Chang Zheng Chen

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1 and mir-181c in early T cell development
    Gwen Liu
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, USA
    PLoS ONE 3:e3592. 2008
  2. pmc Regulation of immune responses and tolerance: the microRNA perspective
    Chang Zheng Chen
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunol Rev 253:112-28. 2013
  3. pmc An unsolved mystery: the target-recognizing RNA species of microRNA genes
    Chang Zheng Chen
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biochimie 95:1663-76. 2013
  4. ncbi request reprint MicroRNAs as regulators of mammalian hematopoiesis
    Chang Zheng Chen
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Institute for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, CA 94305 5175, USA
    Semin Immunol 17:155-65. 2005
  5. pmc Loop nucleotides control primary and mature miRNA function in target recognition and repression
    Si Biao Yue
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA
    RNA Biol 8:1115-23. 2011
  6. ncbi request reprint miR-181a is an intrinsic modulator of T cell sensitivity and selection
    Qi jing Li
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:147-61. 2007
  7. pmc Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1
    Rita Fragoso
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 8:e1002855. 2012
  8. ncbi request reprint Methods for analyzing microRNA expression and function during hematopoietic lineage differentiation
    Hyeyoung Min
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Institute for Stem Cell, Cancer and Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 342:209-27. 2006
  9. pmc MicroRNA programs in normal and aberrant stem and progenitor cells
    Christopher P Arnold
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genome Res 21:798-810. 2011
  10. ncbi request reprint Dissecting microRNA-mediated gene regulation and function in T-cell development
    Tin Ky Mao
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, USA
    Methods Enzymol 427:171-89. 2007

Research Grants

Collaborators

  • David Bartel
  • Julien Sage
  • Anne Brunet
  • Xue Gong
  • Tomoichiro Asano
  • Patrick Viatour
  • Song Wang
  • Warren Pear
  • Tim C P Somervaille
  • Linheng Li
  • Mark M Davis
  • Berthold Gottgens
  • Hyeyoung Min
  • Si Biao Yue
  • Gwen Liu
  • Robin Deis Trujillo
  • Rita Fragoso
  • Steven Schaffert
  • Christopher P Arnold
  • William E O'Gorman
  • Michael L Cleary
  • Yujie Tang
  • Piu Wong
  • Sibiao Yue
  • Harvey F Lodish
  • Frank Kuhnert
  • Tin Ky Mao
  • Qi jing Li
  • Richard Luong
  • Yumi Yashiro-Ohtani
  • Tin Mao
  • ValĂ©rie M Renault
  • Regis Doyonnas
  • Dong Er Zhang
  • Joseph R Biggs
  • Miao Chia Lo
  • John M Perry
  • Ruoying Tan
  • Alessandra Sacco
  • Baiyu Zhou
  • Helen M Blau
  • Masayuki Iwasaki
  • Christine Carico
  • Francesca Ficara
  • Christopher Arnold
  • Jessica Hampton
  • Michael R Mancuso
  • Kryn Stankunas
  • Calvin J Kuo
  • Beiyan Zhou
  • Giselle Sylvester
  • Petra Skare
  • Lawrence O Klein
  • Peter J R Ebert
  • Jacqueline Chau
  • Ravi Braich
  • Juergen Soutschek
  • Muthiah Manoharan

Detail Information

Publications18

  1. pmc Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1 and mir-181c in early T cell development
    Gwen Liu
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, USA
    PLoS ONE 3:e3592. 2008
    ..However, it is unclear whether members of a miRNA gene family, which encode identical or nearly identical mature miRNAs, are functionally interchangeable in vivo...
  2. pmc Regulation of immune responses and tolerance: the microRNA perspective
    Chang Zheng Chen
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunol Rev 253:112-28. 2013
    ....
  3. pmc An unsolved mystery: the target-recognizing RNA species of microRNA genes
    Chang Zheng Chen
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biochimie 95:1663-76. 2013
    ..The integrated framework opens experimental enquiry and permits interpretation of fundamental problems that have so far been precluded. ..
  4. ncbi request reprint MicroRNAs as regulators of mammalian hematopoiesis
    Chang Zheng Chen
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Institute for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, CA 94305 5175, USA
    Semin Immunol 17:155-65. 2005
    ..Here, we provide background on the biogenesis and function of miRNAs and discuss how miRNA-mediated post-transcriptional regulation may influence the development and function of blood cells...
  5. pmc Loop nucleotides control primary and mature miRNA function in target recognition and repression
    Si Biao Yue
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA
    RNA Biol 8:1115-23. 2011
    ....
  6. ncbi request reprint miR-181a is an intrinsic modulator of T cell sensitivity and selection
    Qi jing Li
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:147-61. 2007
    ..Importantly, higher miR-181a expression correlates with greater T cell sensitivity in immature T cells, suggesting that miR-181a acts as an intrinsic antigen sensitivity "rheostat" during T cell development...
  7. pmc Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1
    Rita Fragoso
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 8:e1002855. 2012
    ..Together, these results illustrate that NOTCH oncogene activity in tumor development can be selectively inhibited by targeting the molecular networks controlled by mir-181a-1/b-1...
  8. ncbi request reprint Methods for analyzing microRNA expression and function during hematopoietic lineage differentiation
    Hyeyoung Min
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Institute for Stem Cell, Cancer and Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 342:209-27. 2006
    ..The methods and principles described here should also be applicable to study the roles of miRNAs in the differentiation and function of nonhematopoietic cell types...
  9. pmc MicroRNA programs in normal and aberrant stem and progenitor cells
    Christopher P Arnold
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genome Res 21:798-810. 2011
    ..Together, these analyses reveal the miRNA programs that may control key processes in normal and aberrant stem and progenitor cells, setting the foundations for dissecting post-transcriptional regulatory networks in stem cells...
  10. ncbi request reprint Dissecting microRNA-mediated gene regulation and function in T-cell development
    Tin Ky Mao
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, USA
    Methods Enzymol 427:171-89. 2007
    ....
  11. ncbi request reprint MicroRNAs as oncogenes and tumor suppressors
    Chang Zheng Chen
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Institute for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, Calif, USA
    N Engl J Med 353:1768-71. 2005
  12. pmc The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression
    Piu Wong
    Department of Pathology and Microbiology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Cancer Res 70:3833-42. 2010
    ..Thus, microRNAs quantitatively regulate LSC self-renewal in MLL-associated leukemia in part by modulating the expression of p21, a known regulator of normal stem cell function...
  13. doi request reprint Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126
    Frank Kuhnert
    Division of Hematology, Department of Medicine, Stanford University School of Medicine, CCSR 1155, 269 Campus Drive, Stanford, CA 94305, USA
    Development 135:3989-93. 2008
    ....
  14. pmc The potential functions of primary microRNAs in target recognition and repression
    Robin Deis Trujillo
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA
    EMBO J 29:3272-85. 2010
    ..These findings illustrate that the regulatory information encoded in structured pri-miRNAs may be translated into function through direct interactions with target mRNAs...
  15. ncbi request reprint Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
    David P Bartel
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Genet 5:396-400. 2004
  16. ncbi request reprint MicroRNAs modulate hematopoietic lineage differentiation
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 303:83-6. 2004
    ..Our results indicate that microRNAs are components of the molecular circuitry that controls mouse hematopoiesis and suggest that other microRNAs have similar regulatory roles during other facets of vertebrate development...
  17. doi request reprint Micromanagement of the immune system by microRNAs
    Harvey F Lodish
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Immunol 8:120-30. 2008
    ..Here, we provide an overview of the mechanisms by which miRNAs regulate gene expression, with specific focus on the role of miRNAs in regulating the development of immune cells and in modulating innate and adaptive immune responses...
  18. pmc Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 99:15468-73. 2002
    ..Our overall strategy may be applicable for the identification of markers for other tissue-specific stem cells...

Research Grants8

  1. MicroRNAs' Role in Hematopoietic Lineage Differentiation
    Chang Zheng Chen; Fiscal Year: 2005
    ..The proposed research will also provide methods, insights, and inspiration to those seeking to place miRNAs into other biological processes. ..
  2. MicroRNAs' Role in Hematopoietic Lineage Differentiation
    Chang Zheng Chen; Fiscal Year: 2006
    ..The proposed research will also provide methods, insights, and inspiration to those seeking to place miRNAs into other biological processes. ..
  3. MicroRNAs' Role in Hematopoietic Lineage Differentiation
    Chang Zheng Chen; Fiscal Year: 2007
    ..The proposed research will also provide methods, insights, and inspiration to those seeking to place miRNAs into other biological processes. ..
  4. MicroRNAs as T cell sensitivity Rheostats
    Chang Zheng Chen; Fiscal Year: 2009
    ....
  5. MicroRNAs' Role in Hematopoietic Lineage Differentiation
    Chang Zheng Chen; Fiscal Year: 2009
    ..The proposed research will also provide methods, insights, and inspiration to those seeking to place miRNAs into other biological processes. ..
  6. MicroRNAs as T cell sensitivity Rheostats
    Chang Zheng Chen; Fiscal Year: 2010
    ....
  7. The Role of Pre-miRNA Loop in Target Regulation by microRNA Genes
    Chang Zheng Chen; Fiscal Year: 2009
    ..Please ignore the Administrative Budget Note on page one and the Notice below regarding resubmissions (formerly termed amended) applications as they do not apply to Pioneer Awards. ..