Carol Clayberger

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Granulysin
    Carol Clayberger
    Department of Pediatrics, CCSR 2105, Stanford University, Stanford, CA 94305 5164, USA
    Curr Opin Immunol 15:560-5. 2003
  2. pmc Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription
    Boli Huang
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 178:7081-7. 2007
  3. pmc A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes
    Tania Nikolcheva
    Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, CCSR 2105, Stanford, CA 94305 5164, USA
    J Clin Invest 110:119-26. 2002
  4. pmc Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo
    Meixia Zhou
    Department of Pediatrics, Stanford University, 300 Pasteur Drive, Palo Alto, CA 94305, USA
    J Immunol 178:5496-504. 2007
  5. ncbi request reprint IL-9 is associated with an impaired Th1 immune response in patients with tuberculosis
    Bo Wu
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5164, USA
    Clin Immunol 126:202-10. 2008
  6. pmc Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin
    Qing Li
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305, USA
    Antimicrob Agents Chemother 49:388-97. 2005
  7. pmc IL-24 modulates IFN-gamma expression in patients with tuberculosis
    Bo Wu
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States
    Immunol Lett 117:57-62. 2008
  8. pmc Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes
    Yong Tae Ahn
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5164, USA
    Mol Cell Biol 27:253-66. 2007
  9. ncbi request reprint Granulysin, a cytolytic molecule, is also a chemoattractant and proinflammatory activator
    Anmei Deng
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 174:5243-8. 2005
  10. ncbi request reprint A novel apoptosis pathway activated by the carboxyl terminus of p21
    Chen Dong
    Division of Immunology and Transplantation Biology, Department of Pediatrics, CCSR 2105, 300 Pasteur Dr, Stanford University, Stanford, CA 94305 5164, USA
    Blood 105:1187-94. 2005

Research Grants

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Granulysin
    Carol Clayberger
    Department of Pediatrics, CCSR 2105, Stanford University, Stanford, CA 94305 5164, USA
    Curr Opin Immunol 15:560-5. 2003
    ....
  2. pmc Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription
    Boli Huang
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 178:7081-7. 2007
    ..Finally, knock-down of PRP4 by small interfering RNA markedly decreases CCL5 expression in T lymphocytes. Thus, PRP4-mediated phosphorylation of KLF13 plays a role in the regulation of CCL5 expression in T lymphocytes...
  3. pmc A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes
    Tania Nikolcheva
    Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, CCSR 2105, Stanford, CA 94305 5164, USA
    J Clin Invest 110:119-26. 2002
    ....
  4. pmc Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo
    Meixia Zhou
    Department of Pediatrics, Stanford University, 300 Pasteur Drive, Palo Alto, CA 94305, USA
    J Immunol 178:5496-504. 2007
    ..Furthermore, EMSA and luciferase reporter assays demonstrated that KLF13 binds to multiple sites within the Bcl-X(L) promoter and results in decreased Bcl-X(L) promoter activity, making KLF13 a negative regulator of BCL-X(L)...
  5. ncbi request reprint IL-9 is associated with an impaired Th1 immune response in patients with tuberculosis
    Bo Wu
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5164, USA
    Clin Immunol 126:202-10. 2008
    ..Thus, increased expression of IL-9 may contribute to the development of TB...
  6. pmc Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin
    Qing Li
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305, USA
    Antimicrob Agents Chemother 49:388-97. 2005
    ..The finding that some derivatives of granulysin are hemolytic may have important implications for the design of granulysin-based antimicrobial therapeutics...
  7. pmc IL-24 modulates IFN-gamma expression in patients with tuberculosis
    Bo Wu
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States
    Immunol Lett 117:57-62. 2008
    ..This is the first demonstration that IL-24 may play an important role in IFN-gamma expression following infection with Mtb...
  8. pmc Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes
    Yong Tae Ahn
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5164, USA
    Mol Cell Biol 27:253-66. 2007
    ..These events recruit RNA polymerase II to the RANTES promoter and are responsible for late expression of RANTES in T lymphocytes. Therefore, KLF13 is a key regulator of late RANTES expression in T lymphocytes...
  9. ncbi request reprint Granulysin, a cytolytic molecule, is also a chemoattractant and proinflammatory activator
    Anmei Deng
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 174:5243-8. 2005
    ....
  10. ncbi request reprint A novel apoptosis pathway activated by the carboxyl terminus of p21
    Chen Dong
    Division of Immunology and Transplantation Biology, Department of Pediatrics, CCSR 2105, 300 Pasteur Dr, Stanford University, Stanford, CA 94305 5164, USA
    Blood 105:1187-94. 2005
    ..Targeting the p21 peptide to specific cell populations may allow development of novel therapies to eliminate aberrant cells in human diseases...
  11. pmc Granulysin-mediated tumor rejection in transgenic mice
    Lisa P Huang
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 178:77-84. 2007
    ..These findings demonstrate for the first time an in vivo effect of GNLY and suggest that GNLY may prove a useful therapeutic modality for the treatment of cancer...
  12. ncbi request reprint DQ 65-79, a peptide derived from HLA class II, mimics p21 to block T cell proliferation
    Chen Dong
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
    J Immunol 171:5064-70. 2003
    ..We show here that DQ 65-79 competitively inhibits binding of p21 to PCNA and that both DQ 65-79 and p21 139-160 induce T cell apoptosis, suggesting that DQ 65-79 and p21 act similarly to inhibit cell growth...
  13. ncbi request reprint Glycosylated recombinant human XCL1/lymphotactin exhibits enhanced biologic activity
    Chen Dong
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University, Stanford, CA 94305 5164, USA
    J Immunol Methods 302:136-44. 2005
    ..Comparison of this material with that expressed in E. coli reveals that glycosylation significantly increases the biologic activity of XCL1...
  14. pmc Unique gene expression profiles in infants vaccinated with different strains of Mycobacterium bovis bacille Calmette-Guerin
    Bo Wu
    Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5164, USA
    Infect Immun 75:3658-64. 2007
    ..Thus, different strains of BCG can activate different immune pathways, which may affect long-term vaccine efficacy...
  15. pmc In vitro and in vivo antimicrobial activity of granulysin-derived peptides against Vibrio cholerae
    Ana Paula Galvão da Silva
    Division of Immunology and Transplantation Biology, Department of Pediatrics, CCSR 2105, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Antimicrob Chemother 61:1103-9. 2008
    ..To determine the antibacterial activity of synthetic peptides derived from the cationic antimicrobial peptide granulysin against Vibrio cholerae...
  16. ncbi request reprint Granulysin: a novel host defense molecule
    Alan M Krensky
    Department of Pediatrics, Stanford University, Stanford, CA, USA
    Am J Transplant 5:1789-92. 2005
    ..Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection...
  17. ncbi request reprint Intracellular mediators of granulysin-induced cell death
    Satoshi Okada
    Division of Immunology and Transplantation Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    J Immunol 171:2556-62. 2003
    ..Finally, an increase in intracellular glutathione protects target cells from granulysin-induced lysis, indicating the importance of the redox state in granulysin-mediated cell death...
  18. pmc Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins
    Xi Chen
    Division of Immunology and Transplantation Biology, Department of Pediatrics, CCSR 2105, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biochim Biophys Acta 1768:2421-31. 2007
    ..Neutralization of LPS by Gra-pep is not due to a scavenging effect in solution, but rather proceeds after incorporation into target membranes, suggesting a requisite membrane-bound step...
  19. ncbi request reprint Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes
    An Song
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305 5164, USA
    J Biol Chem 277:30055-65. 2002
    ..The intact CTCCC box on the RANTES promoter is necessary for RFLAT-1-mediated RANTES transcription and is also required for the synergy between RFLAT-1 and NF-kappaB proteins...
  20. pmc Messenger RNA expression of IL-8, FOXP3, and IL-12beta differentiates latent tuberculosis infection from disease
    Bo Wu
    Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    J Immunol 178:3688-94. 2007
    ..Thus, measurement of Ag-specific expression of these three genes may offer a specific and noninvasive means of differentiating between latent Mtb infection and TB...
  21. ncbi request reprint Increased host neuronal survival and motor function in BMT Parkinsonian mice: involvement of immunosuppression
    Gilmor I Keshet
    Baxter Laboratory for Genetic Pharmacology, Stanford University School of Medicine, Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA
    J Comp Neurol 504:690-701. 2007
    ..Further, they suggest that the immune system plays a role in the development of characteristics typical of PD...
  22. ncbi request reprint DQ 65-79, a peptide derived from HLA class II, induces I kappa B expression
    Yun Jiang
    Department of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305 5164, USA
    J Immunol 168:3323-8. 2002
    ..These findings indicate that the DQ 65-79 peptide increases the level of IkappaB proteins, thereby preventing nuclear translocation of the transcription factor, NF-kappaB, and inhibiting T cell proliferation...

Research Grants9

  1. M Tuberculosis CTL Epitopes: Vaccine Design/Evaluation
    Carol Clayberger; Fiscal Year: 2003
    ..and to provide early evidence of efficacy. For TB, which takes years to decades to develop after infection with Mtb, immune correlates with protection are an attractive, and perhaps essential, supplement to efficacy trials. ..
  2. M Tuberculosis CTL Epitopes: Vaccine Design/Evaluation
    Carol Clayberger; Fiscal Year: 2006
    ..For TB, which takes years to decades to develop after infection with Mtb, immune correlates with protection are an attractive, and perhaps essential, supplement to efficacy trials. ..
  3. Granulysin Derived Immunotherapeutics for Biodefense
    Elizabeth Mellins; Fiscal Year: 2007
    ..The information gleaned from these studies should lead to the development of new immunotherapeutics for biodefense and for treatment of antibiotic resistant pathogens. ..
  4. M Tuberculosis CTL Epitopes: Vaccine Design/Evaluation
    Elizabeth Mellins; Fiscal Year: 2007
    ..For TB, which takes years to decades to develop after infection with Mtb, immune correlates with protection are an attractive, and perhaps essential, supplement to efficacy trials. ..