Jeffrey D Axelrod

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Coupling planar cell polarity signaling to morphogenesis
    Jeffrey D Axelrod
    Department of Pathology, L235, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    ScientificWorldJournal 2:434-54. 2002
  2. pmc Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
    Genes Dev 12:2610-22. 1998
  3. pmc Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling
    J D Axelrod
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Genes Dev 15:1182-7. 2001
  4. pmc Cell packing influences planar cell polarity signaling
    Dali Ma
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 105:18800-5. 2008
  5. ncbi request reprint Fidelity in planar cell polarity signalling
    Dali Ma
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nature 421:543-7. 2003
  6. ncbi request reprint Mathematical modeling of planar cell polarity to understand domineering nonautonomy
    Keith Amonlirdviman
    Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305 4035, USA
    Science 307:423-6. 2005
  7. pmc Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling
    Wei Shen Chen
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Cell 133:1093-105. 2008
  8. pmc Naked cuticle targets dishevelled to antagonize Wnt signal transduction
    R Rousset
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 15:658-71. 2001
  9. ncbi request reprint Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling
    David R P Tree
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, CA 94305, USA
    Cell 109:371-81. 2002
  10. pmc Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis
    Dragana Antic
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 5:e8999. 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Coupling planar cell polarity signaling to morphogenesis
    Jeffrey D Axelrod
    Department of Pathology, L235, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    ScientificWorldJournal 2:434-54. 2002
    ..We then discuss how the vertebrate processes of convergent extension and cochlear hair-cell development may relate to Drosophila PCP signaling...
  2. pmc Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
    Genes Dev 12:2610-22. 1998
    ..The PCP signal may selectively result in focal Fz activation and asymmetric relocalization of Dsh to the membrane, where Dsh effects cytoskeletal reorganization to orient prehair initiation...
  3. pmc Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling
    J D Axelrod
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Genes Dev 15:1182-7. 2001
    ..This transition from symmetric to asymmetric Dsh localization requires Dsh function, and reflects an amplification process that generates a steep intracellular activity gradient necessary to determine PCP...
  4. pmc Cell packing influences planar cell polarity signaling
    Dali Ma
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 105:18800-5. 2008
    ..Hence, in the wild type, broad distribution of the global directional cue combines with a local feedback mechanism to overcome irregularities in cell packing geometry during PCP signaling...
  5. ncbi request reprint Fidelity in planar cell polarity signalling
    Dali Ma
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nature 421:543-7. 2003
    ..Subsequent action of the Frizzled feedback loop is sufficient to align all the cells cooperatively. This economical system is therefore highly robust, and produces virtually error-free arrays...
  6. ncbi request reprint Mathematical modeling of planar cell polarity to understand domineering nonautonomy
    Keith Amonlirdviman
    Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305 4035, USA
    Science 307:423-6. 2005
    ..The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy...
  7. pmc Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling
    Wei Shen Chen
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Cell 133:1093-105. 2008
    ....
  8. pmc Naked cuticle targets dishevelled to antagonize Wnt signal transduction
    R Rousset
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 15:658-71. 2001
    ..Our results suggest that Nkd acts directly through Dsh to limit Wg activity and thus determines how efficiently Wnt signals stabilize Armadillo (Arm)/beta-catenin and activate downstream genes...
  9. ncbi request reprint Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling
    David R P Tree
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, CA 94305, USA
    Cell 109:371-81. 2002
    ..This activity is linked to Frizzled activity on the adjacent cell surface. Prickle therefore functions in a feedback loop that amplifies differences between Frizzled levels on adjacent cell surfaces...
  10. pmc Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis
    Dragana Antic
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 5:e8999. 2010
    ..The observation of anterior-posterior PCP in the mouse and in Xenopus embryonic organizers reflects a strong evolutionary conservation of this mechanism that is important for body plan determination...
  11. ncbi request reprint Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton
    C G Winter
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 105:81-91. 2001
    ..Drosophila myosin VIIA, the homolog of the human Usher Syndrome 1B gene, also functions in conjunction with this newly defined portion of the Fz/Dsh signaling pathway to regulate the actin cytoskeleton...
  12. pmc Regulation of PCP by the Fat signaling pathway
    Maja Matis
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 27:2207-20. 2013
    ..We discuss models for the function of this signaling module as well as several unanswered questions that may guide future investigations. ..
  13. pmc Myb promotes centriole amplification and later steps of the multiciliogenesis program
    Fraser E Tan
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 140:4277-86. 2013
    ....
  14. pmc Planar cell polarity signaling: the developing cell's compass
    Eszter K Vladar
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Cold Spring Harb Perspect Biol 1:a002964. 2009
    ..In this review, we discuss apparent similarities and differences in the mechanism that controls PCP as it has been adapted to a broad variety of morphological cellular asymmetries in various organisms...
  15. ncbi request reprint Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye
    Chung Hui Yang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 108:675-88. 2002
    ....
  16. ncbi request reprint Interaction between Wingless and Notch signaling pathways mediated by dishevelled
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 271:1826-32. 1996
    ..It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways...
  17. pmc Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning
    Stephane Vincent
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Development 135:2767-75. 2008
    ..The combination of independent progression of cell identity and arrest of progression by signals facilitates accurate patterning of an extremely plastic developing epidermis...
  18. ncbi request reprint A three-tiered mechanism for regulation of planar cell polarity
    David R P Tree
    Department of Pathology, L235, Stanford University School of Medicine, Stanford, CA 94305, USA
    Semin Cell Dev Biol 13:217-24. 2002
    ..The third modules are tissue specific, acting to translate subcellular asymmetry into the appropriate morphological manifestations in the different cell types...
  19. doi request reprint Pointing in the right direction: new developments in the field of planar cell polarity
    Roy Bayly
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Nat Rev Genet 12:385-91. 2011
    ..However, despite this progress, the search to simplify principles of understanding continues and important mechanistic uncertainties still pose formidable challenges...
  20. pmc Microtubules enable the planar cell polarity of airway cilia
    Eszter K Vladar
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Curr Biol 22:2203-12. 2012
    ..Airway cilia must be physically oriented along the longitudinal tissue axis for concerted, directional motility that is essential for proper mucociliary clearance...
  21. pmc A universal analysis tool for the detection of asymmetric signal distribution in microscopic images
    Maja Matis
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Dev Dyn 241:1301-9. 2012
    ..However, existing quantitative assays to measure this asymmetry in an automated and unbiased manner suffer from significant limitations...
  22. doi request reprint Dishevelled links basal body docking and orientation in ciliated epithelial cells
    Eszter K Vladar
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Trends Cell Biol 18:517-20. 2008
    ....
  23. doi request reprint Progress and challenges in understanding planar cell polarity signaling
    Jeffrey D Axelrod
    Department of Pathology, Stanford University School of Medicine, Room R226a, 300 Pasteur Drive, Stanford, CA 94305, USA
    Semin Cell Dev Biol 20:964-71. 2009
    ..Future studies that shed light on these areas will substantially enhance our understanding of the fascinating yet challenging problem of understanding the mechanisms that generate PCP...
  24. doi request reprint Modeling the control of planar cell polarity
    Jeffrey D Axelrod
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Wiley Interdiscip Rev Syst Biol Med 3:588-605. 2011
    ..Mathematical models at varying levels of inhibition have and are expected to continue contributing in distinct ways to understanding the regulation of PCP signaling...
  25. ncbi request reprint Biology by numbers: mathematical modelling in developmental biology
    Claire J Tomlin
    Department of Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, California 94720, USA
    Nat Rev Genet 8:331-40. 2007
    ..By examining three developmental processes and corresponding mathematical models, this Review addresses the potential of mathematical modelling to help understand development...
  26. doi request reprint Delivering the lateral inhibition punchline: it's all about the timing
    Jeffrey D Axelrod
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Sci Signal 3:pe38. 2010
    ....
  27. ncbi request reprint Cell shape in proliferating epithelia: a multifaceted problem
    Jeffrey D Axelrod
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    Cell 126:643-5. 2006
    ..al., 2006). This pattern is conserved in epithelia from diverse species, suggesting that this distribution is a fundamental property of proliferating epithelial sheets...
  28. pmc Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways
    Vinicio A de Jesus Perez
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 184:83-99. 2009
    ..These findings suggest that the recruitment of both canonical and noncanonical Wnt pathways is required in BMP-2-mediated angiogenesis...
  29. ncbi request reprint Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear
    Michael R Deans
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 27:3139-47. 2007
    ....
  30. doi request reprint Remodeling a tissue: subtraction adds insight
    Jeffrey D Axelrod
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Sci Signal 5:pe52. 2012
    ....
  31. pmc Understanding biology by reverse engineering the control
    Claire J Tomlin
    Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305 4035, USA
    Proc Natl Acad Sci U S A 102:4219-20. 2005
  32. ncbi request reprint A WNTer wonderland in Snowbird
    Xi He
    Neurobiology Program, Children s Hospital and Harvard Medical School, Boston, MA 02115 5724, USA
    Development 133:2597-603. 2006
    ....
  33. ncbi request reprint Strabismus comes into focus
    Jeffrey D Axelrod
    Nat Cell Biol 4:E6-8. 2002
  34. ncbi request reprint A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
    Michael T Veeman
    Howard Hughes Medical Institute, Department of Pharmacology, Center for Developmental Biology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Dev Cell 5:367-77. 2003
    ....
  35. ncbi request reprint D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways
    Abraham Kovoor
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 25:2157-65. 2005
    ..Thus, alterations in RGS9-2 may be a key factor in the pathway leading from D2DRs to the side effects associated with the treatment both of psychoses and Parkinson's disease...
  36. ncbi request reprint Basal bodies, kinocilia and planar cell polarity
    Jeffrey D Axelrod
    Nat Genet 40:10-1. 2008