Research Topics
| K D ChangSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Neurometabolite effects of response to quetiapine and placebo in adolescents with bipolar depressionKiki Chang
Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5540, USA
J Child Adolesc Psychopharmacol 22:261-8. 2012..We examined the effects of quetiapine (QUET), an atypical antipsychotic, on these neurochemicals, and potential predictors of response to QUET in adolescents with bipolar depression...
Cortical magnetic resonance imaging findings in familial pediatric bipolar disorderKiki Chang
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Biol Psychiatry 58:197-203. 2005..We studied gray matter volume, ventricular-to-brain ratios (VBR), and number of WMH in patients with familial, pediatric BD compared with control subjects...- An open-label study of lamotrigine adjunct or monotherapy for the treatment of adolescents with bipolar depressionKiki Chang
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5540, USA
J Am Acad Child Adolesc Psychiatry 45:298-304. 2006..The authors wished to prospectively study the efficacy of lamotrigine as adjunctive or monotherapy in adolescents with bipolar disorder who were experiencing a depressive episode... - Will neuroimaging ever be used to diagnose pediatric bipolar disorder?Kiki Chang
Stanford University School of Medicine, CA 94305 5540, USA
Dev Psychopathol 18:1133-46. 2006.... - Prevention of pediatric bipolar disorder: integration of neurobiological and psychosocial processesKiki Chang
Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
Ann N Y Acad Sci 1094:235-47. 2006..Further research into the biologic and environmental mechanisms of BD development as well as controlled early intervention studies are needed to ameliorate this significant public health problem... - Adult bipolar disorder is continuous with pediatric bipolar disorderKiki Chang
Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Lucile Packard Children s Hospital, California 94305 5540, USA
Can J Psychiatry 52:418-25. 2007..Prospective studies incorporating phenomenological and biological assessment are needed to decisively address this issue... - Temperament characteristics of child and adolescent bipolar offspringKiki D Chang
Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5719, USA
J Affect Disord 77:11-9. 2003..We wished to characterize temperament of children at high risk for bipolar disorder (BD)... - Studies of offspring of parents with bipolar disorderKiki Chang
Pediatric Mood Disorders Clinic, Stanford University School of Medicine, Stanford, CA 94305, USA
Am J Med Genet C Semin Med Genet 123:26-35. 2003..The future holds promise for longitudinal studies of bipolar offspring incorporating all of these facets, including genetic analyses, to further elucidate the factors involved in the evolution of BD... - The use of atypical antipsychotics in pediatric bipolar disorderKiki D Chang
Division of Child and Adolescent Psychiatry, Pediatric Bipolar Disorders Program, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
J Clin Psychiatry 69:4-8. 2008..However, more information is needed about long-term treatment of mania, treatment of bipolar depression, and treatment of comorbid psychiatric conditions... - Effect of divalproex on brain morphometry, chemistry, and function in youth at high-risk for bipolar disorder: a pilot studyKiki Chang
Division of Child and Adolescent Psychiatry, Stanford University School of Medicine, Stanford, California 94305 5540, USA
J Child Adolesc Psychopharmacol 19:51-9. 2009..We sought to examine the effects of divalproex on the structure, chemistry, and function of specific brain regions in children at high-risk for BD... - Challenges in the diagnosis and treatment of pediatric bipolar depressionKiki Chang
Pediatric Bipolar Disorders Program, Stanford University School of Medicine, Stanford, California 94305 5540, USA
Dialogues Clin Neurosci 11:73-80. 2009.... 
Atomoxetine as an adjunct therapy in the treatment of co-morbid attention-deficit/hyperactivity disorder in children and adolescents with bipolar I or II disorderKiki Chang
Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
J Child Adolesc Psychopharmacol 19:547-51. 2009..We conducted an 8-week, open label study to study the efficacy and tolerability of adjunct atomoxetine in euthymic children and adolescents with BPD and ADHD...- A preliminary functional magnetic resonance imaging study of prefrontal-amygdalar activation changes in adolescents with bipolar depression treated with lamotrigineKiki D Chang
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5540, USA
Bipolar Disord 10:426-31. 2008..Therefore, we hypothesized that adolescents with bipolar depression successfully treated with lamotrigine would show decreases in amygdalar activation, and increases in prefrontal activation... - Family environment of children and adolescents with bipolar parentsK D Chang
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5540, USA
Bipolar Disord 3:73-8. 2001..We sought to characterize families with children at high risk for developing BD in order to better understand the contributions of family environment to the development of childhood BD... - Psychiatric phenomenology of child and adolescent bipolar offspringK D Chang
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5540, USA
J Am Acad Child Adolesc Psychiatry 39:453-60. 2000..To establish prodromal signs of and risk factors for childhood bipolar disorder (BD) by characterizing youths at high risk for BD... - Reduced amygdalar gray matter volume in familial pediatric bipolar disorderKiki Chang
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5540, USA
J Am Acad Child Adolesc Psychiatry 44:565-73. 2005..We sought to study morphometric characteristics of these structures in pediatric subjects with familial BD compared with healthy controls... - Mood stabilizer augmentation with olanzapine in acutely manic childrenK D Chang
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5540, USA
J Child Adolesc Psychopharmacol 10:45-9. 2000..Adverse effects included sedation and weight gain. These results suggest that olanzapine may have an antimanic or mood stabilizing effect in acutely manic children with bipolar disorder... - Decreased N-acetylaspartate in children with familial bipolar disorderKiki Chang
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
Biol Psychiatry 53:1059-65. 2003.... - The role of the amygdala in bipolar disorder developmentAmy Garrett
Stanford University School of Medicine, CA 94305, USA
Dev Psychopathol 20:1285-96. 2008..In addition, evidence is accumulating to suggest that this model has flexible outcomes, depending on factors intrinsic and extrinsic to BD, and may follow several possible paths across the course of maturational development... - Divalproex sodium for the treatment of PTSD and conduct disordered youth: a pilot randomized controlled clinical trialHans Steiner
Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5719, USA
Child Psychiatry Hum Dev 38:183-93. 2007..Intent-to-treat analyses showed significant positive associations between receiving high dose of DVP CGI's. Parallel analyses comparing outcome by drug level achieved strengthened the results... - Psychopharmacologic strategies for the treatment of aggression in juvenilesHans Steiner
Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Child Development, Stanford University School of Medicine, California 94503, USA
CNS Spectr 8:298-308. 2003.... - Divalproex sodium reduces overall aggression in youth at high risk for bipolar disorderKirti Saxena
Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Child Development, School of Medicine, Stanford University, 401 Quarry Road, Stanford, CA 94305, USA
J Child Adolesc Psychopharmacol 16:252-9. 2006..The psychopharmacology of aggression in youth is relatively unexplored, even though such maladaptive aggression manifests across many different diagnoses... - Subcortical volumetric correlates of anxiety in familial pediatric bipolar disorder: a preliminary investigationDiana I Simeonova
Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5540, USA
Psychiatry Res 173:113-20. 2009..The overlap between anxiety and familial pediatric BD suggests that anxiety may be one important area of future research in parsing out the heterogeneous nature and complex etiology of early-onset BD... - Attention and memory biases in the offspring of parents with bipolar disorder: indications from a pilot studyIan H Gotlib
Stanford University, Stanford, California 94305, USA
J Child Psychol Psychiatry 46:84-93. 2005..This study examined biases in the processing of emotional stimuli as a potential vulnerability marker of bipolar disorder... - Acute treatment of pediatric bipolar I disorder, manic or mixed episode, with aripiprazole: a randomized, double-blind, placebo-controlled studyRobert L Findling
Department of Psychiatry, Division of Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
J Clin Psychiatry 70:1441-51. 2009..To determine the efficacy and safety of aripiprazole for the treatment of pediatric bipolar I disorder, manic or mixed episode, with or without psychotic features... - Baseline predictors of response to divalproex in conduct disorderKirti Saxena
Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
J Clin Psychiatry 66:1541-8. 2005.... - Atomoxetine for the treatment of attention-deficit/hyperactivity disorder in children and adolescents with bipolar disordersMina Hah
Department of Child and Adolescent Psychiatry at Stanford University, Stanford, California 94305 5719, USA
J Child Adolesc Psychopharmacol 15:996-1004. 2005..Adverse effects of atomoxetine treatment included sedation, nausea, and decreased appetite. These cases suggest that atomoxetine may be a safe and effective treatment for ADHD in conjunction with mood stabilizers in children with BD... - Brain glutamatergic characteristics of pediatric offspring of parents with bipolar disorderManpreet Singh
Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
Psychiatry Res 182:165-71. 2010..Longitudinal studies are necessary to confirm whether prefrontal glutamate decreases only after the onset of full mania... - Divalproex sodium in the treatment of pediatric psychiatric disordersManasi Rana
Division of Child Psychiatry and Child Development, Department of Psychiatry and Behavioral Sciences, Stanford University, School of Medicine, 401 Quarry Road, Stanford, CA 94305 5719, USA
Expert Rev Neurother 5:165-76. 2005..In this drug profile, divalproex sodium and its uses in the pediatric population for psychiatric conditions are reviewed... - Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigationKiki Chang
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5540, USA
Arch Gen Psychiatry 61:781-92. 2004..Neuroimaging studies of adults with BD have implicated the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) in the development of this disorder... - Special issues in the treatment of paediatric bipolar disorderK D Chang
The Department of Psychiatry and Behavioural Sciences, Stanford University School of Medicine, USA
Expert Opin Pharmacother 2:613-22. 2001..Other novel agents are currently being investigated in adult BD and may prove applicable to the paediatric form. Finally, based on the available data, a treatment algorithm for PBD is proposed... - Efficacy profiles of psychopharmacology: divalproex sodium in conduct disorderLeena A Khanzode
Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5719, USA
Child Psychiatry Hum Dev 37:55-64. 2006..This is a rare clinical trial, which provides preliminary evidence for the different profiles of efficacy of medication treatment... - Treatment of aggression with risperidone in children and adolescents with bipolar disorder: a case seriesKirti Saxena
Department of Psychiatry, Stanford University, Palo Alto, CA 94305, USA
Bipolar Disord 8:405-10. 2006..To evaluate the effectiveness and safety of risperidone in children and adolescents with bipolar disorder characterized by aggression and mania, despite treatment with mood stabilizers... - Bipolar offspring: a window into bipolar disorder evolutionKiki Chang
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
Biol Psychiatry 53:945-51. 2003.... - Treatment of rapid-cycling bipolar disorderRobert M Post
Bipolar Collaborative Network, Chevy Chase, MD, USA
CNS Spectr 9:1-11. 2004 - Creativity in familial bipolar disorderDiana I Simeonova
Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Stanford University School of Medicine, Stanford, CA 94305 5540, USA
J Psychiatr Res 39:623-31. 2005.... - Bipolar disorder in children and adolescents: international perspective on epidemiology and phenomenologyCesar A Soutullo
Child and Adolescent Psychiatry Unit, Department of Psychiatry and Medical Psychology, Clinica Universitaria, University of Navarra, Pamplona, Spain
Bipolar Disord 7:497-506. 2005..There is considerable skepticism outside the US over the prevalence of pediatric bipolar disorder (BD). We wished to evaluate the epidemiology of BD in children and adolescents in non-US samples... - Characterization of children of bipolar parents by parent report CBCLKimberly A Dienes
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Division of Child and Adolescent Psychiatry, 401 Quarry Road, Stanford, CA 94305-5719, USA
J Psychiatr Res 36:337-45. 2002..A longitudinal follow-up of this cohort is necessary to ascertain whether this is the case... - Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHDRobert M Post
J Clin Psychiatry 65:898-902. 2004 - Juvenile maladaptive aggression: a review of prevention, treatment, and service configuration and a proposed research agendaDaniel F Connor
Department of Psychiatry MC1410, University of Connecticut Health Center, Farmington 06030 1410, USA
J Clin Psychiatry 67:808-20. 2006..To propose a research agenda for disorders of aggression in child and adolescent psychiatry... - Prevention of bipolar disorder in at-risk children: theoretical assumptions and empirical foundationsDavid J Miklowitz
Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309, USA
Dev Psychopathol 20:881-97. 2008..This model attempts to address the multiple interactions of psychosocial and biological risk factors in the onset and course of bipolar disorder... - Divalproex monotherapy in the treatment of bipolar offspring with mood and behavioral disorders and at least mild affective symptomsKiki D Chang
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif, USA
J Clin Psychiatry 64:936-42. 2003..We studied the efficacy of divalproex in treating child and adolescent bipolar offspring with mood or behavioral disorders who did not yet meet criteria for bipolar I or II disorder... - The bipolar spectrum in children and adolescents: developmental issuesKiki D Chang
Division of Child and Adolescent Psychiatry, Pediatric Bipolar Disorders Program, Stanford University School of Medicine, Stanford, Calif, USA
J Clin Psychiatry 69:e9. 2008..Neuropsychological and biological markers may eventually aid clinicians in distinguishing bipolar spectrum disorders and offering early intervention for at-risk children and adolescents... - Pharmacotherapeutic strategies for pediatric bipolar disorderVishal Madaan
Creighton University University of Nebraska Medical Center, Omaha, NE 68131, USA
Expert Opin Pharmacother 8:1801-19. 2007.... - N-acetylaspartate levels in bipolar offspring with and at high-risk for bipolar disorderKim A Gallelli
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Bipolar Disord 7:589-97. 2005..Longitudinal neuroimaging studies of patients with BD accounting for developmental and treatment factors are needed to further clarify the neurodegenerative aspects of BD... - Review of magnetic resonance imaging and spectroscopy studies in children with bipolar disorderNancy E Adleman
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5719, USA
Expert Rev Neurother 4:69-77. 2004..Future directions of research needed in this area also are discussed in the context of the existing literature... - A pilot study of antidepressant-induced mania in pediatric bipolar disorder: Characteristics, risk factors, and the serotonin transporter geneFiona M Baumer
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305-5540, USA
Biol Psychiatry 60:1005-12. 2006..In this preliminary study, we did not find that the 5-HTT polymorphism significantly influenced vulnerability to AIM...
Research Grants
- Neuroimaging of Children at Risk for Biopolar DisorderKiki Chang; Fiscal Year: 2006..Chang plans to become an independent investigator in the field of pediatric BD and thus contributing to the current knowledge of the neurobiology and development of BD. ..
- Genetic and Neurobiologic Risk Factors for Bipolar Disorder DevelopmentKiki Chang; Fiscal Year: 2007..We will also be able to determine possible gene-effects on brain structure and function in this cohort and create a repository for genetic and neuroimaging data that can be used for future longitudinal studies. ..
- Genetic and Neurobiologic Risk Factors for Bipolar Disorder DevelopmentKiki D Chang; Fiscal Year: 2010..We will also be able to determine possible gene-effects on brain structure and function in this cohort and create a repository for genetic and neuroimaging data that can be used for future longitudinal studies. ..