Bertha H Chen

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse
    B H Chen
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Int Urogynecol J Pelvic Floor Dysfunct 13:80-7; discussion 87. 2002
  2. ncbi request reprint Microarray analysis of differentially expressed genes in vaginal tissues from women with stress urinary incontinence compared with asymptomatic women
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Hum Reprod 21:22-9. 2006
  3. ncbi request reprint Elastin metabolism in pelvic tissues: is it modulated by reproductive hormones?
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Calif 94305 5317, USA
    Am J Obstet Gynecol 192:1605-13. 2005
  4. ncbi request reprint Elastolytic activity in women with stress urinary incontinence and pelvic organ prolapse
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Neurourol Urodyn 23:119-26. 2004
  5. pmc Relaxin increases elastase activity and protease inhibitors in smooth muscle cells from the myometrium compared with cells from leiomyomas
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Fertil Steril 91:1351-4. 2009
  6. ncbi request reprint Menstrual phase-dependent gene expression differences in periurethral vaginal tissue from women with stress incontinence
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Am J Obstet Gynecol 189:89-97. 2003
  7. ncbi request reprint Differences in estrogen modulation of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-1 expression in cultured fibroblasts from continent and incontinent women
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Am J Obstet Gynecol 189:59-65. 2003
  8. ncbi request reprint The role of neutrophil elastase in elastin metabolism of pelvic tissues from women with stress urinary incontinence
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Neurourol Urodyn 26:274-9. 2007
  9. ncbi request reprint Distinctive proliferative phase differences in gene expression in human myometrium and leiomyomata
    Hongbo Wang
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Fertil Steril 80:266-76. 2003
  10. ncbi request reprint Increased expression of latent TGF-beta binding protein-1 and fibrillin-1 in human uterine leiomyomata
    Yangyu Zhao
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA
    Mol Hum Reprod 13:343-9. 2007

Research Grants

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse
    B H Chen
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Int Urogynecol J Pelvic Floor Dysfunct 13:80-7; discussion 87. 2002
    ..Both these findings are consistent with increased collagen breakdown as a pathologic etiology of incontinence...
  2. ncbi request reprint Microarray analysis of differentially expressed genes in vaginal tissues from women with stress urinary incontinence compared with asymptomatic women
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Hum Reprod 21:22-9. 2006
    ..We sought to identify differentially expressed genes involved in extracellular matrix (ECM) metabolism in vaginal tissues from women with SUI in the secretory phase of menses compared with asymptomatic women...
  3. ncbi request reprint Elastin metabolism in pelvic tissues: is it modulated by reproductive hormones?
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Calif 94305 5317, USA
    Am J Obstet Gynecol 192:1605-13. 2005
    ..The purpose of this study was to investigate the effect of relaxin on extracellular matrix protein expression in pelvic fibroblasts that were cultured from women with stress urinary incontinence compared with asymptomatic control subjects...
  4. ncbi request reprint Elastolytic activity in women with stress urinary incontinence and pelvic organ prolapse
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Neurourol Urodyn 23:119-26. 2004
    ....
  5. pmc Relaxin increases elastase activity and protease inhibitors in smooth muscle cells from the myometrium compared with cells from leiomyomas
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Fertil Steril 91:1351-4. 2009
    ..Relaxin increases elastase activity and protease inhibitor expressions in myometrial smooth muscle cells, but no effect was observed in leiomyoma cells...
  6. ncbi request reprint Menstrual phase-dependent gene expression differences in periurethral vaginal tissue from women with stress incontinence
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Am J Obstet Gynecol 189:89-97. 2003
    ....
  7. ncbi request reprint Differences in estrogen modulation of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-1 expression in cultured fibroblasts from continent and incontinent women
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Am J Obstet Gynecol 189:59-65. 2003
    ....
  8. ncbi request reprint The role of neutrophil elastase in elastin metabolism of pelvic tissues from women with stress urinary incontinence
    Bertha Chen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Neurourol Urodyn 26:274-9. 2007
    ..Altered elastin metabolism is implicated in pelvic floor disorders. We studied neutrophil elastase (NE) and matrix metalloproteinase (MMP) activities in vaginal tissues from premenopausal women with stress urinary incontinence (SUI)...
  9. ncbi request reprint Distinctive proliferative phase differences in gene expression in human myometrium and leiomyomata
    Hongbo Wang
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Fertil Steril 80:266-76. 2003
    ..To gain a comprehensive view of the gene expression and regulation involved in uterine leiomyomata and matched normal myometrium using oligonucleotide microarray-based hybridization analysis...
  10. ncbi request reprint Increased expression of latent TGF-beta binding protein-1 and fibrillin-1 in human uterine leiomyomata
    Yangyu Zhao
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA
    Mol Hum Reprod 13:343-9. 2007
    ..Estrogen may be involved in LTBP-1 and FBN-1 expression in leiomyomata. Extracellular matrix metabolism may be different in medium-sized leiomyoma...
  11. ncbi request reprint Expression of CD9 in frozen-thawed mouse oocytes: preliminary experience
    Yan Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Fertil Steril 88:526-9. 2007
    ..The expression levels of both CD9 mRNA and protein in the frozen oocytes were significantly lower than those found in the fresh oocytes...
  12. doi request reprint Effect of relaxin on TGF-beta1 expression in cultured vaginal fibroblasts from women with stress urinary incontinence
    Yan Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA
    Reprod Sci 15:312-20. 2008
    ..05) in the supernatant, cells and ECM of both women with SUI and controls. Relaxin decreased the levels of total and active TGF-beta1 in the ECM isolated from SUI vaginal fibroblasts...
  13. ncbi request reprint Emergency gynecologic imaging
    Aya Kamaya
    Department of Radiology, Stanford University Medical Center, Stanford, CA 94305, USA
    Semin Ultrasound CT MR 29:353-68. 2008
    ..The imaging features of these and other important clinical entities in the female pelvis will be presented...
  14. ncbi request reprint Severe vaginal pain caused by a neuroma in the rectovaginal septum after posterior colporrhaphy
    Leah S Millheiser
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94301, USA
    Obstet Gynecol 108:809-11. 2006
    ..Traumatic vaginal neuromas are a rarely documented finding in the setting of vaginal pain after posterior colporrhaphy. They arise as a result of trauma or surgery and are often mistaken for scar tissue...
  15. ncbi request reprint Metastatic mantle cell lymphoma presenting as a vaginal mass. A case report
    Alexandra Bujor
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Gynecol Obstet Invest 62:217-9. 2006
    ..Vaginal masses are an uncommon finding in well-woman gynecologic examinations. The differential diagnosis includes cysts, leiomyomata, ectopic ureteroceles, infected granuloma, and malignancy...
  16. ncbi request reprint Female urinary incontinence in China: experiences and perspectives
    Leanne Komorowski
    Stanford School of Medicine, Stanford, California, USA
    Health Care Women Int 27:169-81. 2006
    ..Our study was limited by the small sample size and the need for additional reliability/validity measures, but we believe it presented a strong foundation and justification for more rigorous research into UI in China...
  17. ncbi request reprint Do extracellular matrix protein expressions change with cyclic reproductive hormones in pelvic connective tissue from women with stress urinary incontinence?
    Yan Wen
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Hum Reprod 21:1266-73. 2006
    ....
  18. pmc Is lysyl oxidase-like protein-1, alpha-1 antitrypsin, and neutrophil elastase site specific in pelvic organ prolapse?
    Weng Chi Man
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, HH 333, Stanford, CA 94305 5317, USA
    Int Urogynecol J Pelvic Floor Dysfunct 20:1423-9. 2009
    ..We investigated whether the expression of alpha-1 antitrypsin (ATT), neutrophil elastase (NE), and lysyl oxidase-like protein 1 (LOXL-1) vary within the vagina in subjects with pelvic organ prolapse (POP)...
  19. ncbi request reprint Abdominal myomectomy versus uterine fibroid embolization in the treatment of symptomatic uterine leiomyomas
    Mahmood K Razavi
    Department of Vascular and Interventional Radiology, H 3651, Stanford University Vascular Center, 300 Pasteur Dr, CA 94305, USA
    AJR Am J Roentgenol 180:1571-5. 2003
    ..The purpose of this study was to compare treatment efficacy and complications of abdominal myomectomy with those of uterine fibroid embolization in women with symptomatic uterine fibroids...
  20. doi request reprint Radiofrequency treatment of vaginal laxity after vaginal delivery: nonsurgical vaginal tightening
    Leah S Millheiser
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Sex Med 7:3088-95. 2010
    ..Long-term physical and psychological consequences may occur, including loss of sensation and sexual dissatisfaction. One significant issue is the laxity of the vaginal introitus...
  21. pmc Transforming growth interacting factor expression in leiomyoma compared with myometrium
    Jason Yen-Ping Ho
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Fertil Steril 94:1078-83. 2010
    ..To investigate the expression of transforming growth interacting factor (TGIF), a Smad transcriptional corepressor, in leiomyoma and matched myometrial tissue samples and the effect of TGIF overexpression in myometrial cells...
  22. ncbi request reprint Bench to bedside: clinical opportunities for microarray analysis
    Mary Lake Polan
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA
    Fertil Steril 80:291-2. 2003
  23. ncbi request reprint Menopausal symptoms and treatment-related effects of estrogen and progestin in the Women's Health Initiative
    Vanessa M Barnabei
    Department of Obstetrics and Gynecology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Obstet Gynecol 105:1063-73. 2005
    ..To estimate the effects of estrogen plus progestin (E+P) therapy on menopausal symptoms, vaginal bleeding, gynecologic surgery rates, and treatment-related adverse effects in postmenopausal women...
  24. ncbi request reprint A randomized controlled pilot study of acupuncture for postmenopausal hot flashes: effect on nocturnal hot flashes and sleep quality
    Mary I Huang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Fertil Steril 86:700-10. 2006
    ..To assess the effectiveness of acupuncture on postmenopausal nocturnal hot flashes and sleep...

Research Grants5

  1. Collagenolysis and Elastolysis in Urinary Incontinence
    Bertha Chen; Fiscal Year: 2007
    ..Our goal is to identify specific pathophysiologic changes related to reproductive events and aging which underlie the development of SUI as a first step to identifying potential targets for therapeutic intervention. ..