Ching Pin Chang

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Chromatin regulation by Brg1 underlies heart muscle development and disease
    Calvin T Hang
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 466:62-7. 2010
  2. doi request reprint Epigenetics and cardiovascular development
    Ching Pin Chang
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Physiol 74:41-68. 2012
  3. pmc Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract
    Ching Pin Chang
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA
    Development 135:3577-86. 2008
  4. doi request reprint Analysis of the patterning of cardiac outflow tract and great arteries with angiography and vascular casting
    Ching Pin Chang
    Department of Medicine, Division of Cardiovascular Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 843:21-8. 2012
  5. pmc Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development
    Wei Li
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 110:1738-43. 2013
  6. ncbi request reprint A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis
    Ching Pin Chang
    Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
    Cell 118:649-63. 2004
  7. doi request reprint Brg1 governs a positive feedback circuit in the hair follicle for tissue regeneration and repair
    Yiqin Xiong
    Department of Medicine, Division of Cardiovascular Medicine, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 25:169-81. 2013
  8. pmc Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development
    Hai Wu
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:30673-9. 2007
  9. ncbi request reprint NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
    Joseph R Arron
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 441:595-600. 2006
  10. pmc VEGF signaling has distinct spatiotemporal roles during heart valve development
    Kryn Stankunas
    Division of Cardiovascular Medicine, Department of Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Biol 347:325-36. 2010

Research Grants

  1. Mechanisms of Neural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2006
  2. Mechanisms of Neural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2007
  3. Mechanisms of Neural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2009
  4. Mechanisms of Neural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2009
  5. Mechanisms of Nural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2010

Collaborators

Detail Information

Publications29

  1. pmc Chromatin regulation by Brg1 underlies heart muscle development and disease
    Calvin T Hang
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 466:62-7. 2010
    ....
  2. doi request reprint Epigenetics and cardiovascular development
    Ching Pin Chang
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Physiol 74:41-68. 2012
    ..This review focuses on how chromatin-remodeling and histone-modifying factors regulate gene expression to control cardiovascular development...
  3. pmc Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract
    Ching Pin Chang
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA
    Development 135:3577-86. 2008
    ..Thus, Pbx1 makes a crucial contribution to distinct regulatory pathways in cardiovascular development...
  4. doi request reprint Analysis of the patterning of cardiac outflow tract and great arteries with angiography and vascular casting
    Ching Pin Chang
    Department of Medicine, Division of Cardiovascular Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 843:21-8. 2012
    ..This technique can be used to study the development of cardiac outflow tract, semilunar valves, and great arteries as demonstrated previously (Circ Res, 2008; Development 135: 3577-3586, 2008)...
  5. pmc Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development
    Wei Li
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 110:1738-43. 2013
    ..Our findings reveal an important role for Brg1 and its downstream pathways in the survival, differentiation, and migration of the multipotent NCCs critical for mammalian cardiovascular development...
  6. ncbi request reprint A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis
    Ching Pin Chang
    Department of Pathology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
    Cell 118:649-63. 2004
    ..This mechanism also operates in zebrafish, indicating a conserved role for calcineurin/NFAT signaling in vertebrate heart valve morphogenesis...
  7. doi request reprint Brg1 governs a positive feedback circuit in the hair follicle for tissue regeneration and repair
    Yiqin Xiong
    Department of Medicine, Division of Cardiovascular Medicine, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 25:169-81. 2013
    ..Our studies demonstrate a molecular circuit that integrates chromatin remodeling (Brg1), transcriptional regulation (NF-κB, Gli), and intercellular signaling (Shh) to control bulge stem cells during tissue regeneration...
  8. pmc Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development
    Hai Wu
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:30673-9. 2007
    ..Thus, our studies indicate that the DSCR1 gene is a direct transcriptional target of NFATc1 proteins within the endocardium during a critical window of heart valve formation...
  9. ncbi request reprint NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
    Joseph R Arron
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 441:595-600. 2006
    ..More generally, these observations suggest that the destabilization of regulatory circuits can underlie human disease...
  10. pmc VEGF signaling has distinct spatiotemporal roles during heart valve development
    Kryn Stankunas
    Division of Cardiovascular Medicine, Department of Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Biol 347:325-36. 2010
    ..Thus, VEGF roles in the developing valves are dynamic, transitioning from a differentiation role directed by VEGFR1 in the OFT to a morphogenetic role through VEGFR2 primarily in the AVC-derived valves...
  11. pmc Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery
    Ching Pin Chang
    Division of Cardiovascular Medicine, Department of Medicine, Howard Hughes Medical Institute, Stanford University Medical Center, California, USA
    J Clin Invest 113:1051-8. 2004
    ..These studies also emphasize the importance of functional obstruction, resulting from developmental abnormality, in causing congenital obstructive nephropathy...
  12. pmc CHD7 cooperates with PBAF to control multipotent neural crest formation
    Ruchi Bajpai
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 463:958-62. 2010
    ....
  13. pmc Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis
    Kryn Stankunas
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 14:298-311. 2008
    ..Modification of the intervening microenvironment provides a mechanism by which chromatin regulation within one tissue layer coordinates the morphogenesis of an adjacent layer...
  14. pmc SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
    Nesrine El-Bizri
    Cardiopulmonary Research Program, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California, CA, USA
    Development 135:2981-91. 2008
    ..Thus, loss of Bmpr1a, by decreasing MMP2 and/or MMP9 activity, can account for vascular dilatation and persistence of brain microvessels, leading to the impaired organogenesis documented in the brain...
  15. pmc Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development
    Jin Yang
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cardiovasc Res 101:120-9. 2014
    ..Here, we characterized a new calcineurin-NFAT signalling which specifically functions in the epicardium to regulate the development of smooth muscle wall of the coronary arteries...
  16. pmc Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease
    Kryn Stankunas
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Circ Res 103:702-9. 2008
    ..Thus, varied deficiencies in the Pbx gene family produce a full spectrum of cardiac defects involving the outflow tract, providing a framework for determining multigenetic causes of congenital heart anomalies...
  17. pmc Chromatin remodeling in cardiovascular development and physiology
    Pei Han
    CCSR Building, Room 3115 C, 269 Campus Dr, Stanford, CA 94305 5169, USA
    Circ Res 108:378-96. 2011
    ..This review focuses on the roles of ATP-dependent chromatin-remodeling factors and chromatin-modifying enzymes in the control of gene expression during cardiovascular development and disease...
  18. ncbi request reprint Pbx1 activates Fgf10 in the mesenchyme of developing lungs
    Wei Li
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California
    Genesis 52:399-407. 2014
    ..Molecularly, Pbx1 directly binds to the Fgf10 promoter and cooperates with Meis and Hox proteins to transcriptionally activate Fgf10. Our results thus show how Pbx1 controls Fgf10 in the developing lung...
  19. pmc Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation
    Shih Chu Kao
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Science 323:651-4. 2009
    ..Our studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells...
  20. pmc The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development
    Chieh Yu Lin
    Division of Cardiovascular Medicine, Department of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford, California 94305, USA
    J Mol Cell Cardiol 52:1096-102. 2012
    ....
  21. pmc Partitioning the heart: mechanisms of cardiac septation and valve development
    Chien Jung Lin
    Division of Cardiovascular Medicine, Department of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA
    Development 139:3277-99. 2012
    ..Here, we review the morphogenetic events and genetic networks that regulate spatiotemporal interactions between the cells that give rise to septal and valvular tissues and hence partition the heart...
  22. doi request reprint Analysis of the endocardial-to-mesenchymal transformation of heart valve development by collagen gel culture assay
    Yiqin Xiong
    Department of Medicine, Division of Cardiovascular Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 843:101-9. 2012
    ..This culture method also enables ex vivo manipulations of signaling or gene function during EMT to delineate molecular pathways essential for heart valve development...
  23. pmc Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling
    Miriam Zeini
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA
    Development 136:3335-45. 2009
    ....
  24. pmc Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium
    Ahmad Y Sheikh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Edwards Building R354, Stanford, California 94305 5344, USA
    Stem Cells 25:2677-84. 2007
    ..Specifically, we have demonstrated that systemically delivered BMMCs preferentially home to and are retained by injured myocardium. Disclosure of potential conflicts of interest is found at the end of this article...
  25. ncbi request reprint Sonographic staging of the developmental status of mouse embryos in utero
    Ching Pin Chang
    Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA
    Genesis 36:7-11. 2003
    ..Empirically, this approach is applicable to mice of various genetic backgrounds and significantly enhances the efficiency of studying murine embryogenesis...
  26. doi request reprint Use of whole embryo culture for studying heart development
    Calvin T Hang
    Department of Medicine, Division of Cardiovascular Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 843:3-9. 2012
    ..Here we describe a method of embryo culture in a common laboratory setting without using special equipments...
  27. ncbi request reprint Injectable bioartificial myocardial tissue for large-scale intramural cell transfer and functional recovery of injured heart muscle
    Theo Kofidis
    Cardiothoracic Surgery Falk Research Center, Stanford University Medical School, CA 94305, USA
    J Thorac Cardiovasc Surg 128:571-8. 2004
    ..Most tissue-engineering approaches to restore injured heart muscle result in distortion of left ventricular geometry. In the present study we suggest seeding embryonic stem cells in a liquid matrix for myocardial restoration...
  28. ncbi request reprint Clinical use of cardiac ultrasound performed with a hand-carried device in patients admitted for acute cardiac care
    Matteo Rugolotto
    Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California 94305 5233, USA
    Am J Cardiol 90:1040-2. 2002
  29. ncbi request reprint Myocardial restoration with embryonic stem cell bioartificial tissue transplantation
    Theo Kofidis
    Department of Cardiothoracic Surgery, Falk Research Center, Stanford University Medical School, Stanford, California, USA
    J Heart Lung Transplant 24:737-44. 2005
    ..The present study utilizes embryonic stem cells as the substrate of bioartificial myocardial tissue and evaluates engraftment in, and functional recovery of, the recipient heart...

Research Grants6

  1. Mechanisms of Neural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2006
    ..Aim #3: Define the molecular pathways affected by the absence of Pbx1. We will use standard molecular biology and embryology methods to study if Pax3 pathway is downstream of Pbx1 in cardiac development. ..
  2. Mechanisms of Neural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2007
    ..Aim #3: Define the molecular pathways affected by the absence of Pbx1. We will use standard molecular biology and embryology methods to study if Pax3 pathway is downstream of Pbx1 in cardiac development. ..
  3. Mechanisms of Neural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2009
    ..Aim #3: Define the molecular pathways affected by the absence of Pbx1. We will use standard molecular biology and embryology methods to study if Pax3 pathway is downstream of Pbx1 in cardiac development. ..
  4. Mechanisms of Neural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2009
    ..Aim #3: Define the molecular pathways affected by the absence of Pbx1. We will use standard molecular biology and embryology methods to study if Pax3 pathway is downstream of Pbx1 in cardiac development. ..
  5. Mechanisms of Nural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2010
    ..Aim #3: Define the molecular pathways affected by the absence of Pbx1. We will use standard molecular biology and embryology methods to study if Pax3 pathway is downstream of Pbx1 in cardiac development. ..