Deepta Bhattacharya

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. pmc Space-time considerations for hematopoietic stem cell transplantation
    Deepta Bhattacharya
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305 5323, USA
    Eur J Immunol 38:2060-7. 2008
  2. ncbi Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation
    Deepta Bhattacharya
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 179:6808-19. 2007
  3. pmc Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning
    Deepta Bhattacharya
    Department of Pathology, Institute of Cancer and Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 203:73-85. 2006
  4. ncbi Rapid lymphocyte reconstitution of unconditioned immunodeficient mice with non-self-renewing multipotent hematopoietic progenitors
    Deepta Bhattacharya
    Institute of Cancer and Stem Cell Biology and Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Cell Cycle 5:1135-9. 2006
  5. pmc MiDReG: a method of mining developmentally regulated genes using Boolean implications
    Debashis Sahoo
    Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:5732-7. 2010
  6. pmc Gene Expression Commons: an open platform for absolute gene expression profiling
    Jun Seita
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e40321. 2012
  7. pmc Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development
    Matthew A Inlay
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 23:2376-81. 2009
  8. pmc Identification of the earliest natural killer cell-committed progenitor in murine bone marrow
    John W Fathman
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 118:5439-47. 2011
  9. pmc Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells
    Chance John Luckey
    Joslin Diabetes Center, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:3304-9. 2006
  10. pmc Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages
    Holger Karsunky
    Institute of Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, CA, USA
    Blood 111:5562-70. 2008

Research Grants

Detail Information

Publications17

  1. pmc Space-time considerations for hematopoietic stem cell transplantation
    Deepta Bhattacharya
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305 5323, USA
    Eur J Immunol 38:2060-7. 2008
    ..This review will focus on how recent studies using experimental model systems may direct future efforts to implement routine use of HSC transplantation to cure inherited blood disorders...
  2. ncbi Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation
    Deepta Bhattacharya
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 179:6808-19. 2007
    ....
  3. pmc Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning
    Deepta Bhattacharya
    Department of Pathology, Institute of Cancer and Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 203:73-85. 2006
    ..These experiments provide a general mechanism by which transplanted HSCs can correct hematopoietic deficiencies without any host conditioning or with only highly specific and transient lymphoablation...
  4. ncbi Rapid lymphocyte reconstitution of unconditioned immunodeficient mice with non-self-renewing multipotent hematopoietic progenitors
    Deepta Bhattacharya
    Institute of Cancer and Stem Cell Biology and Medicine, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Cell Cycle 5:1135-9. 2006
    ..Based on recent evidence, we discuss novel strategies to achieve the replacement of abnormal HSCs without the use of cytotoxic conditioning regimens...
  5. pmc MiDReG: a method of mining developmentally regulated genes using Boolean implications
    Debashis Sahoo
    Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:5732-7. 2010
    ..These data demonstrate the power of MiDReG in predicting functionally important intermediate genes in a given developmental pathway that is defined by a mutually exclusive gene expression pattern...
  6. pmc Gene Expression Commons: an open platform for absolute gene expression profiling
    Jun Seita
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e40321. 2012
    ....
  7. pmc Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development
    Matthew A Inlay
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 23:2376-81. 2009
    ....
  8. pmc Identification of the earliest natural killer cell-committed progenitor in murine bone marrow
    John W Fathman
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 118:5439-47. 2011
    ..Taken together, our data provide a high-resolution in vivo analysis of the earliest steps of NK cell commitment and maturation...
  9. pmc Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells
    Chance John Luckey
    Joslin Diabetes Center, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:3304-9. 2006
    ..These observations provide evidence that the shared phenotype of self-renewal in the hematopoietic system is linked at the molecular level...
  10. pmc Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages
    Holger Karsunky
    Institute of Stem Cell Biology and Regenerative Medicine, Department of Pathology, Stanford University School of Medicine, CA, USA
    Blood 111:5562-70. 2008
    ..Thus, Flk2 expression defines a homogeneous, readily obtainable subset of bone marrow CLP that is completely lymphoid-committed and can differentiate equivalently well into both B and T lineages...
  11. pmc Niche recycling through division-independent egress of hematopoietic stem cells
    Deepta Bhattacharya
    Institute of Stem Cell Biology and Regenerative Medicine Stanford University School of Medicine Stanford, CA 94305, USA
    J Exp Med 206:2837-50. 2009
    ..These data provide insight as to how HSC replacement can occur despite the residence of endogenous HSCs in niches, and suggest therapeutic interventions that capitalize upon physiological HSC egress...
  12. pmc Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches
    Agnieszka Czechowicz
    Institute of Stem Cell Biology and Regenerative Medicine, Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 318:1296-9. 2007
    ..Subsequent transplantation of these mice with donor HSCs led to chimerism levels of up to 90%. Extrapolation of these methods to humans may enable mild but effective conditioning regimens for transplantation...
  13. ncbi Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging
    Derrick J Rossi
    Department of Pathology, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell Cycle 6:2371-6. 2007
    ..Moreover, the cytoprotection afforded by stem cell quiescence in stress-free, steady-state conditions suggests a mechanism through which potentially dangerous lesions can accumulate in the stem cell pool with age...
  14. doi The biology of allogeneic hematopoietic cell resistance
    Judith A Shizuru
    Stanford University, Stanford, California 94305, USA
    Biol Blood Marrow Transplant 16:S2-7. 2010
    ....
  15. ncbi Hematopoietic stem cells: expression profiling and beyond
    E Camilla Forsberg
    Institute of Cancer and Stem Cell Biology and Medicine, Departments of Pathology and Developmental Biology, Stanford University Medical School, 279 Campus Drive, Stanford, CA 94305, USA
    Stem Cell Rev 2:23-30. 2006
    ....
  16. ncbi Regulation of Ig class switch recombination by NF-kappaB: retroviral expression of RelB in activated B cells inhibits switching to IgG1, but not to IgE
    Deepta Bhattacharya
    Division of Immunology, Cancer Research Laboratory, Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Int Immunol 14:983-91. 2002
    ..Thus, RelB complexes can specifically inhibit CSR to IgG1, but not IgE, in activated, primary B cells...
  17. pmc Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries
    Deepta Bhattacharya
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:8838-43. 2002
    ..These results suggest that CPR is a versatile method that permits functional identification of both wild-type and dominant-negative gene products that regulate cellular responses...

Research Grants2

  1. Functional and Anatomical Characterization of the Hematopoietic Stem Cell Niche
    Deepta Bhattacharya; Fiscal Year: 2007
    ..The goal of this proposal is to better characterize the properties of these niches and to determine how best to utilize these niches for bone marrow transplantation. ..