PAUL SCOTT BUCKMASTER

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Does mossy fiber sprouting give rise to the epileptic state?
    Paul S Buckmaster
    Departments of Comparative Medicine and Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA
    Adv Exp Med Biol 813:161-8. 2014
  2. pmc Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, CA 94305, United States
    Epilepsy Res 102:153-9. 2012
  3. pmc Mossy cell dendritic structure quantified and compared with other hippocampal neurons labeled in rats in vivo
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305 5342, U S A
    Epilepsia 53:9-17. 2012
  4. pmc Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    Epilepsia 52:2057-64. 2011
  5. pmc Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 31:2337-47. 2011
  6. pmc Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 29:8259-69. 2009
  7. ncbi request reprint Testing the disinhibition hypothesis of epileptogenesis in vivo and during spontaneous seizures
    P S Buckmaster
    Departments of Comparative Medicine and Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5410, USA
    J Neurosci 20:6232-40. 2000
  8. ncbi request reprint Does a unique type of CA3 pyramidal cell in primates bypass the dentate gate?
    Paul S Buckmaster
    Department of Comparative Medicine, 300 Pasteur Dr, R321 Edwards Bldg, Stanford University, Stanford, California 94305 5342 USA
    J Neurophysiol 94:896-900. 2005
  9. ncbi request reprint Prolonged infusion of tetrodotoxin does not block mossy fiber sprouting in pilocarpine-treated rats
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Palo Alto, California 94305 5342, USA
    Epilepsia 45:452-8. 2004
  10. ncbi request reprint Dendritic morphology, local circuitry, and intrinsic electrophysiology of principal neurons in the entorhinal cortex of macaque monkeys
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Comp Neurol 470:317-29. 2004

Research Grants

  1. Interneuron-Based Mechanisms of Temporal Lobe Epilepsy
    Paul Buckmaster; Fiscal Year: 2004
  2. DENTATE GYRUS CIRCUITRY IN TEMPORAL LOBE EPILESPY
    Paul Buckmaster; Fiscal Year: 2000
  3. RESEARCH OPPORTUNITIES IN COMPARATIVE MEDICINE
    Paul Buckmaster; Fiscal Year: 2004
  4. DENTATE GYRUS CIRCUITRY IN TEMPORAL LOBE EPILESPY
    Paul Buckmaster; Fiscal Year: 2001
  5. RESEARCH OPPORTUNITIES IN COMPARATIVE MEDICINE
    PAUL SCOTT BUCKMASTER; Fiscal Year: 2010
  6. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    PAUL SCOTT BUCKMASTER; Fiscal Year: 2010
  7. Comparative Medicine Biosciences Training Program
    Paul Buckmaster; Fiscal Year: 2007
  8. Dentate Gyrus Circuitry In Temporal Lobe Epilepsy
    Paul Buckmaster; Fiscal Year: 2005
  9. RESEARCH OPPORTUNITIES IN COMPARATIVE MEDICINE
    Paul Buckmaster; Fiscal Year: 2005
  10. Dentate Gyrus Circuitry In Temporal Lobe Epilepsy
    Paul Buckmaster; Fiscal Year: 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Does mossy fiber sprouting give rise to the epileptic state?
    Paul S Buckmaster
    Departments of Comparative Medicine and Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA
    Adv Exp Med Biol 813:161-8. 2014
    ..The challenge remains to identify which, if any, of the many other structural changes in the hippocampus are epileptogenic. ..
  2. pmc Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, CA 94305, United States
    Epilepsy Res 102:153-9. 2012
    ..Those results are substantially better than that of the total sample in which 31% failed to develop status epilepticus and only 34% developed status epilepticus and survived...
  3. pmc Mossy cell dendritic structure quantified and compared with other hippocampal neurons labeled in rats in vivo
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305 5342, U S A
    Epilepsia 53:9-17. 2012
    ..Therefore, electrotonic properties that depend on soma-dendritic structure are likely to be distinct in mossy cells compared to other neurons...
  4. pmc Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    Epilepsia 52:2057-64. 2011
    ..The functional consequences of γ-aminobutyric acid (GABA)ergic synaptic reorganization are unclear. Development of new methods to suppress epilepsy-related interneuron axon sprouting might be useful experimentally...
  5. pmc Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 31:2337-47. 2011
    ..These findings are consistent with the hypotheses that hilar neuron loss and ectopic granule cells might contribute to temporal lobe epileptogenesis...
  6. pmc Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 29:8259-69. 2009
    ..However, suppression required continual treatment, and rapamycin treatment did not reverse already established axon reorganization...
  7. ncbi request reprint Testing the disinhibition hypothesis of epileptogenesis in vivo and during spontaneous seizures
    P S Buckmaster
    Departments of Comparative Medicine and Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5410, USA
    J Neurosci 20:6232-40. 2000
    ..These findings do not support the disinhibition hypothesis and suggest that in this model of epilepsy seizures initiate by another mechanism or at a different site...
  8. ncbi request reprint Does a unique type of CA3 pyramidal cell in primates bypass the dentate gate?
    Paul S Buckmaster
    Department of Comparative Medicine, 300 Pasteur Dr, R321 Edwards Bldg, Stanford University, Stanford, California 94305 5342 USA
    J Neurophysiol 94:896-900. 2005
    ..These findings do not support the hypothesis that dentate CA3 pyramidal cells receive stronger synaptic input from the entorhinal cortex than do other proximal CA3 pyramidal cells...
  9. ncbi request reprint Prolonged infusion of tetrodotoxin does not block mossy fiber sprouting in pilocarpine-treated rats
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Palo Alto, California 94305 5342, USA
    Epilepsia 45:452-8. 2004
    ..The present study tested the hypothesis that prolonged, focal infusion of tetrodotoxin would block mossy fiber sprouting after an epileptogenic treatment...
  10. ncbi request reprint Dendritic morphology, local circuitry, and intrinsic electrophysiology of principal neurons in the entorhinal cortex of macaque monkeys
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Comp Neurol 470:317-29. 2004
    ..The interspecies differences revealed by this study may influence information processing and pathophysiological processes in the primate entorhinal cortex. J. Comp. Neurol. 470:317-329, 2004...
  11. ncbi request reprint Absence of temporal lobe epilepsy pathology in dogs with medically intractable epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University School of Medicine, CA 94305 5330, USA
    J Vet Intern Med 16:95-9. 2002
    ..These findings demonstrate a lack of hilar neuron loss and granule cell axon reorganization, suggesting that temporal lobe epilepsy is not a common cause of medically intractable epilepsy in dogs...
  12. ncbi request reprint Heightened seizure severity in somatostatin knockout mice
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, 300 Pasteur Drive, R102 Edwards Building, MC 5330, Stanford, CA 94305 5330, USA
    Epilepsy Res 48:43-56. 2002
    ....
  13. ncbi request reprint Axon arbors and synaptic connections of a vulnerable population of interneurons in the dentate gyrus in vivo
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Comp Neurol 445:360-73. 2002
    ....
  14. ncbi request reprint Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305 5330, USA
    J Neurosci 22:6650-8. 2002
    ..Rather, it replaces a distally distributed and disynaptic excitatory feedback circuit with one that is local and monosynaptic...
  15. ncbi request reprint Evoked responses of the dentate gyrus during seizures in developing gerbils with inherited epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University School of Medicine, California 94305 5336, USA
    J Neurophysiol 88:783-93. 2002
    ....
  16. ncbi request reprint Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy
    Masayuki Kobayashi
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305 5342, USA
    J Neurosci 23:2440-52. 2003
    ..Reduced granule cell inhibition in the temporal dentate gyrus preceded the onset of spontaneous recurrent seizures by days to weeks, so it may contribute, but is insufficient, to cause epilepsy...
  17. pmc Dysfunction of the dentate basket cell circuit in a rat model of temporal lobe epilepsy
    Wei Zhang
    Department of Comparative Medicine, Stanford University, Stanford, California 94305 5342, USA
    J Neurosci 29:7846-56. 2009
    ..These findings suggest dysfunction of the dentate basket cell circuit could contribute to hyperexcitability and seizures...
  18. pmc Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy
    Khushdev K Thind
    Department of Comparative Medicine, Stanford University, California 94305, USA
    J Comp Neurol 518:647-67. 2010
    ....
  19. pmc Surviving hilar somatostatin interneurons enlarge, sprout axons, and form new synapses with granule cells in a mouse model of temporal lobe epilepsy
    Wei Zhang
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 29:14247-56. 2009
    ..These epilepsy-related changes in cellular morphology and connectivity may be mechanisms for surviving hilar interneurons to inhibit more granule cells and compensate for the loss of vulnerable interneurons...
  20. pmc Synaptic input to dentate granule cell basal dendrites in a rat model of temporal lobe epilepsy
    Khushdev K Thind
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Comp Neurol 509:190-202. 2008
    ..These findings reveal that basal dendrites are a novel source of inhibitory input, but they primarily receive excitatory synapses...
  21. ncbi request reprint Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy
    Sanjay S Kumar
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 26:4613-23. 2006
    ....
  22. ncbi request reprint Recurrent excitation of granule cells with basal dendrites and low interneuron density and inhibitory postsynaptic current frequency in the dentate gyrus of macaque monkeys
    Jenifer E Austin
    Department of Psychiatry, Stanford University, Stanford, California 94305 5342, USA
    J Comp Neurol 476:205-18. 2004
    ..These primate characteristics may contribute to the susceptibility of the human dentate gyrus to epileptogenic injuries...
  23. ncbi request reprint Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy
    Masayuki Kobayashi
    Department of Comparative Medicine, Stanford University, Stanford, California 94305 5342, USA
    J Neurosci 23:8471-9. 2003
    ..These findings suggest that an epileptogenic injury reduces inhibition of layer II neurons and results in excessive synaptic input to the dentate gyrus...
  24. ncbi request reprint Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy
    Sanjay S Kumar
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 27:1239-46. 2007
    ..These findings suggest that in this model of temporal lobe epilepsy, reduced recurrent inhibition contributes to layer II stellate cell hyperexcitability and hypersynchrony, but increased recurrent excitation does not...
  25. pmc Neuron-specific nuclear antigen NeuN is not detectable in gerbil subtantia nigra pars reticulata
    Sanjay S Kumar
    Department of Comparative Medicine, Stanford University, Stanford, CA 94305 5342, USA
    Brain Res 1142:54-60. 2007
    ..Immunohistochemistry of rat SNr using the same antibody yielded robust staining. These data suggest lack of NeuN-immonoreactivity observed in certain cell-types and brain regions can be species-specific...
  26. pmc Stress coping stimulates hippocampal neurogenesis in adult monkeys
    David M Lyons
    Departments of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:14823-7. 2010
    ..These findings support recent indications that stress coping stimulates hippocampal neurogenesis in adult rodents. Psychotherapies designed to promote stress coping potentially have similar effects in humans with major depression...
  27. ncbi request reprint Stereological analysis of forebrain regions in kainate-treated epileptic rats
    Shaoyun Chen
    Department of Comparative Medicine, Stanford University, Stanford, CA 94305 5342, USA
    Brain Res 1057:141-52. 2005
    ..In this status epilepticus-based model, extrahippocampal damage appears to be more extensive and hippocampal damage appears to be less extensive than that reported for patients with temporal lobe epilepsy...
  28. ncbi request reprint GABAA receptor-mediated IPSCs and alpha1 subunit expression are not reduced in the substantia nigra pars reticulata of gerbils with inherited epilepsy
    Sanjay S Kumar
    Department of Comparative Medicine, Stanford University, Stanford, CA 94305 5342, USA
    J Neurophysiol 95:2446-55. 2006
    ..Therefore reduced expression of GABAA receptors in SNr is not likely to be an epileptogenic mechanism in this model...
  29. doi request reprint Changes in granule cell firing rates precede locally recorded spontaneous seizures by minutes in an animal model of temporal lobe epilepsy
    Mark R Bower
    Department of Comparative Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305 5342, USA
    J Neurophysiol 99:2431-42. 2008
    ..However, these findings show heterogeneous and gradually building changes in activity of individual granule cells minutes before spontaneous seizures...
  30. pmc Prolonged infusion of inhibitors of calcineurin or L-type calcium channels does not block mossy fiber sprouting in a model of temporal lobe epilepsy
    Elizabeth A Ingram
    Department of Comparative Medicine, Stanford University, Stanford, California, USA
    Epilepsia 50:56-64. 2009
    ..Previous studies have provided encouraging evidence that blocking L-type calcium channels or inhibiting calcineurin during epileptogenic treatments suppresses mossy fiber sprouting...
  31. ncbi request reprint Laboratory animal models of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, 300 Pasteur Drive, R321 Edwards Building, Stanford, California 94305 5342, USA
    Comp Med 54:473-85. 2004
    ..How models are created, how they compare with each other and with the disease in human patients, and how they advance our understanding of temporal lobe epilepsy are described...
  32. ncbi request reprint Prolonged infusion of cycloheximide does not block mossy fiber sprouting in a model of temporal lobe epilepsy
    Izumi Toyoda
    School of Veterinary Medicine, University of California Davis, Davis, CA, U S A
    Epilepsia 46:1017-20. 2005
    ..Conflicting reports exist on whether a single dose of the protein synthesis-blocker cycloheximide administered around the time of an epileptogenic injury can block the eventual development of mossy fiber sprouting...

Research Grants32

  1. Interneuron-Based Mechanisms of Temporal Lobe Epilepsy
    Paul Buckmaster; Fiscal Year: 2004
    ..The proposed experiments will provide new data on how inhibitory circuits in the dentate gyrus change in epileptic animals and how those changes may contribute to compensatory mechanisms and epileptogenesis. ..
  2. DENTATE GYRUS CIRCUITRY IN TEMPORAL LOBE EPILESPY
    Paul Buckmaster; Fiscal Year: 2000
    ..These experiments will provide new data on the connectivity of granule cells and establish an experimental approach for evaluating potential treatments designed to influence granule cell axon reorganization. ..
  3. RESEARCH OPPORTUNITIES IN COMPARATIVE MEDICINE
    Paul Buckmaster; Fiscal Year: 2004
    ..abstract_text> ..
  4. DENTATE GYRUS CIRCUITRY IN TEMPORAL LOBE EPILESPY
    Paul Buckmaster; Fiscal Year: 2001
    ..These experiments will provide new data on the connectivity of granule cells and establish an experimental approach for evaluating potential treatments designed to influence granule cell axon reorganization. ..
  5. RESEARCH OPPORTUNITIES IN COMPARATIVE MEDICINE
    PAUL SCOTT BUCKMASTER; Fiscal Year: 2010
    ..The long-term effect of this program, and others like it, is further development of the nation's workforce in laboratory animal medicine, comparative pathology, and comparative medicine. ..
  6. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    PAUL SCOTT BUCKMASTER; Fiscal Year: 2010
    ..Seizures might be caused by inadequate inhibition. This project will investigate in detail how and why inhibition is abnormal in dentate gyrus of a rat model of epilepsy. ..
  7. Comparative Medicine Biosciences Training Program
    Paul Buckmaster; Fiscal Year: 2007
    ..The research opportunities and facilities at Stanford University are substantial and will help trainees succeed in their quest to become independent researchers. ..
  8. Dentate Gyrus Circuitry In Temporal Lobe Epilepsy
    Paul Buckmaster; Fiscal Year: 2005
    ....
  9. RESEARCH OPPORTUNITIES IN COMPARATIVE MEDICINE
    Paul Buckmaster; Fiscal Year: 2005
    ..abstract_text> ..
  10. Dentate Gyrus Circuitry In Temporal Lobe Epilepsy
    Paul Buckmaster; Fiscal Year: 2007
    ....
  11. RESEARCH OPPORTUNITIES IN COMPARATIVE MEDICINE
    Paul Buckmaster; Fiscal Year: 2007
    ..abstract_text> ..
  12. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    Paul Buckmaster; Fiscal Year: 2000
    ....
  13. RESEARCH OPPORTUNITIES IN COMPARATIVE MEDICINE
    Paul Buckmaster; Fiscal Year: 2009
    ..The long-term effect of this program, and others like it, is further development of the nation's workforce in laboratory animal medicine, comparative pathology, and comparative medicine. ..
  14. Dentate Gyrus Circuitry In Temporal Lobe Epilepsy
    Paul Buckmaster; Fiscal Year: 2009
    ....
  15. Interneuron-Based Mechanisms of Temporal Lobe Epilepsy
    Paul Buckmaster; Fiscal Year: 2007
    ..The proposed experiments will provide new data on how inhibitory circuits in the dentate gyrus change in epileptic animals and how those changes may contribute to compensatory mechanisms and epileptogenesis. ..
  16. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    Paul Buckmaster; Fiscal Year: 2002
    ....
  17. DENTATE GYRUS CIRCUITRY IN TEMPORAL LOBE EPILESPY
    Paul Buckmaster; Fiscal Year: 2002
    ..These experiments will provide new data on the connectivity of granule cells and establish an experimental approach for evaluating potential treatments designed to influence granule cell axon reorganization. ..
  18. RESEARCH OPPORTUNITIES IN COMPARATIVE MEDICINE
    Paul Buckmaster; Fiscal Year: 2002
    ..abstract_text> ..
  19. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    Paul Buckmaster; Fiscal Year: 2003
    ....
  20. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    Paul Buckmaster; Fiscal Year: 2001
    ....
  21. DENTATE GYRUS CIRCUITRY IN TEMPORAL LOBE EPILESPY
    Paul Buckmaster; Fiscal Year: 2003
    ..These experiments will provide new data on the connectivity of granule cells and establish an experimental approach for evaluating potential treatments designed to influence granule cell axon reorganization. ..
  22. Interneuron-Based Mechanisms of Temporal Lobe Epilepsy
    Paul Buckmaster; Fiscal Year: 2005
    ..The proposed experiments will provide new data on how inhibitory circuits in the dentate gyrus change in epileptic animals and how those changes may contribute to compensatory mechanisms and epileptogenesis. ..
  23. Interneuron-Based Mechanisms of Temporal Lobe Epilepsy
    Paul Buckmaster; Fiscal Year: 2006
    ..The proposed experiments will provide new data on how inhibitory circuits in the dentate gyrus change in epileptic animals and how those changes may contribute to compensatory mechanisms and epileptogenesis. ..
  24. Dentate Gyrus Circuitry In Temporal Lobe Epilepsy
    PAUL SCOTT BUCKMASTER; Fiscal Year: 2010
    ..This project will test whether a specific abnormal circuit develops in the dentate gyrus and contributes to the generation of spontaneous seizures. ..
  25. Dentate Gyrus Circuitry In Temporal Lobe Epilepsy
    Paul Buckmaster; Fiscal Year: 2006
    ....
  26. Dentate Gyrus Circuitry In Temporal Lobe Epilepsy
    Paul Buckmaster; Fiscal Year: 2009
    ....
  27. RESEARCH OPPORTUNITIES IN COMPARATIVE MEDICINE
    Paul Buckmaster; Fiscal Year: 2003
    ..abstract_text> ..
  28. RESEARCH OPPORTUNITIES IN COMPARATIVE MEDICINE
    Paul Buckmaster; Fiscal Year: 2006
    ..abstract_text> ..