Lynette Cegelski

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint REDOR NMR for drug discovery
    Lynette Cegelski
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA Electronic address
    Bioorg Med Chem Lett 23:5767-75. 2013
  2. doi request reprint Plant cell-wall cross-links by REDOR NMR spectroscopy
    Lynette Cegelski
    Department of Chemistry, Washington University, St Louis, Missouri 63130, United States
    J Am Chem Soc 132:16052-7. 2010
  3. pmc Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus
    Sung Joon Kim
    Department of Chemistry, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    J Mol Biol 377:281-93. 2008
  4. ncbi request reprint REDOR with a relative full-echo reference
    Anil K Mehta
    Department of Chemistry, Washington University, One Brookings Dr, Campus Box 1134, St Louis, MO 63130, USA
    J Magn Reson 163:182-7. 2003
  5. ncbi request reprint Conformational and quantitative characterization of oritavancin-peptidoglycan complexes in whole cells of Staphylococcus aureus by in vivo 13C and 15N labeling
    Lynette Cegelski
    Department of Chemistry, Washington University, St Louis, MO 63130, USA
    J Mol Biol 357:1253-62. 2006
  6. ncbi request reprint Rotational-echo double resonance characterization of the effects of vancomycin on cell wall synthesis in Staphylococcus aureus
    Lynette Cegelski
    Department of Chemistry, Washington University, St Louis, Missouri 63110, USA
    Biochemistry 41:13053-8. 2002
  7. pmc Disruption of Escherichia coli amyloid-integrated biofilm formation at the air-liquid interface by a polysorbate surfactant
    Cynthia Wu
    Department of Chemical Engineering, Stanford University, Stanford, California 94305, United States
    Langmuir 29:920-6. 2013
  8. ncbi request reprint Glycine metabolism in intact leaves by in vivo 13C and 15N labeling
    Lynette Cegelski
    Department of Chemistry, Washington University, St Louis, Missouri 63130, USA
    J Biol Chem 280:39238-45. 2005
  9. ncbi request reprint NMR determination of photorespiration in intact leaves using in vivo 13CO2 labeling
    Lynette Cegelski
    Department of Chemistry, Washington University, St Louis, MO 63130, USA
    J Magn Reson 178:1-10. 2006
  10. ncbi request reprint Rotational-echo double resonance characterization of vancomycin binding sites in Staphylococcus aureus
    Sung Joon Kim
    Department of Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63130, USA
    Biochemistry 41:6967-77. 2002

Collaborators

  • Gerald G Fuller
  • Garland R Marshall
  • Fredrik Almqvist
  • Neal D Hammer
  • Ji Youn Lim
  • Xiaoxue Zhou
  • Oscar A McCrate
  • Cynthia Wu
  • Sung Joon Kim
  • Jacob Schaefer
  • Miguel Saggu
  • Robert D O'Connor
  • Anil K Mehta
  • Younkee Paik
  • Brett Carter
  • Steven G Boxer
  • Dewey Holten
  • Christine Kirmaier
  • Jerome S Pinkner
  • Kaitlyn Faries
  • Courtney Reichhardt
  • Janine M May
  • Kelly S E Tanaka
  • Dirk Stueber
  • Adel Rafai Far
  • Thomas R Parr
  • Evelyne Dietrich
  • Manmilan Singh
  • Susan Bane
  • Scott A Johnson
  • Natasha Shanker
  • David G I Kingston
  • James P Snyder
  • Belhu Metaferia
  • Ana A Alcaraz
  • Rudravajhala Ravindra
  • Chao Yang
  • Shoubin Tang
  • Daniel R Studelska

Detail Information

Publications20

  1. ncbi request reprint REDOR NMR for drug discovery
    Lynette Cegelski
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA Electronic address
    Bioorg Med Chem Lett 23:5767-75. 2013
    ..By way of example, this digest illustrates the versatility of the REDOR approach, with an emphasis on the practical considerations of experimental design and data interpretation. ..
  2. doi request reprint Plant cell-wall cross-links by REDOR NMR spectroscopy
    Lynette Cegelski
    Department of Chemistry, Washington University, St Louis, Missouri 63130, United States
    J Am Chem Soc 132:16052-7. 2010
    ....
  3. pmc Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus
    Sung Joon Kim
    Department of Chemistry, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    J Mol Biol 377:281-93. 2008
    ..The resulting dual mode of action provides a structural framework for coordinated cell-wall assembly that accounts for the enhanced potency of oritavancin and oritavancin-like analogues against vancomycin-resistant organisms...
  4. ncbi request reprint REDOR with a relative full-echo reference
    Anil K Mehta
    Department of Chemistry, Washington University, One Brookings Dr, Campus Box 1134, St Louis, MO 63130, USA
    J Magn Reson 163:182-7. 2003
    ..These determinations were made by dipolar recoupling methods that do not require an absolute measurement of the REDOR full echo (the signal observed without rotor-synchronized dephasing pulses) of the labels in the peptide stem...
  5. ncbi request reprint Conformational and quantitative characterization of oritavancin-peptidoglycan complexes in whole cells of Staphylococcus aureus by in vivo 13C and 15N labeling
    Lynette Cegelski
    Department of Chemistry, Washington University, St Louis, MO 63130, USA
    J Mol Biol 357:1253-62. 2006
    ..Structural details of the binding site are revealed in a model of the glycopeptide-peptidoglycan interaction produced by molecular dynamics simulations with internuclear distance restraints determined by NMR...
  6. ncbi request reprint Rotational-echo double resonance characterization of the effects of vancomycin on cell wall synthesis in Staphylococcus aureus
    Lynette Cegelski
    Department of Chemistry, Washington University, St Louis, Missouri 63110, USA
    Biochemistry 41:13053-8. 2002
    ..These changes suggest that vancomycin (at therapeutic levels) interrupts peptidoglycan synthesis in S. aureus by interference with transglycosylation...
  7. pmc Disruption of Escherichia coli amyloid-integrated biofilm formation at the air-liquid interface by a polysorbate surfactant
    Cynthia Wu
    Department of Chemical Engineering, Stanford University, Stanford, California 94305, United States
    Langmuir 29:920-6. 2013
    ....
  8. ncbi request reprint Glycine metabolism in intact leaves by in vivo 13C and 15N labeling
    Lynette Cegelski
    Department of Chemistry, Washington University, St Louis, Missouri 63130, USA
    J Biol Chem 280:39238-45. 2005
    ..In those leaves with lower levels of available nitrogen (as measured by leaf nitrate and glutamine-glutamate concentrations), the excess glycine is used primarily as glycyl residues in protein...
  9. ncbi request reprint NMR determination of photorespiration in intact leaves using in vivo 13CO2 labeling
    Lynette Cegelski
    Department of Chemistry, Washington University, St Louis, MO 63130, USA
    J Magn Reson 178:1-10. 2006
    ..The net carbon assimilation rates indicate that the rate of decarboxylation of glycine is not directly proportional to the oxygenase activity of Rubisco as is commonly assumed...
  10. ncbi request reprint Rotational-echo double resonance characterization of vancomycin binding sites in Staphylococcus aureus
    Sung Joon Kim
    Department of Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63130, USA
    Biochemistry 41:6967-77. 2002
    ....
  11. pmc Sum of the parts: composition and architecture of the bacterial extracellular matrix
    Oscar A McCrate
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    J Mol Biol 425:4286-94. 2013
    ..Collectively, our NMR spectra and the electron micrographs of the purified ECM inspire us to consider the biofilm matrix not as an undefined slime, but as an assembly of polymers with a defined composition and architecture...
  12. pmc Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation
    Lynette Cegelski
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Chem Biol 5:913-9. 2009
    ..Thus, the ability of FN075 to block the biogenesis of both curli and type 1 pili endows unique anti-biofilm and anti-virulence activities on these compounds...
  13. pmc Curcumin as an amyloid-indicator dye in E. coli
    Oscar A McCrate
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Chem Commun (Camb) 49:4193-5. 2013
    ..coli. Curcumin binds to curliated whole cells and to isolated curli amyloid fibers. Similar to Congo red, curcumin exhibits a red-shift in absorbance and a significant increase in fluorescence upon binding to isolated curli...
  14. pmc Quantitative analysis of amyloid-integrated biofilms formed by uropathogenic Escherichia coli at the air-liquid interface
    Cynthia Wu
    Department of Chemical Engineering, Stanford University, Stanford, California, USA
    Biophys J 103:464-71. 2012
    ..The results suggest that curli, as hydrophobic extracellular amyloid fibers, enhance the strength, viscoelasticity, and resistance to strain of E. coli biofilms formed at the air-liquid interface...
  15. ncbi request reprint Community behavior and amyloid-associated phenotypes among a panel of uropathogenic E. coli
    Ji Youn Lim
    Department of Chemistry, Stanford University, Stanford, CA 94305, United States
    Biochem Biophys Res Commun 443:345-50. 2014
    ..We discuss these results in the context on the previously reported behavior and phenotypes of these isolates in the murine cystitis model in vivo. ..
  16. pmc Nutrient-dependent structural changes in S. aureus peptidoglycan revealed by solid-state NMR spectroscopy
    Xiaoxue Zhou
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Biochemistry 51:8143-53. 2012
    ..Collectively, our observations emphasize the plasticity in bacterial cell-wall assembly and the possibility to manipulate peptidoglycan structure with external stimuli...
  17. pmc Rotational-echo double-resonance NMR distance measurements for the tubulin-bound Paclitaxel conformation
    Younkee Paik
    Department of Chemistry, M C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Am Chem Soc 129:361-70. 2007
    ..In this article, we present experimental results from 2H{19F} REDOR NMR that provide direct confirmation that paclitaxel adopts a T-shaped conformation when it is bound to tubulin...
  18. ncbi request reprint Putative Hydrogen Bond to Tyrosine M208 in Photosynthetic Reaction Centers from Rhodobacter capsulatus Significantly Slows Primary Charge Separation
    Miguel Saggu
    Department of Chemistry, Stanford University, Stanford, California 94305 5012, United States
    J Phys Chem B 118:6721-32. 2014
    ..J. Phys. Chem. 1996, 100, 16761-16770) to destabilize P(+)BA(-) in free energy. Alteration of the environment of Tyr M208 and BA by Glu M204 via this putative hydrogen bond has a powerful influence on primary charge separation. ..
  19. pmc Dimethyl sulfoxide and ethanol elicit increased amyloid biogenesis and amyloid-integrated biofilm formation in Escherichia coli
    Ji Youn Lim
    Department of Chemistry, Stanford University, Stanford, California, USA
    Appl Environ Microbiol 78:3369-78. 2012
    ..The data also support our developing model of the extracellular matrix as an organized assembly of polymeric components, including amyloid fibers, in which composition relates to bacterial physiology and community function...
  20. pmc The biology and future prospects of antivirulence therapies
    Lynette Cegelski
    Department of Molecular Microbiology, Washington University, Saint Louis, Missouri 63110, USA
    Nat Rev Microbiol 6:17-27. 2008
    ..Targeting virulence represents a new paradigm to empower the clinician to prevent and treat infectious diseases...