James J Cai

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. doi request reprint PGEToolbox: A Matlab toolbox for population genetics and evolution
    James J Cai
    Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA
    J Hered 99:438-40. 2008
  2. pmc Relaxed purifying selection and possibly high rate of adaptation in primate lineage-specific genes
    James J Cai
    Department of Biology, Stanford University, USA
    Genome Biol Evol 2:393-409. 2010
  3. pmc Identification of metabolic modifiers that underlie phenotypic variations in energy-balance regulation
    Chia Lin Chang
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Kweishan, Taoyuan, Taiwan
    Diabetes 60:726-34. 2011
  4. pmc Pervasive hitchhiking at coding and regulatory sites in humans
    James J Cai
    Department of Biology, Stanford University, Stanford, CA, USA
    PLoS Genet 5:e1000336. 2009
  5. pmc Similarly strong purifying selection acts on human disease genes of all evolutionary ages
    James J Cai
    Department of Biology, Stanford University
    Genome Biol Evol 2009:131-44. 2009
  6. pmc MBEToolbox: a MATLAB toolbox for sequence data analysis in molecular biology and evolution
    James J Cai
    Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong, China
    BMC Bioinformatics 6:64. 2005
  7. ncbi request reprint Accelerated evolutionary rate may be responsible for the emergence of lineage-specific genes in ascomycota
    James J Cai
    Department of Microbiology, Faculty of Medicine, University of Hong Kong, University Pathology Building, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    J Mol Evol 63:1-11. 2006
  8. pmc Diverse splicing patterns of exonized Alu elements in human tissues
    Lan Lin
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
    PLoS Genet 4:e1000225. 2008

Collaborators

Detail Information

Publications8

  1. doi request reprint PGEToolbox: A Matlab toolbox for population genetics and evolution
    James J Cai
    Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA
    J Hered 99:438-40. 2008
    ..For academic uses, PGEToolbox is available free of charge at http://bioinformatics.org/pgetoolbox...
  2. pmc Relaxed purifying selection and possibly high rate of adaptation in primate lineage-specific genes
    James J Cai
    Department of Biology, Stanford University, USA
    Genome Biol Evol 2:393-409. 2010
    ..Collectively, these results provide strong evidence that younger genes are subject to weaker purifying selection and more tenuous evidence that they also undergo adaptive evolution more frequently...
  3. pmc Identification of metabolic modifiers that underlie phenotypic variations in energy-balance regulation
    Chia Lin Chang
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Kweishan, Taoyuan, Taiwan
    Diabetes 60:726-34. 2011
    ....
  4. pmc Pervasive hitchhiking at coding and regulatory sites in humans
    James J Cai
    Department of Biology, Stanford University, Stanford, CA, USA
    PLoS Genet 5:e1000336. 2009
    ..These findings suggest that the effects of natural selection at linked sites cannot be ignored in the study of neutral human polymorphism...
  5. pmc Similarly strong purifying selection acts on human disease genes of all evolutionary ages
    James J Cai
    Department of Biology, Stanford University
    Genome Biol Evol 2009:131-44. 2009
    ..Young human genes that have been evolving under strong constraint between humans and chimps might also be enriched for genes that encode important primate or even human-specific functions...
  6. pmc MBEToolbox: a MATLAB toolbox for sequence data analysis in molecular biology and evolution
    James J Cai
    Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong, China
    BMC Bioinformatics 6:64. 2005
    ..However, few functions are freely available in MATLAB to perform the sequence data analyses specifically required for molecular biology and evolution...
  7. ncbi request reprint Accelerated evolutionary rate may be responsible for the emergence of lineage-specific genes in ascomycota
    James J Cai
    Department of Microbiology, Faculty of Medicine, University of Hong Kong, University Pathology Building, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    J Mol Evol 63:1-11. 2006
    ..These analyses suggest that accelerated rates of gene evolution may be responsible for the emergence of apparently orphan genes...
  8. pmc Diverse splicing patterns of exonized Alu elements in human tissues
    Lan Lin
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
    PLoS Genet 4:e1000225. 2008
    ..Our results imply that some Alu exonization events may have acquired adaptive benefits during the evolution of primate transcriptomes...