stanford University, Stanford, CA 94305, USA
Science 307:56-7. 2005 - Regulation of dendritic development by neuron-specific chromatin remodeling complexesJiang I Wu
Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
Neuron 56:94-108. 2007.... - Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation controlCristina Mammucari
Department of Biochemistry, Lausanne University, Epalinges, Switzerland
Dev Cell 8:665-76. 2005..Thus, an important interconnection exists between Notch 1 and Calcineurin-NFAT pathways in keratinocyte growth/differentiation control... - Lymphocyte calcium signaling from membrane to nucleusElena M Gallo
Program in Immunology, Stanford University, Stanford, California 94305, USA
Nat Immunol 7:25-32. 2006..Here we review studies of the pathways that allow Ca(2+) entry, the function of Ca(2+) in the regulation of cell polarity and motility and the principles by which Ca(2+)-dependent transcription regulates lymphocyte function... - Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim [corrected]Kirsten Canté-Barrett
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, CA 94305, USA
J Immunol 176:2299-306. 2006..These results localize the decision point in positive vs negative selection to a step downstream of Ca(2+) signaling and suggest that negative selection signals induce Ca(2+)-dependent bim transcription through PKC... - Calcineurin/Nfat signaling is required for perinatal lung maturation and functionVrushank Dave
Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Clin Invest 116:2597-609. 2006..The calcineurin/Nfat pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing... - NFAT signaling and the invention of vertebratesHai Wu
Stanford University and the Howard Hughes Medical Institute, Department of Pathology, Beckman Center, Stanford, CA 94305, USA
Trends Cell Biol 17:251-60. 2007..We review recent evidence supporting this prediction and propose a systematic approach to explore aspects of vertebrate morphogenesis... - Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2Robert B Rose
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3206, USA
Biochemistry 43:7345-55. 2004..We propose that HNF1alpha binding kinetics may distinguish regulation by DCoH2, under thermodynamic control, from regulation by DCoH, under kinetic control... - Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complexTeddy T C Yang
Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
Mol Cell Biol 25:907-20. 2005..Ser(676) is also targeted by the ERK MAP kinase, which interacts with NFAT at a distinct region than RSK. Thus, integration of the ERK/RSK signaling pathway provides a mechanism to modulate NFATc4 transcription activity... - Calcineurin: a central controller of signalling in eukaryotesJose Aramburu
Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Carrer Dr Aiguader 80, 08003 Barcelona, Spain
EMBO Rep 5:343-8. 2004 - Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexesTian H Chi
Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
Nature 418:195-9. 2002..These results indicate that BAF complexes contribute to lineage bifurcation by reciprocally regulating lineage-specific genes, reminiscent of the role of the yeast SWI/SNF complex in mediating mating-type switching... - Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activationMaximilian Diehn
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:11796-801. 2002.... - Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3Colleen M Sheridan
Program in Immunology, Department of Molecular Pharmacology, Howard Hughes Medical Institute, California 94305, USA
J Biol Chem 277:48664-76. 2002.... - Identification of a polymorphic, neuron-specific chromatin remodeling complexIvan Olave
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
Genes Dev 16:2509-17. 2002..We speculate that bBAF complexes create neuronal-specific patterns of chromatin accessibility, thereby imparting new regulatory characteristics to ubiquitous sequence-specific transcription factors in neurons... - Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH geneJ Henri Bayle
Howard Hughes Medical Institute and the Department Pathology, Beckman Center for Molecular and Genetic Medicine, Stanford University, Stanford, California 94305, USA
J Biol Chem 277:28884-91. 2002..DCoH function as it pertains to HNF1 activity appears to be partially complemented by a newly identified homolog, DCoH2... - Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axonsIsabella A Graef
Department of Developmental Biology, 300 Pasteur Drive, Stanford, CA 94305, USA
Cell 113:657-70. 2003..The precise parsing of signals for elongation turning and survival could allow independent control of these processes during development... - Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complexOliver J Rando
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:2824-9. 2002..Based on these findings, we propose a model for PIP2 activation of actin binding by relief of intramolecular capping of actin by Brg1... - Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomicsMarjorie Brand
Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Nat Struct Mol Biol 11:73-80. 2004.... - Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte developmentTian H Chi
Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
Immunity 19:169-82. 2003..Our studies indicate that BAF complexes dynamically remodel chromatin to propel sequential developmental transitions in response to external signals... - Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machineryChing Pin Chang
Division of Cardiovascular Medicine, Department of Medicine, Howard Hughes Medical Institute, Stanford University Medical Center, California, USA
J Clin Invest 113:1051-8. 2004..These studies also emphasize the importance of functional obstruction, resulting from developmental abnormality, in causing congenital obstructive nephropathy... - Monster protein controls calcium entry and fights infectionAmy N Radermacher
Howard Hughes Medical Institute, Department of Pathology, Stanford University, Stanford, CA 94305, USA
Immunity 28:13-4. 2008..In this issue of Immunity, Matza et al. (2007) demonstrate that the huge scaffold protein, AHNAK1, interacts with L-type calcium channels, regulates Ca2+ influx, and defends against Leishmania major infection... - Calcineurin sets the bandwidth for discrimination of signals during thymocyte developmentElena M Gallo
Howard Hughes Medical Institute and the Department of Pathology, Stanford University, Stanford, California 94305, USA
Nature 450:731-5. 2007..This mechanism might be generally useful in the discrimination of graded signals that induce different cell fates... - Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of BimAdrian Liston
Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, 2601, Australia
Immunity 21:817-30. 2004..These findings establish defects in thymic deletion and Bim induction as a key mechanism in the pathogenesis of autoimmunity... - Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophyStephanie A Parsons
Department of Pediatrics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 279:26192-200. 2004..We conclude that calcineurin expression is important during myogenesis and fiber-type switching, but not for muscle growth in response to hypertrophic stimuli... - Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart developmentHai Wu
Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 282:30673-9. 2007..Thus, our studies indicate that the DSCR1 gene is a direct transcriptional target of NFATc1 proteins within the endocardium during a critical window of heart valve formation... - An essential switch in subunit composition of a chromatin remodeling complex during neural developmentJulie Lessard
Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
Neuron 55:201-15. 2007..More broadly, these studies suggest that SWI/SNF-like complexes in vertebrates achieve biological specificity by combinatorial assembly of their subunits... - Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurinKelvin J A Davies
Ethel Percy Andrus Gerontology Center, and Division of Molecular and Computational Biology, The University of Southern California, Los Angeles, CA 90089-0191, USA
FASEB J 21:3023-8. 2007 - Calcineurin B1 is essential for positive but not negative selection during thymocyte developmentJoel R Neilson
Department of Microbiology and Immunology, Beckman Center, Room B211, Stanford, CA 94305, USA
Immunity 20:255-66. 2004.... - Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulationMinggui Pan
Division of Oncology, Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
J Immunol 178:4315-21. 2007..In addition, NFATc1(nuc) destabilizes a positive feedback loop in which NFATc1 activates its own transcription as well as its targets, such as CD40 ligand and Th1/Th2 cytokines... - Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and functionJeremy J Heit
Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
Nature 443:345-9. 2006..Thus, calcineurin/NFAT signalling regulates multiple factors that control growth and hallmark beta-cell functions, revealing unique models for the pathogenesis and therapy of diabetes... - Calcineurin/NFAT signaling in osteoblasts regulates bone massMonte M Winslow
Program in Immunology, Stanford University, Stanford, California 94305, USA
Dev Cell 10:771-82. 2006..Our results indicate that NFATc1 regulates bone mass by functioning in both osteoblasts and osteoclasts... - NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21Joseph R Arron
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 441:595-600. 2006..More generally, these observations suggest that the destabilization of regulatory circuits can underlie human disease... - The calcineurin phosphatase complex modulates immunogenic B cell responsesMonte M Winslow
Program in Immunology, Stanford University, Stanford, California 94305, USA
Immunity 24:141-52. 2006..By several different criteria, calcineurin is dispensable for B cell tolerance, indicating that this phosphatase complex modulates immunogenic, but not tolerogenic, responses in vivo... - Second messenger control of chromatin remodelingOliver J Rando
Nat Struct Biol 10:81-3. 2003
Research Grants
- NFAT Signaling and Down SyndromeGerald R Crabtree; Fiscal Year: 2010..We will test this hypothesis and if correct find molecule that correct the balance and thereby develop new treatments for some of the disabling characteristics of Down Syndrome. ..
- ATP-dependent Chromatin Remodeling in Neural DevelopmentGerald Crabtree; Fiscal Year: 2009..Our studies might provide new avenues for the production of tissues and cells for regeneration of diseased or damaged tissues. ..
- ATP-dependent Chromatin Remodeling in Neural DevelopmentGerald R Crabtree; Fiscal Year: 2010..Our studies might provide new avenues for the production of tissues and cells for regeneration of diseased or damaged tissues. ..
- Signaling by Calcineurin and NFAT in Axonal OutgrowthGerald Crabtree; Fiscal Year: 2007..We believe that this pathway, its target genes and its many modulators will be a rich source of new molecules for therapeutic intervention in neurologic diseases. ..
- Signaling in T Lymphocyte DevelopmentGerald Crabtree; Fiscal Year: 2007..Defining these mechanisms should lead to a more complete understanding of immune defense and provide useful information for development of new therapies. ..
- Mechanisms of Vascular DevelopmentGerald Crabtree; Fiscal Year: 2004..The expression profile of candidate genes will be studied using in situ hybridization, and their functions will be studied with various in vitro angiogenesis assays. ..
- Signaling in Thymocyte SelectionGerald R Crabtree; Fiscal Year: 2010..O -'' :6O a"0-5)'' Q.. C^' ::9 4-- >,O E-- o-0 >-O c(6 fl.. 0)0-0_0 .- ((D 1/. o0' :t- can --0 a)- 4)a) 0-Q iii= L"- -P) .-.. (II o( 'nom 0-a ..