K D Chang

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Neurometabolite effects of response to quetiapine and placebo in adolescents with bipolar depression
    Kiki Chang
    Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5540, USA
    J Child Adolesc Psychopharmacol 22:261-8. 2012
  2. ncbi request reprint Cortical magnetic resonance imaging findings in familial pediatric bipolar disorder
    Kiki Chang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biol Psychiatry 58:197-203. 2005
  3. ncbi request reprint An open-label study of lamotrigine adjunct or monotherapy for the treatment of adolescents with bipolar depression
    Kiki Chang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5540, USA
    J Am Acad Child Adolesc Psychiatry 45:298-304. 2006
  4. ncbi request reprint Will neuroimaging ever be used to diagnose pediatric bipolar disorder?
    Kiki Chang
    Stanford University School of Medicine, CA 94305 5540, USA
    Dev Psychopathol 18:1133-46. 2006
  5. ncbi request reprint Prevention of pediatric bipolar disorder: integration of neurobiological and psychosocial processes
    Kiki Chang
    Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Ann N Y Acad Sci 1094:235-47. 2006
  6. ncbi request reprint Adult bipolar disorder is continuous with pediatric bipolar disorder
    Kiki Chang
    Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Lucile Packard Children s Hospital, California 94305 5540, USA
    Can J Psychiatry 52:418-25. 2007
  7. ncbi request reprint Temperament characteristics of child and adolescent bipolar offspring
    Kiki D Chang
    Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5719, USA
    J Affect Disord 77:11-9. 2003
  8. ncbi request reprint Studies of offspring of parents with bipolar disorder
    Kiki Chang
    Pediatric Mood Disorders Clinic, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Med Genet C Semin Med Genet 123:26-35. 2003
  9. ncbi request reprint The use of atypical antipsychotics in pediatric bipolar disorder
    Kiki D Chang
    Division of Child and Adolescent Psychiatry, Pediatric Bipolar Disorders Program, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    J Clin Psychiatry 69:4-8. 2008
  10. pmc Effect of divalproex on brain morphometry, chemistry, and function in youth at high-risk for bipolar disorder: a pilot study
    Kiki Chang
    Division of Child and Adolescent Psychiatry, Stanford University School of Medicine, Stanford, California 94305 5540, USA
    J Child Adolesc Psychopharmacol 19:51-9. 2009

Collaborators

Detail Information

Publications47

  1. pmc Neurometabolite effects of response to quetiapine and placebo in adolescents with bipolar depression
    Kiki Chang
    Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5540, USA
    J Child Adolesc Psychopharmacol 22:261-8. 2012
    ..We examined the effects of quetiapine (QUET), an atypical antipsychotic, on these neurochemicals, and potential predictors of response to QUET in adolescents with bipolar depression...
  2. ncbi request reprint Cortical magnetic resonance imaging findings in familial pediatric bipolar disorder
    Kiki Chang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Biol Psychiatry 58:197-203. 2005
    ..We studied gray matter volume, ventricular-to-brain ratios (VBR), and number of WMH in patients with familial, pediatric BD compared with control subjects...
  3. ncbi request reprint An open-label study of lamotrigine adjunct or monotherapy for the treatment of adolescents with bipolar depression
    Kiki Chang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5540, USA
    J Am Acad Child Adolesc Psychiatry 45:298-304. 2006
    ..The authors wished to prospectively study the efficacy of lamotrigine as adjunctive or monotherapy in adolescents with bipolar disorder who were experiencing a depressive episode...
  4. ncbi request reprint Will neuroimaging ever be used to diagnose pediatric bipolar disorder?
    Kiki Chang
    Stanford University School of Medicine, CA 94305 5540, USA
    Dev Psychopathol 18:1133-46. 2006
    ....
  5. ncbi request reprint Prevention of pediatric bipolar disorder: integration of neurobiological and psychosocial processes
    Kiki Chang
    Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Ann N Y Acad Sci 1094:235-47. 2006
    ..Further research into the biologic and environmental mechanisms of BD development as well as controlled early intervention studies are needed to ameliorate this significant public health problem...
  6. ncbi request reprint Adult bipolar disorder is continuous with pediatric bipolar disorder
    Kiki Chang
    Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Lucile Packard Children s Hospital, California 94305 5540, USA
    Can J Psychiatry 52:418-25. 2007
    ..Prospective studies incorporating phenomenological and biological assessment are needed to decisively address this issue...
  7. ncbi request reprint Temperament characteristics of child and adolescent bipolar offspring
    Kiki D Chang
    Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5719, USA
    J Affect Disord 77:11-9. 2003
    ..We wished to characterize temperament of children at high risk for bipolar disorder (BD)...
  8. ncbi request reprint Studies of offspring of parents with bipolar disorder
    Kiki Chang
    Pediatric Mood Disorders Clinic, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Med Genet C Semin Med Genet 123:26-35. 2003
    ..The future holds promise for longitudinal studies of bipolar offspring incorporating all of these facets, including genetic analyses, to further elucidate the factors involved in the evolution of BD...
  9. ncbi request reprint The use of atypical antipsychotics in pediatric bipolar disorder
    Kiki D Chang
    Division of Child and Adolescent Psychiatry, Pediatric Bipolar Disorders Program, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    J Clin Psychiatry 69:4-8. 2008
    ..However, more information is needed about long-term treatment of mania, treatment of bipolar depression, and treatment of comorbid psychiatric conditions...
  10. pmc Effect of divalproex on brain morphometry, chemistry, and function in youth at high-risk for bipolar disorder: a pilot study
    Kiki Chang
    Division of Child and Adolescent Psychiatry, Stanford University School of Medicine, Stanford, California 94305 5540, USA
    J Child Adolesc Psychopharmacol 19:51-9. 2009
    ..We sought to examine the effects of divalproex on the structure, chemistry, and function of specific brain regions in children at high-risk for BD...
  11. pmc Challenges in the diagnosis and treatment of pediatric bipolar depression
    Kiki Chang
    Pediatric Bipolar Disorders Program, Stanford University School of Medicine, Stanford, California 94305 5540, USA
    Dialogues Clin Neurosci 11:73-80. 2009
    ....
  12. doi request reprint Atomoxetine as an adjunct therapy in the treatment of co-morbid attention-deficit/hyperactivity disorder in children and adolescents with bipolar I or II disorder
    Kiki Chang
    Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    J Child Adolesc Psychopharmacol 19:547-51. 2009
    ..We conducted an 8-week, open label study to study the efficacy and tolerability of adjunct atomoxetine in euthymic children and adolescents with BPD and ADHD...
  13. doi request reprint A preliminary functional magnetic resonance imaging study of prefrontal-amygdalar activation changes in adolescents with bipolar depression treated with lamotrigine
    Kiki D Chang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5540, USA
    Bipolar Disord 10:426-31. 2008
    ..Therefore, we hypothesized that adolescents with bipolar depression successfully treated with lamotrigine would show decreases in amygdalar activation, and increases in prefrontal activation...
  14. ncbi request reprint Family environment of children and adolescents with bipolar parents
    K D Chang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5540, USA
    Bipolar Disord 3:73-8. 2001
    ..We sought to characterize families with children at high risk for developing BD in order to better understand the contributions of family environment to the development of childhood BD...
  15. ncbi request reprint Psychiatric phenomenology of child and adolescent bipolar offspring
    K D Chang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5540, USA
    J Am Acad Child Adolesc Psychiatry 39:453-60. 2000
    ..To establish prodromal signs of and risk factors for childhood bipolar disorder (BD) by characterizing youths at high risk for BD...
  16. ncbi request reprint Reduced amygdalar gray matter volume in familial pediatric bipolar disorder
    Kiki Chang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5540, USA
    J Am Acad Child Adolesc Psychiatry 44:565-73. 2005
    ..We sought to study morphometric characteristics of these structures in pediatric subjects with familial BD compared with healthy controls...
  17. ncbi request reprint Mood stabilizer augmentation with olanzapine in acutely manic children
    K D Chang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305 5540, USA
    J Child Adolesc Psychopharmacol 10:45-9. 2000
    ..Adverse effects included sedation and weight gain. These results suggest that olanzapine may have an antimanic or mood stabilizing effect in acutely manic children with bipolar disorder...
  18. ncbi request reprint Decreased N-acetylaspartate in children with familial bipolar disorder
    Kiki Chang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Psychiatry 53:1059-65. 2003
    ..We used proton magnetic resonance spectroscopy to investigate dorsolateral prefrontal N-acetylaspartate levels in children with familial bipolar disorder...
  19. doi request reprint The role of the amygdala in bipolar disorder development
    Amy Garrett
    Stanford University School of Medicine, CA 94305, USA
    Dev Psychopathol 20:1285-96. 2008
    ..In addition, evidence is accumulating to suggest that this model has flexible outcomes, depending on factors intrinsic and extrinsic to BD, and may follow several possible paths across the course of maturational development...
  20. ncbi request reprint Divalproex sodium for the treatment of PTSD and conduct disordered youth: a pilot randomized controlled clinical trial
    Hans Steiner
    Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5719, USA
    Child Psychiatry Hum Dev 38:183-93. 2007
    ..Intent-to-treat analyses showed significant positive associations between receiving high dose of DVP CGI's. Parallel analyses comparing outcome by drug level achieved strengthened the results...
  21. ncbi request reprint Psychopharmacologic strategies for the treatment of aggression in juveniles
    Hans Steiner
    Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Child Development, Stanford University School of Medicine, California 94503, USA
    CNS Spectr 8:298-308. 2003
    ....
  22. ncbi request reprint Divalproex sodium reduces overall aggression in youth at high risk for bipolar disorder
    Kirti Saxena
    Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Child Development, School of Medicine, Stanford University, 401 Quarry Road, Stanford, CA 94305, USA
    J Child Adolesc Psychopharmacol 16:252-9. 2006
    ..The psychopharmacology of aggression in youth is relatively unexplored, even though such maladaptive aggression manifests across many different diagnoses...
  23. pmc Subcortical volumetric correlates of anxiety in familial pediatric bipolar disorder: a preliminary investigation
    Diana I Simeonova
    Pediatric Bipolar Disorders Program, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5540, USA
    Psychiatry Res 173:113-20. 2009
    ..The overlap between anxiety and familial pediatric BD suggests that anxiety may be one important area of future research in parsing out the heterogeneous nature and complex etiology of early-onset BD...
  24. ncbi request reprint Attention and memory biases in the offspring of parents with bipolar disorder: indications from a pilot study
    Ian H Gotlib
    Stanford University, Stanford, California 94305, USA
    J Child Psychol Psychiatry 46:84-93. 2005
    ..This study examined biases in the processing of emotional stimuli as a potential vulnerability marker of bipolar disorder...
  25. doi request reprint Acute treatment of pediatric bipolar I disorder, manic or mixed episode, with aripiprazole: a randomized, double-blind, placebo-controlled study
    Robert L Findling
    Department of Psychiatry, Division of Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Psychiatry 70:1441-51. 2009
    ..To determine the efficacy and safety of aripiprazole for the treatment of pediatric bipolar I disorder, manic or mixed episode, with or without psychotic features...
  26. ncbi request reprint Baseline predictors of response to divalproex in conduct disorder
    Kirti Saxena
    Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    J Clin Psychiatry 66:1541-8. 2005
    ....
  27. ncbi request reprint Atomoxetine for the treatment of attention-deficit/hyperactivity disorder in children and adolescents with bipolar disorders
    Mina Hah
    Department of Child and Adolescent Psychiatry at Stanford University, Stanford, California 94305 5719, USA
    J Child Adolesc Psychopharmacol 15:996-1004. 2005
    ..Adverse effects of atomoxetine treatment included sedation, nausea, and decreased appetite. These cases suggest that atomoxetine may be a safe and effective treatment for ADHD in conjunction with mood stabilizers in children with BD...
  28. pmc Brain glutamatergic characteristics of pediatric offspring of parents with bipolar disorder
    Manpreet Singh
    Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Psychiatry Res 182:165-71. 2010
    ..Longitudinal studies are necessary to confirm whether prefrontal glutamate decreases only after the onset of full mania...
  29. ncbi request reprint Divalproex sodium in the treatment of pediatric psychiatric disorders
    Manasi Rana
    Division of Child Psychiatry and Child Development, Department of Psychiatry and Behavioral Sciences, Stanford University, School of Medicine, 401 Quarry Road, Stanford, CA 94305 5719, USA
    Expert Rev Neurother 5:165-76. 2005
    ..In this drug profile, divalproex sodium and its uses in the pediatric population for psychiatric conditions are reviewed...
  30. ncbi request reprint Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigation
    Kiki Chang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5540, USA
    Arch Gen Psychiatry 61:781-92. 2004
    ..Neuroimaging studies of adults with BD have implicated the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) in the development of this disorder...
  31. ncbi request reprint Special issues in the treatment of paediatric bipolar disorder
    K D Chang
    The Department of Psychiatry and Behavioural Sciences, Stanford University School of Medicine, USA
    Expert Opin Pharmacother 2:613-22. 2001
    ..Other novel agents are currently being investigated in adult BD and may prove applicable to the paediatric form. Finally, based on the available data, a treatment algorithm for PBD is proposed...
  32. ncbi request reprint Efficacy profiles of psychopharmacology: divalproex sodium in conduct disorder
    Leena A Khanzode
    Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5719, USA
    Child Psychiatry Hum Dev 37:55-64. 2006
    ..This is a rare clinical trial, which provides preliminary evidence for the different profiles of efficacy of medication treatment...
  33. ncbi request reprint Treatment of aggression with risperidone in children and adolescents with bipolar disorder: a case series
    Kirti Saxena
    Department of Psychiatry, Stanford University, Palo Alto, CA 94305, USA
    Bipolar Disord 8:405-10. 2006
    ..To evaluate the effectiveness and safety of risperidone in children and adolescents with bipolar disorder characterized by aggression and mania, despite treatment with mood stabilizers...
  34. ncbi request reprint Bipolar offspring: a window into bipolar disorder evolution
    Kiki Chang
    Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Psychiatry 53:945-51. 2003
    ....
  35. ncbi request reprint Treatment of rapid-cycling bipolar disorder
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, MD, USA
    CNS Spectr 9:1-11. 2004
  36. ncbi request reprint Creativity in familial bipolar disorder
    Diana I Simeonova
    Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Stanford University School of Medicine, Stanford, CA 94305 5540, USA
    J Psychiatr Res 39:623-31. 2005
    ....
  37. ncbi request reprint Bipolar disorder in children and adolescents: international perspective on epidemiology and phenomenology
    Cesar A Soutullo
    Child and Adolescent Psychiatry Unit, Department of Psychiatry and Medical Psychology, Clinica Universitaria, University of Navarra, Pamplona, Spain
    Bipolar Disord 7:497-506. 2005
    ..There is considerable skepticism outside the US over the prevalence of pediatric bipolar disorder (BD). We wished to evaluate the epidemiology of BD in children and adolescents in non-US samples...
  38. ncbi request reprint Characterization of children of bipolar parents by parent report CBCL
    Kimberly A Dienes
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Division of Child and Adolescent Psychiatry, 401 Quarry Road, Stanford, CA 94305 5719, USA
    J Psychiatr Res 36:337-45. 2002
    ..A longitudinal follow-up of this cohort is necessary to ascertain whether this is the case...
  39. ncbi request reprint Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHD
    Robert M Post
    J Clin Psychiatry 65:898-902. 2004
  40. ncbi request reprint Juvenile maladaptive aggression: a review of prevention, treatment, and service configuration and a proposed research agenda
    Daniel F Connor
    Department of Psychiatry MC1410, University of Connecticut Health Center, Farmington 06030 1410, USA
    J Clin Psychiatry 67:808-20. 2006
    ..To propose a research agenda for disorders of aggression in child and adolescent psychiatry...
  41. pmc Prevention of bipolar disorder in at-risk children: theoretical assumptions and empirical foundations
    David J Miklowitz
    Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Dev Psychopathol 20:881-97. 2008
    ..This model attempts to address the multiple interactions of psychosocial and biological risk factors in the onset and course of bipolar disorder...
  42. ncbi request reprint Divalproex monotherapy in the treatment of bipolar offspring with mood and behavioral disorders and at least mild affective symptoms
    Kiki D Chang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif, USA
    J Clin Psychiatry 64:936-42. 2003
    ..We studied the efficacy of divalproex in treating child and adolescent bipolar offspring with mood or behavioral disorders who did not yet meet criteria for bipolar I or II disorder...
  43. ncbi request reprint The bipolar spectrum in children and adolescents: developmental issues
    Kiki D Chang
    Division of Child and Adolescent Psychiatry, Pediatric Bipolar Disorders Program, Stanford University School of Medicine, Stanford, Calif, USA
    J Clin Psychiatry 69:e9. 2008
    ..Neuropsychological and biological markers may eventually aid clinicians in distinguishing bipolar spectrum disorders and offering early intervention for at-risk children and adolescents...
  44. ncbi request reprint Pharmacotherapeutic strategies for pediatric bipolar disorder
    Vishal Madaan
    Creighton University University of Nebraska Medical Center, Omaha, NE 68131, USA
    Expert Opin Pharmacother 8:1801-19. 2007
    ....
  45. ncbi request reprint N-acetylaspartate levels in bipolar offspring with and at high-risk for bipolar disorder
    Kim A Gallelli
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Bipolar Disord 7:589-97. 2005
    ..To address this question, we used proton magnetic resonance spectroscopy ((1)H-MRS) to compare DLPFC levels of NAA among bipolar offspring with early-onset BD, bipolar offspring with subsyndromal symptoms of BD and healthy children...
  46. ncbi request reprint Review of magnetic resonance imaging and spectroscopy studies in children with bipolar disorder
    Nancy E Adleman
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5719, USA
    Expert Rev Neurother 4:69-77. 2004
    ..Future directions of research needed in this area also are discussed in the context of the existing literature...
  47. ncbi request reprint A pilot study of antidepressant-induced mania in pediatric bipolar disorder: Characteristics, risk factors, and the serotonin transporter gene
    Fiona M Baumer
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5540, USA
    Biol Psychiatry 60:1005-12. 2006
    ..We wished to investigate the frequency of and risk factors for AIM in pediatric patients with or at high risk for BD...

Research Grants5

  1. Neuroimaging of Children at Risk for Biopolar Disorder
    Kiki Chang; Fiscal Year: 2006
    ..Chang plans to become an independent investigator in the field of pediatric BD and thus contributing to the current knowledge of the neurobiology and development of BD. ..
  2. Genetic and Neurobiologic Risk Factors for Bipolar Disorder Development
    Kiki Chang; Fiscal Year: 2007
    ..We will also be able to determine possible gene-effects on brain structure and function in this cohort and create a repository for genetic and neuroimaging data that can be used for future longitudinal studies. ..
  3. Genetic and Neurobiologic Risk Factors for Bipolar Disorder Development
    Kiki D Chang; Fiscal Year: 2010
    ..We will also be able to determine possible gene-effects on brain structure and function in this cohort and create a repository for genetic and neuroimaging data that can be used for future longitudinal studies. ..