Eugene Butcher

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction
    Ikuo Nakamichi
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California, USA
    J Clin Invest 115:3007-14. 2005
  2. pmc Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity
    E J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Exp Med 192:761-8. 2000
  3. ncbi request reprint Can cell systems biology rescue drug discovery?
    Eugene C Butcher
    Department of Pathology, Stanford University, Stanford, California 94305 5324, USA
    Nat Rev Drug Discov 4:461-7. 2005
  4. pmc Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways
    Baohui Xu
    Dept of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Exp Med 197:1255-67. 2003
  5. ncbi request reprint Systems biology in drug discovery
    Eugene C Butcher
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Biotechnol 22:1253-9. 2004
  6. pmc Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues
    Daniel J Campbell
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 195:135-41. 2002
  7. ncbi request reprint Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection
    Ningguo Feng
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 176:5749-59. 2006
  8. pmc CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells
    Eric J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 111:1001-10. 2003
  9. ncbi request reprint The germinal center response is impaired in the absence of T cell-expressed CXCR5
    Carrie N Arnold
    Department of Pathology, Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Immunol 37:100-9. 2007
  10. ncbi request reprint DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27
    Hekla Sigmundsdottir
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 8:285-93. 2007

Research Grants

  1. Regulation of T Cell CCR10 by Sunlight and Vitamin D
    Eugene Butcher; Fiscal Year: 2007
  2. Novel Dendritic Cell Chemoattractant and Receptor
    Eugene Butcher; Fiscal Year: 2009
  3. Regulation of T Cell CCR10 by Sunlight and Vitamin D
    Eugene Butcher; Fiscal Year: 2009
  4. Intestinal Lymphocyte Trafficking
    Eugene Butcher; Fiscal Year: 2009
  5. A Novel Tolergenic Dendritic Cell: Biology & Therapeutic Potential
    Eugene Butcher; Fiscal Year: 2009
  6. Tolerogenic DC as Therapeutic Agents in GVHD
    Eugene C Butcher; Fiscal Year: 2010
  7. A Novel Tolergenic Dendritic Cell: Biology & Therapeutic Potential
    Eugene C Butcher; Fiscal Year: 2010
  8. Intestinal Lymphocyte Trafficking
    Eugene Butcher; Fiscal Year: 2007
  9. ENDOTHELIAL CELL BIOLOGY IN INFLAMMATION
    Eugene Butcher; Fiscal Year: 2007
  10. CHEMOATTRACTANT SIGNALING TO LEUKOCYTE INTEGRINS
    Eugene Butcher; Fiscal Year: 2001

Detail Information

Publications71

  1. pmc Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction
    Ikuo Nakamichi
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California, USA
    J Clin Invest 115:3007-14. 2005
    ..Therefore, hemin-like compounds or hemin-activated macrophages may offer novel therapeutic approaches for preventing acute pancreatitis and its pulmonary complication via upregulation of HO-1...
  2. pmc Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity
    E J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Exp Med 192:761-8. 2000
    ..Selective expression of chemokines by differentiated epithelium may represent an important mechanism for targeting and specialization of immune responses...
  3. ncbi request reprint Can cell systems biology rescue drug discovery?
    Eugene C Butcher
    Department of Pathology, Stanford University, Stanford, California 94305 5324, USA
    Nat Rev Drug Discov 4:461-7. 2005
    ..Drug discovery through cell systems biology could significantly reduce the time and cost of new drug development...
  4. pmc Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways
    Baohui Xu
    Dept of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Exp Med 197:1255-67. 2003
    ..This high level of involvement of alpha4beta1 integrin/VCAM-1 is unique among secondary lymphoid tissues, and may help unify lymphocyte migration pathways and immune responses in BALT and other bronchopulmonary tissues...
  5. ncbi request reprint Systems biology in drug discovery
    Eugene C Butcher
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Biotechnol 22:1253-9. 2004
    ..These systems biology approaches promise to improve decision making in pharmaceutical development...
  6. pmc Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues
    Daniel J Campbell
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 195:135-41. 2002
    ....
  7. ncbi request reprint Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection
    Ningguo Feng
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 176:5749-59. 2006
    ..Hence, our findings indicate that alpha(4)beta(7) along with either CCR9 or CCR10 are sufficient for mediating the intestinal migration of IgA(+) plasmablasts during RV infection...
  8. pmc CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells
    Eric J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 111:1001-10. 2003
    ....
  9. ncbi request reprint The germinal center response is impaired in the absence of T cell-expressed CXCR5
    Carrie N Arnold
    Department of Pathology, Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Immunol 37:100-9. 2007
    ....
  10. ncbi request reprint DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27
    Hekla Sigmundsdottir
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 8:285-93. 2007
    ..Our findings support a model in which dendritic cells process and 'interpret' locally produced metabolites to 'program' T cell homing and microenvironmental positioning...
  11. ncbi request reprint A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts
    Nicole H Lazarus
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Immunol 170:3799-805. 2003
    ..Surprisingly, T cells from mucosal sites fail to respond to MEC. These findings suggest a broad and unifying role for MEC in the physiology of the mucosal IgA immune system...
  12. ncbi request reprint Bovine gamma delta T cell subsets express distinct patterns of chemokine responsiveness and adhesion molecules: a mechanism for tissue-specific gamma delta T cell subset accumulation
    Eric Wilson
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
    J Immunol 169:4970-5. 2002
    ..These results suggest that the tropism of circulating CD8(+)gammadelta T cells for mucosal tissues is due, at least in part, to selective developmental expression of adhesion molecules and chemokine receptors...
  13. ncbi request reprint Liver-infiltrating lymphocytes in end-stage hepatitis C virus: subsets, activation status, and chemokine receptor phenotypes
    Judie Boisvert
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Hepatol 38:67-75. 2003
    ..Chemokines and their receptors are important regulators of immunity, particularly in the migration and localization of circulating leukocytes within peripheral tissues...
  14. pmc The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells
    Edward P Bowman
    Laboratory of Immunology and Vascular Biology, Department of Pathology and the Digestive Disease Center, Stanford University Medical School, Stanford, CA 94305 8444, USA
    J Exp Med 195:269-75. 2002
    ..The migration of IgA-ASC to the intestinal epithelial cell chemokine TECK may help target IgA-producing cells to the gut wall, thus helping define and segregate the intestinal immune response...
  15. ncbi request reprint Cytokine control of memory B cell homing machinery
    Meenakshi P Roy
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 169:1676-82. 2002
    ..CCR7 expression, responsiveness to CCL19, and L-selectin/alpha(4)beta(7) phenotype are coordinately regulated. Thus, IL-2/IL-10 and IL-4 play important and distinctive roles in developing the migratory capacities of memory B cells...
  16. ncbi request reprint CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium
    Tracy L Staton
    Program in Immunology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 7:482-8. 2006
    ..These studies challenge the present understanding of naive alphabeta T cell trafficking and suggest that RTEs may be involved in maintaining a diverse immune repertoire at mucosal surfaces...
  17. pmc Intestinal attraction: CCL25 functions in effector lymphocyte recruitment to the small intestine
    Daniel J Campbell
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94304, USA
    J Clin Invest 110:1079-81. 2002
  18. pmc Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs
    Andreas Beilhack
    Department of Medicine, Stanford University, 269 W Campus Drive, Stanford, CA 94305, USA
    Blood 111:2919-28. 2008
    ..Thus, we demonstrate redundancy of SLOs at different anatomical sites in aGVHD initiation. Only prevention of T-cell entry to all SLOs could completely abrogate the onset of aGVHD...
  19. pmc Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 205:2207-20. 2008
    ..Rather, CCRL2 is able to bind the chemoattractant and increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1...
  20. pmc Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes
    Eric J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Am J Pathol 160:347-55. 2002
    ....
  21. ncbi request reprint Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 280:34661-6. 2005
    ....
  22. pmc CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate
    Eric Wilson
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Exp Med 200:805-9. 2004
    ..We propose that CCL28 is a key regulator of IgA ASC accumulation in the mammary gland and thus controls the passive transfer of IgA antibodies from mother to infant...
  23. pmc Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking
    Hekla Sigmundsdottir
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 9:981-7. 2008
    ....
  24. ncbi request reprint Chemokines in the systemic organization of immunity
    Daniel J Campbell
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Immunol Rev 195:58-71. 2003
    ..Here, we summarize the role of chemokines and their receptors in the spatial organization of the immune system and consider the implications for immune function...
  25. ncbi request reprint Modified representational difference analysis: isolation of differentially expressed mRNAs from rare cell populations
    Edward F O'Hara
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Anal Biochem 336:221-30. 2005
    ..Using MRDA, we isolated cDNAs differentially expressed between limited numbers of human CD4(+) naive and memory T lymphocyte subsets and skin- and gut-homing memory T cell subsets...
  26. pmc Heme oxygenase-1 is induced in peripheral blood mononuclear cells of patients with acute pancreatitis: a potential therapeutic target
    Aida Habtezion
    Stanford Univ School of Medicine, Dept of Medicine, Division of Gastroenterology and Hepatology, 300 Pasteur Dr, Stanford, CA 94305, USA
    Am J Physiol Gastrointest Liver Physiol 300:G12-20. 2011
    ..Leukocytes from AP patients or mice with AP are primed for HO-1 induction by Panhematin, which suggests that Panhematin could offer a therapeutic benefit...
  27. pmc Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues
    Gudrun F Debes
    Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
    Nat Immunol 6:889-94. 2005
    ..The regulated expression of CCR7 by tissue T lymphocytes may control their exit, acting with recruitment mechanisms to regulate lymphocyte transit and accumulation during immune surveillance and inflammation...
  28. ncbi request reprint Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver
    Tohru Sato
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 174:277-83. 2005
    ..We conclude that CXCR6 helps mediate the recruitment of activated CD8 lymphocytes in GvHD-induced hepatitis and may be a useful target to treat pathological inflammation in the liver...
  29. pmc Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease
    Kareem L Graham
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 183:6717-23. 2009
    ..The results imply involvement of CMKLR1 in both the induction and effector phases of disease. We conclude that CMKLR1 participates in the inflammatory mechanisms of EAE and represents a potential therapeutic target in multiple sclerosis...
  30. ncbi request reprint Chemoattractants, extracellular proteases, and the integrated host defense response
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Exp Hematol 34:1021-32. 2006
    ....
  31. ncbi request reprint Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Exp Hematol 34:1106-14. 2006
    ..We examined the regulation of mCMKLR1 expression by exposure to toll-like receptor (TLR) ligands and cytokines. Finally, we evaluated ex vivo human ascites macrophages for huCMKLR1 expression and chemerin responsiveness...
  32. pmc Modeling the role of homologous receptor desensitization in cell gradient sensing
    Francis Lin
    Department of Pathology, Laboratory of Immunology and Vascular Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 181:8335-43. 2008
    ..We propose that homologous receptor desensitization is critical for cellular navigation in complex chemoattractant fields...
  33. ncbi request reprint T cell chemotaxis in a simple microfluidic device
    Francis Lin
    Laboratory of Immunology and Vascular Biology, Department of Pathology, School of Medicine, Stanford University, Stanford, California 94305, USA
    Lab Chip 6:1462-9. 2006
    ..Acknowledging the importance of lymphocyte homing in the adaptive immune response, the ability to study T cell chemotaxis in microfluidic devices offers a new approach for investigating lymphocyte migration and chemotaxis in vitro...
  34. pmc CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease
    Husein Hadeiba
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 9:1253-60. 2008
    ..Our results identify a highly immunosuppressive population of pDCs present in lymphoid tissues...
  35. pmc Lymphocyte electrotaxis in vitro and in vivo
    Francis Lin
    Laboratory of Immunology and Vascular Biology, Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 181:2465-71. 2008
    ..Lymphocyte positioning within tissues can thus be manipulated by externally applied electric fields, and may be influenced by endogenous electrical potential gradients as well...
  36. pmc Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon
    Aida Habtezion
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 108:1445-50. 2011
    ..Therefore, unlike the proapoptotic effect of K8 mutation or absence in hepatocytes, lack of K8 confers resistance to colonocyte apoptosis in a microflora-dependent manner...
  37. ncbi request reprint Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 174:244-51. 2005
    ....
  38. ncbi request reprint Plasma-cell homing
    Eric J Kunkel
    BioSeek, Inc, Burlingame, California 94010, USA
    Nat Rev Immunol 3:822-9. 2003
    ..By directing plasma-cell homing, chemokines might help to determine the character and efficiency of mucosal, inflammatory and systemic antibody responses...
  39. ncbi request reprint Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity
    Chang H Kim
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
    Blood 100:11-6. 2002
    ..Our results identify chemokine receptors that are potentially important for trafficking of human blood NKT cell subsets and reveal their function (cytokine production capacity)-dependent differential trafficking potentials...
  40. ncbi request reprint Chemokines in lymphocyte trafficking and intestinal immunity
    Eric J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Microcirculation 10:313-23. 2003
    ....
  41. ncbi request reprint Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets
    Brent Johnston
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 171:2960-9. 2003
    ..Our results identify subsets of NKT cells with distinct homing and localization patterns, suggesting that these populations play specialized roles in immunological processes in vivo...
  42. pmc Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers
    Chia Chi Ku
    Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    J Virol 76:11425-33. 2002
    ..Viral transfer to migrating T cells in the tonsils may facilitate cell-associated viremia, and preferential infection of CD4 T cells that express skin homing markers may enhance VZV transport to cutaneous sites of replication...
  43. pmc Hematopoietic stem cells are uniquely selective in their migratory response to chemokines
    Douglas E Wright
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 195:1145-54. 2002
    ..The sharply restricted chemotactic responsiveness of HSC is unique among leukocytes and may be necessary for the specific homing of circulating HSC to bone marrow, as well as for the maintenance of HSC in hematopoietic microenvironments...
  44. ncbi request reprint Murine CD8+ recent thymic emigrants are alphaE integrin-positive and CC chemokine ligand 25 responsive
    Tracy L Staton
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 172:7282-8. 2004
    ..This phenotype will also facilitate the identification and isolation of RTE for further studies...
  45. ncbi request reprint Correlation of tissue distribution, developmental phenotype, and intestinal homing receptor expression of antigen-specific B cells during the murine anti-rotavirus immune response
    Kenneth R Youngman
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 168:2173-81. 2002
    ..These results show that alpha(4)beta(7) is tightly regulated during the Ag-specific B cell response to RV and is expressed concurrently with the specific migration of memory and effector B cells to intestinal tissues...
  46. ncbi request reprint Antigen-specific lymphocyte sequestration in lymphoid organs: lack of essential roles for alphaL and alpha4 integrin-dependent adhesion or Galphai protein-coupled receptor signaling
    Carrie N Arnold
    Department of Pathology, Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 173:866-73. 2004
    ..Selective lymphocyte sequestration may be mediated by redundant mechanisms and/or controlled by novel or nonclassical adhesion or trafficking molecules...
  47. ncbi request reprint Chemokines in rapid leukocyte adhesion triggering and migration
    Brent Johnston
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Semin Immunol 14:83-92. 2002
    ..The regulated expression of chemokines and their receptors is a critical determinant for homing of specialized lymphocyte subsets, and controls both tissue and inflammation-specific immune processes...
  48. ncbi request reprint Chemokines and the tissue-specific migration of lymphocytes
    Eric J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 16:1-4. 2002
    ..Constitutively expressed epithelial chemokines may help determine the character of local immune responses and contribute to the systemic organization of the immune system...
  49. ncbi request reprint Targeting T cell responses by selective chemokine receptor expression
    Daniel J Campbell
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    Semin Immunol 15:277-86. 2003
    ..Thus, expression of chemokine receptors defines T cells with tropism for particular tissues and/or microenvironments, and identifies T cell subsets with distinct functional properties...
  50. pmc RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 103:2659-64. 2006
    ..Thus, RabGEF1 plays a critical role in the regulation of SCF/c-Kit-mediated signaling events and biological responses in mast cells...
  51. ncbi request reprint Short-term homing assay reveals a critical role for lymphocyte function-associated antigen-1 in the hepatic recruitment of lymphocytes in graft-versus-host disease
    Tohru Sato
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, and the Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    J Hepatol 44:1132-40. 2006
    ..Although adhesive mechanisms have been implicated in the biology of GvHD hepatitis, the identity of homing receptors involved in the initial recruitment of cells from the blood is not known...
  52. pmc Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets
    Xiao Yan Du
    Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Biol Chem 284:751-8. 2009
    ....
  53. ncbi request reprint Homeostatic chemokines and the targeting of regional immunity
    Eric Kunkel
    Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, CA 94305
    Adv Exp Med Biol 512:65-72. 2002
  54. pmc iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity
    Everett H Meyer
    Division of Immunology, Karp Laboratories, Children s Hospital, Boston, MA 02115, USA
    J Immunol 179:4661-71. 2007
    ..These results establish for the first time that the pulmonary localization of iNKT cells critical for the induction of AHR requires CCR4 expression by iNKT cells...
  55. ncbi request reprint Rotavirus-specific B cells induced by recent infection in adults and children predominantly express the intestinal homing receptor alpha4beta7
    Ana Maria Gonzalez
    Instituto de Genetica Humana Pontificia Universidad Javeriana, Bogota, Colombia
    Virology 305:93-105. 2003
    ....
  56. ncbi request reprint Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cells
    Elitza Germanov
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 181:81-91. 2008
    ..Preformed transcripts for IL-4, but not IFN-gamma, were reduced in CXCR6-/- liver NKT cells. These data identify critical roles for CXCR6/CXCL16 in NKT cell activation and the regulation of NKT cell homeostasis...
  57. pmc Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient mice
    Dag K Skovseth
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Am J Pathol 160:1629-37. 2002
    ..In conclusion, isolated human endothelial cells can integrate with the murine vascular system to form functional capillaries and regain in vivo properties...
  58. pmc Maturation and trafficking markers on rotavirus-specific B cells during acute infection and convalescence in children
    Maria C Jaimes
    V A Palo Alto Health Care System, 3801 Miranda Ave, MC154C, Palo Alto, CA 94304, USA
    J Virol 78:10967-76. 2004
    ..Interestingly, RV memory cells generally lack CCR9 and CCR10 and instead express CCR6, which may enable recruitment to diverse epithelial sites of inflammation...
  59. ncbi request reprint Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism
    Kerry B Goralski
    Department of Pharmacology and College of Pharmacy, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Biol Chem 282:28175-88. 2007
    ..We conclude that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism...
  60. ncbi request reprint Lack of lymphoid chemokines CCL19 and CCL21 enhances allergic airway inflammation in mice
    Baohui Xu
    Department of Environmental Medicine, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Int Immunol 19:775-84. 2007
    ....
  61. ncbi request reprint Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment
    Aida Habtezion
    Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
    J Cell Sci 118:1971-80. 2005
    ..These mice provide a model to investigate epithelial-leukocyte and epithelial-microbial cross-talk...
  62. ncbi request reprint Unique gene expression program of human germinal center T helper cells
    Chang H Kim
    Department of Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Blood 104:1952-60. 2004
    ..This study revealed for the first time the unique gene expression program of GC-Th cells...
  63. ncbi request reprint Chemoattractant induces LFA-1 associated PI 3K activity and cell migration that are dependent on Fyn signaling
    Giovanni Bernardini
    Department of Experimental Medicine and Pathology University, La Sapienza, Rome, Italy
    FASEB J 19:1305-7. 2005
    ....
  64. ncbi request reprint Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982
    Eugene C Butcher
    J Immunol 175:1363-72. 2005
  65. ncbi request reprint A cell-surface molecule involved in organ-specific homing of lymphocytes. 1983
    W Michael Gallatin
    J Immunol 177:5-9. 2006
  66. ncbi request reprint Dendritic cells support sequential reprogramming of chemoattractant receptor profiles during naive to effector T cell differentiation
    Chang H Kim
    Laboratory of Immunology and Hematopoiesis, Department of Veterinary Pathobiology and Purdue Cancer Center, and Biochemistry and Molecular Biology Program, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 171:152-8. 2003
    ....
  67. ncbi request reprint Selectin, platelet plays a critical role in granulocyte access to the pregnant mouse uterus under physiological and pathological conditions
    Uta Fernekorn
    Institute of Immunology and Transfusion Medicine, University of Lubeck, 23538 Lubeck, Germany
    Biol Reprod 76:645-53. 2007
    ..Our results clearly demonstrate the importance of SELP for granulocyte access to the pregnant mouse uterus under physiological and pathological conditions...
  68. ncbi request reprint CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1
    Luca Battistini
    Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Santa Lucia, Rome, Italy
    Blood 101:4775-82. 2003
    ..In conclusion, our results show that CD8+, but not CD4+, T cells from patients with RRMS in the acute phase of the disease display increased ability to be recruited in inflamed brain venules...
  69. pmc Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation
    Megumi Honjo
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 100:1274-9. 2003
    ..Thus, LOX-1 is an adhesion molecule involved in leukocyte recruitment and may represent an attractive target for modulation of endotoxin-induced inflammation...
  70. ncbi request reprint Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin
    Paulina Kulig
    Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Ulica Gronostajowa 7, 30 387 Krakow, Poland
    J Immunol 178:3713-20. 2007
    ..SspB may help direct the recruitment of specialized host cells, including immunoregulatory pDC and/or macrophages, contributing to the ability of S. aureus to elicit and maintain a chronic inflammatory state...
  71. ncbi request reprint Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors
    Laura Piccio
    Department of Pathology, University of Verona, Verona, Italy
    J Immunol 168:1940-9. 2002
    ..In conclusion, our data unveils the molecular mechanisms controlling the recruitment of autoreactive lymphocytes in inflamed cerebral vessels and suggest new insights into the pathogenesis of autoimmune inflammatory diseases of the CNS...

Research Grants33

  1. Regulation of T Cell CCR10 by Sunlight and Vitamin D
    Eugene Butcher; Fiscal Year: 2007
    ..This problem has importance to a basic understanding of tissue- specific immune responses, but also to the specialized immune and inflammatory pathologies associated with skin such as psoriasis, DTH reactions and bullous diseases. ..
  2. Novel Dendritic Cell Chemoattractant and Receptor
    Eugene Butcher; Fiscal Year: 2009
    ..abstract_text> ..
  3. Regulation of T Cell CCR10 by Sunlight and Vitamin D
    Eugene Butcher; Fiscal Year: 2009
    ..This problem has importance to a basic understanding of tissue- specific immune responses, but also to the specialized immune and inflammatory pathologies associated with skin such as psoriasis, DTH reactions and bullous diseases. ..
  4. Intestinal Lymphocyte Trafficking
    Eugene Butcher; Fiscal Year: 2009
    ....
  5. A Novel Tolergenic Dendritic Cell: Biology & Therapeutic Potential
    Eugene Butcher; Fiscal Year: 2009
    ..They will test a novel approach using these cells for transplantation immunotherapy, and may lead to new insights and treatments for autoimmune, allergic and other disorders of the immune system. ..
  6. Tolerogenic DC as Therapeutic Agents in GVHD
    Eugene C Butcher; Fiscal Year: 2010
    ..Together, these studies will define in detail the potential of CCR9+ pDCs to suppress deleterious effects of GVHD in settings modeling situations in which human patients encounter pathogenic GVHD responses. ..
  7. A Novel Tolergenic Dendritic Cell: Biology & Therapeutic Potential
    Eugene C Butcher; Fiscal Year: 2010
    ..They will test a novel approach using these cells for transplantation immunotherapy, and may lead to new insights and treatments for autoimmune, allergic and other disorders of the immune system. ..
  8. Intestinal Lymphocyte Trafficking
    Eugene Butcher; Fiscal Year: 2007
    ....
  9. ENDOTHELIAL CELL BIOLOGY IN INFLAMMATION
    Eugene Butcher; Fiscal Year: 2007
    ..The proposed studies should expand our understanding of the critical role of the vascular endothelium in regulating lymphocyte trafficking during normal and pathologic immune responses. ..
  10. CHEMOATTRACTANT SIGNALING TO LEUKOCYTE INTEGRINS
    Eugene Butcher; Fiscal Year: 2001
    ..These studies should define signaling mechanisms regulating the adhesion of leukocytes and other cells, and may lead to novel therapeutic approaches for the control of neoplastic and inflammatory diseases ..
  11. VASCULAR-MONOCYTE ADHESION MOLECULE IN ATHEROGENESIS
    Eugene Butcher; Fiscal Year: 2002
    ..The proposed studies will elucidate the structure of this novel vascular receptor and its role in monocyte recruitment in atherogenesis. They may lead to new approaches to the regulation of the atherogenic process. ..
  12. CCR9 AND TECK IN INTESTINAL LYMPHOCYTE TRAFFICKING
    Eugene Butcher; Fiscal Year: 2005
    ....
  13. Conference on Leukocyte Trafficking
    Eugene Butcher; Fiscal Year: 2004
    ..abstract_text> ..
  14. Regulation of T Cell CCR10 by Sunlight and Vitamin D
    Eugene C Butcher; Fiscal Year: 2010
    ..This problem has importance to a basic understanding of tissue- specific immune responses, but also to the specialized immune and inflammatory pathologies associated with skin such as psoriasis, DTH reactions and bullous diseases. ..