Anne Brunet

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint A CRTCal link between energy and life span
    Anne Brunet
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Cell Metab 13:358-60. 2011
  2. ncbi request reprint FOXO transcription factors
    MATTHEW E CARTER
    Department of Genetics and Neurosciences Program, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Curr Biol 17:R113-4. 2007
  3. pmc AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, California 94305, USA
    Ann N Y Acad Sci 1170:688-92. 2009
  4. pmc Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Aging Cell 8:113-27. 2009
  5. ncbi request reprint The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, California 94305, USA
    J Biol Chem 282:30107-19. 2007
  6. ncbi request reprint FOXO transcription factors at the interface between longevity and tumor suppression
    Eric L Greer
    Department of Genetics, Stanford University, CA 94305, USA
    Oncogene 24:7410-25. 2005
  7. pmc Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 466:383-7. 2010
  8. pmc Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri
    Dario Riccardo Valenzano
    Department of Genetics, Stanford University, Stanford, California 94305, USA
    Genetics 183:1385-95. 2009
  9. pmc An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
    Eric L Greer
    Department of Genetics, Cancer Biology Program, Stanford University, Stanford, California 94305, USA
    Curr Biol 17:1646-56. 2007
  10. ncbi request reprint Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    Anne Brunet
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Center for Blood Research CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 303:2011-5. 2004

Collaborators

  • Judit Villen
  • Michael Yaffe
  • David A Sinclair
  • THOMAS RANDO
  • MATTHEW E CARTER
  • Eric L Greer
  • Max R Banko
  • Hien Tran
  • Dario Riccardo Valenzano
  • Steven P Gygi
  • Michael E Greenberg
  • Anna G Hauswirth
  • Geraldine S Maro
  • Shuo Han
  • Travis J Maures
  • Or Gozani
  • Erin M Green
  • Dena S Leeman
  • Elisa Zhang
  • Christoph Englert
  • Roarke A Kamber
  • Alessandro Cellerino
  • Kathrin Reichwald
  • David Weber
  • Matthias Platzer
  • Jeanette Kirschner
  • Dara Dowlatshahi
  • Melanie P Gygi
  • Kimmi Hoang
  • Philip R Oskoui
  • Daniel Blanchard
  • Jay M Maniar
  • Eric C Griffith
  • Sandeep R Datta
  • Jill M Grenier
  • Albert J Fornace
  • Lillian W Chiang
  • Peter S DiStefano

Detail Information

Publications16

  1. ncbi request reprint A CRTCal link between energy and life span
    Anne Brunet
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Cell Metab 13:358-60. 2011
    ..A recent study in Nature (Mair et al., 2011) shows that life span extension triggered by the energy-sensing protein kinase AMPK is mediated by an evolutionarily conserved transcriptional circuit involving CRTC-1 and CREB...
  2. ncbi request reprint FOXO transcription factors
    MATTHEW E CARTER
    Department of Genetics and Neurosciences Program, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Curr Biol 17:R113-4. 2007
  3. pmc AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, California 94305, USA
    Ann N Y Acad Sci 1170:688-92. 2009
    ....
  4. pmc Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Aging Cell 8:113-27. 2009
    ..Understanding the genetic network by which different DR regimens extend lifespan has important implications for harnessing the full benefits of DR on lifespan and healthspan...
  5. ncbi request reprint The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, California 94305, USA
    J Biol Chem 282:30107-19. 2007
    ..The regulation of FOXO3 by AMPK may play a crucial role in fine tuning gene expression programs that control energy balance and stress resistance in cells throughout life...
  6. ncbi request reprint FOXO transcription factors at the interface between longevity and tumor suppression
    Eric L Greer
    Department of Genetics, Stanford University, CA 94305, USA
    Oncogene 24:7410-25. 2005
    ..Thus, FOXO proteins translate environmental stimuli into changes in gene expression programs that may coordinate organismal longevity and tumor suppression...
  7. pmc Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 466:383-7. 2010
    ..These results indicate that the longevity of the soma is regulated by an H3K4 methyltransferase/demethylase complex acting in the C. elegans germline...
  8. pmc Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri
    Dario Riccardo Valenzano
    Department of Genetics, Stanford University, Stanford, California 94305, USA
    Genetics 183:1385-95. 2009
    ..furzeri will also facilitate analysis of the genetic architecture of traits that characterize this group of vertebrates, including short life span and adaptation to extreme environmental conditions...
  9. pmc An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
    Eric L Greer
    Department of Genetics, Cancer Biology Program, Stanford University, Stanford, California 94305, USA
    Curr Biol 17:1646-56. 2007
    ..AMP-activated protein kinase (AMPK) is activated by a decrease in energy levels, raising the possibility that AMPK might mediate lifespan extension by DR...
  10. ncbi request reprint Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    Anne Brunet
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Center for Blood Research CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 303:2011-5. 2004
    ..Thus, one way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance...
  11. ncbi request reprint Aging and cancer: killing two birds with one worm
    Anne Brunet
    Nat Genet 39:1306-7. 2007
  12. ncbi request reprint Ageing: from stem to stern
    Anne Brunet
    Nature 449:288-91. 2007
  13. ncbi request reprint [The multiple roles of FOXO transcription factors]
    Anne Brunet
    Med Sci (Paris) 20:856-9. 2004
  14. ncbi request reprint The many forks in FOXO's road
    Hien Tran
    Department of Neurobiology, Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sci STKE 2003:RE5. 2003
    ..A number of studies have also shed light on the signaling pathways that regulate FOXO activity in response to external stimuli and have identified multiple FOXO target genes that mediate this varied set of biological responses...
  15. ncbi request reprint DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
    Hien Tran
    Division of Neuroscience, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 296:530-4. 2002
    ..These findings indicate that in mammals FOXO3a regulates the resistance of cells to stress by inducing DNA repair and thereby may also affect organismal life-span...
  16. pmc 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
    Anne Brunet
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Biol 156:817-28. 2002
    ..These results indicate that 14-3-3 can mediate the relocalization of nuclear ligands by several mechanisms that ensure complete sequestration of the bound 14-3-3 complex in the cytoplasm...

Research Grants9