Research Topics
Species | FRANCIS GERARD BLANKENBERGSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
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Detail Information
Publications
Multi-modality imaging identifies key times for annexin V imaging as an early predictor of therapeutic outcomeStefanie J Mandl
Stanford University, School of Medicine, CA 94305-5208, USA
Mol Imaging 3:1-8. 2004..Multimodality imaging revealed the temporal patterns of tumor cell loss and annexin V uptake revealing a better understanding of the timing of radiolabeled annexin V uptake for its development as a marker of therapeutic efficacy...- Radiolabeling of HYNIC-annexin V with technetium-99m for in vivo imaging of apoptosisFrancis G Blankenberg
Department of Radiology, Stanford University, Palo Alto, California 94305, USA
Nat Protoc 1:108-10. 2006..Once prepared, HYNIC-annexin V can be labeled with 99mTc, a widely available gamma-radiation-emitting radionuclide, for intravenous injection in as little as 30 min without the need for specialized reagents or equipment... 
Recent advances in the molecular imaging of programmed cell death: part II--non-probe-based MRI, ultrasound, and optical clinical imaging techniquesFrancis G Blankenberg
Division of Pediatric Radiology, Department of Radiology, Lucile Salter Packard Children s Hospital, Stanford, California 94304, USA
J Nucl Med 54:1-4. 2013..It is hoped that imaging studies that systematically look at treatment response can soon be performed to address these issues...- Recent advances in the molecular imaging of programmed cell death: part I--pathophysiology and radiotracersFrancis G Blankenberg
Division of Pediatric Radiology, Department of Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA, USA
J Nucl Med 53:1659-62. 2012..In this review we will briefly outline the molecular mechanisms of apoptosis that can be imaged with radiotracers now under development... - Brain uptake of Tc99m-HMPAO correlates with clinical response to the novel redox modulating agent EPI-743 in patients with mitochondrial diseaseFrancis G Blankenberg
Department of Radiology, Divisions of Pediatric Radiology and Nuclear Medicine, Lucile Packard Children s Hospital, Stanford, CA 94305, USA
Mol Genet Metab 107:690-9. 2012..Further studies will be needed to confirm these findings in a more homogenous study population... - In vivo tumor angiogenesis imaging with site-specific labeled (99m)Tc-HYNIC-VEGFFrancis G Blankenberg
Division of Nuclear Medicine Department of Radiology and MIPS Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94304, USA
Eur J Nucl Med Mol Imaging 33:841-8. 2006..We wished to test (99m)Tc-HYNIC-C-tagged VEGF ((99m)Tc-HYNIC-VEGF) for the imaging of tumor vasculature before and after antiangiogenic (low continuous dosing, metronomic) and tumoricidal (high-dose) cyclophosphamide treatment... - Nuclear medicine applications in molecular imaging: 2007 updateF G Blankenberg
Division of Pediatric Radiology, F G B Department of Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA, USA
Q J Nucl Med Mol Imaging 51:99-110. 2007..It concludes the status of agents advocated for detecting angiogenesis and inflammation. The current clinical status of these agents, and their potential roles in diagnosis and treatment are discussed... - In vivo detection of apoptosisFrancis G Blankenberg
Division of Pediatric Radiology, Department of Radiology, Lucile Salter Packard Children s Hospital, Stanford, California, USA
J Nucl Med 49:81S-95S. 2008..Finally, the use of MRI, MR spectroscopy, and ultrasound as possible alternative imaging modalities for the imaging of apoptosis is addressed... - In vivo imaging of apoptosisFrancis G Blankenberg
Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA 94304, USA
Cancer Biol Ther 7:1525-32. 2008.... - Monitoring of treatment-induced apoptosis in oncology with PET and SPECTFrancis G Blankenberg
FGB Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA 94304, USA
Curr Pharm Des 14:2974-82. 2008..In this article we will review therapy reduced tumor apoptosis and the radiotracers used to date to image this process in both animal models and clinical trials... 
Imaging the molecular signatures of apoptosis and injury with radiolabeled annexin VFrancis G Blankenberg
Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, California, USA
Proc Am Thorac Soc 6:469-76. 2009..The latest results from Phase II imaging trials with NSCLC and non-Hodgkin's lymphoma will be also be detailed. Finally, the potential future application of this tracer for the imaging of other pulmonary pathologies will be outlined...- Apoptosis imaging: anti-cancer agents in medicinal chemistryFrancis G Blankenberg
Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, CA, USA
Anticancer Agents Med Chem 9:944-51. 2009..In this article we will outline the existing imaging agents and modalities that are currently undergoing clinical testing and those that could be rapidly translated into humans... - Multimodality molecular imaging of apoptosis in oncologyFrancis G Blankenberg
Department of Radiology, Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, 725 Welch Rd, Palo Alto, CA 94304, USA
AJR Am J Roentgenol 197:308-17. 2011..Imaging of apoptosis can facilitate early assessment of anticancer treatment before tumor shrinkage, which may increase the effectiveness of delivery of chemotherapy and radiation therapy and speed drug development... - Targeted systemic radiotherapy with scVEGF/177Lu leads to sustained disruption of the tumor vasculature and intratumoral apoptosisFrancis G Blankenberg
Department of Radiology MIPS, Stanford University, Palo Alto, California, USA
J Nucl Med 52:1630-7. 2011.... - 99mTc-HYNIC-annexin V SPECT imaging of acute stroke and its response to neuroprotective therapy with anti-Fas ligand antibodyFrancis G Blankenberg
Division of Pediatric Radiology Department of Radiology, Stanford University Hospital, 725 Welch Road, Rm 1673, Lucile Packard Children s Hospital, Palo Alto, CA 94305, USA
Eur J Nucl Med Mol Imaging 33:566-74. 2006..Secondly, we wished to test radiolabeled annexin's ability to monitor therapy in a rodent model of focal ischemic injury... - Molecular imaging: The latest generation of contrast agents and tissue characterization techniquesFrancis G Blankenberg
Division of Pediatric Radiology Department of Radiology, Stanford University Hospital, 300 Pasteur Drive Stanford, CA 94305, USA
J Cell Biochem 90:443-53. 2003..In the current article we will turn our attention to those modalities that are either currently in use or in development for the medical imaging clinic... - Development of radiocontrast agents for vascular imaging: progress to dateFrancis G Blankenberg
Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, California, USA
Am J Cardiovasc Drugs 2:357-65. 2002..Therefore, recently there has been renewed interest in the use of intravascular catheter-based radiation detectors... - Nuclear medicine applications in molecular imagingFrancis G Blankenberg
Department of Radiology Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Stanford, California, USA
J Magn Reson Imaging 16:352-61. 2002.... - Recent advances in the imaging of programmed cell deathFrancis G Blankenberg
Stanford University School of Medicine, Division of Pediatric Radiology, Lucile Salter Packard Children s Hospital, Clinic F, Rm 1673, 725 Welch Road, Palo Alto, CA 94304, USA
Curr Pharm Des 10:1457-67. 2004.... - Tumor imaging using a standardized radiolabeled adapter protein docked to vascular endothelial growth factorFrancis G Blankenberg
Department of Pediatrics, Stanford University, Stanford, California 94304, USA
J Nucl Med 45:1373-80. 2004..The assembly of this complex is based on interactions between human 109-amino acid (HuS) and 15-amino acid (Hu-tag) fragments of ribonuclease I, which serve as an "Adapter protein" and a Docking tag, respectively... - Molecular imaging with single photon emission computed tomography. How new tracers can be employed in the nuclear medicine clinicFrancis G Blankenberg
Department of Radiology, Stanford University Hospital, Lucile Salter Packard Children's Hospital, Palo Alto, CA 94305, USA
IEEE Eng Med Biol Mag 23:51-7. 2004 - Direct site-specific labeling of the Cys-tag moiety in scVEGF with technetium 99mZoia Levashova
Department of Radiology MIPS, Stanford University School of Medicine, Stanford, California 94305, USA
Bioconjug Chem 19:1049-54. 2008..The simple production of scVEGF for direct chelation of (99m)Tc makes it a promising molecular imaging agent for the oncology clinic... - Apoptosis in a rodent model of cranial suture fusion: in situ imaging and gene expression analysisKenton D Fong
Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Calif. 94305-5148, USA
Plast Reconstr Surg 113:2037-47. 2004..These data suggest that although overall apoptotic activity in rat patent and fusing sutures is similar, the pathways mediating apoptosis within each suture are distinct... - Composite spirometric-computed tomography outcome measure in early cystic fibrosis lung diseaseTerry E Robinson
Pediatric Pulmonary Division, Stanford University Medical Center, 701 Welch Road, Whelan Building 3328, Palo Alto, CA 94304 5786
Am J Respir Crit Care Med 168:588-93. 2003.... - Detection of focal hypoxic-ischemic injury and neuronal stress in a rodent model of unilateral MCA occlusion/reperfusion using radiolabeled annexin VCarina Mari
Division of Nuclear Medicine, Department of Radiology, Stanford University Hospital, Stanford, CA 94305, USA
Eur J Nucl Med Mol Imaging 31:733-9. 2004..This pattern suggests that neuronal stress may play a role in the response of the brain to focal injury and be responsible for annexin V uptake outside the region of ischemic insult... - SPECT and PET imaging of EGF receptors with site-specifically labeled EGF and dimeric EGFZoya Levashova
Department of Radiology MIPS, Stanford University School of Medicine, California 94305, USA
Bioconjug Chem 20:742-9. 2009..We expect that nuclear imaging of EGF receptors with these tracers will be useful for clinical diagnosis, therapeutic monitoring, and development of new drugs and treatment regimens... - Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHDJoerg Ermann
Division of Immunology and Rheumatology, The Department of Medicine, Stanford University School of Medicine, CCSR Bldg, Rm 2215-C, 300 Pasteur Dr, Stanford, CA 94305-5166, USA
Blood 105:2220-6. 2005..The ability of Treg cells to efficiently enter the priming sites of pathogenic allo-reactive T cells appears to be a prerequisite for their protective function in aGVHD... - Molecular imaging of changes in the prevalence of vascular endothelial growth factor receptor in sunitinib-treated murine mammary tumorsZoia Levashova
Department of Radiology MIPS, Stanford University, Palo Alto, California, USA
J Nucl Med 51:959-66. 2010.... - The use of (99m)technetium-labeled MCP-1 to assess graft coronary artery disease in rat cardiac allograftsMurray H Kown
Department of Cardiothoracic Surgery, Stanford University School of Medicine, California 94305, USA
J Heart Lung Transplant 21:1009-15. 2002..These data demonstrating increased radiopharmaceutical uptake in hearts with GCAD provide a foundation for the development of a potentially non-invasive imaging assay of this disease process in heart transplantation... - Bcl-2-mediated inhibition of apoptosis in rat cardiac allografts worsens development of graft coronary artery diseaseMurray H Kown
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA
J Heart Lung Transplant 22:986-92. 2003..4%, p = 0.009), was higher for the AdvBcl-2 group. CONCLUSION: Treatment of cardiac allografts with AdvBcl-2 resulted in a reduction of apoptosis that did not significantly improve short-term graft survival, but worsened chronic GCAD... - Imaging vascular endothelial growth factor (VEGF) receptors in turpentine-induced sterile thigh abscesses with radiolabeled single-chain VEGFZoia Levashova
Department of Radiology MIPS, School of Medicine, Stanford University, Stanford, California, USA
J Nucl Med 50:2058-63. 2009..We wished to determine whether labeled forms of single-chain VEGF (scVEGF) could be used to image VEGF receptors in a well-characterized model of sterile soft-tissue inflammation induced by intramuscular injection of turpentine... - Imaging cell death with radiolabeled annexin V in an experimental model of rheumatoid arthritisAnneke M Post
Division of Nuclear Medicine, Department of Radiology, Stanford University, Stanford, California, USA
J Nucl Med 43:1359-65. 2002..002). CONCLUSION: 99mTc-annexin V can detect collagen-induced immune arthritis and its response to steroid therapy before joint destruction... - Analysis of in situ and ex vivo vascular endothelial growth factor receptor expression during experimental aortic aneurysm progressionMaureen M Tedesco
Division of Vascular Surgery, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5642, USA
Arterioscler Thromb Vasc Biol 29:1452-7. 2009..We examined VEGFR expression as a function of AAA disease progression in the Apolipoprotein E-deficient (Apo E(-/-)) murine AAA model...
Research Grants
- scVEGF Targeted Radiotherapy of Mammary and Colonic CancerFrancis Blankenberg; Fiscal Year: 2009..Successful completion of our proposal will give the needed preclinical data for pursuing scVEGF targeted radiotherapy in other models and ultimately clinical applications. ..
- IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXINFrancis Blankenberg; Fiscal Year: 2007..Completion of this proposal will aid in the design and planning of clinical trials that will study the use of serial annexin V imaging as a non-invasive marker of cellular injury and therapeutic efficacy. ..
- IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXINFrancis Blankenberg; Fiscal Year: 2001..abstract_text> ..
- scVEGF Targeted Radiotherapy of Mammary and Colonic CancerFRANCIS GERARD BLANKENBERG; Fiscal Year: 2010..Successful completion of our proposal will give the needed preclinical data for pursuing scVEGF targeted radiotherapy in other models and ultimately clinical applications. ..