Anne Brunet

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Epigenetics of aging and aging-related disease
    Anne Brunet
    Department of Genetics, Stanford University, California Glenn Laboratories for the Biology of Aging, Stanford, California
    J Gerontol A Biol Sci Med Sci 69:S17-20. 2014
  2. pmc Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Aging Cell 8:113-27. 2009
  3. pmc The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor
    V M Renault
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Oncogene 30:3207-21. 2011
  4. pmc The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation
    Jamie O Brett
    Department of Genetics, Stanford University School of Medicine Stanford, CA 94305, USA
    Aging (Albany NY) 3:108-24. 2011
  5. pmc Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
    Eric L Greer
    Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 479:365-71. 2011
  6. pmc Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri, a Vertebrate Model for Aging
    Dario Riccardo Valenzano
    Department of Genetics, Stanford University, Stanford, California 94305
    G3 (Bethesda) 1:531-8. 2011
  7. ncbi request reprint A CRTCal link between energy and life span
    Anne Brunet
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Cell Metab 13:358-60. 2011
  8. pmc The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner
    Travis J Maures
    Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA
    Aging Cell 10:980-90. 2011
  9. pmc Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 466:383-7. 2010
  10. pmc An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
    Eric L Greer
    Department of Genetics, Cancer Biology Program, Stanford University, Stanford, California 94305, USA
    Curr Biol 17:1646-56. 2007

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Epigenetics of aging and aging-related disease
    Anne Brunet
    Department of Genetics, Stanford University, California Glenn Laboratories for the Biology of Aging, Stanford, California
    J Gerontol A Biol Sci Med Sci 69:S17-20. 2014
    ..This short review highlights key epigenetic players in the regulation of aging, as well as both future goals and challenges to the utilization of epigenetic strategies to delay and reverse the main diseases of aging. ..
  2. pmc Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Aging Cell 8:113-27. 2009
    ..Understanding the genetic network by which different DR regimens extend lifespan has important implications for harnessing the full benefits of DR on lifespan and healthspan...
  3. pmc The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor
    V M Renault
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Oncogene 30:3207-21. 2011
    ..Our findings indicate that FoxO3 is a p53 target gene, and suggest that FoxO3 and p53 are part of a regulatory transcriptional network that may have an important role during aging and cancer...
  4. pmc The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation
    Jamie O Brett
    Department of Genetics, Stanford University School of Medicine Stanford, CA 94305, USA
    Aging (Albany NY) 3:108-24. 2011
    ..These results suggest that miR-106b~25 regulates NSPC function and is part of a network involving the insulin/IGF-FoxO pathway, which may have important implications for the homeostasis of the NSC pool during aging...
  5. pmc Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
    Eric L Greer
    Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 479:365-71. 2011
    ..Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants...
  6. pmc Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri, a Vertebrate Model for Aging
    Dario Riccardo Valenzano
    Department of Genetics, Stanford University, Stanford, California 94305
    G3 (Bethesda) 1:531-8. 2011
    ..Transgenesis in this fish will also facilitate the study of other phenotypes, including adult tissue regeneration and cognitive behavior...
  7. ncbi request reprint A CRTCal link between energy and life span
    Anne Brunet
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Cell Metab 13:358-60. 2011
    ..A recent study in Nature (Mair et al., 2011) shows that life span extension triggered by the energy-sensing protein kinase AMPK is mediated by an evolutionarily conserved transcriptional circuit involving CRTC-1 and CREB...
  8. pmc The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner
    Travis J Maures
    Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA
    Aging Cell 10:980-90. 2011
    ..These findings identify the H3K27me3 histone demethylase UTX-1 as a novel regulator of worm lifespan in somatic cells...
  9. pmc Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 466:383-7. 2010
    ..These results indicate that the longevity of the soma is regulated by an H3K4 methyltransferase/demethylase complex acting in the C. elegans germline...
  10. pmc An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
    Eric L Greer
    Department of Genetics, Cancer Biology Program, Stanford University, Stanford, California 94305, USA
    Curr Biol 17:1646-56. 2007
    ..AMP-activated protein kinase (AMPK) is activated by a decrease in energy levels, raising the possibility that AMPK might mediate lifespan extension by DR...
  11. pmc AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, California 94305, USA
    Ann N Y Acad Sci 1170:688-92. 2009
    ....
  12. pmc FoxO3 regulates neural stem cell homeostasis
    Valérie M Renault
    Department of Genetics, Stanford University, CA 94305, USA
    Cell Stem Cell 5:527-39. 2009
    ..The ability of FoxO3 to prevent the premature depletion of NSCs might have important implications for counteracting brain aging in long-lived species...
  13. ncbi request reprint Males shorten the life span of C. elegans hermaphrodites via secreted compounds
    Travis J Maures
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Science 343:541-4. 2014
    ....
  14. pmc FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis
    Ashley E Webb
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Cell Rep 4:477-91. 2013
    ....
  15. pmc Methylation by Set9 modulates FoxO3 stability and transcriptional activity
    DANIEL R CALNAN
    Cancer Biology Program, Stanford University, CA 94305, USA
    Aging (Albany NY) 4:462-79. 2012
    ..The modulation of FoxO3 stability and activity by methylation may be critical for fine-tuning cellular responses to stress stimuli, which may in turn affect FoxO3's ability to promote tumor suppression and longevity...
  16. pmc Histone methylation makes its mark on longevity
    Shuo Han
    Department of Genetics, 300 Pasteur Drive, Stanford University, Stanford, CA 94305, USA
    Trends Cell Biol 22:42-9. 2012
    ....
  17. doi request reprint FOXO flips the longevity SWItch
    Ashley E Webb
    Department of Genetics, Stanford University, Stanford, California 94305, USA
    Nat Cell Biol 15:444-6. 2013
    ..In the nematode Caenorhabditis elegans, FOXO is now shown to recruit the nucleosome remodelling complex SWI/SNF to its target genes, which is essential for FOXO to elicit stress resistance and longevity...
  18. doi request reprint Energy metabolism in adult neural stem cell fate
    Victoria A Rafalski
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Prog Neurobiol 93:182-203. 2011
    ..A better understanding of how neural stem cells are influenced by changes in energy availability will help unravel the complex nature of neural stem cell biology in both the normal and diseased state...
  19. pmc Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons
    Orly L Wapinski
    Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University, Stanford, CA 94305, USA Program in Cancer Biology, Stanford University, Stanford, CA 94305, USA
    Cell 155:621-35. 2013
    ..Thus, a precise match between pioneer factors and the chromatin context at key target genes is determinative for transdifferentiation to neurons and likely other cell types...
  20. doi request reprint Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging
    Ling Liu
    The Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Rep 4:189-204. 2013
    ..These findings highlight the importance of chromatin mapping in understanding unique features of stem cell identity and stem cell aging. ..
  21. ncbi request reprint Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
    Victoria A Rafalski
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Cell Biol 15:614-24. 2013
    ..The identification of drug-targetable enzymes that regulate oligodendrocyte regeneration in adults could facilitate the development of therapies for demyelinating injuries and diseases, such as multiple sclerosis...
  22. pmc Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate
    Victoria A Rafalski
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    J Cell Sci 125:5597-608. 2012
    ..Determining how energy metabolism regulates stem cell fate should shed light on the decline in tissue regeneration that occurs during aging and facilitate the development of therapies for degenerative or metabolic diseases...
  23. ncbi request reprint FOXO transcription factors at the interface between longevity and tumor suppression
    Eric L Greer
    Department of Genetics, Stanford University, CA 94305, USA
    Oncogene 24:7410-25. 2005
    ..Thus, FOXO proteins translate environmental stimuli into changes in gene expression programs that may coordinate organismal longevity and tumor suppression...
  24. ncbi request reprint The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, California 94305, USA
    J Biol Chem 282:30107-19. 2007
    ..The regulation of FOXO3 by AMPK may play a crucial role in fine tuning gene expression programs that control energy balance and stress resistance in cells throughout life...
  25. pmc Bridging the transgenerational gap with epigenetic memory
    Jana P Lim
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Trends Genet 29:176-86. 2013
    ..We also review the current body of evidence implicating chromatin modifications and RNA molecules in mechanisms underlying this unconventional mode of inheritance and discuss its evolutionary implications...
  26. pmc FoxO6 regulates memory consolidation and synaptic function
    Dervis A M Salih
    Department of Genetics, Stanford University, Stanford, California 94305, USA
    Genes Dev 26:2780-801. 2012
    ..Thus, FoxO6 may promote memory consolidation by regulating a program coordinating neuronal connectivity in the hippocampus, which could have important implications for physiological and pathological age-dependent decline in memory...
  27. pmc Aging and reprogramming: a two-way street
    Salah Mahmoudi
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Curr Opin Cell Biol 24:744-56. 2012
    ..Finally, we argue that reprogramming provides a unique opportunity to model aging and perhaps exceptional longevity...
  28. ncbi request reprint FOXO transcription factors
    MATTHEW E CARTER
    Department of Genetics and Neurosciences Program, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Curr Biol 17:R113-4. 2007
  29. pmc MicroRNA programs in normal and aberrant stem and progenitor cells
    Christopher P Arnold
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genome Res 21:798-810. 2011
    ..Together, these analyses reveal the miRNA programs that may control key processes in normal and aberrant stem and progenitor cells, setting the foundations for dissecting post-transcriptional regulatory networks in stem cells...
  30. pmc Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri
    Dario Riccardo Valenzano
    Department of Genetics, Stanford University, Stanford, California 94305, USA
    Genetics 183:1385-95. 2009
    ..furzeri will also facilitate analysis of the genetic architecture of traits that characterize this group of vertebrates, including short life span and adaptation to extreme environmental conditions...
  31. pmc Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis
    Max R Banko
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Mol Cell 44:878-92. 2011
    ..These findings suggest that AMPK coordinates nutrient status with mitosis completion, which may be critical for the organism's response to low nutrients during development, or in adult stem and cancer cells...
  32. doi request reprint Signaling networks in aging
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    J Cell Sci 121:407-12. 2008
  33. ncbi request reprint FOXO transcription factors: key regulators of cellular quality control
    Ashley E Webb
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Trends Biochem Sci 39:159-69. 2014
    ..The ability of FOXO to maintain cellular quality control appears to be critical in processes and pathologies where damaged proteins and organelles accumulate, including aging and neurodegenerative diseases...
  34. pmc FoxO transcription factors in the maintenance of cellular homeostasis during aging
    Dervis A M Salih
    Department of Genetics, Stanford University, Stanford, CA 94305, United States
    Curr Opin Cell Biol 20:126-36. 2008
    ..Given the overwhelming evidence that the FoxO factors promote longevity in invertebrates, this review will also discuss the potential role of the FoxO factors in the aging of mammalian organisms...
  35. ncbi request reprint Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    Anne Brunet
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Center for Blood Research CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 303:2011-5. 2004
    ..Thus, one way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance...
  36. ncbi request reprint DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
    Hien Tran
    Division of Neuroscience, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 296:530-4. 2002
    ..These findings indicate that in mammals FOXO3a regulates the resistance of cells to stress by inducing DNA repair and thereby may also affect organismal life-span...
  37. pmc 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
    Anne Brunet
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Biol 156:817-28. 2002
    ..These results indicate that 14-3-3 can mediate the relocalization of nuclear ligands by several mechanisms that ensure complete sequestration of the bound 14-3-3 complex in the cytoplasm...
  38. ncbi request reprint Aging and cancer: killing two birds with one worm
    Anne Brunet
    Nat Genet 39:1306-7. 2007
  39. ncbi request reprint Ageing: from stem to stern
    Anne Brunet
    Nature 449:288-91. 2007
  40. ncbi request reprint The many forks in FOXO's road
    Hien Tran
    Department of Neurobiology, Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sci STKE 2003:RE5. 2003
    ..A number of studies have also shed light on the signaling pathways that regulate FOXO activity in response to external stimuli and have identified multiple FOXO target genes that mediate this varied set of biological responses...
  41. ncbi request reprint [The multiple roles of FOXO transcription factors]
    Anne Brunet
    Med Sci (Paris) 20:856-9. 2004

Research Grants9

  1. Forkhead transcription factors in the stress response
    Anne Brunet; Fiscal Year: 2005
    ..abstract_text> ..
  2. Forkhead transcription factors in the stress response
    Anne Brunet; Fiscal Year: 2006
    ..abstract_text> ..
  3. Forkhead transcription factors in the stress response
    Anne Brunet; Fiscal Year: 2007
    ..abstract_text> ..
  4. Molecular mechanisms underlying lifespan extension by dietary restriction
    Anne Brunet; Fiscal Year: 2009
    ....
  5. Forkhead transcription factors in the stress response
    Anne Brunet; Fiscal Year: 2009
    ..abstract_text> ..
  6. Molecular mechanisms underlying lifespan extension by dietary restriction
    Anne Brunet; Fiscal Year: 2010
    ....
  7. Molecular mechanisms underlying lifespan extension by dietary restriction
    Anne Brunet; Fiscal Year: 2009
    ....