FRANCIS GERARD BLANKENBERG

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Multi-modality imaging identifies key times for annexin V imaging as an early predictor of therapeutic outcome
    Stefanie J Mandl
    Stanford University, School of Medicine, CA 94305 5208, USA
    Mol Imaging 3:1-8. 2004
  2. ncbi request reprint Radiolabeling of HYNIC-annexin V with technetium-99m for in vivo imaging of apoptosis
    Francis G Blankenberg
    Department of Radiology, Stanford University, Palo Alto, California 94305, USA
    Nat Protoc 1:108-10. 2006
  3. doi request reprint Recent advances in the molecular imaging of programmed cell death: part II--non-probe-based MRI, ultrasound, and optical clinical imaging techniques
    Francis G Blankenberg
    Division of Pediatric Radiology, Department of Radiology, Lucile Salter Packard Children s Hospital, Stanford, California 94304, USA
    J Nucl Med 54:1-4. 2013
  4. doi request reprint Recent advances in the molecular imaging of programmed cell death: part I--pathophysiology and radiotracers
    Francis G Blankenberg
    Division of Pediatric Radiology, Department of Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA, USA
    J Nucl Med 53:1659-62. 2012
  5. doi request reprint Brain uptake of Tc99m-HMPAO correlates with clinical response to the novel redox modulating agent EPI-743 in patients with mitochondrial disease
    Francis G Blankenberg
    Department of Radiology, Divisions of Pediatric Radiology and Nuclear Medicine, Lucile Packard Children s Hospital, Stanford, CA 94305, USA
    Mol Genet Metab 107:690-9. 2012
  6. ncbi request reprint In vivo tumor angiogenesis imaging with site-specific labeled (99m)Tc-HYNIC-VEGF
    Francis G Blankenberg
    Division of Nuclear Medicine Department of Radiology and MIPS Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94304, USA
    Eur J Nucl Med Mol Imaging 33:841-8. 2006
  7. ncbi request reprint Nuclear medicine applications in molecular imaging: 2007 update
    F G Blankenberg
    Division of Pediatric Radiology, F G B Department of Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA, USA
    Q J Nucl Med Mol Imaging 51:99-110. 2007
  8. doi request reprint In vivo detection of apoptosis
    Francis G Blankenberg
    Division of Pediatric Radiology, Department of Radiology, Lucile Salter Packard Children s Hospital, Stanford, California, USA
    J Nucl Med 49:81S-95S. 2008
  9. ncbi request reprint In vivo imaging of apoptosis
    Francis G Blankenberg
    Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA 94304, USA
    Cancer Biol Ther 7:1525-32. 2008
  10. ncbi request reprint Monitoring of treatment-induced apoptosis in oncology with PET and SPECT
    Francis G Blankenberg
    FGB Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA 94304, USA
    Curr Pharm Des 14:2974-82. 2008

Research Grants

  1. scVEGF Targeted Radiotherapy of Mammary and Colonic Cancer
    Francis Blankenberg; Fiscal Year: 2009
  2. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2007
  3. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2001
  4. scVEGF Targeted Radiotherapy of Mammary and Colonic Cancer
    FRANCIS GERARD BLANKENBERG; Fiscal Year: 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Multi-modality imaging identifies key times for annexin V imaging as an early predictor of therapeutic outcome
    Stefanie J Mandl
    Stanford University, School of Medicine, CA 94305 5208, USA
    Mol Imaging 3:1-8. 2004
    ..Multimodality imaging revealed the temporal patterns of tumor cell loss and annexin V uptake revealing a better understanding of the timing of radiolabeled annexin V uptake for its development as a marker of therapeutic efficacy...
  2. ncbi request reprint Radiolabeling of HYNIC-annexin V with technetium-99m for in vivo imaging of apoptosis
    Francis G Blankenberg
    Department of Radiology, Stanford University, Palo Alto, California 94305, USA
    Nat Protoc 1:108-10. 2006
    ..Once prepared, HYNIC-annexin V can be labeled with 99mTc, a widely available gamma-radiation-emitting radionuclide, for intravenous injection in as little as 30 min without the need for specialized reagents or equipment...
  3. doi request reprint Recent advances in the molecular imaging of programmed cell death: part II--non-probe-based MRI, ultrasound, and optical clinical imaging techniques
    Francis G Blankenberg
    Division of Pediatric Radiology, Department of Radiology, Lucile Salter Packard Children s Hospital, Stanford, California 94304, USA
    J Nucl Med 54:1-4. 2013
    ..It is hoped that imaging studies that systematically look at treatment response can soon be performed to address these issues...
  4. doi request reprint Recent advances in the molecular imaging of programmed cell death: part I--pathophysiology and radiotracers
    Francis G Blankenberg
    Division of Pediatric Radiology, Department of Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA, USA
    J Nucl Med 53:1659-62. 2012
    ..In this review we will briefly outline the molecular mechanisms of apoptosis that can be imaged with radiotracers now under development...
  5. doi request reprint Brain uptake of Tc99m-HMPAO correlates with clinical response to the novel redox modulating agent EPI-743 in patients with mitochondrial disease
    Francis G Blankenberg
    Department of Radiology, Divisions of Pediatric Radiology and Nuclear Medicine, Lucile Packard Children s Hospital, Stanford, CA 94305, USA
    Mol Genet Metab 107:690-9. 2012
    ..Further studies will be needed to confirm these findings in a more homogenous study population...
  6. ncbi request reprint In vivo tumor angiogenesis imaging with site-specific labeled (99m)Tc-HYNIC-VEGF
    Francis G Blankenberg
    Division of Nuclear Medicine Department of Radiology and MIPS Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94304, USA
    Eur J Nucl Med Mol Imaging 33:841-8. 2006
    ..We wished to test (99m)Tc-HYNIC-C-tagged VEGF ((99m)Tc-HYNIC-VEGF) for the imaging of tumor vasculature before and after antiangiogenic (low continuous dosing, metronomic) and tumoricidal (high-dose) cyclophosphamide treatment...
  7. ncbi request reprint Nuclear medicine applications in molecular imaging: 2007 update
    F G Blankenberg
    Division of Pediatric Radiology, F G B Department of Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA, USA
    Q J Nucl Med Mol Imaging 51:99-110. 2007
    ..It concludes the status of agents advocated for detecting angiogenesis and inflammation. The current clinical status of these agents, and their potential roles in diagnosis and treatment are discussed...
  8. doi request reprint In vivo detection of apoptosis
    Francis G Blankenberg
    Division of Pediatric Radiology, Department of Radiology, Lucile Salter Packard Children s Hospital, Stanford, California, USA
    J Nucl Med 49:81S-95S. 2008
    ..Finally, the use of MRI, MR spectroscopy, and ultrasound as possible alternative imaging modalities for the imaging of apoptosis is addressed...
  9. ncbi request reprint In vivo imaging of apoptosis
    Francis G Blankenberg
    Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA 94304, USA
    Cancer Biol Ther 7:1525-32. 2008
    ....
  10. ncbi request reprint Monitoring of treatment-induced apoptosis in oncology with PET and SPECT
    Francis G Blankenberg
    FGB Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA 94304, USA
    Curr Pharm Des 14:2974-82. 2008
    ..In this article we will review therapy reduced tumor apoptosis and the radiotracers used to date to image this process in both animal models and clinical trials...
  11. pmc Imaging the molecular signatures of apoptosis and injury with radiolabeled annexin V
    Francis G Blankenberg
    Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, California, USA
    Proc Am Thorac Soc 6:469-76. 2009
    ..The latest results from Phase II imaging trials with NSCLC and non-Hodgkin's lymphoma will be also be detailed. Finally, the potential future application of this tracer for the imaging of other pulmonary pathologies will be outlined...
  12. ncbi request reprint Apoptosis imaging: anti-cancer agents in medicinal chemistry
    Francis G Blankenberg
    Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA, USA
    Anticancer Agents Med Chem 9:944-51. 2009
    ..In this article we will outline the existing imaging agents and modalities that are currently undergoing clinical testing and those that could be rapidly translated into humans...
  13. doi request reprint Multimodality molecular imaging of apoptosis in oncology
    Francis G Blankenberg
    Department of Radiology, Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, 725 Welch Rd, Palo Alto, CA 94304, USA
    AJR Am J Roentgenol 197:308-17. 2011
    ....
  14. doi request reprint Targeted systemic radiotherapy with scVEGF/177Lu leads to sustained disruption of the tumor vasculature and intratumoral apoptosis
    Francis G Blankenberg
    Department of Radiology MIPS, Stanford University, Palo Alto, California, USA
    J Nucl Med 52:1630-7. 2011
    ....
  15. ncbi request reprint 99mTc-HYNIC-annexin V SPECT imaging of acute stroke and its response to neuroprotective therapy with anti-Fas ligand antibody
    Francis G Blankenberg
    Division of Pediatric Radiology Department of Radiology, Stanford University Hospital, 725 Welch Road, Rm 1673, Lucile Packard Children s Hospital, Palo Alto, CA 94305, USA
    Eur J Nucl Med Mol Imaging 33:566-74. 2006
    ..Secondly, we wished to test radiolabeled annexin's ability to monitor therapy in a rodent model of focal ischemic injury...
  16. ncbi request reprint Molecular imaging: The latest generation of contrast agents and tissue characterization techniques
    Francis G Blankenberg
    Division of Pediatric Radiology Department of Radiology, Stanford University Hospital, 300 Pasteur Drive Stanford, CA 94305, USA
    J Cell Biochem 90:443-53. 2003
    ..In the current article we will turn our attention to those modalities that are either currently in use or in development for the medical imaging clinic...
  17. ncbi request reprint Development of radiocontrast agents for vascular imaging: progress to date
    Francis G Blankenberg
    Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, California, USA
    Am J Cardiovasc Drugs 2:357-65. 2002
    ..Therefore, recently there has been renewed interest in the use of intravascular catheter-based radiation detectors...
  18. ncbi request reprint Nuclear medicine applications in molecular imaging
    Francis G Blankenberg
    Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, California, USA
    J Magn Reson Imaging 16:352-61. 2002
    ....
  19. ncbi request reprint Recent advances in the imaging of programmed cell death
    Francis G Blankenberg
    Stanford University School of Medicine, Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Clinic F, Rm 1673, 725 Welch Road, Palo Alto, CA 94304, USA
    Curr Pharm Des 10:1457-67. 2004
    ....
  20. ncbi request reprint Tumor imaging using a standardized radiolabeled adapter protein docked to vascular endothelial growth factor
    Francis G Blankenberg
    Department of Pediatrics, Stanford University, Stanford, California 94304, USA
    J Nucl Med 45:1373-80. 2004
    ..The assembly of this complex is based on interactions between human 109-amino acid (HuS) and 15-amino acid (Hu-tag) fragments of ribonuclease I, which serve as an "Adapter protein" and a Docking tag, respectively...
  21. ncbi request reprint Molecular imaging with single photon emission computed tomography. How new tracers can be employed in the nuclear medicine clinic
    Francis G Blankenberg
    Department of Radiology, Stanford University Hospital, Lucile Salter Packard Children s Hospital, Palo Alto, CA 94305, USA
    IEEE Eng Med Biol Mag 23:51-7. 2004
  22. doi request reprint Direct site-specific labeling of the Cys-tag moiety in scVEGF with technetium 99m
    Zoia Levashova
    Department of Radiology MIPS, Stanford University School of Medicine, Stanford, California 94305, USA
    Bioconjug Chem 19:1049-54. 2008
    ..The simple production of scVEGF for direct chelation of (99m)Tc makes it a promising molecular imaging agent for the oncology clinic...
  23. ncbi request reprint Apoptosis in a rodent model of cranial suture fusion: in situ imaging and gene expression analysis
    Kenton D Fong
    Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Calif 94305 5148, USA
    Plast Reconstr Surg 113:2037-47. 2004
    ..These data suggest that although overall apoptotic activity in rat patent and fusing sutures is similar, the pathways mediating apoptosis within each suture are distinct...
  24. ncbi request reprint Composite spirometric-computed tomography outcome measure in early cystic fibrosis lung disease
    Terry E Robinson
    Pediatric Pulmonary Division, Stanford University Medical Center, 701 Welch Road, Whelan Building 3328, Palo Alto, CA 94304 5786
    Am J Respir Crit Care Med 168:588-93. 2003
    ....
  25. ncbi request reprint Detection of focal hypoxic-ischemic injury and neuronal stress in a rodent model of unilateral MCA occlusion/reperfusion using radiolabeled annexin V
    Carina Mari
    Division of Nuclear Medicine, Department of Radiology, Stanford University Hospital, Stanford, CA 94305, USA
    Eur J Nucl Med Mol Imaging 31:733-9. 2004
    ..This pattern suggests that neuronal stress may play a role in the response of the brain to focal injury and be responsible for annexin V uptake outside the region of ischemic insult...
  26. doi request reprint SPECT and PET imaging of EGF receptors with site-specifically labeled EGF and dimeric EGF
    Zoya Levashova
    Department of Radiology MIPS, Stanford University School of Medicine, California 94305, USA
    Bioconjug Chem 20:742-9. 2009
    ..We expect that nuclear imaging of EGF receptors with these tracers will be useful for clinical diagnosis, therapeutic monitoring, and development of new drugs and treatment regimens...
  27. ncbi request reprint Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD
    Joerg Ermann
    Division of Immunology and Rheumatology, The Department of Medicine, Stanford University School of Medicine, CCSR Bldg, Rm 2215 C, 300 Pasteur Dr, Stanford, CA 94305 5166, USA
    Blood 105:2220-6. 2005
    ..The ability of Treg cells to efficiently enter the priming sites of pathogenic allo-reactive T cells appears to be a prerequisite for their protective function in aGVHD...
  28. doi request reprint Molecular imaging of changes in the prevalence of vascular endothelial growth factor receptor in sunitinib-treated murine mammary tumors
    Zoia Levashova
    Department of Radiology MIPS, Stanford University, Palo Alto, California, USA
    J Nucl Med 51:959-66. 2010
    ....
  29. ncbi request reprint The use of (99m)technetium-labeled MCP-1 to assess graft coronary artery disease in rat cardiac allografts
    Murray H Kown
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, California 94305, USA
    J Heart Lung Transplant 21:1009-15. 2002
    ..This study assessed whether technetium 99m ((99m)Tc)-labeled MCP-1 binds its receptors in chronic cardiac transplants and thereby provides a potential modality to assess GCAD...
  30. ncbi request reprint Bcl-2-mediated inhibition of apoptosis in rat cardiac allografts worsens development of graft coronary artery disease
    Murray H Kown
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA
    J Heart Lung Transplant 22:986-92. 2003
    ..We hypothesized that adenovirally mediated Bcl-2 transfection of donor hearts would reduce the apoptosis that occurs during acute rejection while worsening the development of chronic graft coronary artery disease (GCAD)...
  31. doi request reprint Imaging vascular endothelial growth factor (VEGF) receptors in turpentine-induced sterile thigh abscesses with radiolabeled single-chain VEGF
    Zoia Levashova
    Department of Radiology MIPS, School of Medicine, Stanford University, Stanford, California, USA
    J Nucl Med 50:2058-63. 2009
    ..We wished to determine whether labeled forms of single-chain VEGF (scVEGF) could be used to image VEGF receptors in a well-characterized model of sterile soft-tissue inflammation induced by intramuscular injection of turpentine...
  32. ncbi request reprint Imaging cell death with radiolabeled annexin V in an experimental model of rheumatoid arthritis
    Anneke M Post
    Division of Nuclear Medicine, Department of Radiology, Stanford University, Stanford, California, USA
    J Nucl Med 43:1359-65. 2002
    ..002). CONCLUSION: 99mTc-annexin V can detect collagen-induced immune arthritis and its response to steroid therapy before joint destruction...
  33. pmc Analysis of in situ and ex vivo vascular endothelial growth factor receptor expression during experimental aortic aneurysm progression
    Maureen M Tedesco
    Division of Vascular Surgery, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5642, USA
    Arterioscler Thromb Vasc Biol 29:1452-7. 2009
    ..We examined VEGFR expression as a function of AAA disease progression in the Apolipoprotein E-deficient (Apo E(-/-)) murine AAA model...

Research Grants10

  1. scVEGF Targeted Radiotherapy of Mammary and Colonic Cancer
    Francis Blankenberg; Fiscal Year: 2009
    ..Successful completion of our proposal will give the needed preclinical data for pursuing scVEGF targeted radiotherapy in other models and ultimately clinical applications. ..
  2. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2007
    ..Completion of this proposal will aid in the design and planning of clinical trials that will study the use of serial annexin V imaging as a non-invasive marker of cellular injury and therapeutic efficacy. ..
  3. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2001
    ..abstract_text> ..
  4. scVEGF Targeted Radiotherapy of Mammary and Colonic Cancer
    FRANCIS GERARD BLANKENBERG; Fiscal Year: 2010
    ..Successful completion of our proposal will give the needed preclinical data for pursuing scVEGF targeted radiotherapy in other models and ultimately clinical applications. ..