Ajay Chawla

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance
    Lata Mukundan
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Nat Med 15:1266-72. 2009
  2. pmc Control of macrophage activation and function by PPARs
    Ajay Chawla
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Circ Res 106:1559-69. 2010
  3. pmc Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Cell Metab 7:496-507. 2008
  4. pmc IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity
    Roberto R Ricardo-Gonzalez
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:22617-22. 2010
  5. pmc Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Nature 447:1116-20. 2007
  6. pmc Eosinophils secrete IL-4 to facilitate liver regeneration
    Y P Sharon Goh
    Department of Genetics and Pathology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 110:9914-9. 2013
  7. pmc Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity
    Shannon E Dunn
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
    J Exp Med 207:1599-608. 2010
  8. pmc Connecting type 1 and type 2 diabetes through innate immunity
    Justin I Odegaard
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cold Spring Harb Perspect Med 2:a007724. 2012
  9. pmc Quantitative expansion of ES cell-derived myeloid progenitors capable of differentiating into macrophages
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine and Graduate Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    J Leukoc Biol 81:711-9. 2007
  10. pmc Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
    Divya Vats
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine and Graduate Program in Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell Metab 4:13-24. 2006

Collaborators

Detail Information

Publications18

  1. pmc PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance
    Lata Mukundan
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Nat Med 15:1266-72. 2009
    ..Thus, PPAR-delta has a pivotal role in orchestrating the timely disposal of apoptotic cells by macrophages, ensuring that tolerance to self is maintained...
  2. pmc Control of macrophage activation and function by PPARs
    Ajay Chawla
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Circ Res 106:1559-69. 2010
    ....
  3. pmc Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Cell Metab 7:496-507. 2008
    ..Taken together, these data suggest an unexpected beneficial role for alternatively activated Kupffer cells in metabolic syndrome and type 2 diabetes...
  4. pmc IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity
    Roberto R Ricardo-Gonzalez
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:22617-22. 2010
    ....
  5. pmc Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Nature 447:1116-20. 2007
    ....
  6. pmc Eosinophils secrete IL-4 to facilitate liver regeneration
    Y P Sharon Goh
    Department of Genetics and Pathology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 110:9914-9. 2013
    ..Instead, IL-4 exerts its proliferative actions via IL-4Rα in hepatocytes. Our findings thus provide a unique mechanism by which eosinophil-derived IL-4 stimulates hepatocyte proliferation in regenerating liver...
  7. pmc Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity
    Shannon E Dunn
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
    J Exp Med 207:1599-608. 2010
    ..Collectively, these findings suggest that PPAR-delta serves as an important molecular brake for the control of autoimmune inflammation...
  8. pmc Connecting type 1 and type 2 diabetes through innate immunity
    Justin I Odegaard
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cold Spring Harb Perspect Med 2:a007724. 2012
    ..We conclude with a discussion of the therapeutic implications of this integrated understanding of diabetic pathology...
  9. pmc Quantitative expansion of ES cell-derived myeloid progenitors capable of differentiating into macrophages
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine and Graduate Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    J Leukoc Biol 81:711-9. 2007
    ....
  10. pmc Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
    Divya Vats
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine and Graduate Program in Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell Metab 4:13-24. 2006
    ....
  11. pmc Salmonella require the fatty acid regulator PPARδ for the establishment of a metabolic environment essential for long-term persistence
    Nicholas A Eisele
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Host Microbe 14:171-82. 2013
    ..These data suggest that M2 macrophages represent a unique niche for long-term intracellular bacterial survival and link the PPARδ-regulated metabolic state of the host cell to persistent bacterial infection. ..
  12. pmc Alternative macrophage activation and metabolism
    Justin I Odegaard
    Department of Pathology, Stanford University School of Medicine, California 94305 5103, USA
    Annu Rev Pathol 6:275-97. 2011
    ..The therapeutic implications of this conclusion are profound because they suggest that pharmacologic targeting of macrophage activation, rather than simply inflammation, might be efficacious in treating this global epidemic...
  13. pmc Mechanisms of macrophage activation in obesity-induced insulin resistance
    Justin I Odegaard
    Graduate Program in Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Nat Clin Pract Endocrinol Metab 4:619-26. 2008
    ..The functional importance of macrophage activation is further discussed in the context of host defense to highlight the crosstalk between innate immunity and metabolism...
  14. pmc Type 2 innate lymphoid cells control eosinophil homeostasis
    Jesse C Nussbaum
    Department of Medicine, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 502:245-8. 2013
    ....
  15. pmc In obesity and weight loss, all roads lead to the mighty macrophage
    Alex Red Eagle
    Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 120:3437-40. 2010
    ..In this issue of the JCI, Kosteli and colleagues demonstrate that weight loss is unexpectedly also associated with rapid, albeit transient, recruitment of macrophages to WAT and that this appears to be related to lipolysis...
  16. pmc Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice
    Lily C Chao
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    J Lipid Res 54:806-15. 2013
    ..Collectively, our results suggest that alterations in the Ly6C(lo) monocyte population and bone marrow NR4A expression do not play dominant roles in macrophage polarization or the development of atherosclerosis in mice...
  17. pmc A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes
    Diana Ríos-Cardona
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Dev Biol 317:380-8. 2008
    ..Morpholino injections did not cause spontaneous maturation of oocytes, but did accelerate progesterone-induced maturation. Thus, GPRx contributes to the maintenance of G2-arrest in immature X. laevis oocytes...
  18. ncbi Role of PPARgamma in macrophage biology and atherosclerosis
    Lina Zhang
    Department of Medicine Division of Endocrinology, Stanford University School of Medicine, S025, MC 5103, Stanford, CA 94305 5103, USA
    Trends Endocrinol Metab 15:500-5. 2004
    ..Thiazolidinediones (TZDs) might be developed as anti-atherogenic agents on the basis of their actions as ligands for peroxisome proliferator-activated receptor-gamma (PPARgamma)...

Research Grants11

  1. Immune Triggers of Tissue Regeneration
    Ajay Chawla; Fiscal Year: 2009
    ..Public Health Relevance Macrophages, the sentinels of host defense, are also the first cells to be recruited to site ..
  2. Role of PPARs in Atherosclerosis
    Ajay Chawla; Fiscal Year: 2006
    ..abstract_text> ..
  3. Role of Cytokine Signaling Pathways and Macrophages in Type 2 Diabetes Mellitus
    Ajay Chawla; Fiscal Year: 2007
    ..Thus, our studies are aimed at identifying new therapeutic targets that can improve the action of insulin, and limit or delay the onset of type 2 diabetes mellitus. ..
  4. Transcriptional Control of Macrophage in Atherogenesis
    Ajay Chawla; Fiscal Year: 2007
    ..abstract_text> ..