RICHARD DAVID BLAND

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth
    Anne Hilgendorff
    Department of Pediatrics, Stanford University, Stanford, California 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 303:L215-27. 2012
  2. ncbi request reprint Mechanical ventilation with 40% oxygen reduces pulmonary expression of genes that regulate lung development and impairs alveolar septation in newborn mice
    Richard D Bland
    Department of Pediatrics, Stanford Univ School of Medicine, CCSR Bldg Rm 1225, 269 Campus Dr, Stanford, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1099-110. 2007
  3. ncbi request reprint Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease
    Richard D Bland
    Department of Pediatrics, Stanford University School of Medicine, CCSR Bldg, Rm 1225, 269 Campus Drive, Stanford, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1370-84. 2007
  4. ncbi request reprint Neonatal chronic lung disease in the post-surfactant era
    Richard D Bland
    Stanford University School of Medicine, Stanford, CA 94305 5162, USA
    Biol Neonate 88:181-91. 2005
  5. pmc Inhaled nitric oxide effects on lung structure and function in chronically ventilated preterm lambs
    Richard D Bland
    Department of Pediatrics, Stanford University School of Medicine, CCSR Building, Room 1225, 269 Campus Drive, Stanford, CA 94305 5162, USA
    Am J Respir Crit Care Med 172:899-906. 2005
  6. ncbi request reprint Pulmonary vascular dysfunction in preterm lambs with chronic lung disease
    Richard D Bland
    Department of Pediatrics, Stanford University School of Medicine, CCSR Bldg, Rm 1225, 269 Campus Dr, Stanford, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 285:L76-85. 2003
  7. pmc Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization
    Kurt H Albertine
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84158, USA
    Am J Physiol Lung Cell Mol Physiol 299:L59-72. 2010
  8. pmc Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice
    Lucia M Mokres
    Stanford Univ School of Medicine, CCSR Bldg, Rm 1225, 269 Campus Dr, Stanford, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 298:L23-35. 2010
  9. ncbi request reprint Impaired alveolar development and abnormal lung elastin in preterm lambs with chronic lung injury: potential benefits of retinol treatment
    Richard D Bland
    Department of Pediatrics, Stanford University, Palo Alto, Calif, USA
    Biol Neonate 84:101-2. 2003
  10. ncbi request reprint Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development?
    Richard D Bland
    Am J Physiol Lung Cell Mol Physiol 294:L3-14. 2008

Collaborators

Detail Information

Publications11

  1. pmc Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth
    Anne Hilgendorff
    Department of Pediatrics, Stanford University, Stanford, California 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 303:L215-27. 2012
    ..These results suggest that degradation and remodeling of lung elastin can contribute to defective lung growth in response to MV-O(2) and might be targeted therapeutically to prevent ventilator-induced neonatal lung injury...
  2. ncbi request reprint Mechanical ventilation with 40% oxygen reduces pulmonary expression of genes that regulate lung development and impairs alveolar septation in newborn mice
    Richard D Bland
    Department of Pediatrics, Stanford Univ School of Medicine, CCSR Bldg Rm 1225, 269 Campus Dr, Stanford, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1099-110. 2007
    ..These changes yielded lung structural defects similar to those observed in evolving CLD...
  3. ncbi request reprint Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease
    Richard D Bland
    Department of Pediatrics, Stanford University School of Medicine, CCSR Bldg, Rm 1225, 269 Campus Drive, Stanford, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1370-84. 2007
    ..These changes, coupled with increased lung elastase activity measured in preterm lambs after MV for 1-3 days, likely contribute to CLD...
  4. ncbi request reprint Neonatal chronic lung disease in the post-surfactant era
    Richard D Bland
    Stanford University School of Medicine, Stanford, CA 94305 5162, USA
    Biol Neonate 88:181-91. 2005
    ....
  5. pmc Inhaled nitric oxide effects on lung structure and function in chronically ventilated preterm lambs
    Richard D Bland
    Department of Pediatrics, Stanford University School of Medicine, CCSR Building, Room 1225, 269 Campus Drive, Stanford, CA 94305 5162, USA
    Am J Respir Crit Care Med 172:899-906. 2005
    ..Inhaled nitric oxide (iNO) can reverse neonatal pulmonary hypertension and bronchoconstriction and reduce proliferation of cultured arterial and airway smooth muscle cells...
  6. ncbi request reprint Pulmonary vascular dysfunction in preterm lambs with chronic lung disease
    Richard D Bland
    Department of Pediatrics, Stanford University School of Medicine, CCSR Bldg, Rm 1225, 269 Campus Dr, Stanford, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 285:L76-85. 2003
    ....
  7. pmc Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization
    Kurt H Albertine
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84158, USA
    Am J Physiol Lung Cell Mol Physiol 299:L59-72. 2010
    ..We conclude that vitamin A treatment partially improves lung development in chronically ventilated preterm neonates by modulating expression of tropoelastin, deposition of elastin, and expression of vascular growth factors...
  8. pmc Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice
    Lucia M Mokres
    Stanford Univ School of Medicine, CCSR Bldg, Rm 1225, 269 Campus Dr, Stanford, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 298:L23-35. 2010
    ....
  9. ncbi request reprint Impaired alveolar development and abnormal lung elastin in preterm lambs with chronic lung injury: potential benefits of retinol treatment
    Richard D Bland
    Department of Pediatrics, Stanford University, Palo Alto, Calif, USA
    Biol Neonate 84:101-2. 2003
  10. ncbi request reprint Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development?
    Richard D Bland
    Am J Physiol Lung Cell Mol Physiol 294:L3-14. 2008
    ....
  11. pmc Blunted hypoxic pulmonary vasoconstriction in experimental neonatal chronic lung disease
    Gloria Juliana Rey-Parra
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Am J Respir Crit Care Med 178:399-406. 2008
    ....

Research Grants7

  1. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    Richard Bland; Fiscal Year: 2003
    ....
  2. Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung Elastin
    Richard Bland; Fiscal Year: 2009
    ..Because BPD is similar to emphysema, this research also may lead to better understanding and treatment of chronic obstructive pulmonary disease (COPD) in adults. ..
  3. Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung Elastin
    RICHARD DAVID BLAND; Fiscal Year: 2010
    ..Because BPD is similar to emphysema, this research also may lead to better understanding and treatment of chronic obstructive pulmonary disease (COPD) in adults. ..
  4. Mechanical Ventilation of Newborn Mice:Impact on Alveolarization and Lung Elastin
    Richard Bland; Fiscal Year: 2009
    ..Because BPD is similar to emphysema, this research also may lead to better understanding and treatment of chronic obstructive pulmonary disease (COPD) in adults. ..