Research Topics
Genomes and Genes
Species | Ching Pin ChangSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
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Detail Information
Publications
Epigenetics and cardiovascular developmentChing Pin Chang
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
Annu Rev Physiol 74:41-68. 2012..This review focuses on how chromatin-remodeling and histone-modifying factors regulate gene expression to control cardiovascular development...
Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tractChing Pin Chang
Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA
Development 135:3577-86. 2008..Thus, Pbx1 makes a crucial contribution to distinct regulatory pathways in cardiovascular development...- Analysis of the patterning of cardiac outflow tract and great arteries with angiography and vascular castingChing Pin Chang
Department of Medicine, Division of Cardiovascular Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA
Methods Mol Biol 843:21-8. 2012..This technique can be used to study the development of cardiac outflow tract, semilunar valves, and great arteries as demonstrated previously (Circ Res, 2008; Development 135: 3577-3586, 2008)... 
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesisChing Pin Chang
Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
Cell 118:649-63. 2004..This mechanism also operates in zebrafish, indicating a conserved role for calcineurin/NFAT signaling in vertebrate heart valve morphogenesis...- Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart developmentHai Wu
Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 282:30673-9. 2007..Thus, our studies indicate that the DSCR1 gene is a direct transcriptional target of NFATc1 proteins within the endocardium during a critical window of heart valve formation... - Chromatin regulation by Brg1 underlies heart muscle development and diseaseCalvin T Hang
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 466:62-7. 2010.... - NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21Joseph R Arron
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 441:595-600. 2006..More generally, these observations suggest that the destabilization of regulatory circuits can underlie human disease... - VEGF signaling has distinct spatiotemporal roles during heart valve developmentKryn Stankunas
Division of Cardiovascular Medicine, Department of Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Dev Biol 347:325-36. 2010..Thus, VEGF roles in the developing valves are dynamic, transitioning from a differentiation role directed by VEGFR1 in the OFT to a morphogenetic role through VEGFR2 primarily in the AVC-derived valves... - Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machineryChing Pin Chang
Division of Cardiovascular Medicine, Department of Medicine, Howard Hughes Medical Institute, Stanford University Medical Center, California, USA
J Clin Invest 113:1051-8. 2004..These studies also emphasize the importance of functional obstruction, resulting from developmental abnormality, in causing congenital obstructive nephropathy... - CHD7 cooperates with PBAF to control multipotent neural crest formationRuchi Bajpai
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 463:958-62. 2010.... - Chromatin remodeling in cardiovascular development and physiologyPei Han
CCSR Building, Room 3115 C, 269 Campus Dr, Stanford, CA 94305 5169, USA
Circ Res 108:378-96. 2011..This review focuses on the roles of ATP-dependent chromatin-remodeling factors and chromatin-modifying enzymes in the control of gene expression during cardiovascular development and disease... - Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell developmentWei Li
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 110:1738-43. 2013..Our findings reveal an important role for Brg1 and its downstream pathways in the survival, differentiation, and migration of the multipotent NCCs critical for mammalian cardiovascular development... - Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiationShih Chu Kao
Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Science 323:651-4. 2009..Our studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells... - Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesisKryn Stankunas
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Dev Cell 14:298-311. 2008..Modification of the intervening microenvironment provides a mechanism by which chromatin regulation within one tissue layer coordinates the morphogenesis of an adjacent layer... - Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart diseaseKryn Stankunas
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Circ Res 103:702-9. 2008..Thus, varied deficiencies in the Pbx gene family produce a full spectrum of cardiac defects involving the outflow tract, providing a framework for determining multigenetic causes of congenital heart anomalies... - The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve developmentChieh Yu Lin
Division of Cardiovascular Medicine, Department of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford, California 94305, USA
J Mol Cell Cardiol 52:1096-102. 2012.... - Partitioning the heart: mechanisms of cardiac septation and valve developmentChien Jung Lin
Division of Cardiovascular Medicine, Department of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA
Development 139:3277-99. 2012..Here, we review the morphogenetic events and genetic networks that regulate spatiotemporal interactions between the cells that give rise to septal and valvular tissues and hence partition the heart... - SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesisNesrine El-Bizri
Cardiopulmonary Research Program, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California, CA, USA
Development 135:2981-91. 2008..Thus, loss of Bmpr1a, by decreasing MMP2 and/or MMP9 activity, can account for vascular dilatation and persistence of brain microvessels, leading to the impaired organogenesis documented in the brain... - Analysis of the endocardial-to-mesenchymal transformation of heart valve development by collagen gel culture assayYiqin Xiong
Department of Medicine, Division of Cardiovascular Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA
Methods Mol Biol 843:101-9. 2012..This culture method also enables ex vivo manipulations of signaling or gene function during EMT to delineate molecular pathways essential for heart valve development... - Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardiumAhmad Y Sheikh
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Edwards Building R354, Stanford, California 94305 5344, USA
Stem Cells 25:2677-84. 2007..Specifically, we have demonstrated that systemically delivered BMMCs preferentially home to and are retained by injured myocardium. Disclosure of potential conflicts of interest is found at the end of this article... - Use of whole embryo culture for studying heart developmentCalvin T Hang
Department of Medicine, Division of Cardiovascular Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA
Methods Mol Biol 843:3-9. 2012..Here we describe a method of embryo culture in a common laboratory setting without using special equipments... - Injectable bioartificial myocardial tissue for large-scale intramural cell transfer and functional recovery of injured heart muscleTheo Kofidis
Cardiothoracic Surgery Falk Research Center, Stanford University Medical School, CA 94305, USA
J Thorac Cardiovasc Surg 128:571-8. 2004..Most tissue-engineering approaches to restore injured heart muscle result in distortion of left ventricular geometry. In the present study we suggest seeding embryonic stem cells in a liquid matrix for myocardial restoration... - Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signalingMiriam Zeini
Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA
Development 136:3335-45. 2009.... - Myocardial restoration with embryonic stem cell bioartificial tissue transplantationTheo Kofidis
Department of Cardiothoracic Surgery, Falk Research Center, Stanford University Medical School, Stanford, California, USA
J Heart Lung Transplant 24:737-44. 2005.... - Clinical use of cardiac ultrasound performed with a hand-carried device in patients admitted for acute cardiac careMatteo Rugolotto
Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California 94305-5233, USA
Am J Cardiol 90:1040-2. 2002
Research Grants
- Mechanisms of Neural Crest Cell DevelopmentChing Pin Chang; Fiscal Year: 2007..Aim #3: Define the molecular pathways affected by the absence of Pbx1. We will use standard molecular biology and embryology methods to study if Pax3 pathway is downstream of Pbx1 in cardiac development. ..
- Mechanisms of Neural Crest Cell DevelopmentChing Pin Chang; Fiscal Year: 2009..Aim #3: Define the molecular pathways affected by the absence of Pbx1. We will use standard molecular biology and embryology methods to study if Pax3 pathway is downstream of Pbx1 in cardiac development. ..
- Mechanisms of Nural Crest Cell DevelopmentChing Pin Chang; Fiscal Year: 2010..Aim #3: Define the molecular pathways affected by the absence of Pbx1. We will use standard molecular biology and embryology methods to study if Pax3 pathway is downstream of Pbx1 in cardiac development. ..