Research Topics
Genomes and GenesSpecies | G BarshSummaryAffiliation: Stanford University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Linkage and segregation analysis of black and brindle coat color in domestic dogsJulie A Kerns
Department of Genetics, Stanford University, Stanford, California 94035, USA
Genetics 176:1679-89. 2007..These findings suggest a molecular model for a new component of the melanocortin signaling pathway and reveal how coat-color patterns and pigmentary diversity have been shaped by recent selection...- Effects of hypothalamic neurodegeneration on energy balanceAllison Wanting Xu
Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
PLoS Biol 3:e415. 2005..These findings provide new insight into the roles of hypothalamic neurons in energy balance regulation, and provide a model for understanding defects in human energy balance associated with neurodegeneration and aging... - Identification and preliminary characterization of mouse Adam33Teresa M Gunn
Department of Pediatrics, and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA
BMC Genet 3:2. 2002..Human ADAM33 refers to a testis cDNA clone that does not contain a complete open reading frame, but portions of the predicted protein are similar to Xenopus laevis ADAM13... - What controls variation in human skin color?Gregory S Barsh
Department of Genetics, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA
PLoS Biol 1:E27. 2003 
Genetic and biochemical studies of the Agouti-attractin systemGregory S Barsh
Department of Pediatrics, Stanford University School of Medicine, Stanford CA 94305, USA
J Recept Signal Transduct Res 22:63-77. 2002..Expression in neurectodermal cells during vertebrate evolution may have allowed Atrn to be recruited by the Agouti-melanocortin system to control coat color...- The genetics of pigmentation: from fancy genes to complex traitsG S Barsh
Department of Pediatrics, Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305 5428, USA
Trends Genet 12:299-305. 1996..Recent developments show that homologous genes in humans are responsible not only for rare diseases, such as albinism and piebaldism, but also for common phenotypic variations, such as red hair and fair skin... - Biochemical and genetic studies of pigment-type switchingG Barsh
Department of Pediatrics and Genetics, and the HHMI, Stanford University School of Medicine, California 94305, USA
Pigment Cell Res 13:48-53. 2000..Positional cloning has recently identified the gene mutated in mahogany as a single transmembrane-spanning protein whose ectodomain is orthologous to human Attractin (Atrn)... - Molecular pharmacology of Agouti protein in vitro and in vivoG S Barsh
Department of Pediatrics, Stanford University School of Medicine, California, USA
Ann N Y Acad Sci 885:143-52. 1999..Our findings provide evidence of a novel signaling mechanism whereby alpha-MSH and Agouti protein function as independent ligands that inhibit each other's binding and transduce opposite signals through a single receptor... - Dorsoventral patterning of the mouse coat by Tbx15Sophie I Candille
Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
PLoS Biol 2:E3. 2004.... - Genetic approaches to studying energy balance: perception and integrationGregory S Barsh
1] Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305-5208, USA
Nat Rev Genet 3:589-600. 2002 - Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiationCraig S April
Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
PLoS Genet 3:e9. 2007.... - Accessory proteins for melanocortin signaling: attractin and mahoguninLin He
Departments of Pediatrics and Genetics and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
Ann N Y Acad Sci 994:288-98. 2003..Like Attractin, Mahogunin is conserved in invertebrate genomes, and its absence causes a pleiotropic phenotype that includes spongiform neurodegeneration... - PI3K integrates the action of insulin and leptin on hypothalamic neuronsAllison Wanting Xu
Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
J Clin Invest 115:951-8. 2005..These results suggest a new view of hypothalamic circuitry, in which the effects of leptin and insulin are integrated by anorexigenic but not by orexigenic neurons... - Spongiform degeneration in mahoganoid mutant miceLin He
Department of Pediatrics, Department of Genetics, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 299:710-2. 2003..Similarities in phenotype, expression, and genetic interactions suggest that mahoganoid and Atrn genes are part of a conserved pathway for regulated protein turnover whose function is essential for neuronal viability... - Genetics of dark skin in miceKaren R Fitch
Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
Genes Dev 17:214-28. 2003.... 
Melanocyte-lineage expression of Cre recombinase using Mitf regulatory elementsAzita Alizadeh
Departments of Genetics and Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
Pigment Cell Melanoma Res 21:63-9. 2008..Our results confirm that PKA signaling is a key component of pigment type-switching, and provide a new tool for studying pigment cell biology...- Transcriptional regulation of agouti-related protein (Agrp) in transgenic miceChristopher B Kaelin
Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5323, USA
Endocrinology 145:5798-806. 2004..In addition, we demonstrate that this region allows for the stable expression of Cre recombinase in transgenic mice, providing a genetic tool for studying anabolic neural circuits that control energy balance... - Molecular and evolutionary history of melanism in North American gray wolvesTovi M Anderson
Departments of Genetics and Pediatrics, Stanford University, Stanford, CA 94305, USA
Science 323:1339-43. 2009.... - Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acidChristopher B Kaelin
Department of Genetics and Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
Mol Endocrinol 20:2591-602. 2006.... - Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeedingAllison W Xu
Department of Genetics, Stanford University School of Medicine, San Francisco, California 94143, USA
Endocrinology 148:72-80. 2007.... - Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin geneKwon Yul Ryu
Department of Biological Sciences, Bio X Program, and Department of Genetics, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 105:4016-21. 2008..These findings demonstrate that maintenance of adequate supplies of cellular Ub is essential for neuronal survival and establish that decreased Ub availability is sufficient to cause neuronal dysfunction and death... - A -defensin mutation causes black coat color in domestic dogsSophie I Candille
Departments of Genetics and Pediatrics, Stanford University, Stanford, CA, USA
Science 318:1418-23. 2007..These results expand the functional role of beta-defensins, a protein family previously implicated in innate immunity, and identify an additional class of ligands for signaling through melanocortin receptors... - Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd DogsJulie A Kerns
Departments of Genetics and Pediatrics, Stanford University, Stanford, California 94305, USA
Mamm Genome 15:798-808. 2004.... - Immunology: hepatitis A virus link to atopic diseaseJennifer J McIntire
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305-5208, USA
Nature 425:576. 2003 - Genetics of Sex-linked yellow in the Syrian hamsterAzita Alizadeh
Department of Genetics, Stanford University, Stanford, CA 94305, USA
Genetics 181:1427-36. 2009.... - Ribosomal mutations cause p53-mediated dark skin and pleiotropic effectsKelly A McGowan
Department of Genetics, Division of Radiation and CancerBiology, Stanford University, Stanford, California 94305, USA
Nat Genet 40:963-70. 2008.... - Effects of G-protein mutations on skin colorCatherine D Van Raamsdonk
Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5323, USA
Nat Genet 36:961-8. 2004..Our results provide a mechanism that can explain several aspects of human pigmentary variation and show how polymorphism of essential proteins and signaling pathways can affect a single physiologic system... - A mouse keratin 1 mutation causes dark skin and epidermolytic hyperkeratosisKelly A McGowan
Departments of Genetics, Stanford University School of Medicine, Beckman Center B281, Stanford, CA 94305 5323, USA
J Invest Dermatol 126:1013-6. 2006..Dsk12 recapitulates the gross pathologic, histologic, and genetic aspects of the human disorder, EHK... - Inverse agonist activity of agouti and agouti-related proteinBiao Xin Chai
Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109 0682, USA
Peptides 24:603-9. 2003..These data shed new light on the determinants and mechanism of inverse agonism at the MC4R... - Genetic analysis of attractin homologsWill P Walker
Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
Genesis 45:744-56. 2007..Thus, the two genes are redundant from the perspective of gain-of-function but not loss-of-function mutations... - Association of an Agouti allele with fawn or sable coat color in domestic dogsTom G Berryere
Department of Animal and Poultry Science, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5A8
Mamm Genome 16:262-72. 2005..This work resolves some of the complexity in dog coat color genetics and provides diagnostic opportunities and practical guidelines for breeders... - [Attractin]Shi-liang Shen
Zhonghua Bing Li Xue Za Zhi 34:429-31. 2005 - Activation of Stat3 signaling in AgRP neurons promotes locomotor activityAndrea Mesaros
Department of Mouse Genetics and Metabolism, Institute for Genetics, Center of Molecular Medicine Cologne, and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, D 50674 Cologne, Germany
Cell Metab 7:236-48. 2008..These data demonstrate that Stat3-dependent signaling in AgRP neurons in the ARC controls locomotor activity independently of AgRP regulation... - Induction of brain-region-specific forms of obesity by agoutiMartien J H Kas
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, 3584 CG Utrecht, The Netherlands
J Neurosci 24:10176-81. 2004.... - Is the energy homeostasis system inherently biased toward weight gain?Michael W Schwartz
Department of Medicine, University of Washington, Seattle, USA
Diabetes 52:232-8. 2003..Teleological, molecular, physiological, and clinical aspects of this hypothesis are presented, along with a discussion of currently available supporting evidence... - Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intakeXin Yun Lu
University of Michigan School of Medicine, Mental Health Research Institute, Ann Arbor 48109, USA
Endocrinology 143:3905-15. 2002..These results indicate that 1) the diurnal expression of AGRP mRNA is regulated by corticosterone independently of the light/dark cue; and 2) a normal endogenous corticosterone rhythm is required for generating the diurnal AGRP rhythm... - How the dog got its spotsGregory S Barsh
Nat Genet 39:1304-6. 2007 - Loops and links: structural insights into the remarkable function of the agouti-related proteinGlenn L Millhauser
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
Ann N Y Acad Sci 994:27-35. 2003..Based on these design and structure studies, we propose that the N-terminal loop of AGRP(87-132) makes contact with a receptor exoloop and helps confer AGRP's selectivity for the central MCRs... - AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neuronsMarc Claret
Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
J Clin Invest 117:2325-36. 2007.... - Structures of the agouti signaling proteinJoseph C McNulty
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
J Mol Biol 346:1059-70. 2005..The loop containing the heterogeneous Ala-Pro peptide bond is conserved in mammals, and suggests that ASIP is either trapped by evolution in this unusual configuration or possesses function outside of strict MCR antagonism... - Structural and molecular evolutionary analysis of Agouti and Agouti-related proteinsPilgrim J Jackson
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
Chem Biol 13:1297-305. 2006.... - The role of insulin receptor substrate 2 in hypothalamic and beta cell functionAgharul I Choudhury
Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
J Clin Invest 115:940-50. 2005..Our findings demonstrate a critical role for IRS2 in beta cell and hypothalamic function and provide insights into the role of RIPCre neurons, a distinct hypothalamic neuronal population, in growth and energy homeostasis... - Weight loss regulates inflammation-related genes in white adipose tissue of obese subjectsKarine Clement
INSERM Avenir Paris 6 University, EA 3502, Nutrition Department, AP HP, Hotel Dieu, Paris, France
FASEB J 18:1657-69. 2004..The beneficial effect of weight loss on obesity-related complications may be associated with the modification of the inflammatory profile in adipose tissue... - Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight lossRaffaella Cancello
INSERM Avenir, Paris 6 University EA3502 and Human Research Center on Nutrition CRNH, Hotel Dieu Hospital, AP HP, Paris, France
Diabetes 54:2277-86. 2005..We show that improvement of the inflammatory profile after weight loss is related to a reduced number of macrophages in scWAT. MCP-1, PLAUR, CSF-3, and HIF-1alpha may play roles in the attraction of macrophages in scWAT... - Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of alpha-melanocyte-stimulating hormone in human dermal papilla cellsMarkus Bohm
Department of Dermatology, University of Munster, Von Esmarch Str 58, D 48149 Munster, Germany
Endocrinology 146:4635-46. 2005.... - Agouti-related peptide-expressing neurons are mandatory for feedingEva Gropp
Institute for Genetics and Center for Molecular Medicine (CMMC, Department of Mouse Genetics and Metabolism, University of Cologne, , , Germany
Nat Neurosci 8:1289-91. 2005.... - MC4R neurons weigh in differentlyAllison W Xu
Nat Neurosci 9:15-6. 2006 - Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intakeTadahiro Kitamura
Department of Medicine, Columbia University Medical Center, 1150 St Nicholas Avenue, New York, New York 10032, USA
Nat Med 12:534-40. 2006..Thus, FoxO1 represents a shared component of pathways integrating food intake and peripheral metabolism... - Identification of a Keratin 4 mutation in a chemically induced mouse mutant that models white sponge nevusKelly A McGowan
Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5323, USA
J Invest Dermatol 127:60-4. 2007..Bcc1 recapitulates the gross pathologic, histologic, and genetic aspects of the human disorder, WSN... - In vivo epinephrine-mediated regulation of gene expression in human skeletal muscleNathalie Viguerie
Unité de Recherches sur les Obésités, Institut National de la Sante et de la Recherche Medicale INSERM, Unité 586, Institut Louis Bugnard, Centre Hospitalier Universitaire de Toulouse, Universite Paul Sabatier, 31403 Toulouse, France
J Clin Endocrinol Metab 89:2000-14. 2004..They may contribute to the understanding of skeletal muscle alterations observed in pathological conditions characterized by sympathetic nervous system overdrive... - Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestionEsther van de Wall
Departments of Medicine and Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 12461, USA
Endocrinology 149:1773-85. 2008....
Research Grants
- Genetics of Dark Skin in MiceGregory Barsh; Fiscal Year: 2006....
- MEDICAL SCIENTIST TRAINING PROGRAMGregory Barsh; Fiscal Year: 2007..We propose to continue this trend of innovation and interdisciplinary training, in which training grant resources are leveraged, and 9 - 10 individuals are admitted per year for a program length of 7- 8 years. ..
- Attractin and Mahoganoid in Spongy NeurodegenerationGregory Barsh; Fiscal Year: 2007..Investigating the biochemical, cellular, and genetic relationships between Atrn, Mahoganoid, and PrP is likely to provide general insight into the pathogenesis of spongy degeneration. ..
- REGULATION OF ENERGY BALANCE BY MELANOCORTIN ANTAGONISTSGregory Barsh; Fiscal Year: 2003..abstract_text> ..