Research Topics
Genomes and Genes | Jeffrey D AxelrodSummaryAffiliation: Stanford University Country: USA Publications
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Publications
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathwaysJ D Axelrod
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
Genes Dev 12:2610-22. 1998..The PCP signal may selectively result in focal Fz activation and asymmetric relocalization of Dsh to the membrane, where Dsh effects cytoskeletal reorganization to orient prehair initiation...
Coupling planar cell polarity signaling to morphogenesisJeffrey D Axelrod
Department of Pathology, L235, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
ScientificWorldJournal 2:434-54. 2002..We then discuss how the vertebrate processes of convergent extension and cochlear hair-cell development may relate to Drosophila PCP signaling...- Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signalingJ D Axelrod
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
Genes Dev 15:1182-7. 2001..This transition from symmetric to asymmetric Dsh localization requires Dsh function, and reflects an amplification process that generates a steep intracellular activity gradient necessary to determine PCP... - Cell packing influences planar cell polarity signalingDali Ma
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
Proc Natl Acad Sci U S A 105:18800-5. 2008..Hence, in the wild type, broad distribution of the global directional cue combines with a local feedback mechanism to overcome irregularities in cell packing geometry during PCP signaling... - Fidelity in planar cell polarity signallingDali Ma
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
Nature 421:543-7. 2003..Subsequent action of the Frizzled feedback loop is sufficient to align all the cells cooperatively. This economical system is therefore highly robust, and produces virtually error-free arrays... - Mathematical modeling of planar cell polarity to understand domineering nonautonomyKeith Amonlirdviman
Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305 4035, USA
Science 307:423-6. 2005..The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy... - Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signalingWei Shen Chen
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Cell 133:1093-105. 2008.... - Naked cuticle targets dishevelled to antagonize Wnt signal transductionR Rousset
Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305, USA
Genes Dev 15:658-71. 2001..Our results suggest that Nkd acts directly through Dsh to limit Wg activity and thus determines how efficiently Wnt signals stabilize Armadillo (Arm)/beta-catenin and activate downstream genes... - Prickle mediates feedback amplification to generate asymmetric planar cell polarity signalingDavid R P Tree
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, CA 94305, USA
Cell 109:371-81. 2002..This activity is linked to Frizzled activity on the adjacent cell surface. Prickle therefore functions in a feedback loop that amplifies differences between Frizzled levels on adjacent cell surfaces... - Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesisDragana Antic
Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
PLoS ONE 5:e8999. 2010..The observation of anterior-posterior PCP in the mouse and in Xenopus embryonic organizers reflects a strong evolutionary conservation of this mechanism that is important for body plan determination... - Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeletonC G Winter
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 105:81-91. 2001..Drosophila myosin VIIA, the homolog of the human Usher Syndrome 1B gene, also functions in conjunction with this newly defined portion of the Fz/Dsh signaling pathway to regulate the actin cytoskeleton... - Planar cell polarity signaling: the developing cell's compassEszter K Vladar
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
Cold Spring Harb Perspect Biol 1:a002964. 2009..In this review, we discuss apparent similarities and differences in the mechanism that controls PCP as it has been adapted to a broad variety of morphological cellular asymmetries in various organisms... - Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eyeChung Hui Yang
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 108:675-88. 2002.... - Interaction between Wingless and Notch signaling pathways mediated by dishevelledJ D Axelrod
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Science 271:1826-32. 1996..It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways... - Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterningStephane Vincent
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Development 135:2767-75. 2008..The combination of independent progression of cell identity and arrest of progression by signals facilitates accurate patterning of an extremely plastic developing epidermis... - A three-tiered mechanism for regulation of planar cell polarityDavid R P Tree
Department of Pathology, L235, Stanford University School of Medicine, Stanford, CA 94305, USA
Semin Cell Dev Biol 13:217-24. 2002..The third modules are tissue specific, acting to translate subcellular asymmetry into the appropriate morphological manifestations in the different cell types... 
Pointing in the right direction: new developments in the field of planar cell polarityRoy Bayly
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Nat Rev Genet 12:385-91. 2011..However, despite this progress, the search to simplify principles of understanding continues and important mechanistic uncertainties still pose formidable challenges...- A universal analysis tool for the detection of asymmetric signal distribution in microscopic imagesMaja Matis
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
Dev Dyn 241:1301-9. 2012..However, existing quantitative assays to measure this asymmetry in an automated and unbiased manner suffer from significant limitations... - Progress and challenges in understanding planar cell polarity signalingJeffrey D Axelrod
Department of Pathology, Stanford University School of Medicine, Room R226a, 300 Pasteur Drive, Stanford, CA 94305, USA
Semin Cell Dev Biol 20:964-71. 2009..Future studies that shed light on these areas will substantially enhance our understanding of the fascinating yet challenging problem of understanding the mechanisms that generate PCP... - Modeling the control of planar cell polarityJeffrey D Axelrod
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
Wiley Interdiscip Rev Syst Biol Med 3:588-605. 2011..Mathematical models at varying levels of inhibition have and are expected to continue contributing in distinct ways to understanding the regulation of PCP signaling... - Dishevelled links basal body docking and orientation in ciliated epithelial cellsEszter K Vladar
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
Trends Cell Biol 18:517-20. 2008.... - Biology by numbers: mathematical modelling in developmental biologyClaire J Tomlin
Department of Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, California 94720, USA
Nat Rev Genet 8:331-40. 2007..By examining three developmental processes and corresponding mathematical models, this Review addresses the potential of mathematical modelling to help understand development... - Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathwaysVinicio A de Jesus Perez
Department of Medicine, Stanford University, Stanford, CA 94305, USA
J Cell Biol 184:83-99. 2009..These findings suggest that the recruitment of both canonical and noncanonical Wnt pathways is required in BMP-2-mediated angiogenesis... - Delivering the lateral inhibition punchline: it's all about the timingJeffrey D Axelrod
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Sci Signal 3:pe38. 2010.... - Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner earMichael R Deans
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 27:3139-47. 2007.... - Cell shape in proliferating epithelia: a multifaceted problemJeffrey D Axelrod
Department of Pathology, Stanford University School of Medicine, CA 94305, USA
Cell 126:643-5. 2006..al., 2006). This pattern is conserved in epithelia from diverse species, suggesting that this distribution is a fundamental property of proliferating epithelial sheets... - Microtubules enable the planar cell polarity of airway ciliaEszter K Vladar
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Curr Biol 22:2203-12. 2012..Airway cilia must be physically oriented along the longitudinal tissue axis for concerted, directional motility that is essential for proper mucociliary clearance... - A WNTer wonderland in SnowbirdXi He
Neurobiology Program, Children s Hospital and Harvard Medical School, Boston, MA 02115 5724, USA
Development 133:2597-603. 2006.... - Understanding biology by reverse engineering the controlClaire J Tomlin
Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305-4035, USA
Proc Natl Acad Sci U S A 102:4219-20. 2005 - A second canon. Functions and mechanisms of beta-catenin-independent Wnt signalingMichael T Veeman
Howard Hughes Medical Institute, Department of Pharmacology, Center for Developmental Biology, University of Washington School of Medicine, Seattle, WA 98195, USA
Dev Cell 5:367-77. 2003.... - Strabismus comes into focusJeffrey D Axelrod
Nat Cell Biol 4:E6-8. 2002 - Basal bodies, kinocilia and planar cell polarityJeffrey D Axelrod
Nat Genet 40:10-1. 2008 - D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathwaysAbraham Kovoor
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 25:2157-65. 2005..Thus, alterations in RGS9-2 may be a key factor in the pathway leading from D2DRs to the side effects associated with the treatment both of psychoses and Parkinson's disease...