Research Topics
Genomes and Genes | Mei Sze ChuaSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Molecular profiling of anemia in acute renal allograft rejection using DNA microarraysMei-Sze Chua
Department of Pediatrics, Stanford University School of Medicine, CCSR, Stanford CA, USA
Am J Transplant 3:17-22. 2003..The possible relationship between alterations in the expression of this cluster, reduced renal function, the alloimmune process itself, and other influences on the renal transplant awaits further analysis...- Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinomaMei Sze Chua
Department of Surgery and Asian Liver Center, Stanford University School of Medicine, Stanford, CA, USA
Mod Pathol 20:76-83. 2007..Its significantly elevated expression in hepatocellular carcinoma could be a useful indicator of tumor aggressiveness and therefore patient prognosis... - Gallium maltolate is a promising chemotherapeutic agent for the treatment of hepatocellular carcinomaMei Sze Chua
Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5655, USA
Anticancer Res 26:1739-43. 2006..Since gallium is known to accumulate specifically in HCC tumors but not in non-tumor liver, we investigated two gallium compounds, gallium nitrate (GaN) and gallium maltolate (GaM), as potential new agents for treating HCC... 
Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivoWei Wei
Asian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5655, USA
Int J Cancer 126:2426-36. 2010..Our results suggest that these 3 antagonists of the Tcf4/beta-catenin complex are potential chemotherapeutic agents which may offer a pathway specific option for the clinical management of HCC...
Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicinWei Wei
Asian Liver Center, Department of Surgery, 1201 Welch Road, Stanford University School of Medicine, Stanford, CA 94305, USA
Mol Cancer 10:16. 2011..Recent studies have identified the Frizzled-7 receptor (FZD7), important for activation of Wnt-mediated signaling, as a potential therapeutic target for HCC and other cancers...- N-Myc down-regulated gene 1 mediates proliferation, invasion, and apoptosis of hepatocellular carcinoma cellsXinrui Yan
Asian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5655, USA
Cancer Lett 262:133-42. 2008..These results are consistent with our earlier clinical observations that NDRG1 is associated with more aggressive tumor behavior, and suggest that NDRG1 may be a potential therapeutic target for HCC... - Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cellsWei Wei
Asian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Mol Cancer 8:76. 2009..Since the Wnt/beta-catenin pathway is essential in HCC carcinogenesis, we studied the inhibition of Wnt-1-mediated signaling as a potential molecular target in HCC... - Suppression of glypican 3 inhibits growth of hepatocellular carcinoma cells through up-regulation of TGF-β2Chris K Sun
Asian Liver Center and Department of Surgery, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5655, USA
Neoplasia 13:735-47. 2011..In conclusion, molecular targeting of GPC3 at the translational level offers an effective option for the clinical management of GPC3-positive HCC patients... - Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profilingMinnie Sarwal
Department of Pediatrics, Stanford University, Stanford, Calif, USA
N Engl J Med 349:125-38. 2003..We hypothesized that previously unrecognized molecular heterogeneity might underlie some of the variability in the clinical course of acute renal allograft rejection and in its response to treatment... - Small interfering RNA targeting CDC25B inhibits liver tumor growth in vitro and in vivoXinrui Yan
Asian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Mol Cancer 7:19. 2008..In this study, we validated the over-expression of CDC25B in HCC, and further investigated its potential as a therapeutic target for the management of HCC... - Rodent-specific hypoxia response elements enhance PAI-1 expression through HIF-1 or HIF-2 in mouse hepatoma cellsYong Tae Ahn
Departments of Pediatrics, Stanford University School of Medicine, 300 Pasteur Dr Stanford, CA 94305, USA
Int J Oncol 37:1627-38. 2010.... - Applications of microarrays to renal transplantation: progress and possibilitiesMei-Sze Chua
Department of Pediatrics, Stanford University School of Medicine, G320, 300 Pasteur Drive, Stanford, CA 94305, USA
Front Biosci 8:s913-23. 2003..This article will review the current applications of microarray technology in the field of renal transplantation, and discuss the potential impact of this technology on transplantation medicine... - Increased expression of cytotoxic effector molecules: different interpretations for steroid-based and steroid-free immunosuppressionThomas Satterwhite
Department of Pediatrics, Stanford University School of Medicine, 269 Campus Drive, CCSR, Stanford, California 94305, USA
Pediatr Transplant 7:53-8. 2003.... - Assessment and comparison of magnetic nanoparticles as MRI contrast agents in a rodent model of human hepatocellular carcinomaLihong Bu
Department of Radiology, the Fourth Hospital of Harbin Medical University, Heilongjiang, China
Contrast Media Mol Imaging 7:363-72. 2012..The success of this study suggests that, by improving the synthetic approach and by tuning the surface properties of IONPs, one can arrive at better formulas than Feridex for clinical practice... - In vivo MRSI of hyperpolarized [1-(13)C]pyruvate metabolism in rat hepatocellular carcinomaMoses M Darpolor
Department of Radiology, Stanford University, Stanford, CA 94305 5488, USA
NMR Biomed 24:506-13. 2011.... - Microarrays: new tools for transplantation researchMei-Sze Chua
Department of Pediatrics, Stanford University School of Medicine, G320, 300 Pasteur Drive, CA 94305, Stanford, USA
Pediatr Nephrol 18:319-27. 2003.... - Sprouty 2, an inhibitor of mitogen-activated protein kinase signaling, is down-regulated in hepatocellular carcinomaChee Wai Fong
Signal Transduction Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore
Cancer Res 66:2048-58. 2006.... - Sprouty and cancer: the first terms reportTing Ling Lo
Signal Transduction Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, 6-01, Proteos, Singapore, 138673
Cancer Lett 242:141-50. 2006.... - An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinomaMohini A Patil
Department of Biopharmaceutical Sciences, University of California, San Francisco, CA 94143, USA
Oncogene 24:3737-47. 2005..This approach of integrating other biological information with gene expression in the analysis helps select aberrantly expressed genes in HCC that may be further studied for their diagnostic or therapeutic utility... - Interleukin-8 modulates growth and invasiveness of estrogen receptor-negative breast cancer cellsChen Yao
Division of Breast Surgery, Department of Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
Int J Cancer 121:1949-57. 2007....