Gerald Crabtree

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint Our fragile intellect. Part II
    Gerald R Crabtree
    Beckman Center, B211, Stanford University, Stanford, CA 94305, USA
    Trends Genet 29:3-5. 2013
  2. doi request reprint Our fragile intellect. Part I
    Gerald R Crabtree
    Beckman Center, B211, Stanford University, Stanford, CA 94305, USA
    Trends Genet 29:1-3. 2013
  3. ncbi request reprint Calcium signalling in lymphocytes
    Monte M Winslow
    Program in Immunology and the Howard Hughes Medical Institute, Stanford University, Stanford CA 94305, USA
    Curr Opin Immunol 15:299-307. 2003
  4. ncbi request reprint Cell signaling. Nuclear actin as choreographer of cell morphology and transcription
    Jiang I Wu
    Howared Hughes Medical Institute and Stanford University School of Medicine, Stanford, CA 94305 5323, USA
    Science 316:1710-1. 2007
  5. pmc ATP-dependent chromatin remodeling in neural development
    Andrew S Yoo
    Departments of Developmental Biology and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Curr Opin Neurobiol 19:120-6. 2009
  6. ncbi request reprint Nuclear actin and actin-related proteins in chromatin remodeling
    Ivan A Olave
    Department of Developmental Biology and Department of Pathology, Howard Hughes Medical Institute at Stanford University, Stanford, California 94305, USA
    Annu Rev Biochem 71:755-81. 2002
  7. ncbi request reprint NFAT signaling: choreographing the social lives of cells
    Gerald R Crabtree
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 109:S67-79. 2002
  8. ncbi request reprint A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis
    Ching Pin Chang
    Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
    Cell 118:649-63. 2004
  9. ncbi request reprint Immunology. Decoding calcium signaling
    Monte M Winslow
    Immunology Program, Stanford University, Stanford, CA 94305, USA
    Science 307:56-7. 2005
  10. ncbi request reprint Regulation of dendritic development by neuron-specific chromatin remodeling complexes
    Jiang I Wu
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 56:94-108. 2007

Research Grants

  1. NFAT Signaling and Down Syndrome
    Gerald R Crabtree; Fiscal Year: 2010
  2. ATP-dependent Chromatin Remodeling in Neural Development
    Gerald Crabtree; Fiscal Year: 2009
  3. ATP-dependent Chromatin Remodeling in Neural Development
    Gerald R Crabtree; Fiscal Year: 2010
  4. Signaling by Calcineurin and NFAT in Axonal Outgrowth
    Gerald Crabtree; Fiscal Year: 2007
  5. Signaling in T Lymphocyte Development
    Gerald Crabtree; Fiscal Year: 2007
  6. Mechanisms of Vascular Development
    Gerald Crabtree; Fiscal Year: 2004
  7. Signaling in Thymocyte Selection
    Gerald R Crabtree; Fiscal Year: 2010

Collaborators

Detail Information

Publications42

  1. doi request reprint Our fragile intellect. Part II
    Gerald R Crabtree
    Beckman Center, B211, Stanford University, Stanford, CA 94305, USA
    Trends Genet 29:3-5. 2013
    ..If so, how did we get them in the first place, and when did things begin to change?..
  2. doi request reprint Our fragile intellect. Part I
    Gerald R Crabtree
    Beckman Center, B211, Stanford University, Stanford, CA 94305, USA
    Trends Genet 29:1-3. 2013
    ..New developments in genetics, anthropology, and neurobiology predict that a very large number of genes underlie our intellectual and emotional abilities, making these abilities genetically surprisingly fragile...
  3. ncbi request reprint Calcium signalling in lymphocytes
    Monte M Winslow
    Program in Immunology and the Howard Hughes Medical Institute, Stanford University, Stanford CA 94305, USA
    Curr Opin Immunol 15:299-307. 2003
    ..In addition, recent gene profiling of T lymphocytes has identified the genes that are controlled by [Ca(2+)](i) and the Ca(2+)-dependent phosphatase calcineurin...
  4. ncbi request reprint Cell signaling. Nuclear actin as choreographer of cell morphology and transcription
    Jiang I Wu
    Howared Hughes Medical Institute and Stanford University School of Medicine, Stanford, CA 94305 5323, USA
    Science 316:1710-1. 2007
  5. pmc ATP-dependent chromatin remodeling in neural development
    Andrew S Yoo
    Departments of Developmental Biology and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Curr Opin Neurobiol 19:120-6. 2009
    ..This remodeling complex has dedicated functions at different stages of neural development that appear to arise by combinatorial assembly of its subunits...
  6. ncbi request reprint Nuclear actin and actin-related proteins in chromatin remodeling
    Ivan A Olave
    Department of Developmental Biology and Department of Pathology, Howard Hughes Medical Institute at Stanford University, Stanford, California 94305, USA
    Annu Rev Biochem 71:755-81. 2002
    ....
  7. ncbi request reprint NFAT signaling: choreographing the social lives of cells
    Gerald R Crabtree
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 109:S67-79. 2002
    ..Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell-cell interactions...
  8. ncbi request reprint A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis
    Ching Pin Chang
    Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
    Cell 118:649-63. 2004
    ..This mechanism also operates in zebrafish, indicating a conserved role for calcineurin/NFAT signaling in vertebrate heart valve morphogenesis...
  9. ncbi request reprint Immunology. Decoding calcium signaling
    Monte M Winslow
    Immunology Program, Stanford University, Stanford, CA 94305, USA
    Science 307:56-7. 2005
  10. ncbi request reprint Regulation of dendritic development by neuron-specific chromatin remodeling complexes
    Jiang I Wu
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 56:94-108. 2007
    ....
  11. ncbi request reprint Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control
    Cristina Mammucari
    Department of Biochemistry, Lausanne University, Epalinges, Switzerland
    Dev Cell 8:665-76. 2005
    ..Thus, an important interconnection exists between Notch 1 and Calcineurin-NFAT pathways in keratinocyte growth/differentiation control...
  12. ncbi request reprint Lymphocyte calcium signaling from membrane to nucleus
    Elena M Gallo
    Program in Immunology, Stanford University, Stanford, California 94305, USA
    Nat Immunol 7:25-32. 2006
    ..Here we review studies of the pathways that allow Ca(2+) entry, the function of Ca(2+) in the regulation of cell polarity and motility and the principles by which Ca(2+)-dependent transcription regulates lymphocyte function...
  13. ncbi request reprint Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim [corrected]
    Kirsten Canté-Barrett
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, CA 94305, USA
    J Immunol 176:2299-306. 2006
    ..These results localize the decision point in positive vs negative selection to a step downstream of Ca(2+) signaling and suggest that negative selection signals induce Ca(2+)-dependent bim transcription through PKC...
  14. pmc Calcineurin/Nfat signaling is required for perinatal lung maturation and function
    Vrushank Dave
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:2597-609. 2006
    ..The calcineurin/Nfat pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing...
  15. ncbi request reprint NFAT signaling and the invention of vertebrates
    Hai Wu
    Stanford University and the Howard Hughes Medical Institute, Department of Pathology, Beckman Center, Stanford, CA 94305, USA
    Trends Cell Biol 17:251-60. 2007
    ..We review recent evidence supporting this prediction and propose a systematic approach to explore aspects of vertebrate morphogenesis...
  16. ncbi request reprint Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2
    Robert B Rose
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3206, USA
    Biochemistry 43:7345-55. 2004
    ..We propose that HNF1alpha binding kinetics may distinguish regulation by DCoH2, under thermodynamic control, from regulation by DCoH, under kinetic control...
  17. pmc Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complex
    Teddy T C Yang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 25:907-20. 2005
    ..Ser(676) is also targeted by the ERK MAP kinase, which interacts with NFAT at a distinct region than RSK. Thus, integration of the ERK/RSK signaling pathway provides a mechanism to modulate NFATc4 transcription activity...
  18. pmc Calcineurin: a central controller of signalling in eukaryotes
    Jose Aramburu
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Carrer Dr Aiguader 80, 08003 Barcelona, Spain
    EMBO Rep 5:343-8. 2004
  19. ncbi request reprint Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
    Tian H Chi
    Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 418:195-9. 2002
    ..These results indicate that BAF complexes contribute to lineage bifurcation by reciprocally regulating lineage-specific genes, reminiscent of the role of the yeast SWI/SNF complex in mediating mating-type switching...
  20. pmc Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation
    Maximilian Diehn
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:11796-801. 2002
    ....
  21. ncbi request reprint Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3
    Colleen M Sheridan
    Program in Immunology, Department of Molecular Pharmacology, Howard Hughes Medical Institute, California 94305, USA
    J Biol Chem 277:48664-76. 2002
    ....
  22. pmc Identification of a polymorphic, neuron-specific chromatin remodeling complex
    Ivan Olave
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Genes Dev 16:2509-17. 2002
    ..We speculate that bBAF complexes create neuronal-specific patterns of chromatin accessibility, thereby imparting new regulatory characteristics to ubiquitous sequence-specific transcription factors in neurons...
  23. ncbi request reprint Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH gene
    J Henri Bayle
    Howard Hughes Medical Institute and the Department Pathology, Beckman Center for Molecular and Genetic Medicine, Stanford University, Stanford, California 94305, USA
    J Biol Chem 277:28884-91. 2002
    ..DCoH function as it pertains to HNF1 activity appears to be partially complemented by a newly identified homolog, DCoH2...
  24. ncbi request reprint Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons
    Isabella A Graef
    Department of Developmental Biology, 300 Pasteur Drive, Stanford, CA 94305, USA
    Cell 113:657-70. 2003
    ..The precise parsing of signals for elongation turning and survival could allow independent control of these processes during development...
  25. pmc Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex
    Oliver J Rando
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:2824-9. 2002
    ..Based on these findings, we propose a model for PIP2 activation of actin binding by relief of intramolecular capping of actin by Brg1...
  26. ncbi request reprint Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics
    Marjorie Brand
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nat Struct Mol Biol 11:73-80. 2004
    ....
  27. ncbi request reprint Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development
    Tian H Chi
    Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
    Immunity 19:169-82. 2003
    ..Our studies indicate that BAF complexes dynamically remodel chromatin to propel sequential developmental transitions in response to external signals...
  28. pmc Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery
    Ching Pin Chang
    Division of Cardiovascular Medicine, Department of Medicine, Howard Hughes Medical Institute, Stanford University Medical Center, California, USA
    J Clin Invest 113:1051-8. 2004
    ..These studies also emphasize the importance of functional obstruction, resulting from developmental abnormality, in causing congenital obstructive nephropathy...
  29. doi request reprint Monster protein controls calcium entry and fights infection
    Amy N Radermacher
    Howard Hughes Medical Institute, Department of Pathology, Stanford University, Stanford, CA 94305, USA
    Immunity 28:13-4. 2008
    ..In this issue of Immunity, Matza et al. (2007) demonstrate that the huge scaffold protein, AHNAK1, interacts with L-type calcium channels, regulates Ca2+ influx, and defends against Leishmania major infection...
  30. ncbi request reprint Calcineurin sets the bandwidth for discrimination of signals during thymocyte development
    Elena M Gallo
    Howard Hughes Medical Institute and the Department of Pathology, Stanford University, Stanford, California 94305, USA
    Nature 450:731-5. 2007
    ..This mechanism might be generally useful in the discrimination of graded signals that induce different cell fates...
  31. ncbi request reprint Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim
    Adrian Liston
    Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, 2601, Australia
    Immunity 21:817-30. 2004
    ..These findings establish defects in thymic deletion and Bim induction as a key mechanism in the pathogenesis of autoimmunity...
  32. ncbi request reprint Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy
    Stephanie A Parsons
    Department of Pediatrics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 279:26192-200. 2004
    ..We conclude that calcineurin expression is important during myogenesis and fiber-type switching, but not for muscle growth in response to hypertrophic stimuli...
  33. pmc Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development
    Hai Wu
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:30673-9. 2007
    ..Thus, our studies indicate that the DSCR1 gene is a direct transcriptional target of NFATc1 proteins within the endocardium during a critical window of heart valve formation...
  34. pmc An essential switch in subunit composition of a chromatin remodeling complex during neural development
    Julie Lessard
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 55:201-15. 2007
    ..More broadly, these studies suggest that SWI/SNF-like complexes in vertebrates achieve biological specificity by combinatorial assembly of their subunits...
  35. ncbi request reprint Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin
    Kelvin J A Davies
    Ethel Percy Andrus Gerontology Center, and Division of Molecular and Computational Biology, The University of Southern California, Los Angeles, CA 90089 0191, USA
    FASEB J 21:3023-8. 2007
  36. ncbi request reprint Calcineurin B1 is essential for positive but not negative selection during thymocyte development
    Joel R Neilson
    Department of Microbiology and Immunology, Beckman Center, Room B211, Stanford, CA 94305, USA
    Immunity 20:255-66. 2004
    ....
  37. ncbi request reprint Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulation
    Minggui Pan
    Division of Oncology, Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    J Immunol 178:4315-21. 2007
    ..In addition, NFATc1(nuc) destabilizes a positive feedback loop in which NFATc1 activates its own transcription as well as its targets, such as CD40 ligand and Th1/Th2 cytokines...
  38. ncbi request reprint Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function
    Jeremy J Heit
    Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
    Nature 443:345-9. 2006
    ..Thus, calcineurin/NFAT signalling regulates multiple factors that control growth and hallmark beta-cell functions, revealing unique models for the pathogenesis and therapy of diabetes...
  39. ncbi request reprint Calcineurin/NFAT signaling in osteoblasts regulates bone mass
    Monte M Winslow
    Program in Immunology, Stanford University, Stanford, California 94305, USA
    Dev Cell 10:771-82. 2006
    ..Our results indicate that NFATc1 regulates bone mass by functioning in both osteoblasts and osteoclasts...
  40. ncbi request reprint NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
    Joseph R Arron
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 441:595-600. 2006
    ..More generally, these observations suggest that the destabilization of regulatory circuits can underlie human disease...
  41. ncbi request reprint The calcineurin phosphatase complex modulates immunogenic B cell responses
    Monte M Winslow
    Program in Immunology, Stanford University, Stanford, California 94305, USA
    Immunity 24:141-52. 2006
    ..By several different criteria, calcineurin is dispensable for B cell tolerance, indicating that this phosphatase complex modulates immunogenic, but not tolerogenic, responses in vivo...
  42. ncbi request reprint Second messenger control of chromatin remodeling
    Oliver J Rando
    Nat Struct Biol 10:81-3. 2003

Research Grants21

  1. NFAT Signaling and Down Syndrome
    Gerald R Crabtree; Fiscal Year: 2010
    ..We will test this hypothesis and if correct find molecule that correct the balance and thereby develop new treatments for some of the disabling characteristics of Down Syndrome. ..
  2. ATP-dependent Chromatin Remodeling in Neural Development
    Gerald Crabtree; Fiscal Year: 2009
    ..Our studies might provide new avenues for the production of tissues and cells for regeneration of diseased or damaged tissues. ..
  3. ATP-dependent Chromatin Remodeling in Neural Development
    Gerald R Crabtree; Fiscal Year: 2010
    ..Our studies might provide new avenues for the production of tissues and cells for regeneration of diseased or damaged tissues. ..
  4. Signaling by Calcineurin and NFAT in Axonal Outgrowth
    Gerald Crabtree; Fiscal Year: 2007
    ..We believe that this pathway, its target genes and its many modulators will be a rich source of new molecules for therapeutic intervention in neurologic diseases. ..
  5. Signaling in T Lymphocyte Development
    Gerald Crabtree; Fiscal Year: 2007
    ..Defining these mechanisms should lead to a more complete understanding of immune defense and provide useful information for development of new therapies. ..
  6. Mechanisms of Vascular Development
    Gerald Crabtree; Fiscal Year: 2004
    ..The expression profile of candidate genes will be studied using in situ hybridization, and their functions will be studied with various in vitro angiogenesis assays. ..
  7. Signaling in Thymocyte Selection
    Gerald R Crabtree; Fiscal Year: 2010
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