Benjamin D Cosgrove

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes
    Benjamin D Cosgrove
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
    Conf Proc IEEE Eng Med Biol Soc 2009:5452-5. 2009
  2. pmc Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation
    Benjamin D Cosgrove
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Mol Biosyst 6:1195-206. 2010
  3. pmc Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity
    Benjamin D Cosgrove
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Toxicol Appl Pharmacol 237:317-30. 2009
  4. pmc Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death
    Justin R Pritchard
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cancer Ther 8:2183-92. 2009
  5. doi request reprint An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha
    Benjamin D Cosgrove
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Hepatology 48:276-88. 2008
  6. pmc Microfluidic concentration-enhanced cellular kinase activity assay
    Jeong Hoon Lee
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 131:10340-1. 2009

Collaborators

Detail Information

Publications6

  1. doi request reprint A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes
    Benjamin D Cosgrove
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
    Conf Proc IEEE Eng Med Biol Soc 2009:5452-5. 2009
    ....
  2. pmc Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation
    Benjamin D Cosgrove
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Mol Biosyst 6:1195-206. 2010
    ..Our findings highlight the critical role of kinase signaling in drug/cytokine hepatic cytotoxicity synergies and reveal that hepatic cytotoxicity responses are governed by multi-pathway signaling network balance...
  3. pmc Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity
    Benjamin D Cosgrove
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Toxicol Appl Pharmacol 237:317-30. 2009
    ..Our results suggest that this drug-cytokine co-treatment approach could provide a useful preclinical tool for investigating inflammation-associated idiosyncratic drug hepatotoxicity...
  4. pmc Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death
    Justin R Pritchard
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cancer Ther 8:2183-92. 2009
    ....
  5. doi request reprint An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha
    Benjamin D Cosgrove
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Hepatology 48:276-88. 2008
    ..Exogenous TGF-alpha can either enhance or diminish apoptosis in adenoviral vector-treated and TNF-treated hepatocytes, in a biphasic relationship also mediated by autocrine IL-1alpha/beta feedback...
  6. pmc Microfluidic concentration-enhanced cellular kinase activity assay
    Jeong Hoon Lee
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 131:10340-1. 2009
    ..This device could be a generic and powerful tool for diagnostics and systems biology studies at the single-cell level, if properly optimized and integrated with the cell culture microdevices...