John C Boik
Affiliation: Stanford University
- Quantifying synergism/antagonism using nonlinear mixed-effects modeling: a simulation studyJohn C Boik
Graduate School of Biomedical Sciences, University of Texas, Houston, TX, U S A
Stat Med 27:1040-61. 2008..The MixLow method can be used to quantify drug interactions in any fixed-ratio drug combination study that includes within-group and between-group replicates, and where responses follow a sigmoidal pattern...
- Structure-activity models of oral clearance, cytotoxicity, and LD50: a screen for promising anticancer compoundsJohn C Boik
Department of Experimental Therapeutics, University of Texas M, d, Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
BMC Pharmacol 8:12. 2008..Multitask learning is particularly useful when the number of available training records is small relative to the number of features, as was the case with the oral clearance data...
- A classification model to predict synergism/antagonism of cytotoxic mixtures using protein-drug docking scoresJohn C Boik
Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
BMC Pharmacol 8:13. 2008..Results were compared to models where explanatory variables were constructed using the pseudomolecule approach of Sheridan...