Markus Bredel

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint High-resolution genome-wide mapping of genetic alterations in human glial brain tumors
    Markus Bredel
    Division of Oncology, Center for Clinical Sciences Research, Stanford University School of Medicine, Stanford, California 94305 5151, USA
    Cancer Res 65:4088-96. 2005
  2. ncbi request reprint Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas
    Markus Bredel
    Division of Oncology, Center for Clinical Sciences Research, Stanford University School of Medicine, Stanford, California 94305 5151, USA
    Cancer Res 65:8679-89. 2005
  3. ncbi request reprint DNA topoisomerase IIalpha and Her-2/neu gene dosages in pediatric malignant gliomas
    Claudia Bredel
    Department of General Neurosurgery, Neurocenter, University of Freiburg, D 79106 Freiburg, Germany
    Int J Oncol 26:1187-92. 2005
  4. ncbi request reprint Chemogenomics: an emerging strategy for rapid target and drug discovery
    Markus Bredel
    Division of Oncology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1110, Stanford, California 94305 5151, USA
    Nat Rev Genet 5:262-75. 2004
  5. ncbi request reprint Genomics-based hypothesis generation: a novel approach to unravelling drug resistance in brain tumours?
    Markus Bredel
    Department of General Neurosurgery at the Neurocenter, University of Freiburg, Germany
    Lancet Oncol 5:89-100. 2004
  6. ncbi request reprint Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas
    Markus Bredel
    Division of Oncology, Center for Clinical Sciences Research, Institute for Computational and Mathematical Engineering, Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305 5151, USA
    J Clin Oncol 24:274-87. 2006
  7. ncbi request reprint Integrated high-resolution genome-wide analysis of gene dosage and gene expression in human brain tumors
    Dejan Juric
    Division of Oncology, Center for Clinical Sciences Research, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 377:187-202. 2007
  8. pmc Amplification of whole tumor genomes and gene-by-gene mapping of genomic aberrations from limited sources of fresh-frozen and paraffin-embedded DNA
    Markus Bredel
    Division of Oncology, Clinical Sciences Research, Stanford University School of Medicine, 269 Campus Dr, CCSR 1105, Stanford, CA 94305 5151, USA
    J Mol Diagn 7:171-82. 2005
  9. ncbi request reprint Brain-tumour drug resistance: the bare essentials
    Markus Bredel
    Department of General Neurosurgery, Neurocenter, University of Freiburg, Freiburg, Germany
    Lancet Oncol 3:397-406. 2002
  10. ncbi request reprint DNA topoisomerase IIalpha predicts progression-free and overall survival in pediatric malignant non-brainstem gliomas
    Markus Bredel
    Department of General Neurosurgery, Neurocenter, University of Freiburg, Freiburg, Germany
    Int J Cancer 99:817-20. 2002

Collaborators

Detail Information

Publications18

  1. ncbi request reprint High-resolution genome-wide mapping of genetic alterations in human glial brain tumors
    Markus Bredel
    Division of Oncology, Center for Clinical Sciences Research, Stanford University School of Medicine, Stanford, California 94305 5151, USA
    Cancer Res 65:4088-96. 2005
    ..Finally, five novel minimally deleted regions were identified in a subset of tumors, containing putative candidate tumor suppressor genes (TOPORS, FANCG, RAD51, TP53BP1, and BIK) that could have a role in gliomagenesis...
  2. ncbi request reprint Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas
    Markus Bredel
    Division of Oncology, Center for Clinical Sciences Research, Stanford University School of Medicine, Stanford, California 94305 5151, USA
    Cancer Res 65:8679-89. 2005
    ..This approach has extended existing knowledge about the organizational pattern of gene expression in human gliomas and identified potential novel targets for future therapeutic development...
  3. ncbi request reprint DNA topoisomerase IIalpha and Her-2/neu gene dosages in pediatric malignant gliomas
    Claudia Bredel
    Department of General Neurosurgery, Neurocenter, University of Freiburg, D 79106 Freiburg, Germany
    Int J Oncol 26:1187-92. 2005
    ..The observed intratumor genetic heterogeneity for TIIalpha in PMNBGs may have an impact on the relevance of TIIalpha as a biological constituent of outcome in these neoplasms...
  4. ncbi request reprint Chemogenomics: an emerging strategy for rapid target and drug discovery
    Markus Bredel
    Division of Oncology, Stanford University School of Medicine, 269 Campus Drive, CCSR 1110, Stanford, California 94305 5151, USA
    Nat Rev Genet 5:262-75. 2004
  5. ncbi request reprint Genomics-based hypothesis generation: a novel approach to unravelling drug resistance in brain tumours?
    Markus Bredel
    Department of General Neurosurgery at the Neurocenter, University of Freiburg, Germany
    Lancet Oncol 5:89-100. 2004
    ..Recent progress in high-throughput bioanalytical methods for genome-wide studies has made possible a novel research model of initial hypothesis generation followed by functional testing of the generated hypothesis...
  6. ncbi request reprint Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas
    Markus Bredel
    Division of Oncology, Center for Clinical Sciences Research, Institute for Computational and Mathematical Engineering, Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305 5151, USA
    J Clin Oncol 24:274-87. 2006
    ..Pre-existing and acquired drug resistance are major obstacles to the successful treatment of glioblastomas...
  7. ncbi request reprint Integrated high-resolution genome-wide analysis of gene dosage and gene expression in human brain tumors
    Dejan Juric
    Division of Oncology, Center for Clinical Sciences Research, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 377:187-202. 2007
    ..We have evaluated this approach and confirmed its efficacy in the human glioma genome...
  8. pmc Amplification of whole tumor genomes and gene-by-gene mapping of genomic aberrations from limited sources of fresh-frozen and paraffin-embedded DNA
    Markus Bredel
    Division of Oncology, Clinical Sciences Research, Stanford University School of Medicine, 269 Campus Dr, CCSR 1105, Stanford, CA 94305 5151, USA
    J Mol Diagn 7:171-82. 2005
    ..Therefore, this amplification method should lend itself to high-throughput genetic analyses of limited sources of tumor, such as fine-needle biopsies, laser-microdissected tissue, and small paraffin-embedded specimens...
  9. ncbi request reprint Brain-tumour drug resistance: the bare essentials
    Markus Bredel
    Department of General Neurosurgery, Neurocenter, University of Freiburg, Freiburg, Germany
    Lancet Oncol 3:397-406. 2002
    ..Elucidation of the cellular mechanisms involved in resistance regulation is needed for future progress in efficient approaches to selective modulation of drug resistance in these lesions...
  10. ncbi request reprint DNA topoisomerase IIalpha predicts progression-free and overall survival in pediatric malignant non-brainstem gliomas
    Markus Bredel
    Department of General Neurosurgery, Neurocenter, University of Freiburg, Freiburg, Germany
    Int J Cancer 99:817-20. 2002
    ....
  11. ncbi request reprint Predicting outcome and tailoring treatment in high-grade gliomas
    Markus Bredel
    Department of General Neurosurgery Neurocenter, University of Freiburg, Germany
    Lancet Oncol 4:269-70. 2003
  12. pmc NFKBIA deletion in glioblastomas
    Markus Bredel
    Department of Neurosurgery, Neurocenter, University of Freiburg, Freiburg, Germany
    N Engl J Med 364:627-37. 2011
    ....
  13. ncbi request reprint CHD5 is a tumor suppressor at human 1p36
    Anindya Bagchi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 128:459-75. 2007
    ..We demonstrate that Chd5 functions as a tumor suppressor in vivo and implicate deletion of CHD5 in human cancer. Identification of this tumor suppressor provides new avenues for exploring innovative clinical interventions for cancer...
  14. ncbi request reprint Expression of DNA topoisomerase IIalpha in oligodendroglioma
    Markus Bredel
    Institute of Neurology, Department of Neurosurgery, University of Vienna, Wien, Austria
    Anticancer Res 22:1301-4. 2002
    ..DNA Topoisomerase ha (Topo flu) is a nuclear enzyme whose expression levels are related to tumor cell growth and to resistance to anticancer chemotherapy...
  15. doi request reprint Nomograms as clinicobiological predictors of survival in glioblastoma
    Markus Bredel
    Lancet Oncol 9:5-6. 2008
  16. ncbi request reprint Vascular patterns in glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins: evidence for distinct angiogenic subtypes
    Peter Birner
    Institute of Clinical Pathology, University of Vienna, Austria
    Brain Pathol 13:133-43. 2003
    ..Our findings denote for the first time distinct angiogenic subtypes of human glioblastoma which may prove relevant for anti-angiogenic therapy approaches...
  17. doi request reprint Use of gene signatures to improve risk estimation in cancer
    Chiang Ching Huang
    JAMA 299:1605-6. 2008
  18. ncbi request reprint High expression of DNA topoisomerase IIalpha and Ki-67 antigen is associated with prolonged survival in glioblastoma patients
    Markus Bredel
    Institute of Neurology, University of Vienna, AKH 4J, Wahringer Gurtel 18 20, POB 48, Austria
    Eur J Cancer 38:1343-7. 2002
    ..We conclude that high expression of TIIalpha and Ki-67 appears to be associated with a prolonged survival in our cohort of GB patients...