Euan Ashley

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Preoperative cardiac evaluation: mechanisms, assessment, and reduction of risk
    Euan A Ashley
    Division of Cardiology, Stanford University School of Medicine, Falk CVRB, 300 Pasteur Drive, Stanford, CA 94305, USA
    Thorac Surg Clin 15:263-75. 2005
  2. ncbi request reprint Network analysis of human in-stent restenosis
    Euan A Ashley
    Division of Cardiovascular Medicine, Falk CVRC, Stanford University, Stanford, Calif 94305, USA
    Circulation 114:2644-54. 2006
  3. ncbi request reprint Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise
    Euan A Ashley
    Division of Cardiology, Stanford University, Stanford, California 94305, USA
    J Am Coll Cardiol 48:523-31. 2006
  4. pmc Clinical assessment incorporating a personal genome
    Euan A Ashley
    Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Lancet 375:1525-35. 2010
  5. pmc The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo
    Euan A Ashley
    Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Stanford University, Stanford, CA 94305, USA
    Cardiovasc Res 65:73-82. 2005
  6. doi request reprint Validation of a cardiopulmonary exercise test score in heart failure
    Jonathan Myers
    Division of Cardiology, VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA
    Circ Heart Fail 6:211-8. 2013
  7. pmc Prognostic implications of Q waves and T-wave inversion associated with early repolarization
    Abhimanyu Uberoi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mayo Clin Proc 87:614-9. 2012
  8. ncbi request reprint Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction
    Mary M Chen
    Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Falk CVRC, Stanford University, 300 Pasteur Dr, Stanford, Calif 94305, USA
    Circulation 108:1432-9. 2003
  9. ncbi request reprint Exercise testing scores as an example of better decisions through science
    Euan Ashley
    Cardiology Division 111C, Veterans Affairs Palo Alto Health Care System, Stanford University, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Med Sci Sports Exerc 34:1391-8. 2002
  10. ncbi request reprint Ventilatory power: a novel index that enhances prognostic assessment of patients with heart failure
    Daniel E Forman
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circ Heart Fail 5:621-6. 2012

Detail Information

Publications52

  1. ncbi request reprint Preoperative cardiac evaluation: mechanisms, assessment, and reduction of risk
    Euan A Ashley
    Division of Cardiology, Stanford University School of Medicine, Falk CVRB, 300 Pasteur Drive, Stanford, CA 94305, USA
    Thorac Surg Clin 15:263-75. 2005
    ....
  2. ncbi request reprint Network analysis of human in-stent restenosis
    Euan A Ashley
    Division of Cardiovascular Medicine, Falk CVRC, Stanford University, Stanford, Calif 94305, USA
    Circulation 114:2644-54. 2006
    ..We analyzed human coronary atheroma in de novo and restenotic disease to identify targets of therapy that might avoid these limitations...
  3. ncbi request reprint Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise
    Euan A Ashley
    Division of Cardiology, Stanford University, Stanford, California 94305, USA
    J Am Coll Cardiol 48:523-31. 2006
    ..The purpose of this study was to investigate the phenomenon of left ventricular (LV) dysfunction after ultraendurance exercise...
  4. pmc Clinical assessment incorporating a personal genome
    Euan A Ashley
    Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Lancet 375:1525-35. 2010
    ..The cost of genomic information has fallen steeply, but the clinical translation of genetic risk estimates remains unclear. We aimed to undertake an integrated analysis of a complete human genome in a clinical context...
  5. pmc The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo
    Euan A Ashley
    Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Stanford University, Stanford, CA 94305, USA
    Cardiovasc Res 65:73-82. 2005
    ..The endogenous peptide apelin is differentially regulated in cardiovascular disease but the nature of its role in cardiac function remains unclear...
  6. doi request reprint Validation of a cardiopulmonary exercise test score in heart failure
    Jonathan Myers
    Division of Cardiology, VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA
    Circ Heart Fail 6:211-8. 2013
    ..We recently developed a CPX score that integrated the additive prognostic information from CPX. The purpose of this study was to validate the score in a larger, independent sample of patients...
  7. pmc Prognostic implications of Q waves and T-wave inversion associated with early repolarization
    Abhimanyu Uberoi
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mayo Clin Proc 87:614-9. 2012
    ..To evaluate the prevalence of early polarization (ER) in a stable population and to evaluate the prognostic significance of the association or absence of Q waves or T-wave inversion (TWI)...
  8. ncbi request reprint Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction
    Mary M Chen
    Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Falk CVRC, Stanford University, 300 Pasteur Dr, Stanford, Calif 94305, USA
    Circulation 108:1432-9. 2003
    ..Apelin is among the most potent stimulators of cardiac contractility known. However, no physiological or pathological role for apelin-angiotensin receptor-like 1 (APJ) signaling has ever been described...
  9. ncbi request reprint Exercise testing scores as an example of better decisions through science
    Euan Ashley
    Cardiology Division 111C, Veterans Affairs Palo Alto Health Care System, Stanford University, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Med Sci Sports Exerc 34:1391-8. 2002
    ..Since general practitioners function as gatekeepers and decide which patients must be referred to the cardiologist, they need to optimally use the basic tools they have available (i.e., history, physical exam, and the exercise test)...
  10. ncbi request reprint Ventilatory power: a novel index that enhances prognostic assessment of patients with heart failure
    Daniel E Forman
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circ Heart Fail 5:621-6. 2012
    ....
  11. pmc Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse
    Yoko Kojima
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Cardiovasc Res 87:156-65. 2010
    ..To investigate apelin-APJ (angiotensin receptor-like 1) signalling in vascular remodelling, we have examined the pathophysiological response to carotid ligation in apelin knockout mice...
  12. pmc Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation
    Nicholas J Leeper
    Division of Cardiovascular Medicine, Department of Medicine, Stanford Univ, 300 Pasteur Dr, Stanford, California 94305, USA
    Am J Physiol Heart Circ Physiol 296:H1329-35. 2009
    ..The mechanism appears to be decreased macrophage burden, perhaps related to an apelin-mediated decrease in proinflammatory cytokine and chemokine activation...
  13. doi request reprint Early repolarization in an ambulatory clinical population
    Abhimanyu Uberoi
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA, USA
    Circulation 124:2208-14. 2011
    ..The significance of early repolarization, particularly regarding the morphology of the R-wave downslope, has come under question...
  14. doi request reprint The prognostic value of early repolarization with ST-segment elevation in African Americans
    MARCO V PEREZ
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5233, USA
    Heart Rhythm 9:558-65. 2012
    ..The prognostic value of this pattern in different ethnicities remains controversial...
  15. pmc Endogenous regulation of cardiovascular function by apelin-APJ
    David N Charo
    Department of Medicine Cardiovascular Medicine, Stanford University, Stanford, CA 94305, USA
    Am J Physiol Heart Circ Physiol 297:H1904-13. 2009
    ..Finally, differences in the developmental phenotype between apelin and APJ null mice suggest the possibility of undiscovered APJ ligands or ligand-independent effects of APJ...
  16. doi request reprint Drug discovery in a multidimensional world: systems, patterns, and networks
    Joel T Dudley
    Program in Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA
    J Cardiovasc Transl Res 3:438-47. 2010
    ..When available, specific applications to cardiovascular drug discovery are highlighted and discussed...
  17. doi request reprint New insights for the diagnosis and management of right ventricular failure, from molecular imaging to targeted right ventricular therapy
    Francois Haddad
    Division of Cardiovascular Medicine, Stanford School of Medicine, Palo Alto, California 94305, USA
    Curr Opin Cardiol 25:131-40. 2010
    ..Here, we review new insights on the pathophysiology, assessment and management of right ventricular failure...
  18. doi request reprint Ventricular arrhythmias during clinical treadmill testing and prognosis
    Frederick E Dewey
    Stanford University Medical School, Palo Alto, California, USA
    Arch Intern Med 168:225-34. 2008
    ..Therefore, we aimed to evaluate the clinical correlates and prognostic significance of exercise-associated premature ventricular complexes (PVCs) during and after exercise testing...
  19. ncbi request reprint Prognostic value of heart rate increase at onset of exercise testing
    Nicholas J Leeper
    Stanford University Medical Center, Stanford University Medical School, Calif, USA
    Circulation 115:468-74. 2007
    ..Our aim was to evaluate the prognostic value of early heart rate parameters in patients referred for routine clinical treadmill testing...
  20. doi request reprint Electrocardiographic predictors of atrial fibrillation
    MARCO V PEREZ
    Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Am Heart J 158:622-8. 2009
    ..Noninvasive predictors of AF may help identify patients at risk of developing AF. Our objective was to identify the electrocardiographic characteristics associated with onset of AF...
  21. pmc Low-dose growth hormone is cardioprotective in uremia
    Ralph Rabkin
    Department of Medicine, Stanford University and Research Service, Veterans Administration Health Care System, Palo Alto, California 94304, USA
    J Am Soc Nephrol 19:1774-83. 2008
    ..In contrast, high-dosage GH worsened several of these variables. These results suggest that low-dosage GH may benefit the heart and possibly the carotid arteries in chronic renal failure...
  22. ncbi request reprint Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse
    Patrick Yue
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5406, USA
    Am J Physiol Heart Circ Physiol 292:H2106-18. 2007
    ..In summary, as assessed by CMR, db/db mice develop characteristic structural and functional changes consistent with cardiomyopathy...
  23. pmc Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
    Hyung J Chun
    Department of Medicine and Department of Anesthesiology, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 118:3343-54. 2008
    ..Taken together, these findings indicate that apelin signaling can block Ang II actions in vascular disease by increasing NO production and inhibiting Ang II cellular signaling...
  24. ncbi request reprint Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary disease
    Raymond Tabibiazar
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiovascular Medicine, Stanford, CA, USA
    Physiol Genomics 22:213-26. 2005
    ....
  25. ncbi request reprint Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease
    Raymond Tabibiazar
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Arterioscler Thromb Vasc Biol 25:302-8. 2005
    ..In this study, we sought to identify the genetic pathways that are differentially activated in the aortas of these mice...
  26. doi request reprint The concept of ventricular reserve in heart failure and pulmonary hypertension: an old metric that brings us one step closer in our quest for prediction
    Francois Haddad
    Stanford University School of Medicine, Falk Cardiovascular Research Center, Palo Alto, California, USA
    Curr Opin Cardiol 26:123-31. 2011
    ..Ventricular reserve is the term used to describe the extent of increase or change in ventricular function that occurs during exercise or pharmacological stress (typically with dobutamine)...
  27. doi request reprint Statin use and ventricular arrhythmias during clinical treadmill testing
    Frederick E Dewey
    Department of Internal Medicine, Stanford University, Palo Alto, California, USA
    J Cardiovasc Electrophysiol 20:193-9. 2009
    ..Statin use reduces the incidence of resting ventricular arrhythmias in patients with coronary artery disease; however, the relationship between statin use and exercise-induced ventricular arrhythmias has not been investigated...
  28. doi request reprint Patterns and prognosis of all components of the J-wave pattern in multiethnic athletes and ambulatory patients
    David Muramoto
    Department of Medicine, Stanford University Medical Center, Stanford, CA
    Am Heart J 167:259-66. 2014
    ..We aim to assess the prevalence, patterns, and prognosis of the J-wave pattern among both stable clinical and athlete populations...
  29. doi request reprint Insights into human beta-cardiac myosin function from single molecule and single cell studies
    Sivaraj Sivaramakrishnan
    Department of Biochemistry, Stanford University, Stanford, CA, USA
    J Cardiovasc Transl Res 2:426-40. 2009
    ..Finally, we examine the technical challenges specific to studying beta-cardiac myosin function both using single molecule and single cell approaches...
  30. doi request reprint The impact of ST elevation on athletic screening
    Troy Leo
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Clin J Sport Med 21:433-40. 2011
    ..To demonstrate the prevalence and patterns of ST elevation (STE) in ambulatory individuals and athletes and compare the clinical outcomes...
  31. ncbi request reprint Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease
    Mark A Hlatky
    Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Am Heart J 154:1043-51. 2007
    ..The aim of this study was to assess systematic differences between patients with acute myocardial infarction (MI) and patients with stable angina in matrix metalloproteinase (MMP) circulating levels and genetic polymorphisms...
  32. ncbi request reprint Better decisions through science: exercise testing scores
    Victor Froelicher
    Cardiology Division, Veterans Affairs Palo Alto Health Care System, Stanford University, Palo Alto, CA 94304, USA
    Prog Cardiovasc Dis 44:395-414. 2002
    ..Assessment of the clinical and exercise test data and application of the newer scores can empower the clinician to assure the cardiac patient access to appropriate and cost-effective cardiologic care...
  33. ncbi request reprint Pathway analysis of coronary atherosclerosis
    Jennifer Y King
    Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University, Stanford, California 94305, USA
    Physiol Genomics 23:103-18. 2005
    ....
  34. doi request reprint Age and double product (systolic blood pressure x heart rate) reserve-adjusted modification of the Duke Treadmill Score nomogram in men
    Amir H Sadrzadeh Rafie
    Stanford University School Medicine, Stanford, CA, USA
    Am J Cardiol 102:1407-12. 2008
    ..In conclusion, we propose an age and DP reserve-adjusted DTS nomogram that improves the prognostic estimates of average annual CVD over the DTS alone...
  35. ncbi request reprint Transcriptional profiling of in vitro smooth muscle cell differentiation identifies specific patterns of gene and pathway activation
    Joshua M Spin
    Donald W Reynolds Cardiovascular Clinical Research Center, Stanford University School of Medicine, Stanford, California 94305, USA
    Physiol Genomics 19:292-302. 2004
    ..In addition to confirming the utility of the A404 model, our data provide a large-scale perspective of gene regulation during SMC differentiation...
  36. pmc Apelin enhances directed cardiac differentiation of mouse and human embryonic stem cells
    I Ning E Wang
    Division of Cardiovascular Medicine, Department of Medicine, School of Medicine, Stanford University, Stanford, California, United States of America
    PLoS ONE 7:e38328. 2012
    ..In conclusion, we have demonstrated that the treatment of apelin enhanced cardiac differentiation of mouse and human ESCs and exhibited synergistic effects with mesodermal differentiation factors...
  37. doi request reprint Progressive Dyspnea After CABG: Complication of Retained Epicardial Pacing Wires
    George S Horng
    Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, Stanford, California 94305, USA
    Ann Thorac Surg 86:1352-4. 2008
    ..Removal of the wires by open thoracotomy resulted in significant improvement in dyspnea and near complete resolution of the bronchiectasis and consolidation...
  38. doi request reprint A new era in clinical genetic testing for hypertrophic cardiomyopathy
    Matthew Wheeler
    The Stanford Center for Inherited Cardiovascular Disease, Stanford School of Medicine, Falk CVRB, Stanford, CA 94305, USA
    J Cardiovasc Transl Res 2:381-91. 2009
    ..In summary, our future will be characterized not by lack of genetic information but by our ability to effectively parse it...
  39. doi request reprint Does size matter? Clinical applications of scaling cardiac size and function for body size
    Frederick E Dewey
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Circulation 117:2279-87. 2008
    ..Lack of appropriate consideration of body size in the evaluation of cardiovascular structure and function may adversely affect recognition and treatment of cardiovascular disease states in the adult patient...
  40. ncbi request reprint Perioperative cardiac risk: pathophysiology, assessment and management
    Ramachandra R Sista
    Stanford University, Division of Pulmonary and Critical Care Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Expert Rev Cardiovasc Ther 4:731-43. 2006
    ....
  41. doi request reprint Physical activity and other health behaviors in adults with hypertrophic cardiomyopathy
    Elizabeth Reineck
    Department of Internal Medicine, Division of Cardiovascular Medicine, Penn State University School of Medicine, Hershey, PA, USA
    Am J Cardiol 111:1034-9. 2013
    ..More data are needed on exercise in those with HC to strike a balance between acute risks and the long-term health benefits of exercise...
  42. ncbi request reprint Electrocardiographic arrhythmia risk testing
    Gregory Engel
    Stanford University, Stanford, CA, USA
    Curr Probl Cardiol 29:365-432. 2004
    ..It is likely that a combination of risk evaluation techniques will have the greatest predictive power in enabling identification of patients most likely to benefit from device therapy...
  43. doi request reprint Addition of the electrocardiogram to the preparticipation examination of college athletes
    Vy Van Le
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94304, USA
    Clin J Sport Med 20:98-105. 2010
    ..Because the impact of ECG screening on college athletes has rarely been reported, we analyzed the findings of adding the ECG to the PPE of Stanford athletes...
  44. doi request reprint Mechanisms of exercise intolerance in patients with hypertrophic cardiomyopathy
    Vy Van Le
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am Heart J 158:e27-34. 2009
    ..To determine the relation between echocardiogram findings and exercise capacity in hypertrophic cardiomyopathy (HCM)...
  45. ncbi request reprint Frontiers in nephrology: genomic approaches to understanding the molecular basis of atherosclerosis
    Euan A Ashley
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    J Am Soc Nephrol 18:2853-62. 2007
    ..In this comparison of these differing approaches, the available data are synthesized to reach a new understanding of the complex interplay between vascular wall and immune system components...
  46. ncbi request reprint Emerging therapies for the management of decompensated heart failure: from bench to bedside
    Emil M deGoma
    Stanford University, Stanford, California 94305, USA
    J Am Coll Cardiol 48:2397-409. 2006
    ..These advances allow optimism not only for the advancement of our understanding and management of decompensated heart failure syndromes but for the translational research effort in heart failure biology in general...
  47. pmc Cost-effectiveness of preparticipation screening for prevention of sudden cardiac death in young athletes
    Matthew T Wheeler
    Stanford University, California 94305, USA
    Ann Intern Med 152:276-86. 2010
    ..Inclusion of 12-lead electrocardiography (ECG) in preparticipation screening of young athletes is controversial because of concerns about cost-effectiveness...
  48. ncbi request reprint Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling
    Claire E Sears
    Department of Cardiovascular Medicine, Oxford University, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Circ Res 92:e52-9. 2003
    ..The full text of this article is available at http://www.circresaha.org...
  49. ncbi request reprint Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes
    Euan A Ashley
    University Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
    Circulation 105:3011-6. 2002
    ..Here, we investigated the role of a type 1 NO synthase isoform (NOS1), which has been recently localized to the cardiac sarcoplasmic reticulum, in the regulation of basal and beta-adrenergic myocardial contraction...
  50. pmc Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component?
    Claire E Sears
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Philos Trans R Soc Lond B Biol Sci 359:1021-44. 2004
    ..Whether or not the role of nNOS carries implications for cardiovascular disease remains an intriguing possibility requiring future study...
  51. ncbi request reprint Diagnosing coronary artery disease in diabetic patients
    Euan A Ashley
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Diabetes Metab Res Rev 18:201-8. 2002
    ..Other diagnostic tools are considered, and recommendations are made with respect to screening asymptomatic diabetic patients for coronary artery disease...
  52. ncbi request reprint Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure
    Kwok Shiong Chong
    Glasgow Royal Infirmary, Scottish Cardiopulmonary Transplant Unit, 10 Alexandra Parade, G31 2ER Glasgow, Scotland, United Kingdom
    Eur J Heart Fail 8:355-60. 2006
    ..Our aim was to evaluate plasma apelin concentrations in a large cohort of patients with chronic heart failure (CHF) across a broad spectrum of disease severity...

Research Grants3

  1. Integrative Cardiovascular Biology of Apelin-APJ
    Euan Ashley; Fiscal Year: 2007
    ..The experiments described herein will provide a sound mechanistic basis for the future translation of this body of work to the clinical domain. (End of Abstract) ..
  2. Nanoscale approaches to allelic silencing in myocardial disease states
    Euan Ashley; Fiscal Year: 2009
    ..This familial condition where the heart grows too thick is the most common cause of sudden death in young people and athletes. ..