Research Topics
Genomes and Genes
| Eugene ButcherSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
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Detail Information
Publications
Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 inductionIkuo Nakamichi
Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California, USA
J Clin Invest 115:3007-14. 2005..Therefore, hemin-like compounds or hemin-activated macrophages may offer novel therapeutic approaches for preventing acute pancreatitis and its pulmonary complication via upregulation of HO-1...
Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunityE J Kunkel
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
J Exp Med 192:761-8. 2000..Selective expression of chemokines by differentiated epithelium may represent an important mechanism for targeting and specialization of immune responses...
Can cell systems biology rescue drug discovery?Eugene C Butcher
Department of Pathology, Stanford University, Stanford, California 94305 5324, USA
Nat Rev Drug Discov 4:461-7. 2005..Drug discovery through cell systems biology could significantly reduce the time and cost of new drug development...- Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathwaysBaohui Xu
Dept of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
J Exp Med 197:1255-67. 2003..This high level of involvement of alpha4beta1 integrin/VCAM-1 is unique among secondary lymphoid tissues, and may help unify lymphocyte migration pathways and immune responses in BALT and other bronchopulmonary tissues... - Systems biology in drug discoveryEugene C Butcher
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
Nat Biotechnol 22:1253-9. 2004..These systems biology approaches promise to improve decision making in pharmaceutical development... - Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissuesDaniel J Campbell
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Exp Med 195:135-41. 2002.... - Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infectionNingguo Feng
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 176:5749-59. 2006..Hence, our findings indicate that alpha(4)beta(7) along with either CCR9 or CCR10 are sufficient for mediating the intestinal migration of IgA(+) plasmablasts during RV infection... - CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cellsEric J Kunkel
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
J Clin Invest 111:1001-10. 2003.... - The germinal center response is impaired in the absence of T cell-expressed CXCR5Carrie N Arnold
Department of Pathology, Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, Stanford, CA, USA
Eur J Immunol 37:100-9. 2007.... - DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27Hekla Sigmundsdottir
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 8:285-93. 2007..Our findings support a model in which dendritic cells process and 'interpret' locally produced metabolites to 'program' T cell homing and microenvironmental positioning... - A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablastsNicole H Lazarus
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
J Immunol 170:3799-805. 2003..Surprisingly, T cells from mucosal sites fail to respond to MEC. These findings suggest a broad and unifying role for MEC in the physiology of the mucosal IgA immune system... - Bovine gamma delta T cell subsets express distinct patterns of chemokine responsiveness and adhesion molecules: a mechanism for tissue-specific gamma delta T cell subset accumulationEric Wilson
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
J Immunol 169:4970-5. 2002..These results suggest that the tropism of circulating CD8(+)gammadelta T cells for mucosal tissues is due, at least in part, to selective developmental expression of adhesion molecules and chemokine receptors... - Liver-infiltrating lymphocytes in end-stage hepatitis C virus: subsets, activation status, and chemokine receptor phenotypesJudie Boisvert
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Hepatol 38:67-75. 2003..Chemokines and their receptors are important regulators of immunity, particularly in the migration and localization of circulating leukocytes within peripheral tissues... - The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cellsEdward P Bowman
Laboratory of Immunology and Vascular Biology, Department of Pathology and the Digestive Disease Center, Stanford University Medical School, Stanford, CA 94305 8444, USA
J Exp Med 195:269-75. 2002..The migration of IgA-ASC to the intestinal epithelial cell chemokine TECK may help target IgA-producing cells to the gut wall, thus helping define and segregate the intestinal immune response... - Cytokine control of memory B cell homing machineryMeenakshi P Roy
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 169:1676-82. 2002..CCR7 expression, responsiveness to CCL19, and L-selectin/alpha(4)beta(7) phenotype are coordinately regulated. Thus, IL-2/IL-10 and IL-4 play important and distinctive roles in developing the migratory capacities of memory B cells... - CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epitheliumTracy L Staton
Program in Immunology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 7:482-8. 2006..These studies challenge the present understanding of naive alphabeta T cell trafficking and suggest that RTEs may be involved in maintaining a diverse immune repertoire at mucosal surfaces... - Intestinal attraction: CCL25 functions in effector lymphocyte recruitment to the small intestineDaniel J Campbell
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94304, USA
J Clin Invest 110:1079-81. 2002 - Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organsAndreas Beilhack
Department of Medicine, Stanford University, 269 W Campus Drive, Stanford, CA 94305, USA
Blood 111:2919-28. 2008..Thus, we demonstrate redundancy of SLOs at different anatomical sites in aGVHD initiation. Only prevention of T-cell entry to all SLOs could completely abrogate the onset of aGVHD... - Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxisBrian A Zabel
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Exp Med 205:2207-20. 2008..Rather, CCRL2 is able to bind the chemoattractant and increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1... - Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytesEric J Kunkel
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
Am J Pathol 160:347-55. 2002.... - Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascadesBrian A Zabel
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 280:34661-6. 2005.... - CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonateEric Wilson
Department of Pathology, Stanford University School of Medicine, CA 94305, USA
J Exp Med 200:805-9. 2004..We propose that CCL28 is a key regulator of IgA ASC accumulation in the mammary gland and thus controls the passive transfer of IgA antibodies from mother to infant... - Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte traffickingHekla Sigmundsdottir
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 9:981-7. 2008.... - Chemokines in the systemic organization of immunityDaniel J Campbell
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
Immunol Rev 195:58-71. 2003..Here, we summarize the role of chemokines and their receptors in the spatial organization of the immune system and consider the implications for immune function... - Modified representational difference analysis: isolation of differentially expressed mRNAs from rare cell populationsEdward F O'Hara
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Anal Biochem 336:221-30. 2005..Using MRDA, we isolated cDNAs differentially expressed between limited numbers of human CD4(+) naive and memory T lymphocyte subsets and skin- and gut-homing memory T cell subsets... - Heme oxygenase-1 is induced in peripheral blood mononuclear cells of patients with acute pancreatitis: a potential therapeutic targetAida Habtezion
Stanford Univ School of Medicine, Dept of Medicine, Division of Gastroenterology and Hepatology, 300 Pasteur Dr, Stanford, CA 94305, USA
Am J Physiol Gastrointest Liver Physiol 300:G12-20. 2011..Leukocytes from AP patients or mice with AP are primed for HO-1 induction by Panhematin, which suggests that Panhematin could offer a therapeutic benefit... - Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissuesGudrun F Debes
Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
Nat Immunol 6:889-94. 2005..The regulated expression of CCR7 by tissue T lymphocytes may control their exit, acting with recruitment mechanisms to regulate lymphocyte transit and accumulation during immune surveillance and inflammation... - Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liverTohru Sato
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 174:277-83. 2005..We conclude that CXCR6 helps mediate the recruitment of activated CD8 lymphocytes in GvHD-induced hepatitis and may be a useful target to treat pathological inflammation in the liver... - Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating diseaseKareem L Graham
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 183:6717-23. 2009..The results imply involvement of CMKLR1 in both the induction and effector phases of disease. We conclude that CMKLR1 participates in the inflammatory mechanisms of EAE and represents a potential therapeutic target in multiple sclerosis... - Chemoattractants, extracellular proteases, and the integrated host defense responseBrian A Zabel
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
Exp Hematol 34:1021-32. 2006.... - Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligandsBrian A Zabel
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
Exp Hematol 34:1106-14. 2006..We examined the regulation of mCMKLR1 expression by exposure to toll-like receptor (TLR) ligands and cytokines. Finally, we evaluated ex vivo human ascites macrophages for huCMKLR1 expression and chemerin responsiveness... - Modeling the role of homologous receptor desensitization in cell gradient sensingFrancis Lin
Department of Pathology, Laboratory of Immunology and Vascular Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
J Immunol 181:8335-43. 2008..We propose that homologous receptor desensitization is critical for cellular navigation in complex chemoattractant fields... - T cell chemotaxis in a simple microfluidic deviceFrancis Lin
Laboratory of Immunology and Vascular Biology, Department of Pathology, School of Medicine, Stanford University, Stanford, California 94305, USA
Lab Chip 6:1462-9. 2006..Acknowledging the importance of lymphocyte homing in the adaptive immune response, the ability to study T cell chemotaxis in microfluidic devices offers a new approach for investigating lymphocyte migration and chemotaxis in vitro... - CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host diseaseHusein Hadeiba
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Immunol 9:1253-60. 2008..Our results identify a highly immunosuppressive population of pDCs present in lymphoid tissues... - Lymphocyte electrotaxis in vitro and in vivoFrancis Lin
Laboratory of Immunology and Vascular Biology, Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA
J Immunol 181:2465-71. 2008..Lymphocyte positioning within tissues can thus be manipulated by externally applied electric fields, and may be influenced by endogenous electrical potential gradients as well... - Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colonAida Habtezion
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 108:1445-50. 2011..Therefore, unlike the proapoptotic effect of K8 mutation or absence in hepatocytes, lack of K8 confers resistance to colonocyte apoptosis in a microflora-dependent manner... - Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human bloodBrian A Zabel
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 174:244-51. 2005.... - Plasma-cell homingEric J Kunkel
BioSeek, Inc, Burlingame, California 94010, USA
Nat Rev Immunol 3:822-9. 2003..By directing plasma-cell homing, chemokines might help to determine the character and efficiency of mucosal, inflammatory and systemic antibody responses... - Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacityChang H Kim
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
Blood 100:11-6. 2002..Our results identify chemokine receptors that are potentially important for trafficking of human blood NKT cell subsets and reveal their function (cytokine production capacity)-dependent differential trafficking potentials... - Chemokines in lymphocyte trafficking and intestinal immunityEric J Kunkel
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
Microcirculation 10:313-23. 2003.... - Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsetsBrent Johnston
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 171:2960-9. 2003..Our results identify subsets of NKT cells with distinct homing and localization patterns, suggesting that these populations play specialized roles in immunological processes in vivo... - Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markersChia Chi Ku
Department of Pediatrics, Stanford University, Stanford, California 94305, USA
J Virol 76:11425-33. 2002..Viral transfer to migrating T cells in the tonsils may facilitate cell-associated viremia, and preferential infection of CD4 T cells that express skin homing markers may enhance VZV transport to cutaneous sites of replication... - Hematopoietic stem cells are uniquely selective in their migratory response to chemokinesDouglas E Wright
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Exp Med 195:1145-54. 2002..The sharply restricted chemotactic responsiveness of HSC is unique among leukocytes and may be necessary for the specific homing of circulating HSC to bone marrow, as well as for the maintenance of HSC in hematopoietic microenvironments... - Murine CD8+ recent thymic emigrants are alphaE integrin-positive and CC chemokine ligand 25 responsiveTracy L Staton
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 172:7282-8. 2004..This phenotype will also facilitate the identification and isolation of RTE for further studies... - Correlation of tissue distribution, developmental phenotype, and intestinal homing receptor expression of antigen-specific B cells during the murine anti-rotavirus immune responseKenneth R Youngman
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 168:2173-81. 2002..These results show that alpha(4)beta(7) is tightly regulated during the Ag-specific B cell response to RV and is expressed concurrently with the specific migration of memory and effector B cells to intestinal tissues... - Antigen-specific lymphocyte sequestration in lymphoid organs: lack of essential roles for alphaL and alpha4 integrin-dependent adhesion or Galphai protein-coupled receptor signalingCarrie N Arnold
Department of Pathology, Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 173:866-73. 2004..Selective lymphocyte sequestration may be mediated by redundant mechanisms and/or controlled by novel or nonclassical adhesion or trafficking molecules... - Chemokines in rapid leukocyte adhesion triggering and migrationBrent Johnston
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
Semin Immunol 14:83-92. 2002..The regulated expression of chemokines and their receptors is a critical determinant for homing of specialized lymphocyte subsets, and controls both tissue and inflammation-specific immune processes... - Chemokines and the tissue-specific migration of lymphocytesEric J Kunkel
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Immunity 16:1-4. 2002..Constitutively expressed epithelial chemokines may help determine the character of local immune responses and contribute to the systemic organization of the immune system... - Targeting T cell responses by selective chemokine receptor expressionDaniel J Campbell
Department of Pathology, Stanford University School of Medicine, CA 94305, USA
Semin Immunol 15:277-86. 2003..Thus, expression of chemokine receptors defines T cells with tropism for particular tissues and/or microenvironments, and identifies T cell subsets with distinct functional properties... - RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cellsJanet Kalesnikoff
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
Proc Natl Acad Sci U S A 103:2659-64. 2006..Thus, RabGEF1 plays a critical role in the regulation of SCF/c-Kit-mediated signaling events and biological responses in mast cells... - Short-term homing assay reveals a critical role for lymphocyte function-associated antigen-1 in the hepatic recruitment of lymphocytes in graft-versus-host diseaseTohru Sato
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, and the Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
J Hepatol 44:1132-40. 2006..Although adhesive mechanisms have been implicated in the biology of GvHD hepatitis, the identity of homing receptors involved in the initial recruitment of cells from the blood is not known... - Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and plateletsXiao Yan Du
Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Biol Chem 284:751-8. 2009.... - Homeostatic chemokines and the targeting of regional immunityEric Kunkel
Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, CA 94305
Adv Exp Med Biol 512:65-72. 2002 - iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivityEverett H Meyer
Division of Immunology, Karp Laboratories, Children s Hospital, Boston, MA 02115, USA
J Immunol 179:4661-71. 2007..These results establish for the first time that the pulmonary localization of iNKT cells critical for the induction of AHR requires CCR4 expression by iNKT cells... - Rotavirus-specific B cells induced by recent infection in adults and children predominantly express the intestinal homing receptor alpha4beta7Ana Maria Gonzalez
Instituto de Genetica Humana Pontificia Universidad Javeriana, Bogota, Colombia
Virology 305:93-105. 2003.... - Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cellsElitza Germanov
Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
J Immunol 181:81-91. 2008..Preformed transcripts for IL-4, but not IFN-gamma, were reduced in CXCR6-/- liver NKT cells. These data identify critical roles for CXCR6/CXCL16 in NKT cell activation and the regulation of NKT cell homeostasis... - Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient miceDag K Skovseth
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
Am J Pathol 160:1629-37. 2002..In conclusion, isolated human endothelial cells can integrate with the murine vascular system to form functional capillaries and regain in vivo properties... - Maturation and trafficking markers on rotavirus-specific B cells during acute infection and convalescence in childrenMaria C Jaimes
V A Palo Alto Health Care System, 3801 Miranda Ave, MC154C, Palo Alto, CA 94304, USA
J Virol 78:10967-76. 2004..Interestingly, RV memory cells generally lack CCR9 and CCR10 and instead express CCR6, which may enable recruitment to diverse epithelial sites of inflammation... - Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolismKerry B Goralski
Department of Pharmacology and College of Pharmacy, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
J Biol Chem 282:28175-88. 2007..We conclude that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism... - Lack of lymphoid chemokines CCL19 and CCL21 enhances allergic airway inflammation in miceBaohui Xu
Department of Environmental Medicine, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Int Immunol 19:775-84. 2007.... - Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatmentAida Habtezion
Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
J Cell Sci 118:1971-80. 2005..These mice provide a model to investigate epithelial-leukocyte and epithelial-microbial cross-talk... - Unique gene expression program of human germinal center T helper cellsChang H Kim
Department of Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
Blood 104:1952-60. 2004..This study revealed for the first time the unique gene expression program of GC-Th cells... - Chemoattractant induces LFA-1 associated PI 3K activity and cell migration that are dependent on Fyn signalingGiovanni Bernardini
Department of Experimental Medicine and Pathology University, La Sapienza, Rome, Italy
FASEB J 19:1305-7. 2005.... - Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982Eugene C Butcher
J Immunol 175:1363-72. 2005 - A cell-surface molecule involved in organ-specific homing of lymphocytes. 1983W Michael Gallatin
J Immunol 177:5-9. 2006 - Dendritic cells support sequential reprogramming of chemoattractant receptor profiles during naive to effector T cell differentiationChang H Kim
Laboratory of Immunology and Hematopoiesis, Department of Veterinary Pathobiology and Purdue Cancer Center, and Biochemistry and Molecular Biology Program, Purdue University, West Lafayette, IN 47907, USA
J Immunol 171:152-8. 2003.... - Selectin, platelet plays a critical role in granulocyte access to the pregnant mouse uterus under physiological and pathological conditionsUta Fernekorn
Institute of Immunology and Transfusion Medicine, University of Lubeck, 23538 Lubeck, Germany
Biol Reprod 76:645-53. 2007..Our results clearly demonstrate the importance of SELP for granulocyte access to the pregnant mouse uterus under physiological and pathological conditions... - CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1Luca Battistini
Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Santa Lucia, Rome, Italy
Blood 101:4775-82. 2003..In conclusion, our results show that CD8+, but not CD4+, T cells from patients with RRMS in the acute phase of the disease display increased ability to be recruited in inflamed brain venules... - Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammationMegumi Honjo
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
Proc Natl Acad Sci U S A 100:1274-9. 2003..Thus, LOX-1 is an adhesion molecule involved in leukocyte recruitment and may represent an attractive target for modulation of endotoxin-induced inflammation... - Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerinPaulina Kulig
Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Ulica Gronostajowa 7, 30 387 Krakow, Poland
J Immunol 178:3713-20. 2007..SspB may help direct the recruitment of specialized host cells, including immunoregulatory pDC and/or macrophages, contributing to the ability of S. aureus to elicit and maintain a chronic inflammatory state... - Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptorsLaura Piccio
Department of Pathology, University of Verona, Verona, Italy
J Immunol 168:1940-9. 2002..In conclusion, our data unveils the molecular mechanisms controlling the recruitment of autoreactive lymphocytes in inflamed cerebral vessels and suggest new insights into the pathogenesis of autoimmune inflammatory diseases of the CNS...
Research Grants
- Regulation of T Cell CCR10 by Sunlight and Vitamin DEugene Butcher; Fiscal Year: 2007..This problem has importance to a basic understanding of tissue- specific immune responses, but also to the specialized immune and inflammatory pathologies associated with skin such as psoriasis, DTH reactions and bullous diseases. ..
- Novel Dendritic Cell Chemoattractant and ReceptorEugene Butcher; Fiscal Year: 2009..abstract_text> ..
- Regulation of T Cell CCR10 by Sunlight and Vitamin DEugene Butcher; Fiscal Year: 2009..This problem has importance to a basic understanding of tissue- specific immune responses, but also to the specialized immune and inflammatory pathologies associated with skin such as psoriasis, DTH reactions and bullous diseases. ..
- Intestinal Lymphocyte TraffickingEugene Butcher; Fiscal Year: 2009....
- A Novel Tolergenic Dendritic Cell: Biology & Therapeutic PotentialEugene Butcher; Fiscal Year: 2009..They will test a novel approach using these cells for transplantation immunotherapy, and may lead to new insights and treatments for autoimmune, allergic and other disorders of the immune system. ..
- Tolerogenic DC as Therapeutic Agents in GVHDEugene C Butcher; Fiscal Year: 2010..Together, these studies will define in detail the potential of CCR9+ pDCs to suppress deleterious effects of GVHD in settings modeling situations in which human patients encounter pathogenic GVHD responses. ..
- A Novel Tolergenic Dendritic Cell: Biology & Therapeutic PotentialEugene C Butcher; Fiscal Year: 2010..They will test a novel approach using these cells for transplantation immunotherapy, and may lead to new insights and treatments for autoimmune, allergic and other disorders of the immune system. ..
- Intestinal Lymphocyte TraffickingEugene Butcher; Fiscal Year: 2007....
- ENDOTHELIAL CELL BIOLOGY IN INFLAMMATIONEugene Butcher; Fiscal Year: 2007..The proposed studies should expand our understanding of the critical role of the vascular endothelium in regulating lymphocyte trafficking during normal and pathologic immune responses. ..
- CHEMOATTRACTANT SIGNALING TO LEUKOCYTE INTEGRINSEugene Butcher; Fiscal Year: 2001..These studies should define signaling mechanisms regulating the adhesion of leukocytes and other cells, and may lead to novel therapeutic approaches for the control of neoplastic and inflammatory diseases ..
- VASCULAR-MONOCYTE ADHESION MOLECULE IN ATHEROGENESISEugene Butcher; Fiscal Year: 2002..The proposed studies will elucidate the structure of this novel vascular receptor and its role in monocyte recruitment in atherogenesis. They may lead to new approaches to the regulation of the atherogenic process. ..
- CCR9 AND TECK IN INTESTINAL LYMPHOCYTE TRAFFICKINGEugene Butcher; Fiscal Year: 2005....
- Conference on Leukocyte TraffickingEugene Butcher; Fiscal Year: 2004..abstract_text> ..
- Regulation of T Cell CCR10 by Sunlight and Vitamin DEugene C Butcher; Fiscal Year: 2010..This problem has importance to a basic understanding of tissue- specific immune responses, but also to the specialized immune and inflammatory pathologies associated with skin such as psoriasis, DTH reactions and bullous diseases. ..