Onn Brandman

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels
    Onn Brandman
    Department of Chemical and Systems Biology, Bio X Clark Center W200, Stanford University, Stanford, CA 94305, USA
    Cell 131:1327-39. 2007
  2. pmc Feedback loops shape cellular signals in space and time
    Onn Brandman
    Department of Cellular and Molecular Pharmacology, University of California San Francisco and Howard Hughes Medical Institute, San Francisco, CA 94158, USA
    Science 322:390-5. 2008
  3. pmc Interlinked fast and slow positive feedback loops drive reliable cell decisions
    Onn Brandman
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA, 94305, USA
    Science 310:496-8. 2005

Detail Information

Publications3

  1. pmc STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels
    Onn Brandman
    Department of Chemical and Systems Biology, Bio X Clark Center W200, Stanford University, Stanford, CA 94305, USA
    Cell 131:1327-39. 2007
    ..STIM2, like STIM1, caused Ca2+ influx via activation of the plasma membrane Ca2+ channel Orai1. Our study places STIM2 at the center of a feedback module that keeps basal cytosolic and ER Ca2+ concentrations within tight limits...
  2. pmc Feedback loops shape cellular signals in space and time
    Onn Brandman
    Department of Cellular and Molecular Pharmacology, University of California San Francisco and Howard Hughes Medical Institute, San Francisco, CA 94158, USA
    Science 322:390-5. 2008
    ..We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems...
  3. pmc Interlinked fast and slow positive feedback loops drive reliable cell decisions
    Onn Brandman
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA, 94305, USA
    Science 310:496-8. 2005
    ..Mathematical simulations revealed that linking fast and slow positive feedback loops creates a "dual-time" switch that is both rapidly inducible and resistant to noise in the upstream signaling system...