Xiaoyuan Chen

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi Rapid intracerebroventricular delivery of Cu-DOTA-etanercept after peripheral administration demonstrated by PET imaging
    Edward L Tobinick
    Institute for Neurological Research, a private medical group, Inc, 100 UCLA Medical Plaza, Suites 205 210, Los Angeles, California 90095 USA
    BMC Res Notes 2:28. 2009
  2. ncbi Multimodality imaging of tumor integrin alphavbeta3 expression
    Xiaoyuan Chen
    Molecular Imaging Program at Stanford, MIPS, Department of Radiology, Stanford University, CA 94305, USA
    Mini Rev Med Chem 6:227-34. 2006
  3. ncbi Longitudinal microPET imaging of brain tumor growth with F-18-labeled RGD peptide
    Xiaoyuan Chen
    PET Imaging Science Center, Department of Radiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Imaging Biol 8:9-15. 2006
  4. ncbi Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery
    Xiaoyuan Chen
    Department of Radiology, University of Southern California, Los Angeles, California 90033, USA
    J Med Chem 48:1098-106. 2005
  5. ncbi In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumor xenografts
    Xiaoyuan Chen
    PET Imaging Science Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Cancer Res 64:8009-14. 2004
  6. ncbi Multimodality imaging of the HER-kinase axis in cancer
    Weibo Cai
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 35:186-208. 2008
  7. ncbi Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature
    Weibo Cai
    Molecular Imaging Program at Stanford MIPS, Department of Radiology, and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    J Nucl Med 48:1862-70. 2007
  8. ncbi The temporal correlation of dynamic contrast-enhanced magnetic resonance imaging with tumor angiogenesis in a murine glioblastoma model
    Anand Veeravagu
    Department of Neurosurgery, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA
    Neurol Res 30:952-9. 2008
  9. ncbi Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor alphavbeta3-integrin expression
    Xiaoyuan Chen
    PET Imaging Science Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Nucl Med 45:1776-83. 2004
  10. ncbi (64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression
    Zi Bo Li
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305, USA
    J Nucl Med 48:1162-71. 2007

Research Grants

  1. MicroPET and NIR Fluorescence Imaging Tumor Angiogenesis
    Xiaoyuan Chen; Fiscal Year: 2004
  2. Imaging Alpha (v)beta(3) Integrin Expression
    Xiaoyuan Chen; Fiscal Year: 2006
  3. Radiolabeled RGD Peptides for Breast Cancer Imaging and Therapy
    Xiaoyuan Chen; Fiscal Year: 2007
  4. Quantum Dots for NIR Fluorescence Imaging of Tumor Angiogenesis
    Xiaoyuan Chen; Fiscal Year: 2007

Collaborators

Detail Information

Publications89

  1. ncbi Rapid intracerebroventricular delivery of Cu-DOTA-etanercept after peripheral administration demonstrated by PET imaging
    Edward L Tobinick
    Institute for Neurological Research, a private medical group, Inc, 100 UCLA Medical Plaza, Suites 205 210, Los Angeles, California 90095 USA
    BMC Res Notes 2:28. 2009
    ..Further study of the effects of etanercept and TNF at the level of the choroid plexus may yield valuable insights into the pathogenesis of Alzheimer's disease...
  2. ncbi Multimodality imaging of tumor integrin alphavbeta3 expression
    Xiaoyuan Chen
    Molecular Imaging Program at Stanford, MIPS, Department of Radiology, Stanford University, CA 94305, USA
    Mini Rev Med Chem 6:227-34. 2006
    ..This review highlights some recent advances in multimodality imaging of tumor integrin expression with emphasis on positron emission tomography (PET)...
  3. ncbi Longitudinal microPET imaging of brain tumor growth with F-18-labeled RGD peptide
    Xiaoyuan Chen
    PET Imaging Science Center, Department of Radiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Imaging Biol 8:9-15. 2006
    ....
  4. ncbi Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery
    Xiaoyuan Chen
    Department of Radiology, University of Southern California, Los Angeles, California 90033, USA
    J Med Chem 48:1098-106. 2005
    ..Our results demonstrate the potential of tumor-targeted delivery of paclitaxel based on the specific recognition of cell adhesion molecule alpha(v)beta(3) integrin to reduce toxicity and enhance selective killing of cancer cells...
  5. ncbi In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumor xenografts
    Xiaoyuan Chen
    PET Imaging Science Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Cancer Res 64:8009-14. 2004
    ....
  6. ncbi Multimodality imaging of the HER-kinase axis in cancer
    Weibo Cai
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 35:186-208. 2008
    ..Successful development of new HER-kinase-targeted imaging agents with optimal in vivo stability, targeting efficacy, and desirable pharmacokinetics for clinical translation will enable maximum benefit in cancer patient management...
  7. ncbi Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature
    Weibo Cai
    Molecular Imaging Program at Stanford MIPS, Department of Radiology, and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    J Nucl Med 48:1862-70. 2007
    ..The development of a dual-function PET/near-infrared fluorescence (NIRF) probe can allow for accurate assessment of the pharmacokinetics and tumor-targeting efficacy of QDs...
  8. ncbi The temporal correlation of dynamic contrast-enhanced magnetic resonance imaging with tumor angiogenesis in a murine glioblastoma model
    Anand Veeravagu
    Department of Neurosurgery, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA
    Neurol Res 30:952-9. 2008
    ..The purpose of this study was to characterize changes in tumor vascular permeability, vascular density and vessel morphology in vivo during angiogenesis...
  9. ncbi Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor alphavbeta3-integrin expression
    Xiaoyuan Chen
    PET Imaging Science Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Nucl Med 45:1776-83. 2004
    ..In addition, the same ligand labeled with therapeutic radionuclides may be applicable for integrin-targeted internal radiotherapy...
  10. ncbi (64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression
    Zi Bo Li
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305, USA
    J Nucl Med 48:1162-71. 2007
    ..In this study, we developed (64)Cu-labeled multimeric RGD peptides, E{E[c(RGDyK)](2)}(2) (RGD tetramer) and E(E{E[c(RGDyK)](2)}(2))(2) (RGD octamer), for PET imaging of tumor integrin alpha(v)beta(3) expression...
  11. ncbi 18F-labeled RGD peptide: initial evaluation for imaging brain tumor angiogenesis
    Xiaoyuan Chen
    PET Imaging Science Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Nucl Med Biol 31:179-89. 2004
    ..Hence, N-4-[(18)F]fluorobenzoyl labeled cyclic RGD peptide [(18)F]FB-RGD is a potential tracer for imaging alpha(v)beta(3)-integrin positive tumors in brain and other anatomic locations...
  12. ncbi In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin alpha v beta 3
    Weibo Cai
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305-5484, USA
    Cancer Res 66:9673-81. 2006
    ..Chemotherapeutics or radiotherapeutics using Abegrin as the delivering vehicle may also be effective in treating integrin alpha(v)beta(3)-positive tumors...
  13. ncbi MicroPET imaging of brain tumor angiogenesis with 18F-labeled PEGylated RGD peptide
    Xiaoyuan Chen
    PET Imaging Science Center, Department of Radiology, University of Southern California Keck School of Medicine, 1510 San Pablo St, Suite 350, CA 90033, Los Angeles, USA
    Eur J Nucl Med Mol Imaging 31:1081-9. 2004
    ..In conclusion, PEGylation suitably modifies the physiological behavior of the RGD peptide. [18F]FB-PEG-RGD gave improved tumor retention and in vivo kinetics compared with [18F]FB-RGD...
  14. ncbi PET/NIRF/MRI triple functional iron oxide nanoparticles
    Jin Xie
    Department of Radiology, Biophysics and Bio X Program, Stanford University, Stanford, CA, USA
    Biomaterials 31:3016-22. 2010
    ....
  15. ncbi 64Cu-labeled PEGylated polyethylenimine for cell trafficking and tumor imaging
    Zi Bo Li
    Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA, USA
    Mol Imaging Biol 11:415-23. 2009
    ..In this study, we exploited the potential of (64)Cu-labeled polyethylenimine (PEI) for cell trafficking and tumor imaging as compared to copper-64-pyruvaldehyde-bis(N (4)-methylthiosemicarbazone) ((64)Cu-PTSM)...
  16. ncbi Integrin alphavbeta3-targeted radioimmunotherapy of glioblastoma multiforme
    Anand Veeravagu
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    Clin Cancer Res 14:7330-9. 2008
    ..The purpose of this study was to evaluate the efficacy of a novel 90Y-Abegrin radioimmunotherapeutic agent in murine xenograft glioblastoma models with noninvasive in vivo molecular imaging modalities...
  17. ncbi (18)F, (64)Cu, and (68)Ga labeled RGD-bombesin heterodimeric peptides for PET imaging of breast cancer
    Zhaofei Liu
    Department of Radiology, Biophysics, Stanford University School of Medicine, Stanford, CA94305 5484, USA
    Bioconjug Chem 20:1016-25. 2009
    ..Further development of suitably labeled RGD-BBN tracers for PET imaging of cancer is warranted...
  18. ncbi 18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer
    Xianzhong Zhang
    Molecular Imaging Program at Stanford (MIPS, Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, USA
    J Nucl Med 47:492-501. 2006
    ..CONCLUSION: This study demonstrates that 18F-FB-[Lys3]BBN and PET are suitable for detecting GRPR-positive prostate cancer in vivo...
  19. ncbi Quantitative radioimmunoPET imaging of EphA2 in tumor-bearing mice
    Weibo Cai
    Department of Radiology and Bio X Program, The Molecular Imaging Program at Stanford, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 34:2024-36. 2007
    ..Although many recent reports have focused on blocking the EphA2 signaling pathway in cancer, the in vivo imaging of EphA2 has not yet been investigated...
  20. ncbi Micro-PET imaging of alphavbeta3-integrin expression with 18F-labeled dimeric RGD peptide
    Xiaoyuan Chen
    University of Southern California, Los Angeles, USA
    Mol Imaging 3:96-104. 2004
    ..5 +/- 0.8. The synergistic effect of polyvalency and improved pharmacokinetics may be responsible for the superior imaging characteristics of [18F]FB-E[c(RGDyK)]2...
  21. ncbi Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots
    Kai Chen
    Department of Radiology and Bio X Program, School of Medicine, Stanford University, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 35:2235-44. 2008
    ..The development of a dual-function positron emission tomography (PET)/near-infrared fluorescence (NIRF) probe might allow the accurate assessment of the tumor-targeting efficacy of QDs...
  22. ncbi Semiautomated radiosynthesis and biological evaluation of [18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression
    Frederick T Chin
    Molecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Mol Imaging Biol 10:82-91. 2008
    ..Although further studies are needed, early results also suggest [(18)F]FEAU is a promising PET radiotracer for monitoring HSV1-tk reporter gene expression...
  23. ncbi Monitoring of the biological response to murine hindlimb ischemia with 64Cu-labeled vascular endothelial growth factor-121 positron emission tomography
    Jurgen K Willmann
    Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, Calif, USA
    Circulation 117:915-22. 2008
    ....
  24. ncbi Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting
    Kai Chen
    The Molecular Imaging Program at Stanford, Department of Radiology, Biophysics and Bio X Program, Stanford University, Stanford, CA, USA
    Biomaterials 30:6912-9. 2009
    ..In conclusion, we have developed a novel RGD-IONP conjugate with excellent tumor integrin targeting efficiency and specificity as well as limited RES uptake for molecular MRI...
  25. ncbi microPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4)
    Zhanhong Wu
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA
    J Nucl Med 48:1536-44. 2007
    ..Here we report an example of (18)F-labeled tetrameric RGD peptide for PET of alpha(v)beta(3) expression in both xenograft and spontaneous tumor models...
  26. ncbi Quantitative PET imaging of VEGF receptor expression
    Kai Chen
    Department of Radiology and Bio X Program, Stanford University School of Medicine, CA 94305 5484, USA
    Mol Imaging Biol 11:15-22. 2009
    ..Quantitative positron emission tomography (PET) imaging of VEGFR will facilitate the planning of whether, and when, to start anti-angiogenic treatment and enable more robust and effective monitoring of such treatment...
  27. ncbi PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles
    Ha Young Lee
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 49:1371-9. 2008
    ..The purpose of this study was to develop a bifunctional iron oxide (IO) nanoparticle probe for PET and MRI scans of tumor integrin alphavbeta3 expression...
  28. ncbi Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein
    Hui Wang
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Road, P095, Stanford, CA 94305 5484, USA
    Mol Cancer Ther 7:1044-53. 2008
    ..Ex vivo tissue staining confirmed specific cytotoxicity of RGD4C-TNF against integrin-positive tumor cells and tumor vasculature...
  29. ncbi Evaluation of biodistribution and anti-tumor effect of a dimeric RGD peptide-paclitaxel conjugate in mice with breast cancer
    Qizhen Cao
    Molecular Imaging Program at Stanford, Department of Radiology, Biophysics, and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd, Stanford P095, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 35:1489-98. 2008
    ..In this study, we evaluated the anti-tumor efficacy of a dimeric RGD peptide-paclitaxel conjugate (RGD2-PTX) in an orthotopic MDA-MB-435 breast cancer model...
  30. ncbi In vivo bioluminescence tumor imaging of RGD peptide-modified adenoviral vector encoding firefly luciferase reporter gene
    Gang Niu
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA
    Mol Imaging Biol 9:126-34. 2007
    ..The goal of this study is to demonstrate the feasibility of chemically modified human adenovirus (Ad) vectors for tumor retargeting...
  31. ncbi In vivo tumor-targeted fluorescence imaging using near-infrared non-cadmium quantum dots
    Jinhao Gao
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, School of Medicine, Stanford University, 1201 Welch Road, Stanford, California 94305 5484, USA
    Bioconjug Chem 21:604-9. 2010
    ..The high reproducibility of bioconjunction between QDs and the RGD peptide and the feasibility of QD-RGD bioconjugates as tumor-targeted fluorescence probes warrant the successful application of QDs for in vivo molecular imaging...
  32. ncbi 18F-labeled BBN-RGD heterodimer for prostate cancer imaging
    Zi Bo Li
    Molecular Imaging Program at Stanford, Department of Radiology, Biophysics, and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 49:453-61. 2008
    ..We hypothesize that a peptide ligand recognizing both GRPR and integrin will be advantageous because of its dual-receptor-targeting ability...
  33. ncbi Integrin alpha v beta 3-targeted imaging of lung cancer
    Xiaoyuan Chen
    Molecular Imaging Science Center, Department of Radiology, University of Southern California, Los Angeles, CA 90033, USA
    Neoplasia 7:271-9. 2005
    ..Further studies to improve the receptor binding affinity of the tracer and subsequently to increase the magnitude of tumor uptake without comprising the favorable in vivo kinetics are currently in progress...
  34. ncbi Optical imaging of integrin alphavbeta3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers
    Zhaofei Liu
    Molecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA
    Mol Imaging 9:21-9. 2010
    ..In summary, NIRF imaging with IRDye800-E[PEG4-c(RGDfK)]2 offers an easy, fast, and low-cost way to detect and semiquantify tumor integrin alphavbeta3 expression in living subjects...
  35. ncbi (68)Ga-labeled multimeric RGD peptides for microPET imaging of integrin alpha(v)beta (3) expression
    Zi Bo Li
    Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 35:1100-8. 2008
    ..The goal of this study was to investigate the feasibility of (68)Ga-labeled RGD peptides for tumor imaging...
  36. ncbi Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2
    Xianzhong Zhang
    Molecular Imaging Program at Stanford, MIPS, and Bio X Program, Department of Radiology, Stanford University, California 94305 5484, USA
    J Nucl Med 47:113-21. 2006
    ..We labeled the dimeric RGD peptide E[c(RGDyK)](2) with (18)F and evaluated its tumor-targeting efficacy and pharmacokinetics of (18)F-FB-E[c(RGDyK)](2) ((18)F-FRGD2)...
  37. ncbi Small-animal PET of tumors with (64)Cu-labeled RGD-bombesin heterodimer
    Zhaofei Liu
    Molecular Imaging Program at Stanford, Department of Radiology, Biophysics Program, and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 50:1168-77. 2009
    ..To further investigate the synergistic effect of the dual-receptor targeting of peptide heterodimers, we evaluated (64)Cu-labeled RGD-bombesin for PET imaging of tumors...
  38. ncbi Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene
    Zhengming Xiong
    Molecular Imaging Program at Stanford, MIPS, Department of Radiology, Stanford University School of Medicine, California 94305 5484, USA
    J Nucl Med 47:130-9. 2006
    ....
  39. ncbi RGD-human serum albumin conjugates as efficient tumor targeting probes
    Kai Chen
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Standford, CA 94305 5484, USA
    Mol Imaging 8:65-73. 2009
    ..The success of this study may be generalizable for other peptide-based probes to be conjugated with HSA for prolonged tumor contrast and improved pharmacokinetics...
  40. ncbi Imaging of VEGF receptor in a rat myocardial infarction model using PET
    Martin Rodriguez-Porcel
    Molecular Imaging Program at Stanford, Department of Radiology, Division of Nuclear Medicine, Stanford University, Stanford, CA 94305 5427, USA
    J Nucl Med 49:667-73. 2008
    ..We have developed a PET tracer (64Cu-DOTA-VEGF121 [DOTA is 1,4,7,10-tetraazadodecane-N,N',N'',N'''-tetraacetic acid]) to image VEGF receptor (VEGFR) expression after MI in the living subject...
  41. ncbi Noninvasive imaging of tumor integrin expression using (18)F-labeled RGD dimer peptide with PEG (4) linkers
    Zhaofei Liu
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology, Biophysics, and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    Eur J Nucl Med Mol Imaging 36:1296-307. 2009
    ....
  42. ncbi (68)Ga-labeled cyclic RGD dimers with Gly3 and PEG4 linkers: promising agents for tumor integrin alphavbeta3 PET imaging
    Zhaofei Liu
    Department of Radiology, Biophysics and Bio X, Stanford University, Stanford, CA 94305, USA
    Eur J Nucl Med Mol Imaging 36:947-57. 2009
    ....
  43. ncbi Positron emission tomography imaging of poststroke angiogenesis
    Weibo Cai
    The Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, Stanford, CA, USA
    Stroke 40:270-7. 2009
    ..In this study, we imaged VEGFR expression with positron emission tomography (PET) to noninvasively analyze poststroke angiogenesis...
  44. ncbi PET imaging of colorectal cancer in xenograft-bearing mice by use of an 18F-labeled T84.66 anti-carcinoembryonic antigen diabody
    Weibo Cai
    Molecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 48:304-10. 2007
    ..66 diabody, a genetically engineered noncovalent dimer of single-chain variable fragments, for small-animal PET imaging of CEA expression in xenograft-bearing mice...
  45. ncbi Monitoring therapeutic response of human ovarian cancer to 17-DMAG by noninvasive PET imaging with (64)Cu-DOTA-trastuzumab
    Gang Niu
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 36:1510-9. 2009
    ..In this study, we aimed to noninvasively monitor the HER-2 response to 17-DMAG treatment in xenografted mice...
  46. ncbi (68)Ga-labeled NOTA-RGD-BBN peptide for dual integrin and GRPR-targeted tumor imaging
    Zhaofei Liu
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 36:1483-94. 2009
    ..The goal of this study was to investigate the dual receptor-targeting property and tumor diagnostic value of RGD-BBN heterodimeric peptide labeled with generator-eluted (68)Ga (t(1/2) 68 min, beta(+) 89% and EC 11%), (68)Ga-NOTA-RGD-BBN...
  47. ncbi Multimodality imaging of IL-18--binding protein-Fc therapy of experimental lung metastasis
    Qizhen Cao
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA
    Clin Cancer Res 14:6137-45. 2008
    ....
  48. ncbi Click chemistry for (18)F-labeling of RGD peptides and microPET imaging of tumor integrin alphavbeta3 expression
    Zi Bo Li
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA, USA
    Bioconjug Chem 18:1987-94. 2007
    ..This new (18)F labeling method based on click reaction may also be useful for radiolabeling of other biomolecules with azide groups in high yield...
  49. ncbi 18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2): synthesis and microPET imaging of alphavbeta3 integrin expression
    Zhanhong Wu
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 34:1823-31. 2007
    ..The goal of this study was to improve the radiolabeling yield, without compromising the tumor targeting efficiency and in vivo kinetics, by incorporating a hydrophilic bifunctional mini-PEG spacer...
  50. ncbi A new PET tracer specific for vascular endothelial growth factor receptor 2
    Hui Wang
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 34:2001-10. 2007
    ..The aim of this study was to develop a VEGFR-2-specific PET tracer...
  51. ncbi PET of vascular endothelial growth factor receptor expression
    Weibo Cai
    Molecular Imaging Program at Stanford (MIPS, Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305-5484, USA
    J Nucl Med 47:2048-56. 2006
    ....
  52. ncbi Drug delivery with carbon nanotubes for in vivo cancer treatment
    Zhuang Liu
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Cancer Res 68:6652-60. 2008
    ..Thus, nanotube drug delivery is promising for high treatment efficacy and minimum side effects for future cancer therapy with low drug doses...
  53. ncbi Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody
    Weibo Cai
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd P095, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 34:850-8. 2007
    ..Here we report for the first time the quantitative positron emission tomography (PET) imaging of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab...
  54. ncbi MicroPET imaging of breast cancer alphav-integrin expression with 64Cu-labeled dimeric RGD peptides
    Xiaoyuan Chen
    PET Imaging Science Center, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Mol Imaging Biol 6:350-9. 2004
    ..Both dimeric peptides showed better tumor retention than the previously tested monomeric RGD counterparts, presumably because of bivalency and increase in apparent molecular size...
  55. ncbi MicroPET, MicroSPECT, and NIR fluorescence imaging of biomolecules in vivo
    Zi Bo Li
    Department of Radiology, Stanford University School of Medicine, 94305 5484, Stanford, CA, USA
    Methods Mol Biol 544:461-81. 2009
    ....
  56. ncbi PET of EGFR antibody distribution in head and neck squamous cell carcinoma models
    Gang Niu
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 50:1116-23. 2009
    ....
  57. ncbi Ultrasmall near-infrared non-cadmium quantum dots for in vivo tumor imaging
    Jinhao Gao
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, School of Medicine, Stanford University, Stanford, CA 94305 5484, USA
    Small 6:256-61. 2010
    ..QD800-MPA-HSA may have great potential for in vivo fluorescence imaging...
  58. ncbi microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3]bombesin in human prostate adenocarcinoma xenografts
    Xiaoyuan Chen
    PET Imaging Science Center, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    J Nucl Med 45:1390-7. 2004
    ..CONCLUSION: This study demonstrates that PET imaging of (64)Cu-DOTA-[Lys(3)]BBN is able to detect GRPR-positive prostate cancer...
  59. ncbi HSA coated MnO nanoparticles with prominent MRI contrast for tumor imaging
    Jing Huang
    Department of Radiology and Bio X Program, Stanford University, 1201 Welch Road P087, Stanford, CA 94305, USA
    Chem Commun (Camb) 46:6684-6. 2010
    ..In a U87MG glioblastoma xenograft model, we confirmed that the particles can accumulate efficiently in tumor area to induce effective T1 signal alteration...
  60. ncbi The synthesis of 18F-FDS and its potential application in molecular imaging
    Zi Bo Li
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Mol Imaging Biol 10:92-8. 2008
    ..In this study, we describe the development of 2-deoxy-2-[(18)F]fluorosorbitol ((18)F-FDS) and its possible application in lesion detection around brain area...
  61. ncbi PET imaging of acute and chronic inflammation in living mice
    Qizhen Cao
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 34:1832-42. 2007
    ..In this study, we evaluated the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced acute and chronic inflammation in living mice by PET imaging of TNF-alpha and integrin alpha(v)beta(3) expression...
  62. ncbi Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel
    Andrew R Hsu
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 48:445-54. 2007
    ....
  63. ncbi Non-invasive PET imaging of EGFR degradation induced by a heat shock protein 90 inhibitor
    Gang Niu
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305 5484, USA
    Mol Imaging Biol 10:99-106. 2008
    ..The aim of this study is to non-invasively monitor the epidermal growth factor receptor (EGFR) response to a Hsp90 inhibitor-17-AAG treatment in a PC-3 prostate cancer model...
  64. ncbi Near-infrared fluorescent RGD peptides for optical imaging of integrin alphavbeta3 expression in living mice
    Zhen Cheng
    Molecular Imaging Program at Stanford (MIPS, Department of Radiology and Bio-X Program, Stanford University, California 94305-5344, USA
    Bioconjug Chem 16:1433-41. 2005
    ..The multmerization of RGD peptide results in moderate improvement of imaging characteristics of the tetramer, compared to that of the monomer and dimeric counterparts...
  65. ncbi Firefly luciferase-based dynamic bioluminescence imaging: a noninvasive technique to assess tumor angiogenesis
    Amy Sun
    Department of Biological Sciences, Stanford University School of Medicine, Stanford, California, USA
    Neurosurgery 66:751-7; discussion 757. 2010
    ..We describe the use of dynamic BLI as a noninvasive method of assessing vessel permeability during brain tumor growth...
  66. ncbi A thiol-reactive 18F-labeling agent, N-[2-(4-18F-fluorobenzamido)ethyl]maleimide, and synthesis of RGD peptide-based tracer for PET imaging of alpha v beta 3 integrin expression
    Weibo Cai
    Molecular Imaging Program at Stanford (MIPS) and Bio-X Program, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305-5484, USA
    J Nucl Med 47:1172-80. 2006
    ..The new synthon 18F-FBEM developed in this study will also be useful for radiolabeling of other thiolated biomolecules...
  67. ncbi Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging
    Eun Kyoung Ryu
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Med Chem 51:1817-23. 2008
    ..Noninvasive microPET imaging studies revealed the absence of [(18)F]- 1 in rat brain, since it fails to cross the blood-brain barrier. This study demonstrates the suitability of [ (18)F]- 1 for imaging peripheral delta-opioid receptors...
  68. ncbi MicroPET and autoradiographic imaging of breast cancer alpha v-integrin expression using 18F- and 64Cu-labeled RGD peptide
    Xiaoyuan Chen
    PET Imaging Science Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Bioconjug Chem 15:41-9. 2004
    ..Further modification of the RGD peptide and optimization of the tracer for prolonged tumor uptake and improved in vivo kinetics are being explored...
  69. ncbi microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide
    Yun Wu
    Molecular Imaging Program at Stanford (MIPS, Department of Radiology and Bio-X Program, Stanford University, Stanford, California 94305, USA
    J Nucl Med 46:1707-18. 2005
    ..0164 mSv/MBq. CONCLUSION: The high integrin and avidity and favorable biokinetics make (64)Cu-DOTA-E{E[c(RGDfK)](2)}(2) a promising agent for peptide receptor radionuclide imaging and therapy of integrin-positive tumors...
  70. ncbi Pharmacokinetics and tumor retention of 125I-labeled RGD peptide are improved by PEGylation
    Xiaoyuan Chen
    Department of Radiology, University of Southern California, Los Angeles, CA 90033, USA
    Nucl Med Biol 31:11-9. 2004
    ..Compared to the 125I-RGD analog, this PEGylated RGD peptide revealed faster blood clearance, lower kidney uptake, and prolonged tumor uptake without compromising the receptor targeting ability...
  71. ncbi Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects
    Weibo Cai
    Molecular Imaging Program (MIPS, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nano Lett 6:669-76. 2006
    ..The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery...
  72. ncbi Near-infrared fluorescence imaging of tumor integrin alpha v beta 3 expression with Cy7-labeled RGD multimers
    Yun Wu
    Molecular Imaging Program at Stanford (MIPS, Department of Radiology and Bio-X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305-5484, USA
    Mol Imaging Biol 8:226-36. 2006
    ..CONCLUSIONS: Noninvasive NIR fluorescence imaging is able to detect and semiquantify tumor integrin expression based upon the highly potent tetrameric RGD peptide probe...
  73. ncbi Preparation and characterization of 99mTc(CO)3-BPy-RGD complex as alphav beta3 integrin receptor-targeted imaging agent
    Xianzhong Zhang
    Department of Radiology, Molecular Imaging Program at Stanford and Bio X, Stanford University School of Medicine, Stanford, CA 94305, USA
    Appl Radiat Isot 65:70-8. 2007
    ....
  74. ncbi In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in an orthotopic glioblastoma model
    Andrew R Hsu
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Imaging Biol 8:315-23. 2006
    ..This study suggests that NIRF via fluorescently labeled RGD peptides may provide enhanced surveillance of tumor angiogenesis and anti-integrin treatment efficacy in orthotopic brain tumor models...
  75. ncbi Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism
    Weibo Cai
    Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305-5484, USA
    Anticancer Agents Med Chem 6:407-28. 2006
    ..Lastly, integrin targeted delivery (drugs, genes, and radioisotopes) and imaging (optical, MRI, ultrasound, SPECT, and PET) is discussed in detail...
  76. ncbi Near-infrared fluorescent deoxyglucose analogue for tumor optical imaging in cell culture and living mice
    Zhen Cheng
    Molecular Imaging Program at Stanford (MIPS, Department of Radiology, Stanford University, Stanford, California, 94305-5344, USA
    Bioconjug Chem 17:662-9. 2006
    ..To develop NIR glucose analogues with the ability to target GLUTs/hexokinase, it is highly important to select NIR dyes with a reasonable molecular size...
  77. ncbi Evaluation of a (99m)Tc-labeled cyclic RGD tetramer for noninvasive imaging integrin alpha(v)beta3-positive breast cancer
    Shuang Liu
    School of Health Sciences, Purdue University, West Lafayette, Indiana 47907 2051, USA
    Bioconjug Chem 18:438-46. 2007
    ..i. The high tumor uptake and fast renal excretion make [99mTc(HYNIC-tetramer)(tricine)(TPPTS)] a promising radiotracer for noninvasive imaging of the integrin alphavbeta3-positive tumors by SPECT...
  78. ncbi Vascular endothelial growth factor and vascular endothelial growth factor receptor inhibitors as anti-angiogenic agents in cancer therapy
    Anand Veeravagu
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Recent Pat Anticancer Drug Discov 2:59-71. 2007
    ..This review will focus on patents which target VEGF-[A-F] and/or VEGFR-[1-3] for use in anti-cancer treatment...
  79. ncbi Discovery of small molecule integrin alphavbeta3 antagonists as novel anticancer agents
    Raveendra Dayam
    Department of Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90033, USA
    J Med Chem 49:4526-34. 2006
    ..These small-molecule compounds could be conjugated to paclitaxel for selective delivery to alphavbeta3 positive metastatic cancer cells...
  80. ncbi Multimodality molecular imaging of tumor angiogenesis
    Weibo Cai
    Department of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53792 3252, USA
    J Nucl Med 49:113S-28S. 2008
    ..Not limited to cancer, these novel agents can also have broad applications for many other angiogenesis-related diseases...
  81. ncbi Small-animal PET of melanocortin 1 receptor expression using a 18F-labeled alpha-melanocyte-stimulating hormone analog
    Zhen Cheng
    Molecular Imaging Program at Stanford, Stanford University, Stanford, California 94305, USA
    J Nucl Med 48:987-94. 2007
    ..It is a promising molecular target for diagnosis and therapy of melanomas. However, (18)F compounds have not been successfully developed for imaging the MC1R...
  82. ncbi How molecular imaging is speeding up antiangiogenic drug development
    Weibo Cai
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Stanford University School of Medicine, 1201 Welch Road, P095, Stanford, CA 94305-5484, USA
    Mol Cancer Ther 5:2624-33. 2006
    ..Molecular imaging has enormous potential in improving the efficiency of the drug development process, including the specific area of antiangiogenic drugs...
  83. ncbi 64Cu-Labeled triphenylphosphonium and triphenylarsonium cations as highly tumor-selective imaging agents
    Jianjun Wang
    School of Health Sciences, Purdue University, West Lafayette, Indiana, USA
    J Med Chem 50:5057-69. 2007
    ..The 64Cu-labeled TPP/TPA cations are very selective radiotracers that are able to provide the information of mitochondrial bioenergetic function in tumors by monitoring mitochondrial potential in a noninvasive fashion...
  84. ncbi Imaging of urokinase-type plasminogen activator receptor expression using a 64Cu-labeled linear peptide antagonist by microPET
    Zi Bo Li
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    Clin Cancer Res 14:4758-66. 2008
    ..Noninvasive imaging of this receptor in vivo with radiolabeled peptides that specifically target uPAR may therefore be useful to decipher the potential invasiveness of malignant lesions...
  85. ncbi Preparation of peptide-conjugated quantum dots for tumor vasculature-targeted imaging
    Weibo Cai
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Protoc 3:89-96. 2008
    ..In general, QD conjugation and in vitro validation of the peptide-conjugated QDs can be accomplished within 1-2 d; in vivo imaging will take another 1-2 d depending on the experimental design...
  86. ncbi Molecular imaging can accelerate anti-angiogenic drug development and testing
    Andrei Iagaru
    Stanford University School of Medicine, Stanford, CA, USA
    Nat Clin Pract Oncol 4:556-7. 2007
  87. ncbi Comparative in vitro and in vivo evaluation of two 64Cu-labeled bombesin analogs in a mouse model of human prostate adenocarcinoma
    Yi-Shan Yang
    Department of Radiology and Bio-X Program, The Molecular Imaging Program at Stanford (MIPS, Stanford University School of Medicine, Stanford, CA 94305-5484, USA
    Nucl Med Biol 33:371-80. 2006
    ..This study demonstrated that both tracers are suitable for targeted PET imaging to detect the expression of GRPR in prostate cancer, while 64Cu-DOTA-[Lys3]BBN may have a better potential for clinical translation...
  88. ncbi 64Cu-labeled alpha-melanocyte-stimulating hormone analog for microPET imaging of melanocortin 1 receptor expression
    Zhen Cheng
    Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, Stanford, California 94305 5344, USA
    Bioconjug Chem 18:765-72. 2007
    ..This study demonstrates that 64Cu-DOTA-NAPamide is a promising molecular probe for alpha-MSH receptor positive melanoma PET imaging as well as MC1R expression imaging in living mice...
  89. ncbi Effects of targeting moiety, linker, bifunctional chelator, and molecular charge on biological properties of 64Cu-labeled triphenylphosphonium cations
    Young Seung Kim
    School of Health Sciences, Purdue University, West Lafayette, IN, USA
    J Med Chem 51:2971-84. 2008
    ..Considering the tumor uptake and tumor/liver ratios, 64Cu(DO2A-xy-TPP)+ is the best candidate for more extensive evaluations in different tumor-bearing animal models...

Research Grants7

  1. MicroPET and NIR Fluorescence Imaging Tumor Angiogenesis
    Xiaoyuan Chen; Fiscal Year: 2004
    ..All the results obtained here will be used for future application of a R01 type grant. ..
  2. Imaging Alpha (v)beta(3) Integrin Expression
    Xiaoyuan Chen; Fiscal Year: 2006
    ..abstract_text> ..
  3. Radiolabeled RGD Peptides for Breast Cancer Imaging and Therapy
    Xiaoyuan Chen; Fiscal Year: 2007
    ..The same ligands labeled with therapeutic isotopes will allow targeted internal radiotherapy of integrin positive tumors. ..
  4. Quantum Dots for NIR Fluorescence Imaging of Tumor Angiogenesis
    Xiaoyuan Chen; Fiscal Year: 2007
    ..The QDs with suitable imaging quality will be subjected to acute and chronic toxicity studies. The success of this approach will allow clinical translation of QD based probe for fluorescence imaging. ..